Linda M Thienpont

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Feasibility study of the use of frozen human sera in split-sample comparison of immunoassays with candidate reference measurement procedures for total thyroxine and total triiodothyronine measurements
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    Clin Chem 51:2303-11. 2005
  2. doi request reprint State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem 54:1290-7. 2008
  3. doi request reprint Accuracy in clinical chemistry - who will kiss Sleeping Beauty awake?
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem Lab Med 46:1220-2. 2008
  4. doi request reprint Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 2: free thyroxine and free triiodothyronine
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 56:912-20. 2010
  5. doi request reprint Standardization of measurements of 25-hydroxyvitamin D3 and D2
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Scand J Clin Lab Invest Suppl 243:41-9. 2012
  6. ncbi request reprint Metrologic traceability of total thyroxine measurements in human serum: efforts to establish a network of reference measurement laboratories
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Gent, Belgium
    Clin Chem 51:161-8. 2005
  7. doi request reprint Traceability to a common standard for protein measurements by immunoassay for in-vitro diagnostic purposes
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chim Acta 411:2058-61. 2010
  8. doi request reprint Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 1: thyroid-stimulating hormone
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 56:902-11. 2010
  9. ncbi request reprint Measurement of free thyroxine in laboratory medicine--proposal of measurand definition
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 45:563-4. 2007
  10. ncbi request reprint Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 45:934-6. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Feasibility study of the use of frozen human sera in split-sample comparison of immunoassays with candidate reference measurement procedures for total thyroxine and total triiodothyronine measurements
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    Clin Chem 51:2303-11. 2005
    ..Processed, frozen single-donation sera, assigned target values by candidate reference measurement procedures (cRMPs), were used with immunoassays for total thyroxine (TT(4)) and triiodothyronine (TT(3)) as models...
  2. doi request reprint State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem 54:1290-7. 2008
    ....
  3. doi request reprint Accuracy in clinical chemistry - who will kiss Sleeping Beauty awake?
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem Lab Med 46:1220-2. 2008
    ..The driving force towards accuracy should come from the test developers, while the lead should be taken by the clinical chemistry community, itself being guided by the clinical professions...
  4. doi request reprint Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 2: free thyroxine and free triiodothyronine
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 56:912-20. 2010
    ..The IFCC Scientific Division established a Working Group to resolve issues of method performance to meet clinical requirements...
  5. doi request reprint Standardization of measurements of 25-hydroxyvitamin D3 and D2
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Scand J Clin Lab Invest Suppl 243:41-9. 2012
    ....
  6. ncbi request reprint Metrologic traceability of total thyroxine measurements in human serum: efforts to establish a network of reference measurement laboratories
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Gent, Belgium
    Clin Chem 51:161-8. 2005
    ..Here we report the results of a European project to investigate the feasibility of developing a RMS for serum total thyroxine...
  7. doi request reprint Traceability to a common standard for protein measurements by immunoassay for in-vitro diagnostic purposes
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chim Acta 411:2058-61. 2010
    ..This is due to a lack of understanding of metrological concepts and of acceptance of a pragmatic metrological concept for mixture analysis...
  8. doi request reprint Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 1: thyroid-stimulating hormone
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 56:902-11. 2010
    ..However, between-assay discrepancies in TSH results limit the application of clinical practice guidelines...
  9. ncbi request reprint Measurement of free thyroxine in laboratory medicine--proposal of measurand definition
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 45:563-4. 2007
  10. ncbi request reprint Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 45:934-6. 2007
    ..The WG-STFT stresses that according to this recommendation it is a prerequisite to strictly adhere to the defined equilibrium dialysis procedure, whereas it is permissible to introduce variants in the ID-LC/tandem MS procedure...
  11. doi request reprint Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 3: total thyroxine and total triiodothyronine
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 56:921-9. 2010
    ....
  12. doi request reprint Standardization activities in the field of thyroid function tests: a status report
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 48:1577-83. 2010
    ..However, the current status of standardization hampers the interchangeability of results. To improve this situation, the Working Group for Standardization of Thyroid Function Tests was established...
  13. ncbi request reprint Metrological traceability of calibration in the estimation and use of common medical decision-making criteria
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem Lab Med 42:842-50. 2004
    ..Finally, laboratory medicine scientific and professional societies, diagnostics manufacturers, and clinicians are urged to share responsibilities for understanding the implications of metrological traceability of routine measurements...
  14. ncbi request reprint Use of frozen sera for FT4 standardization: investigation by equilibrium dialysis combined with isotope dilution-mass spectrometry and immunoassay
    Katleen Van Uytfanghe
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 52:1817-21. 2006
    ..To that purpose, we applied equilibrium dialysis (ED) in combination with isotope dilution-liquid chromatography/tandem mass spectrometry (ID-LC-tandem MS)...
  15. ncbi request reprint Pilot study for the standardization of insulin immunoassays with isotope dilution liquid chromatography/tandem mass spectrometry
    Diego Rodríguez-Cabaleiro
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 53:1462-9. 2007
    ..In view of this demand, we conducted a pilot study to investigate the feasibility of such a standardization project with our isotope dilution-liquid chromatography/tandem mass spectrometry (ID-LC/tandem MS) procedure...
  16. ncbi request reprint Evaluation of a candidate reference measurement procedure for serum free testosterone based on ultrafiltration and isotope dilution-gas chromatography-mass spectrometry
    Katleen Van Uytfanghe
    Laboratory for Analytical Chemistry and Laboratory for Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem 50:2101-10. 2004
    ..The use of equilibrium dialysis (ED) or ultrafiltration (UF) is advocated. Our objective was to develop such a candidate RMP...
  17. ncbi request reprint Feasibility of standardization of serum C-peptide immunoassays with isotope-dilution liquid chromatography-tandem mass spectrometry
    Diego Rodriguez Cabaleiro
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem 52:1193-6. 2006
    ..For serum peptides, isotope-dilution liquid chromatography-mass spectrometry (ID-LC/MS) is recommended as a reference measurement procedure...
  18. ncbi request reprint Application of a C-peptide electrospray ionization-isotope dilution-liquid chromatography-tandem mass spectrometry measurement procedure for the evaluation of five C-peptide immunoassays for urine
    Colette Fierens
    Laboratorium voor Analytische Chemie, Faculteit Farmaceutische Wetenschappen, Universiteit Gent, Harelbekestraat 72, B 9000 Gent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 792:249-59. 2003
    ..From the spread of the data around the regression line in comparison with the 95% prediction intervals from the total RSD, sample-related effects and/or specificity problems were apparent and investigated...
  19. doi request reprint Status of serum-calcium and -albumin measurement in Argentina assessed in 300 representative laboratories with 20 fresh frozen single donation sera
    Hedwig C M Stepman
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 49:1829-36. 2011
    ..To eliminate these confounding factors, a study using frozen single donation sera was undertaken with the focus on serum-calcium and -albumin measurement...
  20. ncbi request reprint Standardization of C-peptide measurements in urine by method comparison with isotope-dilution mass spectrometry
    Colette Fierens
    Laboratorium voor Analytische Chemie, Faculteit Farmaceutische Wetenschappen, Universiteit Gent, Harelbekestraat 72, B 9000 Gent, Belgium
    Clin Chem 49:992-4. 2003
  21. doi request reprint IFCC international conventional reference procedure for the measurement of free thyroxine in serum: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group for Standardization of Thyroid Function Tests (WG-STFT)(1)
    Sofie K Van Houcke
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 49:1275-81. 2011
    ..We recommend a protocol for successful calibration, measurement and monitoring of the accuracy/trueness and precision of the candidate conventional RMP. For details on our ID-LC/tandem MS procedures, we refer to the Supplement...
  22. ncbi request reprint Pilot external quality assessment survey for post-market vigilance of in vitro diagnostic medical devices and investigation of trueness of participants' results
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem Lab Med 41:183-6. 2003
    ..The survey pointed out to the other participants, interchanging instrument, reagent and calibrator, that they are themselves responsible for the problems shown and hence also for problem-solving...
  23. doi request reprint Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry
    Hedwig C M Stepman
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem 57:441-8. 2011
    ..We aimed at developing candidate RMPs on the basis of isotope- dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) for separate quantification of serum 25(OH)D2 and 25(OH)D3...
  24. doi request reprint Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D₃ in serum of infants and adults
    Hedwig C M Stepman
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 49:253-6. 2011
    ..A second objective was mass spectrometric investigation of the presence and prevalence of the 3-epi metabolite in serum from adults...
  25. doi request reprint Long-term stability of laboratory tests and practical implications for quality management
    Sofie K Van Houcke
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Clin Chem Lab Med 51:1227-31. 2013
    ..We used multiyear patient and internal quality control (IQC) data from two laboratories for tests to monitor chronic kidney and thyroid disease...
  26. doi request reprint Specifications for trueness and precision of a reference measurement system for serum/plasma 25-hydroxyvitamin D analysis
    Dietmar Stöckl
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Clin Chim Acta 408:8-13. 2009
    ..The divergence in analytical quality of serum/plasma 25-hydroxy-vitamin D analysis calls for defining specifications for a reference measurement system...
  27. ncbi request reprint About the z-multiplier in total error calculations
    Dietmar Stöckl
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem Lab Med 46:1648-9. 2008
    ..96 in the absence of SE is of considerable magnitude (one-sided 95% probability). Up to now, no SE/RE ratio dependent z-values have been considered. Here, we present z-values for SE/RE ratios ranging from 0 to 1...
  28. doi request reprint Introduction of non-linearity by data transformation in method comparison and commutability studies
    Dietmar Stöckl
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem Lab Med 46:1784-5. 2008
    ..We show that in the case of a considerable constant difference in the relationship between the x- and y-data, logarithmic transformation introduces non-linearity...
  29. ncbi request reprint Reference measurement systems in clinical chemistry
    Linda M Thienpont
    Laboratorium voor Analytische Chemie Fac Farmaceutische Wetenschappen, Universiteit Gent, Harelbekestraat 72, B 9000, Ghent, Belgium
    Clin Chim Acta 323:73-87. 2002
    ..In clinical chemistry, traceability of measurements is of high priority...
  30. doi request reprint Trueness verification of actual creatinine assays in the European market demonstrates a disappointing variability that needs substantial improvement. An international study in the framework of the EC4 creatinine standardization working group
    Joris R Delanghe
    University Hospital, Gent, Belgium
    Clin Chem Lab Med 46:1319-25. 2008
    ..The European In Vitro Diagnostics (IVD) directive requires traceability to reference methods and materials of analytes. It is a task of the profession to verify the trueness of results and IVD compatibility...
  31. ncbi request reprint Differences in serum ionized and total magnesium values during chronic renal failure between nondiabetic and diabetic patients: a cross-sectional study
    Katy Dewitte
    Faculty of Pharmaceutical Sciences, Laboratory for Analytical Chemistry, Ghent University, Harelbekestraat 72, Ghent 9000, Belgium
    Diabetes Care 27:2503-5. 2004
  32. ncbi request reprint "Good samples make good assays" – the problem of sourcing clinical samples for a standardization project
    Sofie K Van Houcke
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    Clin Chem Lab Med 51:967-72. 2013
    ....
  33. doi request reprint Method validation across the disciplines--critical investigation of major validation criteria and associated experimental protocols
    Dietmar Stöckl
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2180-90. 2009
    ..Last but not least, we give incentive towards a modernized validation design...
  34. ncbi request reprint Development of a simplified sample pretreatment procedure as part of an isotope dilution-liquid chromatography/tandem mass spectrometry candidate reference measurement procedure for serum total thyroxine
    Katleen Van Uytfanghe
    Rapid Commun Mass Spectrom 18:1539-40. 2004
  35. ncbi request reprint Analytic bias of thyroid function tests: analysis of a College of American Pathologists fresh frozen serum pool by 3900 clinical laboratories
    Bernard W Steele
    Department of Pathology, University of Miami School of Medicine, Miami, Fla, USA
    Arch Pathol Lab Med 129:310-7. 2005
    ..In proficiency testing surveys, there are differences in the values reported by users of various analytic methods. Two contributors to this variation are calibrator bias and matrix effects of proficiency testing materials...
  36. doi request reprint A major step forward in the routine measurement of serum free thyroid hormones
    Linda M Thienpont
    Clin Chem 54:625-6. 2008
  37. ncbi request reprint Creatinine measurement: state of the art in accuracy and interlaboratory harmonization
    W Greg Miller
    Virginia Commonwealth University, Richmond 23298 0286, USA
    Arch Pathol Lab Med 129:297-304. 2005
    ..The National Kidney Disease Education Program recommends calculating glomerular filtration rate from serum creatinine concentration. Accurate creatinine measurements are necessary for this calculation...
  38. ncbi request reprint Improvement of sample pretreatment prior to analysis of C-peptide in serum by isotope-dilution liquid chromatography/tandem mass spectrometry
    Diego Rodríguez-Cabaleiro
    Rapid Commun Mass Spectrom 19:3600-2. 2005
  39. ncbi request reprint Application of the Bland-Altman plot for interpretation of method-comparison studies: a critical investigation of its practice
    Katy Dewitte
    Clin Chem 48:799-801; author reply 801-2. 2002
  40. ncbi request reprint Interpreting method comparison studies by use of the bland-altman plot: reflecting the importance of sample size by incorporating confidence limits and predefined error limits in the graphic
    Dietmar Stöckl
    Clin Chem 50:2216-8. 2004
  41. ncbi request reprint New liquid chromatography/electrospray ionisation tandem mass spectrometry measurement procedure for quantitative analysis of human insulin in serum
    Katleen Van Uytfanghe
    Rapid Commun Mass Spectrom 21:819-21. 2007
  42. doi request reprint State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry
    W Greg Miller
    Department of Pathology, Virginia Commonwealth University, PO Box 980286, Richmond, VA 23298 0286, USA
    Arch Pathol Lab Med 132:838-46. 2008
    ..Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established...