Research Topics
Genomes and Genes | Jean Marc KaufmanSummaryAffiliation: Ghent University Country: Belgium Publications
| Collaborators
|
Detail Information
Publications
Efficacy and safety of strontium ranelate in the treatment of osteoporosis in menJ M Kaufman
Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Clin Endocrinol Metab 98:592-601. 2013..Conclusions: The effects of strontium ranelate on BMD in osteoporotic men were similar to those in postmenopausal osteoporotic women, supporting its use in the treatment of osteoporosis in men...- Treatment of osteoporosis in menJ M Kaufman
Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185, B9000 Gent, Belgium
Bone 53:134-44. 2013..Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline) are discussed... 
Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapyJ M Kaufman
Department of Endocrinology, Ghent University Hospital, 9K121E, De Pintelaan 185, Ghent, Belgium
Osteoporos Int 16:510-6. 2005..01). In conclusion, men who received teriparatide and who may have received follow-up antiresorptive therapy had a decreased risk of moderate and severe vertebral fractures...- The decline of androgen levels in elderly men and its clinical and therapeutic implicationsJean M Kaufman
Department of Endocrinology, Ghent University Hospital, Ghent B 9000, Belgium
Endocr Rev 26:833-76. 2005.... - Osteoporosis in menJean M Kaufman
Ghent University Hospital, Department of Endocrinology, Gent, Belgium
Best Pract Res Clin Endocrinol Metab 22:787-812. 2008..e. bisphosphonates and teriparatide), is limited, so that they should be applied with discernment based on clinical judgement and careful estimation of fracture risk... - Role of sex steroids in the regulation of bone metabolism in the adult skeletonJ-M Kaufman
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium
Ann Endocrinol (Paris) 67:119-22. 2006 - Sex hormone-binding globulin as an independent determinant of cortical bone status in men at the age of peak bone massGriet Vanbillemont
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9K12IE, 9000 Ghent, Belgium
J Clin Endocrinol Metab 95:1579-86. 2010..A large fraction of these hormones are bound by SHBG, and previous studies have shown that SHBG could be a determinant of bone characteristics... - Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturationBruno Lapauw
Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B 9000 Ghent, Belgium
J Clin Endocrinol Metab 94:4300-8. 2009..Pathophysiology of deficient bone mass acquisition in male idiopathic osteoporosis (IO) remains poorly understood... - Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young menGreet Roef
Department of Endocrinology and Metabolic Bone Diseases, Ghent University Hospital, Belgium
Eur J Endocrinol 167:719-26. 2012..Therefore, we have investigated the relationship between thyroid hormone concentrations and body composition together with metabolic parameters in a population of healthy euthyroid men... - Are serum leptin and the Gln223Arg polymorphism of the leptin receptor determinants of bone homeostasis in elderly men?Patricia Crabbe
Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Belgium
Eur J Endocrinol 154:707-14. 2006..This study assesses the contribution in elderly men of leptin and the Gln223Arg leptin receptor gene (LEPR) polymorphism to the variation in bone homeostasis, in relation to body composition and free estradiol as major confounders... - Prevalence of low bone mass in relation to estrogen treatment and body composition in male-to-female transsexual personsGuy T'sjoen
Department of Endocrinology, Ghent University Hospital, Belgium
J Clin Densitom 12:306-13. 2009..oral estrogens. Low bone mass is not uncommon in M --> F transsexual persons. Smaller bone size, and a strikingly lower muscle mass compared with men appear to underlie these findings... - Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone massGreet Roef
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Eur J Endocrinol 164:1027-34. 2011..Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are additional candidate determinants of adult bone mass... - Vitamin D binding protein, bone status and body composition in community-dwelling elderly menYouri E C Taes
Laboratory of Clinical Chemistry, Microbiology and Immunology 2P8, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Bone 38:701-7. 2006..In conclusion, serum 1,25(OH)(2)-vitamin D concentrations are codetermined by DBP-phenotypes and DBP-concentrations. No major effect of DBP-polymorphism was demonstrated on BMD, bone turnover markers or body composition... - Body composition, volumetric and areal bone parameters in male-to-female transsexual personsBruno Lapauw
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Bone 43:1016-21. 2008..Given the importance of sex steroids for developing and maintaining bone mass, bone health is a matter of concern in daily management of these patients... - Birth weight in relation to sex steroid status and body composition in young healthy male siblingsGriet Vanbillemont
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Clin Endocrinol Metab 95:1587-94. 2010..From studies in children with intrauterine growth restriction, low birth weight has been associated with altered gonadotropin concentrations... 
Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish populationWillem Dhooge
Department of Endocrinology, University Hospital Ghent, Belgium
Environ Health Perspect 114:1670-6. 2006..In humans, fertility-related effects are less documented...- Prevalent fractures are related to cortical bone geometry in young healthy men at age of peak bone massYouri Taes
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
J Bone Miner Res 25:1433-40. 2010..Moreover, the data suggest different mechanisms of childhood fractures and fractures during adult life... - Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblingsVeerle Bogaert
Department of Endocrinology, Ghent University Hospital, Belgium
Clin Endocrinol (Oxf) 69:129-35. 2008..This study investigates heritability estimates of sex steroid serum concentrations and body composition as well as the genetic and environmental components of their interrelation... - Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy menVeerle Bogaert
Department of Endocrinology, 9 K12 I E, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Eur J Endocrinol 161:171-7. 2009.... - Fat mass is negatively associated with cortical bone size in young healthy male siblingsYouri E C Taes
Department of Endocrinology, Ghent University Hospital, Belgium
J Clin Endocrinol Metab 94:2325-31. 2009..Whereas lean mass exerts a positive influence on bone size, the relationship between fat and bone remains unclear... - Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult menPatricia Crabbe
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
J Bone Miner Res 20:1951-9. 2005..We studied whether the LRP5 gene contributes to the clinical phenotype of IO in men. Mutation analysis in 66 IO men revealed a range of sequence variants, of which two missense variants were shown to be of functional relevance... - Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy menGriet Vanbillemont
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Clin Endocrinol (Oxf) 76:111-8. 2012..We investigated to what extent different determinants contribute to the variation in SHBG levels in healthy young men... - Early smoking is associated with peak bone mass and prevalent fractures in young, healthy menYouri Taes
Department of Endocrinology, Ghent University Hospital, Belgium
J Bone Miner Res 25:379-87. 2010.... - Regional variations in semen quality of community-dwelling young men from Flanders are not paralleled by hormonal indices of testicular functionWillem Dhooge
Department of Endocrinology, Study Centre for Carcinogenesis and Primary Prevention of Cancer, University Hospital, Ghent, 185 De Pintelaan, B 9000 Ghent, Belgium
J Androl 28:435-43. 2007.... - Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese femalesMargot Berings
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
PLoS ONE 7:e45145. 2012.... - Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblingsBruno M Lapauw
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
J Bone Miner Res 24:1075-85. 2009..E(2), but not T, levels are positively associated with vBMD and modulate the impact of physical activity on bone size at the tibia... - Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young menBruno Lapauw
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Diabetes Care 33:1831-3. 2010..To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition... - Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly menGriet Vanbillemont
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Clin Endocrinol (Oxf) 70:303-10. 2009..The aim of this study was to examine the influence of a missense mutation in exon 8 (Asp327Asn) and a (TAAAA)(n)-repeat in the promoter region of the SHBG gene, on SHBG and sex steroid serum concentrations in a population of healthy men... - Testosterone, androgen receptor gene CAG repeat length, mood and behaviour in adolescent malesHans Vermeersch
Department of Sociology, University of Ghent, Ghent, Belgium
Eur J Endocrinol 163:319-28. 2010.... - A genome-wide linkage scan for low spinal bone mineral density in a single extended family confirms linkage to 1p36.3Andy Willaert
Department of Medical Genetics, Ghent University Hospital, Ghent, Belgium
Eur J Hum Genet 16:970-6. 2008..3. Although no specific disease causing mutation has yet been found, the delineation of a relatively small candidate region in a single extended family opens perspectives to identify a major gene for spinal BMD... - Estrogen receptor signaling is an unstable feature of the gonadotropic LbetaT2 cell lineFrank Eertmans
Department of Endocrinology, 6K12IE, Ghent University Hospital, De Pintelaan, 185, B 9000 Ghent, Belgium
Mol Cell Endocrinol 273:16-24. 2007..Nevertheless, this cell line does not seem to be a suitable in vitro model for the study of estrogenic regulatory effects at the level of the pituitary gonadotrophs in view of the unstable nature of ER signaling in LbetaT2 cells... - Estrogen-specific action on bone geometry and volumetric bone density: longitudinal observations in an adult with complete androgen insensitivityYouri Taes
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Bone 45:392-7. 2009..In this report we describe changes in bone size and volumetric bone density in a complete androgen insensitive subject (CAIS) due to a mutation in the androgen receptor during 5 years of estrogen treatment... - Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levelsEls Elaut
Department of Sexology and Gender Problems, Ghent University Hospital, Belgium
Eur J Endocrinol 158:393-9. 2008..This study wishes to document the HSDD prevalence among transsexual women and the possible association to androgen levels... - Mediators of physical activity change in a behavioral modification program for type 2 diabetes patientsDelfien Van Dyck
Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium
Int J Behav Nutr Phys Act 8:105. 2011..Our purpose was to examine mediation effects of changes in psychosocial variables on changes in physical activity in type 2 diabetes patients... - Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studiesGuy Vandenplas
Heart Center, Ghent University Hospital, Ghent, Belgium
Heart 98:1478-82. 2012..The literature provides no clear answer as to whether total oestradiol (E2) concentrations increase the risk of incident cardiovascular disease (CVD) in healthy men... - Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese menHélène De Naeyer
Department of Abdominal Surgery, University Hospital, Ghent, Belgium
Obes Facts 4:407-16. 2011..To evaluate the role of lipolytic enzymes or mitochondria in lipotoxicity, we studied expression levels of genes and proteins involved in lipolysis and mitochondrial DNA (mtDNA) content... - Difference in receptor-binding contributes to difference in biological activity between the unique guinea pig GnRH and mammalian GnRHChang Qing Gao
Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium
Neurosci Lett 507:124-6. 2012.... - A novel mutation c.118delA in exon 1 of the androgen receptor gene resulting in complete androgen insensitivity syndrome within a large familyKarel Decaestecker
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Fertil Steril 89:1260.e3-7. 2008..To confirm the clinical diagnosis of complete androgen insensitivity syndrome (CAIS) by molecular genetic testing and to offer carriership testing in female relatives should a disease-causing mutation be found... - Dual energy x-ray absorptiometry-based assessment of male patients using standardized bone density values and a national reference databaseStefan Goemaere
Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium
J Clin Densitom 10:25-33. 2007..The current data provide a basis to implement a nation-wide, uniform expression of BMD in male patients and allow harmonization of the BMD-based diagnosis and treatment of osteoporosis in men... - Influence of exogenous oestrogen or (anti-) androgen administration on soluble transferrin receptor in human plasmaGuy G T'Sjoen
Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
J Endocrinol 186:61-7. 2005..This assumption is supported by the positive correlation that was found to exist between plasma sTfR and IGF-I after the interventions (P<0.05)... - Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell lineFrank Eertmans
Department of Endocrinology, 6K12IE, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
J Cell Physiol 212:583-90. 2007..In conclusion, our data indicate IGF-IR and ER interactions in the alphaT3-1 cell line, an in vitro model for the pituitary gonadotrophs, hereby suggesting a role of IGF-I in the regulation of gonadotropin synthesis and secretion... - Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese menJohannes B Ruige
Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium
J Clin Endocrinol Metab 97:E1187-91. 2012..Low testosterone accompanied by elevated estradiol associates with the development of metabolic dysfunction in men... - Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly menGuy G T'Sjoen
Department of Endocrinology, Unit for Osteoporosis and Metabolic Bone Diseases, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
J Am Geriatr Soc 53:636-42. 2005.... - Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibitionGuy G T'Sjoen
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Clin Endocrinol Metab 90:5717-22. 2005..Aging in men is associated with a decline in serum testosterone (T) levels... - Investigation of the potential association of vitamin D binding protein with lipoproteinsMarijn M Speeckaert
Department of Clinical Chemistry, Ghent University Hospital, Gent, Belgium
Ann Clin Biochem 47:143-50. 2010..We have previously reported a correlation between serum DBP and lipid parameters in a cystic fibrosis population. In the present study, the relationship between serum DBP, lipoprotein fractions and vitamin D is investigated... - Estradiol, testosterone, differential association and aggressive and non-aggressive risk-taking in adolescent girlsHans Vermeersch
Department of Sociology, University of Ghent, and Department of Endocrinology, University Hospital Ghent, Ghent 9000, Belgium
Psychoneuroendocrinology 33:897-908. 2008..In addition, significant interactions between differential association and FE2 were found indicating that the relationship between FE2 and NART and ART was particularly strong in girls with high levels of differential association... - The role of testosterone in aggressive and non-aggressive risk-taking in adolescent boysHans Vermeersch
Department of Sociology, University of Ghent, Korte Meer 5, Ghent 9000, Belgium
Horm Behav 53:463-71. 2008..Our results indicate that hormone-related interests and predispositions may influence the development of affiliations with risk-taking peers, a factor which is crucial in understanding adolescent RT... - Reproductive parameters of community-dwelling men from 2 regions in flanders are associated with the consumption of self-grown vegetablesWillem Dhooge
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
J Androl 28:836-46. 2007..We could not exclude pesticide exposure by inappropriate application or other factors such as nutritional deficiency, physical activity, or stress as contributors to the observed regional differences... - Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brainChang Qing Gao
Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium
Neurosci Lett 487:246-9. 2011.... - The effects of a pedometer-based behavioral modification program with telephone support on physical activity and sedentary behavior in type 2 diabetes patientsKarlijn P De Greef
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Patient Educ Couns 84:275-9. 2011..Effectiveness of a behavioral modification program on physical activity (PA) and sedentary behavior in diabetes patients... - Physical function measurements predict mortality in ambulatory older menStefanie L De Buyser
Department of Geriatrics, Ghent University Hospital, Ghent, Belgium
Eur J Clin Invest 43:379-86. 2013..To assess and compare the predictive value of physical function measurements (PFMs) for all-cause mortality in older men and to evaluate the Timed Up and Go test (TUG) as a predictor in subjects with underlying comorbidity... - Development of a highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatizationTom Fiers
Ghent University Hospital, Department of Hormonology, De Pintelaan 185, 9000 Gent, Belgium
J Chromatogr B Analyt Technol Biomed Life Sci 893:57-62. 2012.... - Ability of peripheral bone assessments to predict areal bone mineral density at hip in community-dwelling elderly menStefan Goemaere
Unit for Osteoporosis and Metabolic Bone Diseases, Departments of Endocrinology and Rheumatology, Ghent University Hospital, Gent, Belgium
J Clin Densitom 5:219-28. 2002..It is concluded that peripheral measurements cannot be used as a substitute for hip DXA. However, they might be useful to guide patient referral for central DXA... - Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysisJohannes B Ruige
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Heart 97:870-5. 2011..The literature provides no clear answer as to whether low endogenous testosterone increases risk of cardiovascular disease (CVD) in healthy men... - Value and pitfalls in iodine fortification and supplementation in the 21st centuryMarijn M Speeckaert
Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Br J Nutr 106:964-73. 2011..Besides the multiple beneficial effects of supplementation, we present in this review a critical look at the possible side effects... - Osteoporotic fracture treatmentNadine Hollevoet
Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
Acta Orthop Belg 77:441-7. 2011..Low bone mineral density is not only associated with an increased fracture risk but also with more fracture displacement and reduction loss. The specific problems and main treatment options for these fragility fractures are reviewed...