Koen Van Crombruggen

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint Damage-associated molecular patterns and their receptors in upper airway pathologies
    Koen Van Crombruggen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Cell Mol Life Sci 70:4307-21. 2013
  2. doi request reprint RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 129:1515-21.e8. 2012
  3. doi request reprint Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 383:613-26. 2011
  4. doi request reprint Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
  5. doi request reprint Chronic sinusitis and rhinitis: clinical terminology "Chronic Rhinosinusitis" further supported
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    Rhinology 48:54-8. 2010
  6. pmc Mixed T Helper Cell Signatures In Chronic Rhinosinusitis with and without Polyps
    Lara Derycke
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e97581. 2014
  7. ncbi request reprint The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered
    Rogério Pezato
    Upper Airway Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, Belgium Department of Otolaryngology Head and Neck Surgery, Federal University of Sao Paulo, Brazil Electronic address
    Immunobiology 219:729-36. 2014
  8. pmc Suppression of Cytokine Release by Fluticasone Furoate vs. Mometasone Furoate in Human Nasal Tissue Ex-Vivo
    Nan Zhang
    Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e93754. 2014
  9. pmc Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
    Fenila Jacob
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Purinergic Signal 9:285-306. 2013
  10. pmc A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
    Nan Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Evid Based Complement Alternat Med 2012:673145. 2012

Collaborators

Detail Information

Publications10

  1. doi request reprint Damage-associated molecular patterns and their receptors in upper airway pathologies
    Koen Van Crombruggen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Cell Mol Life Sci 70:4307-21. 2013
    ..It is, however, of importance to assess these molecules again from a point of view as a DAMP in order to further unravel the pathogenesis of CRS...
  2. doi request reprint RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 129:1515-21.e8. 2012
    ..RAGE is reported to play a role in diverse pathologies including lower airway conditions, but the exact mechanism of action remains poorly understood. In the upper airways, the involvement of RAGE remains completely unexplored...
  3. doi request reprint Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 383:613-26. 2011
    ..These vasodilatations can be suppressed by the EP(1/3) receptor agonist sulprostone at subnanomolar concentrations...
  4. doi request reprint Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
    ..This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of CRS to further unravel its pathogenesis...
  5. doi request reprint Chronic sinusitis and rhinitis: clinical terminology "Chronic Rhinosinusitis" further supported
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    Rhinology 48:54-8. 2010
    ..We therefore investigated the immunological background of the chronically inflamed nasal and sinusal mucosa...
  6. pmc Mixed T Helper Cell Signatures In Chronic Rhinosinusitis with and without Polyps
    Lara Derycke
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e97581. 2014
    ..The aim of this study was to characterize the intracytoplasmatic cytokines ofTcells infiltrating theinflamed sinonasal mucosa...
  7. ncbi request reprint The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered
    Rogério Pezato
    Upper Airway Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, Belgium Department of Otolaryngology Head and Neck Surgery, Federal University of Sao Paulo, Brazil Electronic address
    Immunobiology 219:729-36. 2014
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized as a Th2-driven disease. Activated dendritic cells (DCs) are the main T-cell activators; their role in the chronic inflammatory process of nasal polyposis is still unclear...
  8. pmc Suppression of Cytokine Release by Fluticasone Furoate vs. Mometasone Furoate in Human Nasal Tissue Ex-Vivo
    Nan Zhang
    Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e93754. 2014
    ..Topical glucocorticosteroids are the first line therapy for airway inflammation. Modern compounds with higher efficacy have been developed, but head-to-head comparison studies are sparse...
  9. pmc Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
    Fenila Jacob
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Purinergic Signal 9:285-306. 2013
    ..We finally discuss the therapeutic potential of P2 receptor subtype selective drugs in inflammatory conditions...
  10. pmc A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
    Nan Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Evid Based Complement Alternat Med 2012:673145. 2012
    ..The combination of S. baicalensis and E. senticosus may be able to significantly block allergic early-and late-phase mediators and substantially suppress the release of proinflammatory, and Th1-, Th2-, and Th17-derived cytokines...