Kurt G Tournoy

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Screening and diagnosis of NSCLC
    J P van Meerbeeck
    Ghent University Hospital, Thoracic Oncology Unit, Belgium
    Ann Oncol 15:iv65-70. 2004
  2. doi request reprint Mediastinal staging of lung cancer: novel concepts
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Medicine and Thoracic Oncology, Ghent, Belgium
    Lancet Oncol 13:e221-9. 2012
  3. doi request reprint Are EUS-FNA and EBUS-TBNA specimens reliable for subtyping non-small cell lung cancer?
    K G Tournoy
    Department of Respiratory Medicine and Thoracic Oncology, Ghent University Hospital, Belgium
    Lung Cancer 76:46-50. 2012
  4. doi request reprint EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncologic Network, Ghent University Hospital, Ghent, Belgium
    Lung Cancer 63:45-9. 2009
  5. ncbi request reprint Endoscopic ultrasound reduces surgical mediastinal staging in lung cancer: a randomized trial
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Medicine, Building 7K12 I E, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Respir Crit Care Med 177:531-5. 2008
  6. doi request reprint The yield of endoscopic ultrasound in lung cancer staging: does lymph node size matter?
    Kurt G Tournoy
    Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan, Ghent, Belgium
    J Thorac Oncol 3:245-9. 2008
  7. ncbi request reprint The role of immune tolerance in asthma pathogenesis
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Diseases, Gent, Belgium
    Curr Allergy Asthma Rep 6:437-43. 2006
  8. ncbi request reprint Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Ghent University, Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium
    Clin Exp Allergy 36:8-20. 2006
  9. doi request reprint Transesophageal endoscopic ultrasound with fine needle aspiration in the preoperative staging of malignant pleural mesothelioma
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncology Network, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Clin Cancer Res 14:6259-63. 2008
  10. ncbi request reprint Esophageal endoscopic ultrasound with fine-needle aspiration with an on-site cytopathologist: high accuracy for the diagnosis of mediastinal lymphadenopathy
    Kurt G Tournoy
    Department of Pulmonary Diseases, Endoscopy Unit, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Chest 128:3004-9. 2005

Detail Information

Publications39

  1. ncbi request reprint Screening and diagnosis of NSCLC
    J P van Meerbeeck
    Ghent University Hospital, Thoracic Oncology Unit, Belgium
    Ann Oncol 15:iv65-70. 2004
  2. doi request reprint Mediastinal staging of lung cancer: novel concepts
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Medicine and Thoracic Oncology, Ghent, Belgium
    Lancet Oncol 13:e221-9. 2012
    ..Further refinement of this recommendation is likely in the near future because data suggest that the confirmatory mediastinoscopy is particularly useful for patients with enlarged or FDG-avid lymph nodes...
  3. doi request reprint Are EUS-FNA and EBUS-TBNA specimens reliable for subtyping non-small cell lung cancer?
    K G Tournoy
    Department of Respiratory Medicine and Thoracic Oncology, Ghent University Hospital, Belgium
    Lung Cancer 76:46-50. 2012
    ..In conclusion, for patients with NSCLC in whom subtyping is relevant, a diagnostic technique yielding larger samples (FNA with cell block preparation or biopsies) should be preferred...
  4. doi request reprint EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncologic Network, Ghent University Hospital, Ghent, Belgium
    Lung Cancer 63:45-9. 2009
    ..Obtaining a tissue diagnosis of malignancy is challenging in patients with suspected lung cancer presenting with centrally located intrapulmonary masses...
  5. ncbi request reprint Endoscopic ultrasound reduces surgical mediastinal staging in lung cancer: a randomized trial
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Medicine, Building 7K12 I E, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Respir Crit Care Med 177:531-5. 2008
    ..Linear transesophageal endoscopic ultrasound with real-time guided fine-needle aspiration (EUS-FNA) is a promising, nonsurgical tool for mediastinal staging...
  6. doi request reprint The yield of endoscopic ultrasound in lung cancer staging: does lymph node size matter?
    Kurt G Tournoy
    Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan, Ghent, Belgium
    J Thorac Oncol 3:245-9. 2008
    ..We compared the performance of EUS-FNA to show malignant invasion in enlarged versus small MLN...
  7. ncbi request reprint The role of immune tolerance in asthma pathogenesis
    Kurt G Tournoy
    Ghent University Hospital, Department of Respiratory Diseases, Gent, Belgium
    Curr Allergy Asthma Rep 6:437-43. 2006
    ..In this review, we discuss immune tolerance and the evidence supporting its role in asthma pathogenesis...
  8. ncbi request reprint Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Ghent University, Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium
    Clin Exp Allergy 36:8-20. 2006
    ..Here we review the available knowledge about allergen-induced suppressive immunity obtained from animal models taking into account the different developmental stages of allergic airway disease...
  9. doi request reprint Transesophageal endoscopic ultrasound with fine needle aspiration in the preoperative staging of malignant pleural mesothelioma
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncology Network, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Clin Cancer Res 14:6259-63. 2008
    ..Transesophageal endoscopic ultrasound with real-time guided fine needle aspiration (EUS-FNA) enables accurate MLN staging in lung cancer...
  10. ncbi request reprint Esophageal endoscopic ultrasound with fine-needle aspiration with an on-site cytopathologist: high accuracy for the diagnosis of mediastinal lymphadenopathy
    Kurt G Tournoy
    Department of Pulmonary Diseases, Endoscopy Unit, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Chest 128:3004-9. 2005
    ....
  11. ncbi request reprint The sound of the parasite. Diagnosing mediastinal cysts with endoscopic ultrasound techniques
    Kurt G Tournoy
    Department of Respiratory Diseases, Endoscopy Unit, Ghent University Hospital, Ghent, Belgium
    Respiration 75:98-9. 2008
  12. doi request reprint Endoscopic and endobronchial ultrasonography according to the proposed lymph node map definition in the seventh edition of the tumor, node, metastasis classification for lung cancer
    Kurt G Tournoy
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    J Thorac Oncol 4:1576-84. 2009
    ....
  13. doi request reprint The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis
    K G Tournoy
    Dept of Respiratory Medicine, Building 7K12 I E, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Eur Respir J 35:1329-35. 2010
    ..This large prospective implementation study (trial number NCT00888212; ClinicalTrials.gov) shows that endoscopic ultrasound is valuable for diagnosing sarcoidosis after negative flexible bronchoscopy results...
  14. doi request reprint Endobronchial ultrasound-guided transbronchial needle biopsy for M1 staging of extrathoracic malignancies
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Ann Oncol 22:127-31. 2011
    ..Endobronchial ultrasound with real-time-guided transbronchial fine-needle aspiration (EBUS-TBNA) is a minimally invasive alternative for surgical staging of lung cancer...
  15. pmc Integrated FDG-PET/CT does not make invasive staging of the intrathoracic lymph nodes in non-small cell lung cancer redundant: a prospective study
    K G Tournoy
    Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Thorax 62:696-701. 2007
    ..The accuracy of FDG-PET scans for staging of lymph nodes is too low to replace invasive nodal staging. It is unknown whether the accuracy of integrated FDG-PET/CT scanning makes invasive staging redundant...
  16. doi request reprint Comparison of acute inflammatory and chronic structural asthma-like responses between C57BL/6 and BALB/c mice
    Chris L Van Hove
    Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Int Arch Allergy Immunol 149:195-207. 2009
    ..In both mice and humans, genetic differences can have a profound influence on allergy, inflammation, airway responsiveness and structural changes...
  17. doi request reprint Short cigarette smoke exposure facilitates sensitisation and asthma development in mice
    Ellen A Lanckacker
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium
    Eur Respir J 41:1189-99. 2013
    ..Short cigarette smoke exposure is sufficient to facilitate allergic sensitisation and the development of low-dose HDM-induced allergic asthma, possibly by affecting dendritic cell function...
  18. pmc Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance
    Chris L Van Hove
    Department of Respiratory Diseases, Ghent University, Ghent, Belgium
    Respir Res 9:42. 2008
    ..We have recently shown that, in allergic mice, the airway inflammation can be cleared by repeated allergen challenge, resulting in the establishment of a state of inhalational tolerance...
  19. doi request reprint Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent
    Sharen Provoost
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 129:483-91. 2012
    ..Dendritic cells (DCs) are important mediators in immune regulation. We previously showed that the inhalation of DEPs increased the accumulation of DCs in the lung and enhanced the T(H)2 response in the mediastinal lymph node...
  20. pmc Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation
    Tania Maes
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Respir Res 11:7. 2010
    ..Clinical data are compared with findings from murine models of asthma and inhalable pollutant exposure. Moreover, the potential mechanisms by which both pollutants could aggravate asthma are discussed...
  21. pmc Cigarette smoke exposure facilitates allergic sensitization in mice
    Katrien B Moerloose
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Respir Res 7:49. 2006
    ..Active and passive smoking are considered as risk factors for asthma development. The mechanisms involved are currently unexplained...
  22. doi request reprint Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells
    Sharen Provoost
    Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium
    J Immunol 184:426-32. 2010
    ..This resulted in an enhanced T cell recruitment and effector differentiation in the MLN. These data suggest that DEP inhalation modulates immune responses in the lung via stimulation of DC function...
  23. doi request reprint Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints
    Pieter Bogaert
    Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    Am J Physiol Lung Cell Mol Physiol 300:L679-90. 2011
    ..These differential signatures, superimposed onto a generic inflammatory signature, denote distinctive inflammatory checkpoints potentially involved in orchestrating neutrophil-dominated asthma...
  24. doi request reprint NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation
    Sharen Provoost
    Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, 9000 Ghent, Belgium
    J Immunol 187:3331-7. 2011
    ..In addition, DEP initiates inflammation independent of the classical NLRP3/caspase-1 pathway, suggesting that other proteases might be involved...
  25. ncbi request reprint Prolonged inhaled allergen exposure can induce persistent tolerance
    Chris L Van Hove
    Department of Respiratory Diseases, Faculty of Medicine, Ghent University and Ghent University Hospital 7K12 I E, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Respir Cell Mol Biol 36:573-84. 2007
    ..Our data further suggest that the mechanism of the disease inhibition after allergic airway inflammation differs from the anti-inflammatory mechanisms observed during acute eosinophilic airway inflammation...
  26. doi request reprint Gene therapy for allergic airway diseases
    Tania Maes
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Curr Allergy Asthma Rep 11:163-72. 2011
    ..In this review, we focus on preclinical models to describe the recent developments and major breakthroughs for treating allergic airway diseases with gene therapy...
  27. pmc Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma
    Pieter Bogaert
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    Am J Pathol 174:3-13. 2009
    ..On this basis, we propose that asthma allergens cause severe noneosinophilic asthma because of sensitization in the presence of hypersensitivity pneumonitis-promoting danger signaling...
  28. ncbi request reprint The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma
    Katelijne O De Swert
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Allergy Clin Immunol 113:1093-9. 2004
    ..Human data suggest a role for these peptides in asthma, but the exact role of tachykinins and their receptors in allergic airway inflammation is still a matter of debate...
  29. ncbi request reprint The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent
    K G Tournoy
    Department of Respiratory Diseases 7 K12 I E, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Immunol 166:6982-91. 2001
    ..They also demonstrate that human allergen-specific Th1 lymphocytes can be driven to a Th2 phenotype...
  30. pmc Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?
    An I D'hulst
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Respir Res 6:147. 2005
    ....
  31. ncbi request reprint Is Th1 the solution for Th2 in asthma?
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Clin Exp Allergy 32:17-29. 2002
  32. ncbi request reprint Counterbalancing of TH2-driven allergic airway inflammation by IL-12 does not require IL-10
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 107:483-91. 2001
    ..The TH1-promoting cytokine IL-12 is capable of inhibiting the TH2-driven allergen-induced airway changes in mice and is therefore regarded as an interesting strategy for treating asthma...
  33. doi request reprint Decreased FOXP3 protein expression in patients with asthma
    S Provoost
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Allergy 64:1539-46. 2009
    ..In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma...
  34. doi request reprint Chronic inflammation in asthma: a contest of persistence vs resolution
    C L Van Hove
    Department of Respiratory Medicine, Laboratory of Translational Research in Obstructive Pulmonary Diseases, Ghent University, Ghent, Belgium
    Allergy 63:1095-109. 2008
    ..Here, we review and discuss the current knowledge about these endogenous anti-inflammatory mediators in clinical and experimental asthma...
  35. ncbi request reprint New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5
    J C Kips
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 17:499-506. 2001
    ..Some of these compounds have proven to be biologically active in man. The challenge now is to establish their therapeutic role in asthma...
  36. pmc Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
    Didier D Cataldo
    Department of Respiratory Diseases and Laboratory of Biology of Tumours and Development, University of Liege, Liege, Belgium
    Am J Pathol 161:491-8. 2002
    ..In contrast, the expression of tissue inhibitor of metalloproteinases-1 was enhanced after allergen exposure in both groups. We conclude that MMP-9 plays a key role in the development of airway inflammation after allergen exposure...
  37. ncbi request reprint New American College of Chest Physicians guidelines on mediastinal staging and management of stage IIIA-N2 non-small cell lung cancer: a European perspective
    Kurt G Tournoy
    Pol Arch Med Wewn 118:175-8. 2008
  38. doi request reprint Lung cancer staging with minimally invasive endoscopic techniques
    Jouke T Annema
    JAMA 299:2510; author reply 2510-1. 2008
  39. ncbi request reprint Comment on "A novel pathway that regulates inflammatory disease in the respiratory tract"
    Chris L Van Hove
    J Immunol 178:7501; author reply 7501-2. 2007