Research Topics
Genomes and Genes | Filip Van ImmerseelSummaryAffiliation: Ghent University Country: Belgium Publications
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Publications
Protection of laying hens against Salmonella Enteritidis by immunization with type 1 fimbriaeJeroen De Buck
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 105:93-101. 2005..in the immunized hens but not in the control hens. In conclusion, we demonstrated that the immunization of laying hens with type 1 fimbriae reduced the number of contaminated eggs and reduced the colonization of the reproductive organs...- The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacyF Van Immerseel
Ghent University, Faculty of Veterinary Medicine, Research Group Veterinary Public Health and Zoonoses, Department of Pathology, Bacteriology and Avian Diseases, Salisburylaan 133, B 9820, Merelbeke, Belgium
Avian Pathol 35:182-8. 2006..If diets can be designed to stimulate organic acid production in the caecum, it may be possible to control Salmonella spp. via even easier and more cost-effective measures, compared with addition of acids to feed or drinking water... 
The influence of the cage system and colonisation of Salmonella Enteritidis on the microbial gut flora of laying hens studied by T-RFLP and 454 pyrosequencingSteen Nordentoft
National Veterinary Institute, Technical University of Denmark, Section for Poultry, Fish and Fur Animals, Hangovej 2, DK 8200 Aarhus N, Denmark
BMC Microbiol 11:187. 2011..The distribution of genera in the microbiota in caecum was furthermore described by next generation sequencing of 16S rDNA libraries...
Mutations influencing expression of the Salmonella enterica serovar Enteritidis pathogenicity island I key regulator hilAFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
Antonie Van Leeuwenhoek 94:455-61. 2008..Mutants having decreased and increased hilA expression were more and less invasive in the human colon carcinoma cell line T84 compared to wild type strain bacteria, respectively...- The effect of oral administration of a homologous hilA mutant strain on the long-term colonization and transmission of Salmonella Enteritidis in broiler chickensLotte Bohez
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vaccine 26:372-8. 2008.... - Supplementation of coated butyric acid in the feed reduces colonization and shedding of Salmonella in poultryF Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Poult Sci 84:1851-6. 2005..enteritidis bacteria in the ceca at slaughter age, although at enrichment level... - Clostridium perfringens in poultry: an emerging threat for animal and public healthFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Avian Pathol 33:537-49. 2004..The most cost-effective control will probably be achieved by balancing the composition of the feed... - Isolation of a clonal population of Clostridium perfringens type A from a Belgian Blue calf with abomasal ulcerationF Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Comp Pathol 143:289-93. 2010..Clostridium perfringens type A was isolated from multiple ulcers and from the intestinal contents of the animal and pulsed field gel electrophoresis confirmed that the isolates comprised a genetically clonal population... - Intermittent long-term shedding and induction of carrier birds after infection of chickens early posthatch with a low or high dose of Salmonella enteritidisF Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Poult Sci 83:1911-6. 2004..It can be concluded that infection of newly hatched chicks with a low dose of Salmonella Enteritidis can lead to persistent infection until onset of lay, hereby excreting Salmonella bacteria intermittently... - Stress-induced survival strategies enable Salmonella Enteritidis to persistently colonize the chicken oviduct tissue and cope with antimicrobial factors in egg white: A hypothesis to explain a pandemicFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Gut Pathog 2:23. 2010..Salmonella Enteritidis is much more capable to persistently colonize the laying hen reproductive tract and to survive in the hostile egg white, as compared to other serotypes... - Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar EnteritidisF Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Belgium
Appl Environ Microbiol 70:3582-7. 2004..Thus, MCFA are potentially useful products for reducing the level of colonization of chicks and could ultimately aid in the reduction of the number of contaminated eggs in the food supply... - A limited role for SsrA/B in persistent Salmonella Typhimurium infections in pigsFilip Boyen
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 128:364-73. 2008..These results suggest that the ssrA/B gene of Salmonella Typhimurium plays a limited role in the persistent intestinal colonization of pigs... - Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilersLeen Timbermont
Research Group Veterinary Public Health and Zoonoses, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Belgium
Comp Immunol Microbiol Infect Dis 32:503-12. 2009..These results suggest the presence of host specific virulence factors in C. perfringens strains, isolated from chickens with intestinal necrotic enteritis lesions... - The Salmonella Pathogenicity Island 2 regulator ssrA promotes reproductive tract but not intestinal colonization in chickensLotte Bohez
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 126:216-24. 2008..These findings indicate that the SPI-2 regulator ssrA promotes reproductive tract colonization, but is not essential for intestinal colonization of chickens with the host non-specific serotype Enteritidis... - Colonization strategy of Campylobacter jejuni results in persistent infection of the chicken gutKim Van Deun
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, Merelbeke, Belgium
Vet Microbiol 130:285-97. 2008..These findings suggest a novel colonization mechanism by escaping rapid mucosal clearance through short-term epithelial invasion and evasion, combined with fast replication in the mucus... - The effect of vaccination with a Salmonella enteritidis aroA mutant on early cellular responses in caecal lamina propria of newly-hatched chickensFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vaccine 20:3034-41. 2002.... - Short-chain fatty acids and L-lactate as feed additives to control Campylobacter jejuni infections in broilersKim Van Deun
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Merelbeke, Belgium
Avian Pathol 37:379-83. 2008..jejuni in the applied test conditions. This might be partially ascribed to the protective effect of mucous and the rapid absorption of butyrate by the enterocytes... - Salmonella enterica serovar Enteritidis colonization of the chicken caecum requires the HilA regulatory proteinLotte Bohez
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 116:202-10. 2006..It is concluded that hilA is involved in long-term shedding and colonization of S. Enteritidis in the chicken caeca... - Poultry as a host for the zoonotic pathogen Campylobacter jejuniDavid Hermans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
Vector Borne Zoonotic Dis 12:89-98. 2012..jejuni in broiler flocks. As a result, the number of human campylobacteriosis cases associated with the chicken vector remains strikingly high... - Long-term colonisation-inhibition studies to protect broilers against colonisation with Salmonella Enteritidis, using Salmonella Pathogenicity Island 1 and 2 mutantsLotte Bohez
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vaccine 25:4235-43. 2007..The approach of vaccination with a hilA mutant strain can be a valuable basis for development of vaccine strains for broilers protection... - Anaerostipes butyraticus sp. nov., an anaerobic, butyrate-producing bacterium from Clostridium cluster XIVa isolated from broiler chicken caecal content, and emended description of the genus AnaerostipesVenessa Eeckhaut
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Int J Syst Evol Microbiol 60:1108-12. 2010..nov. is proposed. The type strain is 35-7(T) (=LMG 24724(T) =DSM 22094(T)). An emended description of the genus Anaerostipes is also provided... - Campylobacter control in poultry by current intervention measures ineffective: urgent need for intensified fundamental researchDavid Hermans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Vet Microbiol 152:219-28. 2011..This review gives an up-to-date overview of suggested on-farm control measures to reduce the prevalence and colonization of Campylobacter in poultry... - Oral immunisation of laying hens with the live vaccine strains of TAD Salmonella vac E and TAD Salmonella vac T reduces internal egg contamination with Salmonella EnteritidisInne Gantois
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vaccine 24:6250-5. 2006..In conclusion, these data indicate that vaccination of laying hens with these live vaccines could be considered as a valuable tool in controlling internal egg contamination... - Virulence properties of Campylobacter jejuni isolates of poultry and human originKim Van Deun
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
J Med Microbiol 56:1284-9. 2007..These data suggest that all four virulence properties are widespread among C. jejuni isolates, but that a higher degree of bile-salt resistance and more pronounced CDT production are associated with strains causing enteritis in humans... - Cats as a risk for transmission of antimicrobial drug-resistant SalmonellaFilip Van Immerseel
Ghent University, Merelbeke, Belgium
Emerg Infect Dis 10:2169-74. 2004..Cats that excrete Salmonella can pose a public health hazard to people who are highly susceptible to Salmonella, such as children, the elderly, and immunocompromised persons... - Salmonella Typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigsFilip Boyen
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Microbes Infect 8:2899-907. 2006..This study shows that SPI-1 plays a crucial role in the invasion and colonization of the porcine gut and in the induction of influx of neutrophils towards the intestinal lumen, but not in the colonization of the tonsils... - The cinnamon-oil ingredient trans-cinnamaldehyde fails to target Campylobacter jejuni strain KC 40 in the broiler chicken cecum despite marked in vitro activityDavid Hermans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Food Prot 74:1729-34. 2011..jejuni numbers were not reduced compared with those in nontreated ceca at 2 and 24 h after injection. In conclusion, this study shows a marked discrepancy between in vitro and in vivo activity of CIN against C. jejuni strain KC 40... - A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gutDavid Hermans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Crit Rev Microbiol 38:17-29. 2012..jejuni in chicks and to develop effective control measures to clear this zoonotic pathogen from poultry lines... - Intra-species growth-inhibition by Clostridium perfringens is a possible virulence trait in necrotic enteritis in broilersLeen Timbermont
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 137:388-91. 2009..It is proposed that, in addition to toxin production, intra-species growth-inhibition may be a virulence trait that contributes to the ability of certain C. perfringens strains to cause necrotic enteritis in broilers... - Induction of the carrier state in pigeons infected with Salmonella enterica subspecies enterica serovar typhimurium PT99 by treatment with florfenicol: a matter of pharmacokineticsFrank Pasmans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Antimicrob Agents Chemother 52:954-61. 2008..In conclusion, the oral application of florfenicol for the treatment of pigeon paratyphoid contributes to the development of carrier animals through sub-MIC concentrations in plasma that do not inhibit intracellular persistency... - Quantification of gut lesions in a subclinical necrotic enteritis modelAhmad R Gholamiandehkordi
Research Group Veterinary Public Health and Zoonoses, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Avian Pathol 36:375-82. 2007..perfringens inoculations is a suitable model for necrotic enteritis without inducing mortality of the animals. C. perfringens and Eimeria act synergistically in inducing grossly visible gut damage... - The cereal type in feed influences gut wall morphology and intestinal immune cell infiltration in broiler chickensEmma Teirlynck
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Br J Nutr 102:1453-61. 2009..In conclusion, a wheat/rye-based diet evoked mucosal damage, an alteration in the composition of the microbiota and an inflammatory bowel type of condition... - Assessment of virulence of pigeon isolates of Salmonella enterica subsp. enterica serovar typhimurium variant copenhagen for humansFrank Pasmans
Department of Pathology, Bacteriology, and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
J Clin Microbiol 42:2000-2. 2004..However, the high virulence for mice of the tested strain implies that rodents may act as reservoirs... - Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocationKim Van Deun
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium
Br J Nutr 100:480-4. 2008..The present study showed that butyrate is able to protect Caco-2 cells from two major virulence mechanisms of C. jejuni, namely invasion and translocation, but not from a decline in transepithelial resistance... - Antimicrobial resistance in Clostridium perfringens isolates from broilers in BelgiumAhmadreza Gholamiandehkordi
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Res Commun 33:1031-7. 2009..These data are consistent with data derived from studies carried out in 1980 and in 2004, indicating that no changes in antimicrobial resistance patterns have taken place during time in C. perfringens isolates from broilers in Belgium... - Mechanisms of egg contamination by Salmonella EnteritidisInne Gantois
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Research Group Veterinary Public Health and Zoonoses, Ghent University, Merelbeke, Belgium
FEMS Microbiol Rev 33:718-38. 2009..This appears to require a unique combination of genes encoding for improved cell wall protection and repairing cellular and molecular damage, among others... - Dynamics of immune cell infiltration in the caecal lamina propria of chickens after neonatal infection with a Salmonella enteritidis strainFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820, Merelbeke, Belgium
Dev Comp Immunol 26:355-64. 2002..The structural maturation of the mucosa-associated lymphoid tissues is antigen driven, since B-cells organise in a follicular pattern... - Effect of type 1 fimbriae of Salmonella enterica serotype Enteritidis on bacteraemia and reproductive tract infection in laying hensJeroen De Buck
Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Avian Pathol 33:314-20. 2004..Thus, the absence of type 1 fimbriae prolongs bacteraemia, modifies reproductive tract infection and reduces egg shell contamination by Salmonella enterica serovar Enteritidis... - Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitroFilip Van Immerseel
Department of Pathology, Bacteriology, and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium
Avian Dis 48:384-91. 2004..These interactions of S. enteritidis with primary chicken cecal epithelial cells were similar to the interactions with other epithelial cell types... - Butyricicoccus pullicaecorum gen. nov., sp. nov., an anaerobic, butyrate-producing bacterium isolated from the caecal content of a broiler chickenVenessa Eeckhaut
Department of Pathology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Int J Syst Evol Microbiol 58:2799-802. 2008..nov., sp. nov. The type strain of Butyricicoccus pullicaecorum is 25-3(T) (=LMG 24109(T) =CCUG 55265(T)). The DNA G+C content of strain 25-3(T) was 54.5 mol% ... - Molecular and phenotypical characterization of Clostridium perfringens isolates from poultry flocks with different disease statusAhmad R Gholamiandekhordi
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium
Vet Microbiol 113:143-52. 2006..It was shown that in vitro alpha toxin production of C. perfringens isolates from diseased flocks was not higher than in vitro alpha toxin production from isolates derived from healthy flocks... - Rethinking our understanding of the pathogenesis of necrotic enteritis in chickensFilip Van Immerseel
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Trends Microbiol 17:32-6. 2009..Recent research is creating a paradigm shift in our understanding of the pathogenesis of NE and is now providing information that will be necessary to monitor and control the incidence of NE in poultry... - Adhesion of Salmonella enterica serotype Enteritidis isolates to chicken isthmal glandular secretionsJeroen De Buck
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 93:223-33. 2003..It is hypothesized that the binding of S. Enteritidis to isthmal secretions could play a role in the contamination of eggs through incorporation of the bacteria in the shell membranes... - Colonization factors of Campylobacter jejuni in the chicken gutDavid Hermans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Vet Res 42:82. 2011..jejuni identified to date. These factors may contribute to our understanding on how C. jejuni survival and colonization in chicks is mediated, as well as provide potential targets for effective subunit vaccine development... - Host adaptation of pigeon isolates of Salmonella enterica subsp. enterica serovar Typhimurium variant Copenhagen phage type 99 is associated with enhanced macrophage cytotoxicityFrank Pasmans
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Infect Immun 71:6068-74. 2003..These data suggest that the phage type 99 strains used in this study are highly adapted to pigeons and should be classified as a host-restricted lineage of the serovar Typhimurium... - Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilliPieter Van den Abbeele
Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
Microb Biotechnol 5:106-15. 2012..This may lead to more in vivo-like microbial communities in such dynamic, long-term in vitro simulations and allow the study of the unique mucosal microbiota in health and disease... - Detection of Batrachochytrium dendrobatidis in Mexican bolitoglossine salamanders using an optimal sampling protocolPascale Van Rooij
Laboratory of Bacteriology and Mycology, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Ecohealth 8:237-43. 2011.... - A live Salmonella enterica serovar Enteritidis vaccine allows serological differentiation between vaccinated and infected animalsConnie Adriaensen
Viral Genetics Laboratory, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Infect Immun 75:2461-8. 2007..enterica serovar Enteritidis challenge strain but not against intestinal colonization. These data demonstrate that nonflagellated attenuated Salmonella mutants can be used as marker vaccines...