R Pauwels

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
  2. ncbi Short-term cigarette smoke exposure enhances allergic airway inflammation in mice
    Katrien B Moerloose
    D V M, Department of Respiratory Diseases, Ghent University Hospital, Heymansinstituut 4de verdieping, De Pintelaan 185, Ghent B 9000, Belgium
    Am J Respir Crit Care Med 172:168-72. 2005
  3. ncbi Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 364:613-20. 2004
  4. ncbi Similarities and differences in asthma and chronic obstructive pulmonary disease exacerbations
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Proc Am Thorac Soc 1:73-6. 2004
  5. ncbi COPD exacerbations: the importance of a standard definition
    R Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium
    Respir Med 98:99-107. 2004
  6. ncbi Formoterol as relief medication in asthma: a worldwide safety and effectiveness trial
    R A Pauwels
    Dept of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Eur Respir J 22:787-94. 2003
  7. ncbi Systemic effects of inhaled fluticasone propionate and budesonide in adult patients with asthma
    E Derom
    Department of Respiratory Diseases, University Hospital of Ghent, Ghent, Belgium
    Am J Respir Crit Care Med 160:157-61. 1999
  8. ncbi The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction
    V Schelfhout
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Pulm Pharmacol Ther 21:276-84. 2008
  9. ncbi Lung deposition and protective effect of terbutaline delivered from pressurized metered-dose inhalers and the Turbuhaler in asthmatic individuals
    E Derom
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Am J Respir Crit Care Med 164:1398-402. 2001
  10. ncbi The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
    V Schelfhout
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pulm Pharmacol Ther 19:413-8. 2006

Collaborators

Detail Information

Publications42

  1. doi The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  2. ncbi Short-term cigarette smoke exposure enhances allergic airway inflammation in mice
    Katrien B Moerloose
    D V M, Department of Respiratory Diseases, Ghent University Hospital, Heymansinstituut 4de verdieping, De Pintelaan 185, Ghent B 9000, Belgium
    Am J Respir Crit Care Med 172:168-72. 2005
    ..Epidemiologic studies suggest that tobacco smoke contributes to the prevalence and occurrence of exacerbations in asthma. The effect of active smoking in adolescents with atopy is poorly understood...
  3. ncbi Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 364:613-20. 2004
    ..If exposure is stopped, the disease may still progress due to the decline in lung function that normally occurs with aging, and some persistence of the inflammatory response...
  4. ncbi Similarities and differences in asthma and chronic obstructive pulmonary disease exacerbations
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Proc Am Thorac Soc 1:73-6. 2004
    ..Inhaled corticosteroids, long-acting inhaled beta(2)-agonists, combination therapy with both, and the long-acting inhaled anticholinergic tiotropium decrease the exacerbation rate in COPD...
  5. ncbi COPD exacerbations: the importance of a standard definition
    R Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium
    Respir Med 98:99-107. 2004
    ....
  6. ncbi Formoterol as relief medication in asthma: a worldwide safety and effectiveness trial
    R A Pauwels
    Dept of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Eur Respir J 22:787-94. 2003
    ..This real-life study demonstrates that formoterol as-needed has a similar safety profile to salbutamol, and its use as a reliever therapy is associated with fewer asthma symptoms and exacerbations...
  7. ncbi Systemic effects of inhaled fluticasone propionate and budesonide in adult patients with asthma
    E Derom
    Department of Respiratory Diseases, University Hospital of Ghent, Ghent, Belgium
    Am J Respir Crit Care Med 160:157-61. 1999
    ..We conclude that high doses of BUD and FP (in particular the latter), inhaled via their respective dry powder inhalers for 1 wk, result in a measurable systemic activity in patients with asthma...
  8. ncbi The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction
    V Schelfhout
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Pulm Pharmacol Ther 21:276-84. 2008
    ..We suggest that leukotrienes play a limited role in the bronchoconstrictor effect of neurokinin A in patients with asthma...
  9. ncbi Lung deposition and protective effect of terbutaline delivered from pressurized metered-dose inhalers and the Turbuhaler in asthmatic individuals
    E Derom
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Am J Respir Crit Care Med 164:1398-402. 2001
    ..1 and 3.2 times greater for histamine and methacholine, respectively. We conclude that pulmonary deposition of terbutaline was predictive of the clinical response...
  10. ncbi The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
    V Schelfhout
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pulm Pharmacol Ther 19:413-8. 2006
    ..This did not occur under placebo treatment. A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8h post-dose in mild asthmatics...
  11. ncbi COPD: the scope of the problem in Europe
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Chest 117:332S-5S. 2000
    ..This article reviews a selection of important data that have become available since the consensus statement was published, with a specific focus on epidemiology and treatment...
  12. ncbi Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease
    G F Joos
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Int J Clin Pract 57:906-9. 2003
    ..In this review we summarise the clinical development of this compound...
  13. ncbi Formoterol--where does it fit in the current guidelines?
    R Pauwels
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Respir Med 95:S30-4. 2001
    ....
  14. ncbi Tracheobronchomegaly--the Mounier-Kuhn syndrome: report of two cases and review of the literature
    J Van Schoor
    Dept of Respiratory Diseases, University Hospital, Ghent, Belgium
    Eur Respir J 4:1303-6. 1991
    ..The airways of the second patient were visualized using computed tomography. The dimensions of the airways of our patients are compared with the normal values supplied in the literature...
  15. ncbi Role of corticosteroids in stable chronic obstructive pulmonary disease
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Curr Opin Pulm Med 7:79-83. 2001
    ....
  16. ncbi Indirect bronchial hyper-responsiveness: the coming of age of a specific group of bronchial challenges
    J Van Schoor
    Department of Respiratory Diseases, Ghent University Hospital, B 9000 Ghent, Belgium
    Clin Exp Allergy 35:250-61. 2005
  17. ncbi Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease
    G R Bullock
    Department of Pathology, Blok A 503, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 115:117-24. 2001
    ..This correlated well with the reduced lung function as expressed by the forced expiratory volume...
  18. ncbi Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies)
    Guy F Joos
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 25:597-612, vii-viii. 2005
    ..Intranasal corticosteroids are given as first-line therapy for moderate to severe persistent rhinitis. Depending on the dominant symptom, H1-antihistamines, decongestants, or ipratropium can be added after re-evaluation...
  19. ncbi Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice
    Ken Bracke
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 138:169-79. 2005
    ..These results indicate that cigarette smoke increases the expression of MMP-12 and Cathepsin D in the lungs of mice, and that not only macrophages but also DCs produce MMP-12...
  20. ncbi Pharmacokinetic and pharmacodynamic properties of inhaled beclometasone dipropionate delivered via hydrofluoroalkane-containing devices
    Eric Derom
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Clin Pharmacokinet 44:815-36. 2005
    ..Good studies on the bioequivalence between the reference beclometasone dipropionate formulation and the Modulite or Beclazone formulations are not available...
  21. ncbi Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University Medical Center, 1200 Main St West, Hamilton, ON, Canada
    Chest 129:1478-85. 2006
    ..Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease...
  22. ncbi Role of the tachykinin NK(1) receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea
    Katelijne O De Swert
    Department Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Pulm Pharmacol Ther 20:588-95. 2007
    ..In conclusion, the 5-hydroxytryptamine-induced tracheal contraction includes a cholinergic mechanism that requires the presence of the tachykinin NK(1) receptor...
  23. ncbi Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation
    Tania Maes
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 141:354-68. 2006
    ..We investigated whether Toll-like receptor 4 (TLR4) is implicated in cigarette smoke (CS)-induced pulmonary inflammation in a murine model of COPD...
  24. ncbi Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study
    Wan C Tan
    iCAPTURE Centre, UBC, St Paul s Hospital, Vancouver, and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Respirology 11:767-75. 2006
    ..The present analysis compared the efficacy of early intervention with inhaled budesonide in Caucasian and Asian patients over the first 3 years of the inhaled Steroid Treatment As Regular Therapy in early asthma study...
  25. ncbi Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
    ....
  26. pmc The severity of airways obstruction as a determinant of treatment response in COPD
    Peter Calverley
    Clinical Research Centre, University Hospital Aintree, Liverpool, UK
    Int J Chron Obstruct Pulmon Dis 1:209-18. 2006
    ....
  27. ncbi Matrix metalloproteinases in asthma and COPD
    Ingel K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Curr Opin Pharmacol 5:257-63. 2005
    ..There is increasing evidence that MMPs are involved in the pathogenesis of both asthma and COPD, and several MMPs are possible therapeutic targets in these common chronic airway diseases...
  28. pmc Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
    Didier D Cataldo
    Department of Respiratory Diseases and Laboratory of Biology of Tumours and Development, University of Liege, Liege, Belgium
    Am J Pathol 161:491-8. 2002
    ..In contrast, the expression of tissue inhibitor of metalloproteinases-1 was enhanced after allergen exposure in both groups. We conclude that MMP-9 plays a key role in the development of airway inflammation after allergen exposure...
  29. ncbi Effect of combining salmeterol and fluticasone on the progression of airway remodeling
    Nele J Vanacker
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Am J Respir Crit Care Med 166:1128-34. 2002
    ..We conclude that the combination of salmeterol and fluticasone propionate enhances aspects of allergen-induced airway remodeling. This is not accompanied by changes in airway responsiveness...
  30. ncbi Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study
    Johan C Kips
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Crit Care Med 167:1655-9. 2003
    ..We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials...
  31. ncbi Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 361:1071-6. 2003
    ..Although inhaled glucocorticosteroids are recommended for persistent asthma, their long-term effect on recent onset, mild, persistent asthma has yet to be established...
  32. ncbi The role of neural inflammation in asthma and chronic obstructive pulmonary disease
    Guy F Joos
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Ann N Y Acad Sci 992:218-30. 2003
    ..It is suggested that dual NK(1)/NK(2) and triple NK(1)/NK(2)/NK(3) tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases...
  33. ncbi Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  34. ncbi Cost-effectiveness analysis of early intervention with budesonide in mild persistent asthma
    Sean D Sullivan
    Department of Pharmacy and Health Services, University of Washington, Seattle, Washington 98195 7630, USA
    J Allergy Clin Immunol 112:1229-36. 2003
    ....
  35. ncbi The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma
    Katelijne O De Swert
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Allergy Clin Immunol 113:1093-9. 2004
    ..Human data suggest a role for these peptides in asthma, but the exact role of tachykinins and their receptors in allergic airway inflammation is still a matter of debate...
  36. ncbi Efficacy of flow- vs impedance-guided autoadjustable continuous positive airway pressure: a randomized cross-over trial
    Dirk A Pevernagie
    Department of Respiratroy Diseases, Ghent University Hospital, Belgium
    Chest 126:25-30. 2004
    ....
  37. ncbi Identification and characterization of human pulmonary dendritic cells
    Ingel K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Cell Mol Biol 32:177-84. 2005
    ..The presence of CD1a+ DC in the human lung was confirmed. The identification and characterization of different human pulmonary DC subtypes is of great importance for the future development of DC-based immunotherapies...
  38. ncbi The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness
    Charles A Rizzo
    Allergy, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Allergy Clin Immunol 109:404-9. 2002
    ..The role of IL-5-induced eosinophilia in airway hyperresponsiveness has been questioned. In addition, eosinophil-independent IL-5-induced airway hyperresponsiveness has been demonstrated in animals...
  39. ncbi Effect of age on allergen-induced structural airway changes in brown Norway rats
    Els Palmans
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Am J Respir Crit Care Med 165:1280-4. 2002
    ..08 +/- 0.46 versus 3.62 +/- 0.29 microm2/microm basement membrane; p < 0.005). In conclusion, in young rats airways are more susceptible to allergen-induced inflammatory and structural airway changes...
  40. ncbi Outcome of pregnancy in a randomized controlled study of patients with asthma exposed to budesonide
    Michael Silverman
    Division of Child Health, University of Leicester, Leicester, England
    Ann Allergy Asthma Immunol 95:566-70. 2005
    ..However, data from large randomized controlled trials are lacking...
  41. ncbi Comfort and pressure profiles of two auto-adjustable positive airway pressure devices: a technical report
    Katrien B Hertegonne
    Department of Respiratory Diseases, Ghent University Hospital, De Pinteloaan 185, Gent 9000, Belgium
    Respir Med 97:903-8. 2003
    ..The purpose of this study was to compare comfort parameters and pressure profiles of the AutoSet (Resmed) and the SOMNOsmart (Weinmann), two auto-adjustable positive airway pressure (APAP) devices...
  42. ncbi Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary updated 2003
    Leonardo Fabbri
    COPD 1:105-41; discussion 103-4. 2004