De Ruyck Kim

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Prediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the gamma-H2AX foci assay and association with chromosomal radiosensitivity
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Oncol Rep 23:571-8. 2010
  2. ncbi Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinoma
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology, and Medical Physics, Ghent University, Gent, Belgium
    J Nucl Med 45:612-8. 2004
  3. ncbi Association of TGFbeta1 polymorphisms involved in radiation toxicity with TGFbeta1 secretion in vitro
    De Ruyck Kim
    Department of Basic Medical Sciences, Ghent University, Belgium
    Cytokine 50:37-41. 2010
  4. ncbi Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?
    K De Ruyck
    Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, Ghent B 9000, Belgium
    Br J Cancer 98:1723-38. 2008
  5. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
  6. ncbi TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Gent University Hospital, Belgium
    Int J Radiat Oncol Biol Phys 65:1240-8. 2006
  7. ncbi Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy
    Kim De Ruyck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 81:537-44. 2011
  8. ncbi Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
    Int J Radiat Oncol Biol Phys 62:1140-9. 2005
  9. ncbi Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence
    K De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Gent, Belgium
    Radiat Res 164:237-44. 2005
  10. ncbi A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure
    Petra Willems
    Department of Basic Medical Science, Ghent University, 9000 Ghent, Belgium
    J Cancer Res Clin Oncol 135:1159-68. 2009

Collaborators

Detail Information

Publications18

  1. ncbi Prediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the gamma-H2AX foci assay and association with chromosomal radiosensitivity
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Oncol Rep 23:571-8. 2010
    ..This applies as well to the assessment of the repair kinetics after an HDR dose as to the determination of the number of residual foci after a LDR dose...
  2. ncbi Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinoma
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology, and Medical Physics, Ghent University, Gent, Belgium
    J Nucl Med 45:612-8. 2004
    ..To this end, dicentric chromosomes (DCs) were scored in metaphase spreads of peripheral blood cultures. The equivalent total-body dose was deduced from the DC yields using an in vitro dose-response curve...
  3. ncbi Association of TGFbeta1 polymorphisms involved in radiation toxicity with TGFbeta1 secretion in vitro
    De Ruyck Kim
    Department of Basic Medical Sciences, Ghent University, Belgium
    Cytokine 50:37-41. 2010
    ..The inter-individual variation in TGFbeta1 levels for individuals with the same genotype was too large to obtain statistically significant differences among genotypes...
  4. ncbi Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?
    K De Ruyck
    Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, Ghent B 9000, Belgium
    Br J Cancer 98:1723-38. 2008
    ....
  5. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
    ..In conclusion, the APE1 Asp148Glu polymorphism is highly predictive for lung cancer, and cumulative cigarette smoking modifies the associations between the XRCC1 Arg399Gln and the XPD Lys751Gln polymorphisms and lung cancer risk...
  6. ncbi TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Gent University Hospital, Belgium
    Int J Radiat Oncol Biol Phys 65:1240-8. 2006
    ..552delAGG, -800G>A, -509C>T, Leu10Pro, Arg25Pro, Thr263Ile) and the occurrence of late normal tissue reactions after gynecologic radiotherapy (RT)...
  7. ncbi Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy
    Kim De Ruyck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 81:537-44. 2011
    ..To construct a model for the prediction of acute esophagitis in lung cancer patients receiving chemoradiotherapy by combining clinical data, treatment parameters, and genotyping profile...
  8. ncbi Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
    Int J Radiat Oncol Biol Phys 62:1140-9. 2005
    ..541A>G, IVS5-14 17.893A>G, 241Thr/Met), and OGG1 (326Ser/Cys) with the development of late radiotherapy (RT) reactions and to assess the correlation between in vitro chromosomal radiosensitivity and clinical radiosensitivity...
  9. ncbi Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence
    K De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Gent, Belgium
    Radiat Res 164:237-44. 2005
    ....
  10. ncbi A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure
    Petra Willems
    Department of Basic Medical Science, Ghent University, 9000 Ghent, Belgium
    J Cancer Res Clin Oncol 135:1159-68. 2009
    ..As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined...
  11. ncbi Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity
    Petra Willems
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Ghent, Belgium
    Genes Chromosomes Cancer 47:137-48. 2008
    ..The HV genotype of c.1781G>T (XRCC6Ku70) [corrected] on the contrary, seems to protect against breast cancer and ionizing radiation induced micronuclei...
  12. ncbi Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation
    Ans Baeyens
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Center for Medical Genetics, Gent University Hospital, Belgium
    Cancer Genet Cytogenet 163:106-12. 2005
    ..These conclusions are, however, very preliminary, because of the small numbers of CHEK2 1100delC breast cancer patients studied...
  13. ncbi Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 73:1187-95. 2009
    ..1843A>G, c.562-14A>G, c.722C>T), Rad51 (c.-3429G>C, c.-3392G>T), Lig4 (c.26C>T, c.1704T>C), Ku70 (c.-1310C>G), and Ku80 (c.2110-2408G>A) and the occurrence of acute reactions after radiotherapy...
  14. ncbi Predicting risk of radiation-induced lung injury
    Indira Madani
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    J Thorac Oncol 2:864-74. 2007
    ..Genetic variability and the complexity of RILI and its underlying molecular mechanisms make identification of biological risk predictors challenging. Further investigations are needed to develop more effective risk predictors of RILI...
  15. ncbi Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption
    Joke Werbrouck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Ghent University Hospital, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 656:74-81. 2008
    ..The protective effect seen for the Rad51 c.-3429 and polymorphism was most prominent among the group of heavy smokers (>25 PY). No associations with risk for HNSCC were found for the other SNPs in genes of the DNA DSB repair pathways...
  16. ncbi Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients
    Kim De Ruyck
    Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, Gent, Belgium
    Pharmacogenomics 11:1053-63. 2010
    ....
  17. ncbi mBAND analysis of chromosome aberrations in lymphocytes exposed in vitro to alpha-particles and gamma-rays
    E Janet Tawn
    Westlakes Research Institute, Moor Row, Cumbria, UK
    Int J Radiat Biol 84:447-53. 2008
    ..To investigate the profiles of chromosome damage induced in vitro by exposure to alpha-particles and gamma-rays...
  18. ncbi The characterization and transmissibility of chromosome aberrations induced in peripheral blood lymphocytes by in vitro alpha-particle radiation
    E Janet Tawn
    Westlakes Research Institute, Moor Row, Cumbria, United Kingdom
    Radiat Res 168:666-74. 2007
    ..Since stochastic effects of radiation are attributable to genetic changes in viable cells, translocations in stable cells may be a better measure when considering the comparative risks of different qualities of radiation...