Sam Possemiers

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Gent, Belgium
    Fitoterapia 82:53-66. 2011
  2. ncbi request reprint The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Ghent University, Belgium
    Curr Pharm Des 15:2051-65. 2009
  3. pmc Disposition of hop prenylflavonoids in human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
    Mol Nutr Food Res 54:S284-94. 2010
  4. doi request reprint Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents
    Selin Bolca
    Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Nutr 139:2293-300. 2009
  5. ncbi request reprint Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Nutr 137:2242-6. 2007
  6. ncbi request reprint Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Gent, Belgium
    J Nutr 138:1310-6. 2008
  7. ncbi request reprint Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women
    Selin Bolca
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Br J Nutr 98:950-9. 2007
  8. doi request reprint Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Environ Microbiol 13:2667-80. 2011
  9. ncbi request reprint Metabolism of isoflavones, lignans and prenylflavonoids by intestinal bacteria: producer phenotyping and relation with intestinal community
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University Ugent, Coupure Links, Ghent, Belgium
    FEMS Microbiol Ecol 61:372-83. 2007
  10. doi request reprint Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    J Agric Food Chem 61:9819-27. 2013

Collaborators

Detail Information

Publications28

  1. doi request reprint The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Gent, Belgium
    Fitoterapia 82:53-66. 2011
    ..Moreover, knowledge about intestinal processes may offer innovative strategies for targeted product development...
  2. ncbi request reprint The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Ghent University, Belgium
    Curr Pharm Des 15:2051-65. 2009
    ....
  3. pmc Disposition of hop prenylflavonoids in human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
    Mol Nutr Food Res 54:S284-94. 2010
    ..6+/-118.8 fmol/g, p=0.009) and glandular (241.6+/-93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue...
  4. doi request reprint Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents
    Selin Bolca
    Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Nutr 139:2293-300. 2009
    ..These findings support the importance of personalized screening when assessing the efficacy of such products and mixtures...
  5. ncbi request reprint Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Nutr 137:2242-6. 2007
    ..850 (1.215-2.817), P = 0.004] intake were more likely to be strong equol producers. Finally, we validated the daidzein metabolism by fecal cultures as screening assay to identify equol producers without dietary intervention...
  6. ncbi request reprint Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Gent, Belgium
    J Nutr 138:1310-6. 2008
    ..In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats...
  7. ncbi request reprint Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women
    Selin Bolca
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Br J Nutr 98:950-9. 2007
    ..Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products...
  8. doi request reprint Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Environ Microbiol 13:2667-80. 2011
    ..g. propionate by Akkermansia muciniphila), so that prebiotics may potentially improve gut health along the entire length of the intestine...
  9. ncbi request reprint Metabolism of isoflavones, lignans and prenylflavonoids by intestinal bacteria: producer phenotyping and relation with intestinal community
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University Ugent, Coupure Links, Ghent, Belgium
    FEMS Microbiol Ecol 61:372-83. 2007
    ....
  10. doi request reprint Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    J Agric Food Chem 61:9819-27. 2013
    ..In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase. ..
  11. pmc Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Appl Environ Microbiol 76:5237-46. 2010
    ....
  12. doi request reprint Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends
    Massimo Marzorati
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
    Antonie Van Leeuwenhoek 103:409-20. 2013
    ..e. bifidobacteria or lactobacilli)-conventional molecular ecological approaches, such as PCR-DGGE and qPCR, still remain a very useful complementary tool...
  13. pmc Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Microb Biotechnol 5:106-15. 2012
    ..This may lead to more in vivo-like microbial communities in such dynamic, long-term in vitro simulations and allow the study of the unique mucosal microbiota in health and disease...
  14. ncbi request reprint Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem
    Ellen Eeckhaut
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Coupure Links 653, B 9000 Gent, Belgium
    J Agric Food Chem 56:4806-12. 2008
    ..Enterolignan phenotypes remained stable throughout the experimental period. The establishment of END and ENL production equilibria reflected the subdominance of ENL-producing bacteria in the gastrointestinal tract...
  15. doi request reprint The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Ghent, Belgium
    FEMS Microbiol Rev 35:681-704. 2011
    ..Finally, commensals that become renegade or a decreased exposure to essential coevolved microorganisms may cause particular health problems such as inflammatory bowel diseases, obesity or allergies...
  16. doi request reprint Disposition of soy isoflavones in normal human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering and the Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Am J Clin Nutr 91:976-84. 2010
    ..Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered...
  17. doi request reprint Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines
    Charlotte Grootaert
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, B 9000 Ghent, Belgium
    Environ Microbiol 13:1778-89. 2011
    ....
  18. doi request reprint In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability
    Gabriele Gross
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    J Agric Food Chem 58:10236-46. 2010
    ..In conclusion, varying metabolite pathways among individuals result in different metabolome profiles and therefore related health effects are hypothesized to differ between subjects...
  19. pmc The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro
    Massimo Marzorati
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    BMC Microbiol 14:133. 2014
    ....
  20. doi request reprint Human faecal microbiota display variable patterns of glycerol metabolism
    Rosemarie De Weirdt
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Ghent, Belgium
    FEMS Microbiol Ecol 74:601-11. 2010
    ..Given the importance of hydrogen-consuming processes in the gut, this work suggests that glycerol may have potential as a tool for modulating fermentation kinetics and profiles in the gastrointestinal tract...
  21. ncbi request reprint Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Gent University UGent, Coupure Links 653, Gent, Belgium
    J Agric Food Chem 53:6281-8. 2005
    ....
  22. ncbi request reprint Administration of equol-producing bacteria alters the equol production status in the Simulator of the Gastrointestinal Microbial Ecosystem (SHIME)
    Karel Decroos
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Nutr 136:946-52. 2006
    ..Although further confirmation in in vivo studies is required, these results validate the concept that administering EPC4 could constitute a novel means for converting a nonequol-producer into a producer...
  23. doi request reprint In vitro model to study the modulation of the mucin-adhered bacterial community
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
    Appl Microbiol Biotechnol 83:349-59. 2009
    ..g., IBD) as well as for its modulation with functional foods like prebiotics...
  24. doi request reprint A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, B 9000 Ghent, Belgium
    J Agric Food Chem 61:9380-92. 2013
    ..Moreover, by combination of the SHIME with Caco-2 cells and Caco-2/THP1 cocultures, a significant decrease in pro-inflammatory cytokines was observed at the end of the treatment period...
  25. ncbi request reprint Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem
    Tom Van de Wiele
    Laboratory Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    FEMS Microbiol Ecol 51:143-53. 2004
    ....
  26. ncbi request reprint Characterization of the bactericidal effect of dietary sphingosine and its activity under intestinal conditions
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, Belgium
    Int J Food Microbiol 105:59-70. 2005
    ..Yet, because of its broad spectrum membrane disrupting activity, it could be very useful under controlled conditions...
  27. ncbi request reprint Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children
    Isabelle E J A Francois
    Fugeia NV, Arenberg Science Park, Gaston Geenslaan 1, Leuven Laboratory of Microbial Ecology and Technology LabMet, Ghent University, Gent Translational Research for Gastrointestinal Disorders Targid and Leuven Food Science and Nutrition Research Centre LFoRCe, University Hospitals UZ Leuven, Leuven, Belgium Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Laboratory of Food Chemistry and Biochemistry and Leuven Food Science and Nutrition Research Centre LFoRCe, KU Leuven, Leuven, Belgium
    J Pediatr Gastroenterol Nutr 58:647-53. 2014
    ..We assessed whether wheat bran extract (WBE) containing arabinoxylan-oligosaccharides (AXOS) elicited a prebiotic effect and modulated gastrointestinal (GI) parameters in healthy preadolescent children upon consumption in a beverage...
  28. doi request reprint Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    Environ Microbiol Rep 1:100-9. 2009
    ....