Rudy Van Coster


Affiliation: Ghent University
Country: Belgium


  1. Van Driessche B, Verloo P, Herregods N, Mondelaers V, Dehoorne J, Van Coster R, et al. Recurrent arterial ischemic stroke with good response to mycophenolate mofetil. Eur J Paediatr Neurol. 2018;: pubmed publisher
    ..We describe a subject with multiple relapses despite treatment with corticosteroids and immunosuppressive agents, and stabilization of his clinical condition and of the radiological signs under mycophenolate mofetil treatment. ..
  2. Neupane J, Vandewoestyne M, Ghimire S, Lu Y, Qian C, Van Coster R, et al. Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice. Mitochondrion. 2014;18:27-33 pubmed publisher
    ..We show that NT in the germ line is potent to prevent transmission of heritable mtDNA disorders with the applicability for patients attempting reproduction. ..
  3. Heindryckx B, Neupane J, Vandewoestyne M, Christodoulou C, Jackers Y, Gerris J, et al. Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis. Mitochondrion. 2014;18:12-7 pubmed publisher
    ..95). This is the first case of mutation-free baby born from a MELAS patient after TE biopsy and supports the applicability of blastocyst PGD for patients with mtDNA disorders to establish healthy offspring. ..
  4. Vantroys E, Smet J, Vanlander A, Vergult S, De Bruyne R, Roels F, et al. Severe hepatopathy and neurological deterioration after start of valproate treatment in a 6-year-old child with mitochondrial tryptophanyl-tRNA synthetase deficiency. Orphanet J Rare Dis. 2018;13:80 pubmed publisher
    ..The subject reported here was first diagnosed as having cerebral palsy. Only after a mitochondriotoxic medication was started, the disease became progressive, and the diagnosis of a mitochondrial defect was made. ..
  5. Vanlander A, Muiño Mosquera L, Panzer J, Deconinck T, Smet J, Seneca S, et al. Megaconial muscular dystrophy caused by mitochondrial membrane homeostasis defect, new insights from skeletal and heart muscle analyses. Mitochondrion. 2016;27:32-8 pubmed publisher
    ..A likely hypothesis is that the biochemical findings are caused by an abnormal lipid profile in the inner mitochondrial membrane resulting from a defective choline kinase B activity. ..
  6. Verhelst H, de Waele L, Deconinck N, Ceulemans B, Willekens B, Van Coster R. Multiple sclerosis in Belgian children: A multicentre retrospective study. Eur J Paediatr Neurol. 2017;21:358-366 pubmed publisher
    ..An early and correct diagnosis of paediatric MS is essential to start early adequate treatment. As illustrated by our study cohort, current treatment options in childhood are unsatisfactory. ..
  7. request reprint
    Van Coster R, Gerlo E, Giardina T, Engelke U, Smet J, De Praeter C, et al. Aminoacylase I deficiency: a novel inborn error of metabolism. Biochem Biophys Res Commun. 2005;338:1322-6 pubmed
    ..The mutation was also detected in 5/161 controls. To exclude the possibility of a genetic polymorphism, protein expression studies were performed showing that the mutant protein had lost catalytic activity. ..
  8. Debray F, Stümpfig C, Vanlander A, Dideberg V, Josse C, Caberg J, et al. Mutation of the iron-sulfur cluster assembly gene IBA57 causes fatal infantile leukodystrophy. J Inherit Metab Dis. 2015;38:1147-53 pubmed publisher
    ..In the affected patient, the biochemical phenotype was characterized by a defect in the respiratory chain complexes I and II and a decrease in mitochondrial protein lipoylation, both resulting from impaired assembly of Fe/S clusters. ..
  9. De Paepe B, Van Coster R. A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders. Nutrients. 2017;9: pubmed publisher
    ..The obtained results are encouraging, but clearly show that achieving normalization of OXPHOS function with this strategy alone could prove to be an unattainable goal. ..

More Information


  1. Vantroys E, Larson A, Friederich M, Knight K, Swanson M, Powell C, et al. New insights into the phenotype of FARS2 deficiency. Mol Genet Metab. 2017;122:172-181 pubmed publisher