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Affiliation: Ghent University
Neupane J, Vandewoestyne M, Ghimire S, Lu Y, Qian C, Van Coster R, et al. Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice. Mitochondrion. 2014;18:27-33 pubmed publisher
..We show that NT in the germ line is potent to prevent transmission of heritable mtDNA disorders with the applicability for patients attempting reproduction. ..
Lu Y, Ferrer Buitrago M, Popovic M, Neupane J, De Vos W, Lierman S, et al. Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes. Reprod Biomed Online. 2018;36:396-407 pubmed publisher
..In conclusion, appropriate treatment strategies, including clinical utilization of IVM oocytes from Study group patients, warrant further investigation. ..