Thibaut Van Zele

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Endoscopic skull base reconstruction after endoscopic endonasal approach
    T Van Zele
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    B-ENT 7:41-6. 2011
  2. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
  3. ncbi Microsurgical teaching: our experience
    Emanuele Cigna
    University of Rome La Sapienza, Department of Dermatology and Plastic Surgery, Rome, Italy
    J Plast Reconstr Aesthet Surg 63:e529-31. 2010
  4. ncbi Local complement activation in nasal polyposis
    Thibaut Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Laryngoscope 119:1753-8. 2009
  5. ncbi Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7. 2008
  6. ncbi Local immunoglobulin production in nasal polyposis is modulated by superantigens
    T Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 37:1840-7. 2007
  7. ncbi Chronic rhinosinusitis with and without nasal polyps: what is the difference?
    Wouter Huvenne
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 9:213-20. 2009
  8. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
  9. ncbi Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT-Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  10. ncbi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008

Detail Information

Publications23

  1. ncbi Endoscopic skull base reconstruction after endoscopic endonasal approach
    T Van Zele
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    B-ENT 7:41-6. 2011
    ..These flaps have significantly reduced the morbidity and risk of post-operative CSF leaks after endoscopic endonasal approaches...
  2. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    ..There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps...
  3. ncbi Microsurgical teaching: our experience
    Emanuele Cigna
    University of Rome La Sapienza, Department of Dermatology and Plastic Surgery, Rome, Italy
    J Plast Reconstr Aesthet Surg 63:e529-31. 2010
    ..To overcome this dilemma, we have developed a three-step approach to optimise microsurgery training, particularly when there is no access to animal laboratories...
  4. ncbi Local complement activation in nasal polyposis
    Thibaut Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Laryngoscope 119:1753-8. 2009
    ....
  5. ncbi Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7. 2008
    ..The purpose of this study was to investigate the presence of S. aureus enterotoxin genes and the agr subtype in bacterial DNA of S. aureus strains isolated from the middle meatus of nasal polyp and control patients...
  6. ncbi Local immunoglobulin production in nasal polyposis is modulated by superantigens
    T Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 37:1840-7. 2007
    ..We aimed to study the systemic and local production of Igs in relation to plasma cells, B cells and specific IgE to SAEs...
  7. ncbi Chronic rhinosinusitis with and without nasal polyps: what is the difference?
    Wouter Huvenne
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 9:213-20. 2009
    ..This disease differentiation will not only increase our knowledge of the pathophysiology of sinusitis but may lead to new diagnostic and therapeutic strategies specifically targeted and adapted to the diagnosed disease entity...
  8. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    ..Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis...
  9. ncbi Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT-Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  10. ncbi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps...
  11. ncbi Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 121:110-5. 2008
    ..Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis...
  12. ncbi T-cell regulation in chronic paranasal sinus disease
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 121:1435-41, 1441.e1-3. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without nasal polyps (CRSsNP) represents a predominant T(H)1 milieu...
  13. ncbi Pathophysiology of chronic rhinosinusitis
    Peter Tomassen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic Audiological Science, Ghent University, Ghent, Belgium
    Proc Am Thorac Soc 8:115-20. 2011
    ..Identification of specific disease subgroups and their etiologies is an important and challenging task for future research...
  14. ncbi Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 118:1133-41. 2006
    ..Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels...
  15. ncbi Local inflammation in chronic upper airway disease
    Lien Calus
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Curr Pharm Des 18:2336-46. 2012
    ..Defining and predicting response to therapy in individual CRS patients is a challenge for future research...
  16. ncbi Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Upper Airways Research Laboratory, Gent University Hospital, Belgium
    Am J Rhinol 20:456-60. 2006
    ..We studied the possible impact of SE-induced immune responses on the eicosanoid production in nasal polyp (NP) patients...
  17. ncbi Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 131:110-6.e1. 2013
    ..Omalizumab is a human anti-IgE mAb with proved efficacy in patients with severe allergic asthma. Omalizumab could be a treatment option for patients with nasal polyps and asthma...
  18. ncbi Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 128:989-95.e1-8. 2011
    ..Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival...
  19. ncbi Superantigens and nasal polyps
    Claus Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Curr Allergy Asthma Rep 3:523-31. 2003
    ..This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis...
  20. ncbi Chronic rhinosinusitis: From one disease to different phenotypes
    Claus Bachert
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium Department of Oto Rhino Laryngology, Zhongshan City Peoples Hospital, Zhongshan, Guangdong, China
    Pediatr Allergy Immunol 23:2-4. 2012
    ..Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma...
  21. ncbi Does rhinitis lead to asthma?
    Paul Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University, Belgium
    Rhinology 45:112-21. 2007
    ..Basic research has demonstrated numerous similarities in inflammatory and immunological mechanisms...
  22. ncbi Stripping of a fistula for complete second branchial cleft
    Thibaut Van Zele
    Department of Head and Neck Surgery, Ghent University Hospital, De Pintelaan, 185 B 9000 Ghent, Belgium
    J Plast Reconstr Aesthet Surg 63:1052-4. 2010
    ..This technique uses a limited skin incision with an excellent cosmetic result and very low morbidity; and furthermore, it shortens the procedure and hospitalisation time...
  23. ncbi Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
    Thibaut Van Zele
    J Allergy Clin Immunol 114:981-3. 2004