R Raedt

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Cell therapy in models for temporal lobe epilepsy
    R Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, De Pintelaan 145, B 9000 Ghent, Belgium
    Seizure 16:565-78. 2007
  2. ncbi Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus
    Robrecht Raedt
    Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsy Res 87:148-59. 2009
  3. ncbi Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model
    Robrecht Raedt
    Department of Neurology, Ghent University Hospital, Ghent, Belgium
    J Neurochem 117:461-9. 2011
  4. ncbi Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat
    R Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium
    Acta Neurol Scand 119:293-303. 2009
  5. ncbi Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Belgium
    Exp Neurol 203:542-54. 2007
  6. ncbi Cell therapy for neurological disorders: a comprehensive review
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 105:158-70. 2005
  7. ncbi Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsia 48:1952-63. 2007
  8. ncbi Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures
    V De Herdt
    Department of Neurology, Ghent University Hospital, Belgium
    Acta Neurol Scand 121:271-6. 2010
  9. ncbi Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate
    Tim De Smedt
    Laboratory for Clinical and Experimental Neurophysiology, University Hospital Ghent, Belgium
    Seizure 16:620-6. 2007
  10. ncbi Deep brain stimulation for epilepsy: knowledge gained from experimental animal models
    T Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 109:63-80. 2009

Collaborators

Detail Information

Publications32

  1. ncbi Cell therapy in models for temporal lobe epilepsy
    R Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, De Pintelaan 145, B 9000 Ghent, Belgium
    Seizure 16:565-78. 2007
    ..Even though several studies show encouraging results, more studies need to be done in animal models with spontaneous seizures in order to have a better comparison to the human situation...
  2. ncbi Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus
    Robrecht Raedt
    Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsy Res 87:148-59. 2009
    ..In this study the fate of adult-derived neurosphere cells was evaluated after transplantation in the lesioned hippocampus of the intrahippocampal kainic acid (KA) model for TLE...
  3. ncbi Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model
    Robrecht Raedt
    Department of Neurology, Ghent University Hospital, Ghent, Belgium
    J Neurochem 117:461-9. 2011
    ....
  4. ncbi Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat
    R Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium
    Acta Neurol Scand 119:293-303. 2009
    ..However to date, precise electroencephalographic (EEG) and clinical characterization of spontaneous seizures in this epilepsy model using long-term video-EEG monitoring has not been performed...
  5. ncbi Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Belgium
    Exp Neurol 203:542-54. 2007
    ....
  6. ncbi Cell therapy for neurological disorders: a comprehensive review
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 105:158-70. 2005
    ..Also results of preclinical and clinical transplantation studies in three different disease models are critically evaluated...
  7. ncbi Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition
    Robrecht Raedt
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsia 48:1952-63. 2007
    ..In this study, we used low-dose whole brain radiation to suppress hippocampal neurogenesis and then studied the effect of this treatment on epileptogenesis in a kindling model for TLE...
  8. ncbi Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures
    V De Herdt
    Department of Neurology, Ghent University Hospital, Belgium
    Acta Neurol Scand 121:271-6. 2010
    ..This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS...
  9. ncbi Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate
    Tim De Smedt
    Laboratory for Clinical and Experimental Neurophysiology, University Hospital Ghent, Belgium
    Seizure 16:620-6. 2007
    ..Subsequently, the anticonvulsant profile of a relatively new anti-epileptic drug, topiramate, was evaluated in a cross-over design to further validate this rapid kindling model...
  10. ncbi Deep brain stimulation for epilepsy: knowledge gained from experimental animal models
    T Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 109:63-80. 2009
    ..Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications...
  11. ncbi Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve
    V De Herdt
    Laboratory for Clinical and Experimental Neurophysiology, Reference Center for Refractory Epilepsy, Department of Neurology 1K12IA, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Neuroimmunol 212:102-5. 2009
    ..These results suggest an immediate effect of VNS on the hypothalamic pituitary-adrenal (HPA) axis and support the role of the vagal nerve in immunomodulation...
  12. ncbi Predictive factors for outcome of invasive video-EEG monitoring and subsequent resective surgery in patients with refractory epilepsy
    Evelien Carrette
    Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, Belgium
    Clin Neurol Neurosurg 112:118-26. 2010
    ..The aim of the study is to identify predictive factors for outcome of IVEM and resective surgery (RS). These factors may optimize the patient flow following the non-invasive presurgical evaluation towards IVEM and RS or other treatments...
  13. ncbi Vagus nerve stimulation and the postictal state
    Kristl Vonck
    Reference Center for Refractory Epilepsy and Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Gent, Belgium
    Epilepsy Behav 19:182-5. 2010
    ..Both the clinical symptoms and the basic research hypotheses of the postictal state show similarities with clinical effects induced by VNS and its underlying mechanisms of action...
  14. ncbi Evolution in VNS therapy for refractory epilepsy, experience with Demipulse devices at Ghent University Hospital
    Riëm El Tahry
    Department of Neurology, Ghent University Hospital, Reference Center for Refractory Epilepsy, Gent, Belgium
    Seizure 19:531-5. 2010
    ..e. the VNS Therapy Demipulse Model 103. Treatment efficacy and side effects, as well as technical and practical enhancements useful for the patient and for the medical staff are discussed in this study...
  15. ncbi Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery
    Annelies Van Dycke
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium
    Seizure 19:390-6. 2010
    ....
  16. ncbi Quantitative analysis of adenosine using liquid chromatography/atmospheric pressure chemical ionization-tandem mass spectrometry (LC/APCI-MS/MS)
    Annelies Van Dycke
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1493-8. 2010
    ..5 min. These results demonstrate that this method is a useful tool to measure adenosine concentrations in culture medium released from stem cells in vitro...
  17. ncbi Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat
    Tine Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Ghent University Hospital, Ghent, Belgium
    Neuroimage 52:55-61. 2010
    ..Our study demonstrates an innovative approach to visualize the effects of DBS and can be a useful tool in evaluating the effect of various stimulation paradigms and target areas for DBS...
  18. ncbi Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats
    Tine Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsy Res 88:239-46. 2010
    ..In conclusion, high frequency stimulation at 130Hz is more effective than LFS (5Hz) in affecting excitability in epileptic rats. This is reflected in a higher AD threshold and longer AD latency during application of stimulation...
  19. ncbi A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital
    Riëm El Tahry
    Reference Centre for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, De Pintelaan 185, K12IA, Gent 9000, Belgium
    Epilepsy Res 92:231-9. 2010
    ..In this feasibility study, three patients were implanted with ADNS-300 for therapeutic VNS. In addition, compound action potentials (CAPs) were recorded to evaluate activation of the vagus nerve in response to VNS...
  20. ncbi Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood
    Stefanie Dedeurwaerdere
    Laboratory for Clinical and Experimental Neurophysiology and Reference Centre for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Seizure 14:403-11. 2005
    ..The aim of this study was to investigate the effect of early chronic levetiracetam (LEV) treatment on the development of SWDs in young and adult GAERS...
  21. ncbi Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam
    Tim De Smedt
    Reference Center for Refractory Epilepsy, Department of Neurology, Heymans Institute, Second Floor, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Epilepsy Res 67:109-16. 2005
    ....
  22. ncbi Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy
    Veerle De Herdt
    Laboratory for Clinical and Experimental Neurophysiology, Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, 9000 Gent, Belgium
    J Neuroimmunol 214:104-8. 2009
    ..The present study shows that cytokine induction by PBMC isolated from patients with refractory epilepsy is altered by long-term vagus nerve stimulation...
  23. ncbi High frequency deep brain stimulation in the hippocampus modifies seizure characteristics in kindled rats
    Tine Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Epilepsia 48:1543-50. 2007
    ..The target for HFS is the hippocampus, as this structure is often presumed to be the seizure focus in human TLE...
  24. ncbi Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data
    Tim De Smedt
    Laboratory for Clinical and Experimental Neurophysiology Reference Center for Refractory Epilepsy, University Hospital Ghent, Ghent, Belgium
    CNS Drug Rev 13:43-56. 2007
    ..The clinical studies with LEV will be discussed in the second part of this review article to be published subsequently...
  25. ncbi Electrical stimulation for the treatment of epilepsy
    Paul Boon
    Reference Center for Refractory Epilepsy and Laboratory for Clinical and Experimental Neurophysiology LCEN, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Neurotherapeutics 6:218-27. 2009
    ..Further progress in understanding the mechanism of action of DBS for epilepsy is a necessary step to making this therapy more efficacious and established...
  26. ncbi A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy
    Evelien Carrette
    Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, 1K12IA, 185 De Pintelaan, B 9000 Gent, Belgium
    Clin Neurol Neurosurg 110:797-803. 2008
    ..At Ghent University Hospital, the feasibility and efficacy of the modified Atkins' diet was evaluated in adult patients with refractory epilepsy. The Atkins' diet restricts carbohydrate intake and was originally designed for weight loss...
  27. ncbi Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug
    Tim De Smedt
    Laboratory for Clinical and Experimental Neurophysiology Reference Center for Refractory Epilepsy, University Hospital Ghent, Ghent, Belgium
    CNS Drug Rev 13:57-78. 2007
    ....
  28. ncbi Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures
    Annelies Van Dycke
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsia 51:1721-8. 2010
    ..In this study we evaluate the antiepileptic effect of local delivery of adenosine in the kainic acid rat model, a validated model for temporal lobe epilepsy...
  29. ncbi Magnetoencephalography in epilepsy patients carrying a vagus nerve stimulator
    Evelien Carrette
    Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Epilepsy Res 93:44-52. 2011
    ..This study demonstrates the feasibility of MEG in VNS patients. MEG changed management in 20% and further supported the proposed management in 40% illustrating the clinical value of MEG in the PE of VNS patients...
  30. ncbi Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors
    Frank Timmermans
    Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, University Hospital, B 9000 Ghent, Belgium
    Arterioscler Thromb Vasc Biol 27:1572-9. 2007
    ..Addressing this issue might lead to a better understanding of the lineage and phenotype of the precursor(s) that give rise to both cell types in vitro and may contribute to a consensus on their flowcytometric enumeration...
  31. ncbi Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy
    Stefanie Dedeurwaerdere
    Laboratory for Clinical and Experimental Neurophysiology, and Reference Centre for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 106:91-7. 2006
    ....
  32. ncbi Neurostimulation for refractory epilepsy
    Kristl Vonck
    Reference Center for Refractory Epilepsy and Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Gent, Belgium
    Acta Neurol Belg 103:213-7. 2003
    ....