Mireille Van Gele

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes
    Mireille Van Gele
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    J Invest Dermatol 128:2474-84. 2008
  2. doi request reprint Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations
    Mireille Van Gele
    Ghent University Hospital, Department of Dermatology, Belgium
    Expert Opin Drug Deliv 8:705-20. 2011
  3. doi request reprint Griscelli syndrome: a model system to study vesicular trafficking
    Mireille Van Gele
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    Pigment Cell Melanoma Res 22:268-82. 2009
  4. doi request reprint miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells
    Peter Dynoodt
    Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Oncol 42:1443-51. 2013
  5. doi request reprint Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients
    Reinhart Speeckaert
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    Eur J Cancer 48:2004-11. 2012
  6. ncbi request reprint Melanocyte-specific immune response in a patient with multiple regressing nevi and a history of melanoma
    Reinhart Speeckaert
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 31:3697-703. 2011
  7. doi request reprint Development of a 3D pigmented skin model to evaluate RNAi-induced depigmentation
    Mireille Van Gele
    Department of Dermatology Laboratory of Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium
    Exp Dermatol 20:773-5. 2011
  8. ncbi request reprint Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia
    Sofie Lust
    Ghent University Hospital, Department of Hematology, De Pintelaan 185, 1P7, B 9000 Ghent, Belgium
    Anticancer Res 29:3797-805. 2009
  9. ncbi request reprint The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562
    Sofie Lust
    Department of Hematology, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium
    Mol Nutr Food Res 54:823-32. 2010
  10. pmc P-cadherin counteracts myosin II-B function: implications in melanoma progression
    Koen Jacobs
    Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent University, De Pintelaan 185, Ghent 9000, Belgium
    Mol Cancer 9:255. 2010

Collaborators

Detail Information

Publications17

  1. doi request reprint Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes
    Mireille Van Gele
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    J Invest Dermatol 128:2474-84. 2008
    ..We conclude that our siRNA-based strategy provides a previously unreported tool to block the intracellular melanosome movement in primary human melanocytes and may become an innovative drug to treat hyperpigmentation...
  2. doi request reprint Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations
    Mireille Van Gele
    Ghent University Hospital, Department of Dermatology, Belgium
    Expert Opin Drug Deliv 8:705-20. 2011
    ..New transdermal drug candidates need to be tested extensively before being used on humans. In this regard, in vitro permeation methods are highly important to predict in vivo permeation of drugs...
  3. doi request reprint Griscelli syndrome: a model system to study vesicular trafficking
    Mireille Van Gele
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    Pigment Cell Melanoma Res 22:268-82. 2009
    ..Finally, we discuss how the gathered knowledge about the RAB27A-MLPH-MYO5A tripartite complex can be translated into a possible therapeutic application to reduce (hyper)pigmentation of the skin...
  4. doi request reprint miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells
    Peter Dynoodt
    Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Oncol 42:1443-51. 2013
    ..Despite the fact that it remains unclear which genes or pathways are regulated by miR-145 in melanoma, miR-145 may serve as a useful therapeutic agent in melanoma when re-expressed in situ...
  5. doi request reprint Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients
    Reinhart Speeckaert
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    Eur J Cancer 48:2004-11. 2012
    ..In this study, we investigated the expression of IDO in sentinel nodes of melanoma patients to determine its prognostic relevance...
  6. ncbi request reprint Melanocyte-specific immune response in a patient with multiple regressing nevi and a history of melanoma
    Reinhart Speeckaert
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 31:3697-703. 2011
    ..The aim of this study was to provide evidence of an effective immunosurveillance of pigment lesions in a patient at high risk of melanoma...
  7. doi request reprint Development of a 3D pigmented skin model to evaluate RNAi-induced depigmentation
    Mireille Van Gele
    Department of Dermatology Laboratory of Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium
    Exp Dermatol 20:773-5. 2011
    ..Therefore, this self-made 3D skin model will be a useful and easy tool to validate the whitening potential of candidate genes with a presumed function in melanin synthesis or transfer...
  8. ncbi request reprint Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia
    Sofie Lust
    Ghent University Hospital, Department of Hematology, De Pintelaan 185, 1P7, B 9000 Ghent, Belgium
    Anticancer Res 29:3797-805. 2009
    ..Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. A novel approach to overcome chemotherapy resistance may be targeting the endoplasmic reticulum (ER)...
  9. ncbi request reprint The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562
    Sofie Lust
    Department of Hematology, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium
    Mol Nutr Food Res 54:823-32. 2010
    ..In conclusion, our results suggest that TAN is able to induce apoptosis in Bcr-Abl+ cells via cell cycle arrest and the induction of the unfolded protein response, and has synergistic cytotoxicity with imatinib...
  10. pmc P-cadherin counteracts myosin II-B function: implications in melanoma progression
    Koen Jacobs
    Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent University, De Pintelaan 185, Ghent 9000, Belgium
    Mol Cancer 9:255. 2010
    ..The strong invasive and metastatic nature of cutaneous melanoma implies a deregulated interplay between intercellular adhesion and migration-related molecules..
  11. doi request reprint Lipid-mediated gene delivery to the skin
    Barbara Geusens
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Pharm Sci 43:199-211. 2011
    ..Apart from simple topical application onto the skin, liposomes have also been described in combination with delivery enhancing techniques. Here we describe this combined approach for some specific skin disorders...
  12. ncbi request reprint The biology of hyperpigmentation syndromes
    Reinhart Speeckaert
    Department of Dermatology, Ghent University Hospital, Gent, Belgium
    Pigment Cell Melanoma Res 27:512-24. 2014
    ..The identification of novel genes or key players involved in hyperpigmentary disorders is becoming increasingly important in view of the development of safer and more efficient treatments. ..
  13. ncbi request reprint Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma
    Mireille Van Gele
    Center for Medical Genetics, Ghent University Hospital, Ghent B 9000, Belgium
    Oncogene 23:2732-42. 2004
    ..Real-time quantitative RT-PCR analysis of these genes on 26 additional MCC and SCLC samples confirmed their diagnostic classification potential, opening opportunities for new investigations into these aggressive cancers...
  14. ncbi request reprint Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia
    Jerina Boelens
    Department of Hematology, Ghent University Hospital, Ghent, Belgium
    Leuk Res 33:1335-43. 2009
    ..Therefore, the downregulation of ZAP-70 and P-SYK per se during treatment with GCs is not sufficient to induce apoptosis, and different mechanisms must therefore be responsible for the increased steroid sensitivity of ZAP-70+ CLL...
  15. doi request reprint The role of RhoC in growth and metastatic capacity of melanoma
    Barbara Boone
    Dermatology Research Unit, Department of Dermatology, Ghent University Hospital, Ghent, Belgium
    J Cutan Pathol 36:629-36. 2009
    ..In melanoma, RhoC is upregulated in highly metastatic tumors. Induced expression in melanoma cell lines resulted in invasion and metastasis, whereas inhibition of RhoC reversed the metastatic phenotype both in vitro and in vivo...
  16. ncbi request reprint Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma
    Mireille Van Gele
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Int J Cancer 101:137-45. 2002
    ..We provid a detailed description of chromosomal translocations occurring in MCC that could be useful to direct future intensive investigation of these chromosomal regions...
  17. ncbi request reprint Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma
    J Helen Leonard
    Queensland Radium Institute Research Unit, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    Int J Cancer 101:103-10. 2002
    ....