Philippe Van Lint

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis
    Philippe Van Lint
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology Ghent University, Ghent, Belgium
    J Immunol 175:7642-9. 2005
  2. ncbi request reprint Matrix metalloproteinase-8: cleavage can be decisive
    Philippe Van Lint
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, FSVM Building, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Cytokine Growth Factor Rev 17:217-23. 2006
  3. ncbi request reprint Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice
    Maarten Van Roy
    Department of Molecular Biomedical Research, VIB, Ghent University, Technologiepark 927, 9052 Ghent Zwijnaarde, Belgium
    Mol Cancer Ther 6:2563-71. 2007
  4. ncbi request reprint Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
    Wim Van Molle
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cancer Res 67:7301-7. 2007
  5. ncbi request reprint Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
    Roosmarijn E Vandenbroucke
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    J Neurosci 32:9805-16. 2012
  6. ncbi request reprint Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock
    Ben Wielockx
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Ghent, Belgium
    J Immunol 178:5069-75. 2007
  7. ncbi request reprint Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
    Philippe Van Lint
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    J Leukoc Biol 82:1375-81. 2007

Collaborators

  • Claude Libert
  • Carlos Lopez-Otin
  • George Kollias
  • Agnes Noel
  • Maarten Van Roy
  • Ineke Vanlaere
  • Ben Wielockx
  • Roosmarijn E Vandenbroucke
  • Leen Puim├Ęge
  • Wim Van Molle
  • Georges Leclercq
  • Delphine Demeestere
  • Cristina Campestre
  • Eline Dejonckheere
  • Elien Van Wonterghem
  • Patrick Matthys
  • Filip Van Hauwermeiren
  • Riet De Rycke
  • Conor Mc Guire
  • Tom Van Bogaert
  • Ineke Van Laere
  • Kenji Sekikawa
  • Lien Dejager
  • Stephen Shapiro
  • Frans van Roy
  • Carole Wilson
  • Jan Staelens

Detail Information

Publications7

  1. ncbi request reprint Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis
    Philippe Van Lint
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology Ghent University, Ghent, Belgium
    J Immunol 175:7642-9. 2005
    ..Our findings provide evidence that MMP-8 plays an essential role in acute liver failure and might be a promising new target for the treatment for this illness...
  2. ncbi request reprint Matrix metalloproteinase-8: cleavage can be decisive
    Philippe Van Lint
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, FSVM Building, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Cytokine Growth Factor Rev 17:217-23. 2006
    ..This review intends to give the reader an overview of the most interesting recent findings concerning the role of MMP-8 in inflammation and in cancer progression...
  3. ncbi request reprint Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice
    Maarten Van Roy
    Department of Molecular Biomedical Research, VIB, Ghent University, Technologiepark 927, 9052 Ghent Zwijnaarde, Belgium
    Mol Cancer Ther 6:2563-71. 2007
    ....
  4. ncbi request reprint Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
    Wim Van Molle
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cancer Res 67:7301-7. 2007
    ..We conclude that zinc protects against TNF in a HSP70-dependent way and that protection by zinc could be helpful in developing a safer anticancer therapy with TNF/IFNgamma...
  5. ncbi request reprint Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
    Roosmarijn E Vandenbroucke
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    J Neurosci 32:9805-16. 2012
    ..In conclusion, we identify MMP8 as an essential mediator in SIRS and, hence, a potential drug target. We also propose that the mechanism of action of MMP8 involves disruption of the BCSFB integrity...
  6. ncbi request reprint Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock
    Ben Wielockx
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Ghent, Belgium
    J Immunol 178:5069-75. 2007
    ..Definition of a critical region of 13 Mb on chromosome 6 was the highest mapping resolution obtained. Further analysis of candidate genes may provide a powerful tool to control TNF-induced pathologies in humans...
  7. ncbi request reprint Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
    Philippe Van Lint
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    J Leukoc Biol 82:1375-81. 2007
    ..This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration...