Peter Vandenabeele

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint Necrotic cell death and 'necrostatins': now we can control cellular explosion
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Trends Biochem Sci 33:352-5. 2008
  2. pmc Protein synthesis persists during necrotic cell death
    Xavier Saelens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB and Ghent University, B9052 Ghent, Belgium
    J Cell Biol 168:545-51. 2005
  3. pmc Caspase-14 reveals its secrets
    Geertrui Denecker
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, 9052 Ghent, Belgium
    J Cell Biol 180:451-8. 2008
  4. pmc Caspases leave the beaten track: caspase-mediated activation of NF-kappaB
    Mohamed Lamkanfi
    Unit of Molecular Signaling and Cell Death, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, VIB, Ghent University, B 9052 Ghent, Belgium
    J Cell Biol 173:165-71. 2006
  5. pmc Caspase deficiency alters the murine gut microbiome
    B M Brinkman
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cell Death Dis 2:e220. 2011
  6. pmc Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
    N Takahashi
    Department for Molecular Biomedical Research, VIB, Ghent University, Ghent, Belgium
    Cell Death Dis 3:e437. 2012
  7. pmc Many faces of DAMPs in cancer therapy
    O Krysko
    The Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, UZ Gent, MRB, Ghent, Belgium
    Cell Death Dis 4:e631. 2013
  8. ncbi request reprint Caspase inhibitors promote alternative cell death pathways
    Peter Vandenabeele
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology VIB, Ghent, Belgium
    Sci STKE 2006:pe44. 2006
  9. doi request reprint The role of the kinases RIP1 and RIP3 in TNF-induced necrosis
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Zwijnaarde, Belgium
    Sci Signal 3:re4. 2010
  10. ncbi request reprint Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD
    Tom Vanden Berghe
    Molecular Signalling and Cell Death Unit, Department of Molecular Biomedical Research, the Flanders Interuniversity Institute for Biotechnology VIB and Gent University, Technologiepark 927, B 9052 Zwijnaarde, Belgium
    J Biol Chem 279:7925-33. 2004

Detail Information

Publications117 found, 100 shown here

  1. doi request reprint Necrotic cell death and 'necrostatins': now we can control cellular explosion
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Trends Biochem Sci 33:352-5. 2008
    ..In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models...
  2. pmc Protein synthesis persists during necrotic cell death
    Xavier Saelens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB and Ghent University, B9052 Ghent, Belgium
    J Cell Biol 168:545-51. 2005
    ..Collectively, these results show that, in contrast to apoptotic cells, necrotic dying cells retain the opportunity to synthesize proteins...
  3. pmc Caspase-14 reveals its secrets
    Geertrui Denecker
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, 9052 Ghent, Belgium
    J Cell Biol 180:451-8. 2008
    ..Here, we review the current knowledge on caspase-14 in skin homeostasis and disease...
  4. pmc Caspases leave the beaten track: caspase-mediated activation of NF-kappaB
    Mohamed Lamkanfi
    Unit of Molecular Signaling and Cell Death, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, VIB, Ghent University, B 9052 Ghent, Belgium
    J Cell Biol 173:165-71. 2006
    ..Two different mechanisms by which caspases activate the NF-kappaB pathway are discussed...
  5. pmc Caspase deficiency alters the murine gut microbiome
    B M Brinkman
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cell Death Dis 2:e220. 2011
    ..Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora...
  6. pmc Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
    N Takahashi
    Department for Molecular Biomedical Research, VIB, Ghent University, Ghent, Belgium
    Cell Death Dis 3:e437. 2012
    ..Importantly, Nec-1s did not exhibit this low dose toxicity, stressing again the preferred use of Nec-1s in vivo. Our findings have important implications for the interpretation of Nec-1-based data in experimental disease models...
  7. pmc Many faces of DAMPs in cancer therapy
    O Krysko
    The Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, UZ Gent, MRB, Ghent, Belgium
    Cell Death Dis 4:e631. 2013
    ..In this review, we will critically evaluate the beneficial and detrimental roles of DAMPs in cancer therapy, focusing mainly on CRT, ATP and HMGB1...
  8. ncbi request reprint Caspase inhibitors promote alternative cell death pathways
    Peter Vandenabeele
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology VIB, Ghent, Belgium
    Sci STKE 2006:pe44. 2006
    ....
  9. doi request reprint The role of the kinases RIP1 and RIP3 in TNF-induced necrosis
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Zwijnaarde, Belgium
    Sci Signal 3:re4. 2010
    ....
  10. ncbi request reprint Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD
    Tom Vanden Berghe
    Molecular Signalling and Cell Death Unit, Department of Molecular Biomedical Research, the Flanders Interuniversity Institute for Biotechnology VIB and Gent University, Technologiepark 927, B 9052 Zwijnaarde, Belgium
    J Biol Chem 279:7925-33. 2004
    ..However, when procaspase-8 C/A and RIP1 are expressed simultaneously, FADD-DED preferentially recruits procaspase-8 C/A...
  11. ncbi request reprint INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, VIB Ghent University, Technologiepark 927, Zwijnaarde B 9052, Belgium
    J Biol Chem 279:51729-38. 2004
    ..Our data show that INCA is a novel intracellular regulator of procaspase-1 activation, involved in the regulation of pro-IL-1beta processing and its release during inflammation...
  12. doi request reprint The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
    Lieselotte Vande Walle
    VIB, Department for Molecular Biomedical Research, B 9052 Zwijnaarde, Belgium
    Cell Res 20:421-33. 2010
    ....
  13. ncbi request reprint Necrosis is associated with IL-6 production but apoptosis is not
    Tom Vanden Berghe
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Technologiepark 927, B 9052, Ghent Zwijnaarde, Belgium
    Cell Signal 18:328-35. 2006
    ..This suggests that the activation of inflammatory pathways is distinct from the activation of necrotic cell death sensu strictu...
  14. doi request reprint Determination of apoptotic and necrotic cell death in vitro and in vivo
    Tom Vanden Berghe
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Methods 61:117-29. 2013
    ..A particular problem in defining necrosis is that in the absence of phagocytosis, apoptotic cells become secondary necrotic and develop morphologic and biochemical features of primary necrosis...
  15. ncbi request reprint A novel caspase-2 complex containing TRAF2 and RIP1
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Ghent University and Flemish Interuniversity Institute for Biotechnology, Technologiepark 927, Zwijnaarde B 9052, Belgium
    J Biol Chem 280:6923-32. 2005
    ....
  16. ncbi request reprint Toxic proteins released from mitochondria in cell death
    Xavier Saelens
    Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Shell Van Montagu Building, Ghent B9052, Belgium
    Oncogene 23:2861-74. 2004
    ..A better understanding of these functions may help to develop new strategies to treat cancer...
  17. doi request reprint Immunogenic cell death and DAMPs in cancer therapy
    Dmitri V Krysko
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, VIB Ghent University Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium ugent be
    Nat Rev Cancer 12:860-75. 2012
    ..In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD...
  18. pmc Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis
    Linde Duprez
    Department for Molecular Biomedical Research VIB, Ghent University, Technologiepark 927, Gent Zwijnaarde 9052, Belgium
    J Biol Chem 287:14863-72. 2012
    ....
  19. doi request reprint Inflammatory mediators in Escherichia coli-induced mastitis in mice
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Comp Immunol Microbiol Infect Dis 31:551-65. 2008
    ..In conclusion, the current study provides novel insights on the contribution of major regulatory proteins to the acute inflammatory host response at the local and systemic level during E. coli mastitis in mice...
  20. ncbi request reprint More than one way to die: methods to determine TNF-induced apoptosis and necrosis
    Tom Vanden Berghe
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    Methods Mol Med 98:101-26. 2004
    ..Here we describe a selection of techniques used to distinguish both modes of TNFR-1-induced cell death, namely apoptotic or necrotic cell death...
  21. doi request reprint Methods for distinguishing apoptotic from necrotic cells and measuring their clearance
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Methods Enzymol 442:307-41. 2008
    ..A selection of techniques that can be used to study internalization mechanisms used by phagocytes to engulf dying cells is also presented, such as scanning and transmission electron microscopy and fluorescence microscopy...
  22. pmc Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production
    Greet Brouckaert
    Molecular Signalling and Cell Death Unit, Department of Molecular Biomedical Research, VIB, Ghent University, Ghent Belgium
    Mol Biol Cell 15:1089-100. 2004
    ..Uptake of neither apoptotic nor necrotic L929 cells by macrophages modulated the expression of proinflammatory cytokines by the phagocytes...
  23. ncbi request reprint Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology, Ghent University, B 9052 Zwijnaarde, Belgium
    J Biol Chem 279:24785-93. 2004
    ..These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways: proteolysis of pro-IL-1beta, and RIP2-dependent activation of NF-kappaB and p38 MAPK mediated by the caspase recruitment domain...
  24. doi request reprint RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome
    Linde Duprez
    Department for Molecular Biomedical Research, the Flanders Institute for Biotechnology VIB, 9052 Ghent, Belgium
    Immunity 35:908-18. 2011
    ....
  25. ncbi request reprint Caspase-14 protects against epidermal UVB photodamage and water loss
    Geertrui Denecker
    Department for Molecular Biomedical Research, VIB, Technologie Park 927, B 9052, Ghent, Belgium
    Nat Cell Biol 9:666-74. 2007
    ..Removal of the stratum corneum indicate that caspase-14 controls the UVB scavenging capacity of the stratum corneum...
  26. doi request reprint Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock
    Tom Vanden Berghe
    1 Inflammation Research Center, VIB, Ghent, Belgium
    Am J Respir Crit Care Med 189:282-91. 2014
    ..Conclusions: Our data point toward the therapeutic potential of neutralizing IL-1 and IL-18 simultaneously in sepsis, rather than inhibiting the upstream inflammatory caspases. ..
  27. doi request reprint Apoptosis and necrosis: detection, discrimination and phagocytosis
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Methods 44:205-21. 2008
    ....
  28. doi request reprint Caspase substrates: easily caught in deep waters?
    Dieter Demon
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Trends Biotechnol 27:680-8. 2009
    ..Here, we critically review recently published procedures used to generate a proteome-wide view of caspase substrates...
  29. doi request reprint Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture
    Kristel Demeyere
    Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Immunol Immunopathol 153:45-56. 2013
    ..This indicates that the secretion of the latter pro-inflammatory cytokine is a bystander effect rather than a regulator of PICD in bovine neutrophils, in marked contrast to the IL-1β-dependent pyroptosis reported for macrophages...
  30. pmc Regulation of the expression and processing of caspase-12
    Michael Kalai
    Department of Molecular Biomedical Research, Unit of Molecular Signalling and Cell Death, Ghent University, Ledeganckstraat 35, B 9000 Ghent, Belgium
    J Cell Biol 162:457-67. 2003
    ..Similar processing occurs in TNF-, LPS-, Fas ligand-, and thapsigargin (Tg)-induced apoptosis. However, B16/B16 melanoma cells die when treated with the ER stress-inducing agent Tg whether they express caspase-12 or not...
  31. doi request reprint Molecular mechanisms of necroptosis: an ordered cellular explosion
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, Ghent University, Belgium
    Nat Rev Mol Cell Biol 11:700-14. 2010
    ..Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death...
  32. ncbi request reprint Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors
    Bart Depuydt
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB and Gent University, 9052 Ghent Zwijnaarde, Belgium
    J Cell Sci 118:497-504. 2005
    ..These data confirm the capacity of TNFR2 to generate an apoptotic cell death signal independent of TNFR1...
  33. doi request reprint Tumor necrosis factor-mediated cell death: to break or to burst, that's the question
    Franky Van Herreweghe
    Unit for Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, VIB, Technologiepark 927, 9052, Ghent Zwijnaarde, Belgium
    Cell Mol Life Sci 67:1567-79. 2010
    ....
  34. ncbi request reprint Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis
    Tom Vanden Berghe
    Molecular Signaling and Cell Death Unit, Department of Molecular Biomedical Research, VIB, Gent University, B 9000 Gent, Belgium
    J Biol Chem 278:5622-9. 2003
    ..Thus, the availability of proteins such as receptor-interacting protein, Fas-associated death domain, and caspase-8 can determine whether TNFR1 activation will lead to apoptosis or to necrosis...
  35. doi request reprint Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis
    Araceli Diez-Fraile
    Faculty of Medicine and Health Sciences, Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Anat Rec (Hoboken) 293:890-9. 2010
    ..We provide direct evidence for the presence of CaR in preovulatory granulosa explants and suggest a pivotal role for CaR in follicle selection...
  36. pmc Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures
    Saskia Lippens
    Department of Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, Flanders Interuniversity Institute for Biotechnology VIB and Ghent University, Zwijnaarde, Belgium
    Am J Pathol 165:833-41. 2004
    ..Our data indicate that caspase-14 plays an important role in terminal epidermal differentiation, and its absence may contribute to the psoriatic phenotype...
  37. doi request reprint Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Belgium
    Trends Immunol 32:157-64. 2011
    ..Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies...
  38. ncbi request reprint Inflammatory caspases: targets for novel therapies
    Sigrid Cornelis
    Department for Molecular Biomedical Research, VIB, B9052 Ghent, Belgium
    Curr Pharm Des 13:367-85. 2007
    ..Finally, we point out recent approaches identifying novel peptidomimetic or non-peptide caspase inhibitors with suitable clinical profiles...
  39. doi request reprint Caspase-14-deficient mice are more prone to the development of parakeratosis
    Esther Hoste
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Invest Dermatol 133:742-50. 2013
    ....
  40. doi request reprint Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin
    Esther Hoste
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Invest Dermatol 131:2233-41. 2011
    ..Taken together, we identified caspase-14 as a crucial protease in FLG catabolism...
  41. pmc cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
    Mathieu J M Bertrand
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    PLoS ONE 6:e22356. 2011
    ..Finally, we identified Lys51 and Lys145 of RIP4 as two critical residues for cIAP1-mediated ubiquitination and NF-κB activation...
  42. pmc Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling
    Kristof Kersse
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, B 9052 Ghent Zwijnaarde, Belgium
    J Biol Chem 286:35874-82. 2011
    ..These findings indicate that the CARD of procaspase-1 is differently involved in the formation of procaspase-1 activating platforms and procaspase-1-mediated, RIP2-dependent NF-κB activation...
  43. ncbi request reprint Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1
    Sigrid Cornelis
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB Ghent University, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Oncogene 24:1552-62. 2005
    ..These results suggest an important role for caspase-9 mediated cleavage of Raf-1 in the negative feedback regulation of hematopoietic cell apoptosis induced by growth factor withdrawal...
  44. doi request reprint Cell death in the skin
    Saskia Lippens
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB, Ghent, Belgium
    Apoptosis 14:549-69. 2009
    ..Deregulation of cell death mechanisms in the skin can lead to diseases such as cancer, necrolysis and graft-versus-host disease. Here we review the apoptotic and the anti-apoptotic mechanisms in skin homeostasis and disease...
  45. doi request reprint The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
    ..Therefore, a deeper knowledge of the regulation of these serine protease cascades could form the basis for development of appropriate treatments for skin disorders such as Netherton syndrome...
  46. pmc Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
    Magdalena Wejda
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, Ghent University, B 9052 Ghent Zwijnaarde, Belgium
    J Biol Chem 287:33983-95. 2012
    ....
  47. pmc Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity
    Dieter Demon
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, Ghent 9052, Belgium
    Mol Cell Proteomics 8:2700-14. 2009
    ..Interestingly, specific cleavage by caspase-7 relies on excluding recognition by caspase-3 and not on increasing binding for caspase-7...
  48. pmc The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
    Benjamin Vandendriessche
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    PLoS ONE 8:e72155. 2013
    ..We speculate that, considering the central role of sGC signaling in many pathways required for maintenance of (micro)circulatory homeostasis, BAY 58-2667 supports organ function by recoupling inter-organ communication pathways. ..
  49. doi request reprint NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation
    Sharen Provoost
    Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, 9000 Ghent, Belgium
    J Immunol 187:3331-7. 2011
    ..In addition, DEP initiates inflammation independent of the classical NLRP3/caspase-1 pathway, suggesting that other proteases might be involved...
  50. doi request reprint IP3, a small molecule with a powerful message
    Elke Decrock
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Biochim Biophys Acta 1833:1772-86. 2013
    ..Finally, we highlight several pathological conditions in which anomalous intercellular IP3/Ca(2+) signaling might play a role. This article is part of a Special Issue entitled:12th European Symposium on Calcium...
  51. pmc Autophagy: for better or for worse
    Ellen Wirawan
    VIB, Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Ghent Zwijnaarde, Belgium
    Cell Res 22:43-61. 2012
    ..In addition, we present a brief overview of the possible contribution of defective autophagic signaling to disease...
  52. ncbi request reprint Proteome-wide Identification of HtrA2/Omi Substrates
    Lieselotte Vande Walle
    Department of Molecular Biomedical Research, VIB, 9052, Ghent, Belgium
    J Proteome Res 6:1006-15. 2007
    ..Our results suggest that HtrA2/Omi has a rather narrow cleavage site preference and that cytoskeletal proteins are prime targets of this protease...
  53. ncbi request reprint Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype
    Brigitta M Brinkman
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium Laboratory of Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium Department of Structural Biology, VIB, Brussels, Belgium Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium and BCCM LMG Bacteria Collection, Faculty of Sciences, Ghent University, Ghent, Belgium
    Inflamm Bowel Dis 19:2560-7. 2013
    ..Our findings also have important implications for the experimental design of disease studies in genetically modified mice and conclusions drawn from them...
  54. ncbi request reprint Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response
    Nele Festjens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Schell Van Montagu Building, Technologiepark 927, B 9052 Ghent, Belgium
    Biochim Biophys Acta 1757:1371-87. 2006
    ..Thus detailed knowledge of necrosis may be exploited in therapeutic strategies...
  55. ncbi request reprint Methods for extracting biochemical information from bacterial Raman spectra: focus on a group of structurally similar biomolecules--fatty acids
    Joke De Gelder
    Ghent University, Department of Analytical Chemistry, Proeftuinstraat 86, B 9000 Ghent, Belgium
    Anal Chim Acta 603:167-75. 2007
    ....
  56. doi request reprint Use of dendrograms of slice spectra as a new graphical tool for the interpretation of two-dimensional correlation spectra
    Kris De Gussem
    Ghent University, Department of Analytical Chemistry, Proeftuinstraat 86, 9000 Ghent, Belgium
    Appl Spectrosc 63:73-80. 2009
    ..The procedure enabled us to reveal the reaction steps in two simulated datasets and a dataset that comprises Raman spectra of oxidating latex of Lactarius fluens (Basidiomycota, Fungi)...
  57. doi request reprint Caspase-14 overexpression in hairless mice is not involved in utricle formation
    Michael Devos
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    Exp Dermatol 22:484-6. 2013
    ..However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation. ..
  58. ncbi request reprint Necroptosis: the release of damage-associated molecular patterns and its physiological relevance
    Agnieszka Kaczmarek
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Immunity 38:209-23. 2013
    ....
  59. ncbi request reprint Molecular mechanisms and pathophysiology of necrotic cell death
    Nele Vanlangenakker
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Curr Mol Med 8:207-20. 2008
    ....
  60. doi request reprint Beclin1: a role in membrane dynamics and beyond
    Ellen Wirawan
    Unit for Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Ghent, Belgium
    Autophagy 8:6-17. 2012
    ..In this review, we focus on Beclin1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin1-associated pathologies...
  61. ncbi request reprint RIP kinases at the crossroads of cell death and survival
    Wim Declercq
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Cell 138:229-32. 2009
    ..Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival...
  62. ncbi request reprint Caspase-containing complexes in the regulation of cell death and inflammation
    Nele Festjens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Schell Van Montagu Building, Technologiepark 927, B 9052 Ghent, Belgium
    Biol Chem 387:1005-16. 2006
    ..Inhibitory protein families such as FLIPs and CARD-only proteins prevent the recruitment of caspases in these sensing complexes, avoiding inappropriate initiation of cell death or inflammation...
  63. ncbi request reprint NADPH oxidases: new players in TNF-induced necrotic cell death
    Tom Vanden Berghe
    Department for Molecular Biomedical Research, VIB, Technologiepark 927, B 9052, Ghent, Belgium
    Mol Cell 26:769-71. 2007
    ..In a recent issue of Molecular Cell, Kim et al. (2007) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1-dependent recruitment and activation of the ROS-generating Nox1 NADPH oxidase complex...
  64. ncbi request reprint Clearance of apoptotic and necrotic cells and its immunological consequences
    Dmitri V Krysko
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Apoptosis 11:1709-26. 2006
    ....
  65. doi request reprint NOD-like receptors and the innate immune system: coping with danger, damage and death
    Kristof Kersse
    Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Technologiepark 927, B 9052 Ghent, Belgium
    Cytokine Growth Factor Rev 22:257-76. 2011
    ..We review the roles of NLR family members in health and disease, with emphasis on the signaling mechanisms in cell death and inflammation...
  66. doi request reprint The death-fold superfamily of homotypic interaction motifs
    Kristof Kersse
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent Zwijnaarde, Belgium
    Trends Biochem Sci 36:541-52. 2011
    ..Insights into the mechanisms of interaction of death-fold domains will be useful to design strategies for specific modulation of complex formation and might lead to novel therapeutic applications...
  67. ncbi request reprint Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death
    Nele Festjens
    Molecular Signaling and Cell Death Unit, Department of Molecular Biomedical Research, VIB and Ghent University, Ghent, Belgium
    Acta Haematol 111:7-27. 2004
    ....
  68. doi request reprint Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways
    Agnieszka Kaczmarek
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Pathol 226:598-608. 2012
    ....
  69. ncbi request reprint Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta
    Peter Schotte
    Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology VIB, Ghent Unniversity, Ghent, Belgium
    J Biol Chem 279:25134-42. 2004
    ..These results highlight a previously unknown function of Rho GTPases in the activation of caspase-1 and give new insight on the role of YopE in immune-escape mechanisms of Yersinia...
  70. doi request reprint SitePredicting the cleavage of proteinase substrates
    Jelle Verspurten
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, Ghent, Belgium
    Trends Biochem Sci 34:319-23. 2009
    ..Comparison of the different programs shows that SitePrediction makes it possible to derive more reliable predictions. In addition, this tool allows the use of a wide range of proteinases...
  71. doi request reprint Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    J Immunol 185:6306-16. 2010
    ..Hydroxylase inhibition could represent a promising alternative treatment strategy for hypoxic inflammatory diseases, including inflammatory bowel disease...
  72. ncbi request reprint Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy
    Dmitri V Krysko
    Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Godshuizenlaan 4, B 9000 Ghent, Belgium
    J Morphol 258:336-45. 2003
    ..The present report provides a basis for future studies aimed at discovering molecular pathways that precede these diverse mechanisms of uptake...
  73. ncbi request reprint Identification of Inorganic Pigments Used in Porcelain Cards Based on Fusing Raman and X-ray Fluorescence (XRF) Data
    Annelien Deneckere
    Ghent University, Research group Raman spectroscopy, Department of Analytical Chemistry, Krijgslaan 281, S12, B 9000 Ghent, Belgium
    Appl Spectrosc 65:1281-90. 2011
    ..The results show that the classification based on the fused Raman-XRF data is significantly better than the classifications based on the Raman data or the XRF data separately...
  74. doi request reprint Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases
    Olga Krysko
    Department of Oto Rhino Laryngology, Ghent University Hospital, UZ Gent, MRB, Belgium
    Apoptosis 15:1137-46. 2010
    ..Finally, we will address possible therapeutic strategies, such as the use of macrolide antibiotics and statins, for modulating apoptotic cell clearance...
  75. ncbi request reprint Evaluation of a spectral searching algorithm for the comparison of Raman band positions
    Peter Vandenabeele
    Ghent University, Department of Archaeology, Ghent, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 80:27-31. 2011
    ..Moreover, this study evaluates the performances of this algorithm for identifying different compounds in mixtures, by using an iterative approach...
  76. doi request reprint Multi-disciplinary investigation of the tomb of Menna (TT69), Theban Necropolis, Egypt
    Peter Vandenabeele
    Ghent University, Department of Archaeology and Ancient History of Europe, Blandijnberg 2, B 9000 Ghent, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 73:546-52. 2009
    ..The project worked with a large team of people with different backgrounds and sensitive technical equipment. Working conditions were quite hostile, including elevated temperatures and dust hampering the examinations...
  77. ncbi request reprint Evaluation of an accurate calibration and spectral standardization procedure for Raman spectroscopy
    Didier Hutsebaut
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
    Analyst 130:1204-14. 2005
    ..A two-step standardization procedure is proposed to deal with spectral shifts...
  78. ncbi request reprint Raman spectroscopic study of Lactarius spores (Russulales, Fungi)
    Kris De Gussem
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 61:2896-908. 2005
    ..The presence of trehalose is not equivocally shown, due to overlapping bands. Raman band positions are reported for the observed bands of the different species and reference products...
  79. ncbi request reprint Raman spectroscopic monitoring of Lactarius latex
    Kris De Gussem
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Phytochemistry 67:2580-9. 2006
    ..L. lacunarum latex spectra are thoroughly investigated by 2D correlation analysis and are compared with latex spectra of other species (L. chrysorrheus, L. deterrimus, L. fluens, L. glyciosmus and L. salmonicolor)...
  80. ncbi request reprint Raman spectroscopic analysis of Mexican natural artists' materials
    Peter Vandenabeele
    Ghent University, Department of Analytical Chemistry, Proeftuinstraat 86, B 9000 Ghent, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 68:1085-8. 2007
    ..Aje gum and gutta gum are not gums, since they are resinous (terpenoid) in nature. Aje is a rare animal resin originating from Coccus axin...
  81. doi request reprint In situ investigations of vault paintings in the Antwerp cathedral
    Annelien Deneckere
    Department of Analytical Chemistry, Ghent University, B 9000 Ghent, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 75:511-9. 2010
    ..The presence of gypsum (CaSO(4)x2H(2)O) on the mediaeval vault painting probably indicates that degradation took place...
  82. ncbi request reprint Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates
    Liesbeth M Ceelen
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    J Morphol 270:921-8. 2009
    ..The current study shows for the first time that H. pullorum causes mitotic catastrophe resulting in primary necrosis in mouse hepatocytes...
  83. doi request reprint In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Cell Microbiol 10:1249-58. 2008
    ....
  84. pmc The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection
    Marlies Galle
    Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    PLoS ONE 7:e41547. 2012
    ..These results demonstrate a T3SS effector toxin independent role for the T3SS, in particular the T3SS translocator protein PopB, in the pathogenicity of P. aeruginosa during acute lung infection...
  85. ncbi request reprint A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
    Geert van Loo
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Cytokine 22:62-70. 2003
    ....
  86. doi request reprint Life and death of female gametes during oogenesis and folliculogenesis
    Dmitri V Krysko
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB, Technologiepark 927, 9052 Ghent, Zwijnaarde, Belgium
    Apoptosis 13:1065-87. 2008
    ..Potential therapeutic strategies for combating premature ovarian failure are also addressed...
  87. ncbi request reprint Mitochondrial intermembrane proteins in cell death
    Maria van Gurp
    Molecular Signaling and Cell Death Unit, Department of Molecular Biomedical Research, VIB and Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Biochem Biophys Res Commun 304:487-97. 2003
    ..These mitochondrial factors may contribute to both caspase-dependent and caspase-independent processes in apoptotic cell death...
  88. ncbi request reprint Major cell death pathways at a glance
    Linde Duprez
    VIB, Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Microbes Infect 11:1050-62. 2009
    ..In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis, necrosis, autophagic cell death and pyroptosis...
  89. doi request reprint The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Nat Rev Immunol 12:833-44. 2012
    ..Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases...
  90. doi request reprint Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches
    Stephanie Verschuere
    Department of Pathology, University Hospital Ghent, 5 Blok A, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 137:293-301. 2012
    ....
  91. ncbi request reprint Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis
    Wim Declercq
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Immunity 35:493-5. 2011
    ..In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor protein FADD sensitizes keratinocytes to RIPK3-dependent necrotic cell death, which leads to severe skin inflammation...
  92. ncbi request reprint Raman spectroscopic study of bacterial endospores
    Joke De Gelder
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, 9000, Ghent, Belgium
    Anal Bioanal Chem 389:2143-51. 2007
    ..These bands were assigned to the incorporation of cysteine residues in spore coat proteins. In conclusion, Raman spectroscopy is a fast technique to provide useful information about several spore components...
  93. ncbi request reprint Raman microspectroscopy as an identification tool within the phylogenetically homogeneous 'Bacillus subtilis' group
    Didier Hutsebaut
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, Ghent, Belgium
    Syst Appl Microbiol 29:650-60. 2006
    ..subtilis group'. Considering the vague borderline between the species studied, Raman spectroscopy can be regarded here as a promising application for identifications at the species level...
  94. ncbi request reprint Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling
    Alison F Littlejohn
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland AB25 2ZD, UK
    Biochem Pharmacol 65:91-9. 2003
    ..Therefore, downstream TNF receptor signaling events are differentially influenced by caspases...
  95. pmc Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not
    Ahmed A A Mohamed
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, U K
    Biochem J 366:145-55. 2002
    ..Taken together these results show delineated ERK-activation pathways employed by TNFR subtypes...
  96. ncbi request reprint Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas
    Rudi Beyaert
    Department of Molecular Biology, University of Gent Flanders Interuniversity Institute for Biotechnology, Belgium
    Int Rev Cytol 214:225-72. 2002
    ..A third signal transduction pathway that is activated in response to TNF is the mitogen-activated protein kinase cascade, which plays an important role in the modulation of transcriptional gene activation...
  97. pmc The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail
    Helen Storey
    Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, U K
    Biochem J 366:15-22. 2002
    ....
  98. ncbi request reprint Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells
    Nathalie Vanderheyde
    Laboratory of Experimental Immunology, Universite Libre de Bruxelles ULB, Immunology, 808 Route de Lennik, B 1070, Belgium
    Immunol Lett 91:99-101. 2004
    ..Tumor necrosis factor (TNF) was shown to critically contribute to tumor growth inhibition in this system...
  99. ncbi request reprint Chemotaxonomical identification of spores of macrofungi: possibilities of Raman spectroscopy
    Kris De Gussem
    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, 9000 Gent, Belgium
    Anal Bioanal Chem 387:2823-32. 2007
    ..By using linear discriminant analysis, approximately 90% of the spectra can be assigned to the correct genus, but identification on the species level was not possible...
  100. ncbi request reprint Analysis of post-Byzantine icons from the Church of the Assumption in Cephalonia, Ionian Islands, Greece: a multi-method approach
    Eleni Kouloumpi
    National Gallery Alexandros Soutzos Museum, Conservation Department, Physicochemical Laboratory, 1 Michalacopoulou Street, 116 01 Athens, Greece
    Anal Chim Acta 598:169-79. 2007
    ..One of the aims of this paper is to provide a scientific background to the technology of the Ionian post-Byzantine icons...
  101. ncbi request reprint Differential activation of nuclear factor-kappaB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly
    Shona M McFarlane
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK
    FEBS Lett 515:119-26. 2002
    ..TNFR2 activation did not degrade IkappaBbeta. However, TNF-effects on NF-kappaB activation occurred predominantly through TNFR1, with TNFR2 activating the transcription factor poorly...