Frank Van Breusegem

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Changes in hydrogen peroxide homeostasis trigger an active cell death process in tobacco
    James F Dat
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant J 33:621-32. 2003
  2. pmc Unraveling the tapestry of networks involving reactive oxygen species in plants
    Frank Van Breusegem
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Belgium
    Plant Physiol 147:978-84. 2008
  3. pmc Reactive oxygen species in plant cell death
    Frank Van Breusegem
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 141:384-90. 2006
  4. pmc AtWRKY15 perturbation abolishes the mitochondrial stress response that steers osmotic stress tolerance in Arabidopsis
    Sandy Vanderauwera
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Proc Natl Acad Sci U S A 109:20113-8. 2012
  5. pmc Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis
    Sandy Vanderauwera
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:806-21. 2005
  6. pmc Extranuclear protection of chromosomal DNA from oxidative stress
    Sandy Vanderauwera
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 108:1711-6. 2011
  7. ncbi request reprint Metacaspase activity of Arabidopsis thaliana is regulated by S-nitrosylation of a critical cysteine residue
    Beatrice Belenghi
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    J Biol Chem 282:1352-8. 2007
  8. ncbi request reprint Catalase deficiency drastically affects gene expression induced by high light in Arabidopsis thaliana
    Steven Vandenabeele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Plant J 39:45-58. 2004
  9. pmc Nitric oxide- and hydrogen peroxide-responsive gene regulation during cell death induction in tobacco
    Elisa Zago
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 141:404-11. 2006
  10. pmc Abscisic acid deficiency causes changes in cuticle permeability and pectin composition that influence tomato resistance to Botrytis cinerea
    Katrien Curvers
    Department of Plant Biotechnology and Genetics, Ghent University, Ghent, Belgium
    Plant Physiol 154:847-60. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Changes in hydrogen peroxide homeostasis trigger an active cell death process in tobacco
    James F Dat
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant J 33:621-32. 2003
    ..This oxidase-dependent oxidative burst is essential for cell death, but it is not required for the accumulation of defense proteins, suggesting a more prominent role for the oxidative burst in abiotic stress-induced cell death...
  2. pmc Unraveling the tapestry of networks involving reactive oxygen species in plants
    Frank Van Breusegem
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Belgium
    Plant Physiol 147:978-84. 2008
  3. pmc Reactive oxygen species in plant cell death
    Frank Van Breusegem
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 141:384-90. 2006
  4. pmc AtWRKY15 perturbation abolishes the mitochondrial stress response that steers osmotic stress tolerance in Arabidopsis
    Sandy Vanderauwera
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Proc Natl Acad Sci U S A 109:20113-8. 2012
    ..We show that mitochondrial calcium-flux sensing might be important for regulating an active mitochondrial retrograde signaling and launching an appropriate defense response to confer salt-stress tolerance...
  5. pmc Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis
    Sandy Vanderauwera
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:806-21. 2005
    ..This cluster comprises the complete known anthocyanin regulatory and biosynthetic pathway, together with genes encoding unknown proteins...
  6. pmc Extranuclear protection of chromosomal DNA from oxidative stress
    Sandy Vanderauwera
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 108:1711-6. 2011
    ..This response is correlated with enhanced tolerance to oxidative stress, DNA stress-causing agents, and inhibited programmed cell death...
  7. ncbi request reprint Metacaspase activity of Arabidopsis thaliana is regulated by S-nitrosylation of a critical cysteine residue
    Beatrice Belenghi
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    J Biol Chem 282:1352-8. 2007
    ..This cysteine is absent in caspases and paracaspases but is conserved in all reported metacaspases...
  8. ncbi request reprint Catalase deficiency drastically affects gene expression induced by high light in Arabidopsis thaliana
    Steven Vandenabeele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Plant J 39:45-58. 2004
    ..Thus, photorespiratory H(2)O(2) has a direct impact on transcriptional programs in plants...
  9. pmc Nitric oxide- and hydrogen peroxide-responsive gene regulation during cell death induction in tobacco
    Elisa Zago
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 141:404-11. 2006
    ....
  10. pmc Abscisic acid deficiency causes changes in cuticle permeability and pectin composition that influence tomato resistance to Botrytis cinerea
    Katrien Curvers
    Department of Plant Biotechnology and Genetics, Ghent University, Ghent, Belgium
    Plant Physiol 154:847-60. 2010
    ..These results show that endogenous plant ABA levels affect the composition of the tomato cuticle and cell wall and demonstrate the importance of cuticle and cell wall chemistry in shaping the outcome of this plant-fungus interaction...
  11. doi request reprint Hydrogen peroxide-induced gene expression across kingdoms: a comparative analysis
    Korneel Vandenbroucke
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent, Belgium
    Mol Biol Evol 25:507-16. 2008
    ....
  12. pmc Are metacaspases caspases?
    Dominique Vercammen
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, 9052 Gent, Belgium
    J Cell Biol 179:375-80. 2007
    ..We further suggest that metacaspases and paracaspases, although sharing structural and mechanistic features with the metazoan caspases, form a distinct family of clan CD cysteine peptidases...
  13. pmc Developmental stage specificity and the role of mitochondrial metabolism in the response of Arabidopsis leaves to prolonged mild osmotic stress
    Aleksandra Skirycz
    Department of Plant Biotechnology and Genetics, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 152:226-44. 2010
    ..Taken together, our data underline the value of analyzing stress responses in development and demonstrate the importance of mitochondrial respiration for sustaining cell proliferation under osmotic stress conditions...
  14. ncbi request reprint Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development
    Olivier Van Aken
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, 9052 Gent, Belgium
    Plant J 52:850-64. 2007
    ..We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues...
  15. pmc Silencing of poly(ADP-ribose) polymerase in plants alters abiotic stress signal transduction
    Sandy Vanderauwera
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Technologiepark 927, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 104:15150-5. 2007
    ..We show that in PARP2-deficient Arabidopsis plants, the observed abiotic stress resistance can also be explained by alterations in abscisic acid levels that facilitate the induction of a wide set of defense-related genes...
  16. doi request reprint Natural substrates of plant proteases: how can protease degradomics extend our knowledge?
    Liana Tsiatsiani
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Ghent, Belgium
    Physiol Plant 145:28-40. 2012
    ..Here, we review the current knowledge on the identity of natural plant protease substrates and describe recently established degradomics technologies that should allow proteome-wide studies of plant proteases in the near future...
  17. ncbi request reprint Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9
    Dominique Vercammen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    J Mol Biol 364:625-36. 2006
    ..Both AtMC9 and AtSerpin1 were localized in the extracellular space, suggesting an in vivo interaction as well. To our knowledge, this is the first report of plant protease inhibition by a plant serpin...
  18. ncbi request reprint A Temperature-sensitive mutation in the Arabidopsis thaliana phosphomannomutase gene disrupts protein glycosylation and triggers cell death
    Frank A Hoeberichts
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Ghent University, 9052 Gent, Belgium
    J Biol Chem 283:5708-18. 2008
    ....
  19. pmc Perturbation of indole-3-butyric acid homeostasis by the UDP-glucosyltransferase UGT74E2 modulates Arabidopsis architecture and water stress tolerance
    Vanesa B Tognetti
    Department of Plant Systems Biology, VIB, Ghent University, 9052 Gent, Belgium
    Plant Cell 22:2660-79. 2010
    ....
  20. pmc Transcriptomic footprints disclose specificity of reactive oxygen species signaling in Arabidopsis
    Ilya Gadjev
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 141:436-45. 2006
    ..Our analysis provides a framework that will assist future efforts to address the impact of ROS signals within environmental stress conditions and elucidate the molecular mechanisms of the oxidative stress response in plants...
  21. ncbi request reprint A technology platform for the fast production of monoclonal recombinant antibodies against plant proteins and peptides
    Dominique Eeckhout
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    J Immunol Methods 294:181-7. 2004
    ..We are convinced that this antibody platform will further stimulate applications of recombinant antibodies such as the diagnostic detection or immunomodulation of specific antigens in plants...
  22. pmc Potential use of a serpin from Arabidopsis for pest control
    Fernando Alvarez-Alfageme
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium
    PLoS ONE 6:e20278. 2011
    ..Nymphs of A. pisum exposed to diets containing AtSerpin1 suffered high mortality levels (LC(50) = 637 µg ml(-1)). The results indicate that AtSerpin1 is a good candidate for exploitation in pest control...
  23. ncbi request reprint Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine
    Dominique Vercammen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    J Biol Chem 279:45329-36. 2004
    ..These findings suggest that type II metacaspases are not directly responsible for earlier reported caspase-like activities in plants...
  24. pmc Cryptogein-induced transcriptional reprogramming in tobacco is light dependent
    Frank A Hoeberichts
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Plant Physiol 163:263-75. 2013
    ....
  25. pmc Resistance to Botrytis cinerea in sitiens, an abscisic acid-deficient tomato mutant, involves timely production of hydrogen peroxide and cell wall modifications in the epidermis
    Bob Asselbergh
    Laboratory of Phytopathology, Ghent University, B 9000 Ghent, Belgium
    Plant Physiol 144:1863-77. 2007
    ..cinerea...
  26. pmc A comprehensive analysis of hydrogen peroxide-induced gene expression in tobacco
    Steven Vandenabeele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 100:16113-8. 2003
    ....
  27. doi request reprint How relevant are flavonoids as antioxidants in plants?
    Iker Hernández
    Department of Plant Systems Biology, Ghent University, 9052 Gent, Belgium
    Trends Plant Sci 14:125-32. 2009
    ..Thereby, the widely accepted antioxidant function of flavonoids in plants is still a matter of debate...
  28. doi request reprint A subcellular localization compendium of hydrogen peroxide-induced proteins
    Annelies Inzé
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Plant Cell Environ 35:308-20. 2012
    ..Furthermore, the effect of increased H(2)O(2) levels on the subcellular localization of a subset of proteins was assessed...
  29. doi request reprint Stress homeostasis - the redox and auxin perspective
    Vanesa B Tognetti
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Plant Cell Environ 35:321-33. 2012
    ..In this review, we aim at surveying how the integration of environmental stress-related signals is modulated by crosstalk between ROS and auxin regulatory networks...
  30. ncbi request reprint Reactive oxygen species as signals that modulate plant stress responses and programmed cell death
    Tsanko S Gechev
    Institute of Plant Sciences, ETH Zurich, Switzerland
    Bioessays 28:1091-101. 2006
    ....
  31. ncbi request reprint Double antisense plants lacking ascorbate peroxidase and catalase are less sensitive to oxidative stress than single antisense plants lacking ascorbate peroxidase or catalase
    Ludmila Rizhsky
    Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant J 32:329-42. 2002
    ..In addition, our findings demonstrate that the plant genome has a high degree of plasticity and will respond differently to different stressful conditions, namely, lack of APX, lack of CAT, or lack of both APX and CAT...
  32. ncbi request reprint Conditional oxidative stress responses in the Arabidopsis photorespiratory mutant cat2 demonstrate that redox state is a key modulator of daylength-dependent gene expression, and define photoperiod as a crucial factor in the regulation of H2O2-induced cel
    Guillaume Queval
    Institut de Biotechnologie des Plantes, Universite de Paris Sud XI, 91405 Orsay Cedex, France
    Plant J 52:640-57. 2007
    ..Together, the data reveal the influence of photoperiodic events on redox signalling, and define distinct photoperiod-dependent strategies in the acclimation versus cell-death decision in stress conditions...
  33. ncbi request reprint Reactive oxygen gene network of plants
    Ron Mittler
    Department of Biochemistry, Mail Stop 200, University of Nevada, Reno, NV 89557, USA
    Trends Plant Sci 9:490-8. 2004
  34. pmc Fatty acid hydroperoxides and H2O2 in the execution of hypersensitive cell death in tobacco leaves
    Jean Luc Montillet
    Commissariat à l Energie Atomique Cadarache, Direction des Sciences du Vivant, Département d Ecophysiologie Végétale et de Microbiologie, Laboratoire de Radiobiologie Végétale, F 13108 Saint Paul lez Durance Cedex, France
    Plant Physiol 138:1516-26. 2005
    ..Our results demonstrate, therefore, the tight interplay between H(2)O(2) and lipid hydroperoxides and underscore the importance of light during the hypersensitive response...
  35. ncbi request reprint Signal transduction during oxidative stress
    Eva Vranová
    Vakgroep Moleculaire Genetica, Departement Plantengenetica, Vlaams Interuniversitair Instituut voor Biotechnologie VIB, Universiteit Gent, KL Ledeganckstraat 35, B 9000 Gent, Belgium
    J Exp Bot 53:1227-36. 2002
    ..Special attention is given to AOS and redox-regulated gene expression and the role of kinases and phosphatases in redox signal transduction...