R A Pauwels

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
    R A Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    N Engl J Med 340:1948-53. 1999
  2. ncbi request reprint Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 361:1071-6. 2003
  3. ncbi request reprint Formoterol--where does it fit in the current guidelines?
    R Pauwels
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Respir Med 95:S30-4. 2001
  4. ncbi request reprint The inhaled Steroid Treatment as Regular Therapy in early asthma (START) study: rationale and design
    R A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Control Clin Trials 22:405-19. 2001
  5. ncbi request reprint Role of corticosteroids in stable chronic obstructive pulmonary disease
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Curr Opin Pulm Med 7:79-83. 2001
  6. ncbi request reprint COPD: the scope of the problem in Europe
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Chest 117:332S-5S. 2000
  7. ncbi request reprint The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent
    K G Tournoy
    Department of Respiratory Diseases 7 K12 I E, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Immunol 166:6982-91. 2001
  8. ncbi request reprint Sensitization to inhaled antigen by intratracheal instillation of dendritic cells
    B N Lambrecht
    Respiratory Diseases Pathology, University Hospital Ghent, Belgium
    Clin Exp Allergy 30:214-24. 2000
  9. ncbi request reprint Fluticasone inhibits the progression of allergen-induced structural airway changes
    N J Vanacker
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 32:914-20. 2002
  10. ncbi request reprint Fluticasone inhibits but does not reverse allergen-induced structural airway changes
    N J Vanacker
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Am J Respir Crit Care Med 163:674-9. 2001

Detail Information

Publications54

  1. ncbi request reprint Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
    R A Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    N Engl J Med 340:1948-53. 1999
    ....
  2. ncbi request reprint Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 361:1071-6. 2003
    ..Although inhaled glucocorticosteroids are recommended for persistent asthma, their long-term effect on recent onset, mild, persistent asthma has yet to be established...
  3. ncbi request reprint Formoterol--where does it fit in the current guidelines?
    R Pauwels
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Respir Med 95:S30-4. 2001
    ....
  4. ncbi request reprint The inhaled Steroid Treatment as Regular Therapy in early asthma (START) study: rationale and design
    R A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Control Clin Trials 22:405-19. 2001
    ..These measures have been chosen to reflect the progression of mild asthma toward more severe asthma and the extent of irreversible airflow limitation, which should reflect the degree of airway remodeling...
  5. ncbi request reprint Role of corticosteroids in stable chronic obstructive pulmonary disease
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Curr Opin Pulm Med 7:79-83. 2001
    ....
  6. ncbi request reprint COPD: the scope of the problem in Europe
    R Pauwels
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Chest 117:332S-5S. 2000
    ..This article reviews a selection of important data that have become available since the consensus statement was published, with a specific focus on epidemiology and treatment...
  7. ncbi request reprint The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent
    K G Tournoy
    Department of Respiratory Diseases 7 K12 I E, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Immunol 166:6982-91. 2001
    ..They also demonstrate that human allergen-specific Th1 lymphocytes can be driven to a Th2 phenotype...
  8. ncbi request reprint Sensitization to inhaled antigen by intratracheal instillation of dendritic cells
    B N Lambrecht
    Respiratory Diseases Pathology, University Hospital Ghent, Belgium
    Clin Exp Allergy 30:214-24. 2000
    ..Airway dendritic cells (DCs) capture and present inhaled antigen. It is not known whether antigen presentation by DCs in the airways is sufficient to induce sensitization to inhaled antigen in vivo...
  9. ncbi request reprint Fluticasone inhibits the progression of allergen-induced structural airway changes
    N J Vanacker
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 32:914-20. 2002
    ..Inhaled corticosteroids are widely used as first-line therapy in patients with asthma. The concept of early introduction is more and more accepted...
  10. ncbi request reprint Fluticasone inhibits but does not reverse allergen-induced structural airway changes
    N J Vanacker
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Am J Respir Crit Care Med 163:674-9. 2001
    ..In conclusion, concomitant treatment with FP partly inhibits structural airway changes as well as hyperresponsiveness induced by OA exposure. Post hoc treatment fails to reverse established airway remodeling...
  11. ncbi request reprint Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation
    B N Lambrecht
    Department of Respiratory Diseases University Hospital Ghent, Ghent, Belgium
    Eur J Immunol 29:3815-25. 1999
    ..In conclusion, these results demonstrate that endogenously produced SP contributes to T cell proliferation induced by DC or TCR / CD28 stimulation...
  12. ncbi request reprint Tachykinin antagonists and the airways
    G F Joos
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Arch Int Pharmacodyn Ther 329:205-19. 1995
    ..However, FK224 failed to block the bronchoconstrictor effect of NKA in asthmatics and the dose of CP99994, needed to antagonize tachykinin effects in man, remains to be determined...
  13. ncbi request reprint Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
    B N Lambrecht
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    J Immunol 160:4090-7. 1998
    ..Altering the function of airway DC may therefore be an important target for new anti-asthma therapy...
  14. ncbi request reprint Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
    A I D'hulst
    Dept of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur Respir J 28:102-12. 2006
    ....
  15. ncbi request reprint Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats
    B N Lambrecht
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Am J Respir Cell Mol Biol 20:1165-74. 1999
    ..We conclude that allergen exposition in sensitized rats increases the number of DC in the airways and the production of progenitors for DC in the bone marrow...
  16. ncbi request reprint Prolonged allergen exposure induces structural airway changes in sensitized rats
    E Palmans
    Department of Respiratory Diseases, University Hospital Gent, Gent, Belgium
    Am J Respir Crit Care Med 161:627-35. 2000
    ..The study data further indicate that depending on the extent and distribution of remodeling, changes in the extracellular matrix can enhance or protect against AHR...
  17. ncbi request reprint Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats
    N J Vanacker
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 20:873-9. 2002
    ..However, for a similar systemic activity, prednisolone was ineffective in preventing airway remodelling...
  18. ncbi request reprint The mechanism of tachykinin-induced bronchoconstriction in the rat
    G F Joos
    Department of Respiratory Diseases, University Hospital, State University of Ghent, Belgium
    Am Rev Respir Dis 137:1038-44. 1988
    ..We suggest that tachykinins cause bronchoconstriction by stimulation of postganglionic vagal nerve endings and mast cells...
  19. ncbi request reprint MK-571, a potent antagonist of leukotriene D4-induced bronchoconstriction in the human
    J C Kips
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Am Rev Respir Dis 144:617-21. 1991
    ....
  20. pmc Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
    K Y Vermaelen
    Department of Respiratory Diseases, Ghent University Hospital, Ghent B 9000, Belgium
    J Exp Med 193:51-60. 2001
    ..These results validate the unique sentinel role of airway DCs, picking up antigen in the airways and delivering it in an immunogenic form to the T cells in the TLNs...
  21. ncbi request reprint The effect of aerosolized SK&F 104353-Z2 on the bronchoconstrictor effect of leukotriene D4 in asthmatics
    G F Joos
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Pulm Pharmacol 4:37-42. 1991
    ..On the active treatment day, the dose-response curve for LTD4 was significantly shifted to the right.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro
    G F Joos
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    Eur J Pharmacol 338:259-68. 1997
    ..In conclusion, tachykinins contract Fisher 344 rat trachea by releasing 5-HT from mast cells, an effect mediated by a tachykinin NK1 receptor...
  23. ncbi request reprint Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice
    J C Kips
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Int Arch Allergy Immunol 107:115-8. 1995
    ..These results suggest that suppressing Th2 cell development in vivo might have profound inhibitory effects on allergen-induced airway changes...
  24. ncbi request reprint Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice
    K G Tournoy
    University Hospital Gent, Department of Respiratory Diseases, Belgium
    Eur J Immunol 28:3221-30. 1998
    ..In conclusion, TM-beta1 pretreatment of SCID mice significantly improves the survival and functionality of the Hu-PBL graft...
  25. ncbi request reprint Repeated allergen exposure changes collagen composition in airways of sensitised Brown Norway rats
    E Palmans
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 20:280-5. 2002
    ..This suggests that some aspects of airway remodelling in asthma could be driven by long-term allergen exposure...
  26. ncbi request reprint A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma
    J C Kips
    Department of Respiratory Diseases, University Hospital Ghent, Ghent, Belgium
    Am J Respir Crit Care Med 161:996-1001. 2000
    ..In conclusion, no significant differences in sputum markers of airway inflammation were observed during a 1-yr treatment with a low dose of inhaled budesonide plus formoterol compared with a higher dose of budesonide...
  27. ncbi request reprint Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma
    J Van Schoor
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 19:997-1002. 2002
    ..A 2-week course of an inhaled steroid reduces bronchial responsiveness to neurokinin A, an effect more pronounced than the reduction in bronchial responsiveness to methacholine...
  28. ncbi request reprint Characterization of the adenosine receptors in the airways
    R A Pauwels
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Arch Int Pharmacodyn Ther 329:151-60. 1995
    ..We, therefore, conclude that the adenosine-induced bronchoconstriction in the rat is most likely due to binding of adenosine to different receptor subtypes including the A1, A2B and A3 subtypes...
  29. ncbi request reprint Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
    G F Joos
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 23:76-81. 2004
    ..08 doubling doses, which decreased to a difference of 0.90 doubling doses 10 h after treatment. The results shown in this report indicate that DNK333 blocks neurokinin A-induced bronchoconstriction in patients with asthma...
  30. ncbi request reprint Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists
    G F Joos
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Pharmacol 429:239-50. 2001
    ..Compounds that are able to block two or three tachykinin receptors hold promise for the treatment of airways diseases such as asthma and/or chronic obstructive pulmonary disease...
  31. pmc Mouse strain and conditioning regimen determine survival and function of human leucocytes in immunodeficient mice
    K G Tournoy
    Department of Respiratory Diseases, University Hospital Gent, Belgium
    Clin Exp Immunol 119:231-9. 2000
    ..In conclusion, reducing the function of the innate immune system in immunodeficient mice improves survival of the human graft and can result in an activation of the memory B cells without the need for recall antigen exposure...
  32. pmc Elevated MMP-12 protein levels in induced sputum from patients with COPD
    I K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12 IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Thorax 61:196-201. 2006
    ..In mice, MMP-12 plays a crucial role in the development of cigarette smoke induced emphysema. A study was undertaken to investigate the role of MMP-12 in the development of COPD in human smokers...
  33. ncbi request reprint The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours
    E Y Derom
    Department of Respiratory Diseases, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 89:811-5. 1992
    ..We conclude that inhalation of 50 or 100 micrograms of salmeterol causes a long-lasting bronchodilatation and protects against methacholine-induced bronchoconstriction for at least 12 hours...
  34. ncbi request reprint Time course of cigarette smoke-induced pulmonary inflammation in mice
    A I D'hulst
    Dept of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur Respir J 26:204-13. 2005
    ..In conclusion, the time course of the changes in inflammatory and dendritic cells in both bronchoalveolar lavage and the pulmonary compartment of cigarette smoke-exposed mice was carefully characterised...
  35. ncbi request reprint Murine models of asthma
    J C Kips
    Dept of Medical Genetics, Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Eur Respir J 22:374-82. 2003
    ..A large section of this report is therefore devoted to an overview of airway function and its measurement in mice...
  36. ncbi request reprint Formoterol as relief medication in asthma: a worldwide safety and effectiveness trial
    R A Pauwels
    Dept of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Eur Respir J 22:787-94. 2003
    ..This real-life study demonstrates that formoterol as-needed has a similar safety profile to salbutamol, and its use as a reliever therapy is associated with fewer asthma symptoms and exacerbations...
  37. pmc Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia
    R A Peleman
    Division of Infectious Diseases, Department of Internal Medicine, University Hospital Ghent, 185 De Pintelaan, B9000 Ghent, Belgium
    Antimicrob Agents Chemother 44:178-80. 2000
    ..1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1.1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoalveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11)...
  38. doi request reprint Bronchodilatory effects of aclidinium bromide, a long-acting muscarinic antagonist, in COPD patients
    G F Joos
    Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, B9000 Ghent, Belgium
    Respir Med 104:865-72. 2010
    ..This study evaluated the pharmacodynamics, pharmacokinetics, safety and tolerability of ascending doses of aclidinium bromide in patients with COPD...
  39. ncbi request reprint Murine models of COPD
    G G Brusselle
    Department of Respiratory Diseases, Ghent University Hospital and Ghent University, Belgium
    Pulm Pharmacol Ther 19:155-65. 2006
    ..g. the inhalation of tobacco smoke), can offer valuable information on both the physiological function of the gene of interest as well as the pathophysiological mechanisms of diseases with complex traits such as COPD...
  40. ncbi request reprint Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways
    P R Germonpre
    Department of Respiratory Diseases, University of Ghent, University Hospital Ghent, Belgium
    Eur J Pharmacol 324:249-55. 1997
    ..We conclude that, in the airways of Fisher 344 rats, the neurogenic increase in plasma protein extravasation is caused by activation of both tachykinin NK1 receptors and 5-HT2 receptors...
  41. ncbi request reprint Is Th1 the solution for Th2 in asthma?
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Clin Exp Allergy 32:17-29. 2002
  42. ncbi request reprint New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5
    J C Kips
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 17:499-506. 2001
    ..Some of these compounds have proven to be biologically active in man. The challenge now is to establish their therapeutic role in asthma...
  43. ncbi request reprint Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea
    K G Tournoy
    Dept Respiratory Diseases, Ghent University Hospital, De Pintelaan, Ghent, Belgium
    Eur Respir J 21:3-10. 2003
    ..Substance P induced a relaxation in precontracted tracheas in NK1R WT but not in NK1R-/- mice. The data presented here provide direct evidence that the NK1 receptor augments cholinergic neurotransmission in mouse trachea...
  44. ncbi request reprint Effect of ozone exposure on allergic sensitization and airway inflammation induced by dendritic cells
    P O Depuydt
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 32:391-6. 2002
    ..Epidemiological studies suggest that ozone exposure is related to increased asthma symptoms. Dendritic cells (DCs) are the principal antigen-presenting cells in the airways...
  45. ncbi request reprint Tachykinin receptor antagonists: potential in airways diseases
    G F Joos
    Department of Respiratory Diseases, Ghent University Hospital, Belgium
    Curr Opin Pharmacol 1:235-41. 2001
    ..In the past three years, work has entered the clinic and selective or dual-selective NK1/NK2 receptor antagonists appear to have the potential to affect the different aspects of asthma and COPD...
  46. ncbi request reprint Counterbalancing of TH2-driven allergic airway inflammation by IL-12 does not require IL-10
    K G Tournoy
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 107:483-91. 2001
    ..The TH1-promoting cytokine IL-12 is capable of inhibiting the TH2-driven allergen-induced airway changes in mice and is therefore regarded as an interesting strategy for treating asthma...
  47. ncbi request reprint National and international guidelines for COPD: the need for evidence
    R A Pauwels
    Department of Respiratory Diseases, University Hospital, Gent
    Chest 117:20S-2S. 2000
    ..There will be guidance on the management of chronic disease and acute exacerbations, education, prevention, and socioeconomics...
  48. ncbi request reprint Effects of formoterol (Oxis Turbuhaler) and ipratropium on exercise capacity in patients with COPD
    J J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Respir Med 96:559-66. 2002
    ..However, a negative dose-response relation for formoterol was unexpected and needs further investigation...
  49. pmc Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
    B N Lambrecht
    Department of Pulmonary Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Clin Invest 106:551-9. 2000
    ..These data demonstrate that DCs in the airways induce sensitization to inhaled antigen and that molecules expressed on the surface of these cells are critical for the development of Th2-dependent airway eosinophilia...
  50. ncbi request reprint Cost-effectiveness of formoterol and salbutamol as asthma reliever medication in Sweden and in Spain
    B Lindgren
    Lund University Centre for Health Economics, Lund University, Lund, Sweden
    Int J Clin Pract 59:62-8. 2005
    ....
  51. pmc Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease
    D D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, and Department of Medicine, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
    Thorax 60:992-7. 2005
    ..Clinical studies suggest that inhaled corticosteroids reduce exacerbations and improve health status in chronic obstructive pulmonary disease (COPD). However, their effect on mortality is unknown...
  52. ncbi request reprint [Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease]
    D D Sin
    Rev Port Pneumol 11:603-7. 2005
  53. ncbi request reprint Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells
    J Zhu
    Department of Gene Therapy, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:2220-8. 2001
    ....
  54. ncbi request reprint Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study
    L Watson
    Department of Epidemiology and Statistics, University of Groningen, Hanzeplein 1, p a P1 129B, 9713 GZ Groningen, The Netherlands
    Respir Med 100:746-53. 2006
    ..We analysed data from 3 years follow-up in 178 women and 464 men with COPD, participants in the Euroscop Study who were smokers unexposed to inhaled corticosteroids...