Dirk Inze

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Cell cycle regulation in plant development
    Dirk Inze
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Annu Rev Genet 40:77-105. 2006
  2. pmc Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor
    Lieven De Veylder
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, Belgium
    EMBO J 21:1360-8. 2002
  3. pmc Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis
    Marieke Dubois
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Plant Physiol 162:319-32. 2013
  4. pmc Auxin-mediated cell cycle activation during early lateral root initiation
    Kristiina Himanen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant Cell 14:2339-51. 2002
  5. pmc Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis
    Sandy Vanderauwera
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:806-21. 2005
  6. ncbi request reprint Exploration of jasmonate signalling via automated and standardized transient expression assays in tobacco cells
    Valerie De Sutter
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Plant J 44:1065-76. 2005
  7. pmc Genome-wide identification of potential plant E2F target genes
    Klaas Vandepoele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:316-28. 2005
  8. pmc The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis
    Véronique Boudolf
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 16:2683-92. 2004
  9. doi request reprint Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process
    Megan Andriankaja
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Dev Cell 22:64-78. 2012
  10. pmc Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana
    Jelle Van Leene
    Department of Plant Systems Biology, VIB, Ghent, Belgium
    Mol Syst Biol 6:397. 2010

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Cell cycle regulation in plant development
    Dirk Inze
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Annu Rev Genet 40:77-105. 2006
    ..Here, we review the molecular mechanisms that regulate cell division and endoreduplication and we discuss our understanding, albeit very limited, on how the cell cycle is integrated with plant development...
  2. pmc Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor
    Lieven De Veylder
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, Belgium
    EMBO J 21:1360-8. 2002
    ..Because E2Fa--DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development...
  3. pmc Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis
    Marieke Dubois
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Plant Physiol 162:319-32. 2013
    ....
  4. pmc Auxin-mediated cell cycle activation during early lateral root initiation
    Kristiina Himanen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant Cell 14:2339-51. 2002
    ..KRP2 appears to regulate early lateral root initiation by blocking the G1-to-S transition and to be regulated transcriptionally by auxin...
  5. pmc Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis
    Sandy Vanderauwera
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:806-21. 2005
    ..This cluster comprises the complete known anthocyanin regulatory and biosynthetic pathway, together with genes encoding unknown proteins...
  6. ncbi request reprint Exploration of jasmonate signalling via automated and standardized transient expression assays in tobacco cells
    Valerie De Sutter
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Plant J 44:1065-76. 2005
    ..In addition, combinatorial tests showed that these two factors act synergistically to induce PMT transcriptional activity. The development and use of high-throughput plant transient expression assays are discussed...
  7. pmc Genome-wide identification of potential plant E2F target genes
    Klaas Vandepoele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    Plant Physiol 139:316-28. 2005
    ..These genes encode proteins involved in cell cycle regulation, DNA replication, and chromatin dynamics. In addition, we identified several genes for potentially novel S phase regulatory proteins...
  8. pmc The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis
    Véronique Boudolf
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 16:2683-92. 2004
    ..These findings illustrate a cross talking mechanism between the G1-S and G2-M transition points...
  9. doi request reprint Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process
    Megan Andriankaja
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Dev Cell 22:64-78. 2012
    ..Hence, differentiation of the photosynthetic machinery is important for regulating the exit from proliferation...
  10. pmc Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana
    Jelle Van Leene
    Department of Plant Systems Biology, VIB, Ghent, Belgium
    Mol Syst Biol 6:397. 2010
    ....
  11. pmc Genetic complexity of cellulose synthase a gene function in Arabidopsis embryogenesis
    Tom Beeckman
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9000 Gent, Belgium
    Plant Physiol 130:1883-93. 2002
    ..The embryonic phenotype of the presumed rsw1 null mutant indicates that the RSW1(CESA1) product has a critical, nonredundant function, but is nevertheless not strictly required for primary cell wall formation...
  12. doi request reprint Systematic analysis of cell-cycle gene expression during Arabidopsis development
    Janice de Almeida Engler
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, 9052 Gent, Belgium
    Plant J 59:645-60. 2009
    ..The lack of regulatory motifs in the upstream regions of the analyzed genes suggests the absence of a universal transcriptional control mechanism for all cell-cycle genes...
  13. pmc A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization
    Marleen Vanstraelen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 135:1417-29. 2004
    ..The data show that phosphorylation of the CDKA;1 site provokes a conformational change in the structure of KCA with implications in folding and dimerization...
  14. pmc Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network
    Joanna Boruc
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Plant Cell 22:1264-80. 2010
    ..The obtained interaction map constitutes a framework for further in-depth analysis of the cell cycle machinery...
  15. pmc Bimodular auxin response controls organogenesis in Arabidopsis
    Ive De Smet
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 107:2705-10. 2010
    ..The genetic framework in which two successive auxin response modules control early steps of a developmental process adds an extra dimension to the complexity of auxin's action...
  16. ncbi request reprint Catalase deficiency drastically affects gene expression induced by high light in Arabidopsis thaliana
    Steven Vandenabeele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Plant J 39:45-58. 2004
    ..Thus, photorespiratory H(2)O(2) has a direct impact on transcriptional programs in plants...
  17. pmc Cell cycle progression in the pericycle is not sufficient for SOLITARY ROOT/IAA14-mediated lateral root initiation in Arabidopsis thaliana
    Steffen Vanneste
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Cell 17:3035-50. 2005
    ....
  18. pmc Genome-wide analysis of gene expression profiles associated with cell cycle transitions in growing organs of Arabidopsis
    Gerrit T S Beemster
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 138:734-43. 2005
    ..Most of those had an M phase-dependent expression pattern and, in addition to many known cell cycle-related genes, there were at least 90 that were unknown or previously not associated with proliferation...
  19. pmc The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes
    Aurine Verkest
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 17:1723-36. 2005
    ..Moreover, the proposed model allowed a dynamical simulation of the in vivo observations, validating the sufficiency of the regulatory interactions between CDKA;1, KRP2, and CDKB1;1 in fine-tuning the mitosis-to-endocycle transition...
  20. doi request reprint Brassinosteroid production and signaling differentially control cell division and expansion in the leaf
    Miroslava K Zhiponova
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    New Phytol 197:490-502. 2013
    ..This correlated with an increase in cyclin-dependent kinase activity, suggesting a role for BRs in control of mitosis...
  21. pmc CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset
    Véronique Boudolf
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, 9052 Ghent, Belgium
    Plant Physiol 150:1482-93. 2009
    ..We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3...
  22. ncbi request reprint A technology platform for the fast production of monoclonal recombinant antibodies against plant proteins and peptides
    Dominique Eeckhout
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    J Immunol Methods 294:181-7. 2004
    ..We are convinced that this antibody platform will further stimulate applications of recombinant antibodies such as the diagnostic detection or immunomodulation of specific antigens in plants...
  23. pmc Nitric oxide- and hydrogen peroxide-responsive gene regulation during cell death induction in tobacco
    Elisa Zago
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 141:404-11. 2006
    ....
  24. pmc DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity
    Hannes Claeys
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Plant Physiol 159:739-47. 2012
    ..This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation...
  25. pmc Model-based analysis of Arabidopsis leaf epidermal cells reveals distinct division and expansion patterns for pavement and guard cells
    Leila Kheibarshekan Asl
    Department of Applied Mathematics and Computer Science, Ghent University, 9000 Ghent, Belgium
    Plant Physiol 156:2172-83. 2011
    ..We conclude that cell division seems to occur independently from the status of cell expansion, whereas the cell cycle might act as a timer rather than as a size-regulated machinery...
  26. pmc Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset
    Amandine Radziejwoski
    Department of Plant Systems Biology, VIB, Gent, Belgium
    EMBO J 30:355-63. 2011
    ..As E2Fe/DEL1 levels decreased upon UV-B treatment, we hypothesize that the coordinated transcriptional induction of PHR1 with the endoreduplication onset contributes to the adaptation of plants exposed to UV-B stress...
  27. pmc A high-throughput bimolecular fluorescence complementation protein-protein interaction screen identifies functional Arabidopsis CDKA/B-CYCD4/5 complexes
    Joanna Boruc
    Department of Plant Systems Biology, VIB, Ghent University, Gent, Belgium
    Plant Signal Behav 5:1276-81. 2010
    ..We demonstrate that these complexes promote cell proliferation in Arabidopsis and we discuss their putative mode of action in plant development...
  28. pmc Increased leaf size: different means to an end
    Nathalie Gonzalez
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Plant Physiol 153:1261-79. 2010
    ..The analysis of transgenic lines simultaneously overexpressing two growth-enhancing genes further supports the concept that multiple pathways independently converge on organ size control in Arabidopsis...
  29. pmc Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis
    Steffen Vanneste
    Department of Plant Systems Biology, VIB, Ghent, Belgium
    EMBO J 30:3430-41. 2011
    ..Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development...
  30. pmc The Arabidopsis thaliana homolog of yeast BRE1 has a function in cell cycle regulation during early leaf and root growth
    Delphine Fleury
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 19:417-32. 2007
    ..Based on the mutant characterization, we postulate that HUB1 mediates gene activation and cell cycle regulation probably through chromatin modifications...
  31. pmc A functional genomics approach toward the understanding of secondary metabolism in plant cells
    Alain Goossens
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Proc Natl Acad Sci U S A 100:8595-600. 2003
    ..This method, which in addition to transcriptome data also generates gene tags, in the future might lead to the creation of novel tools for metabolic engineering of medicinal plant systems in general...
  32. ncbi request reprint Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development
    Olivier Van Aken
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, 9052 Gent, Belgium
    Plant J 52:850-64. 2007
    ..We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues...
  33. pmc SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization
    Núbia B Eloy
    Department of Plant Systems Biology, VIB, Ghent University, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 109:13853-8. 2012
    ..Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis...
  34. pmc Pause-and-stop: the effects of osmotic stress on cell proliferation during early leaf development in Arabidopsis and a role for ethylene signaling in cell cycle arrest
    Aleksandra Skirycz
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Plant Cell 23:1876-88. 2011
    ..Nonetheless, the potential to partially recover the decreased cell numbers remains due to the activity of meristemoids. Together, these data present a conceptual framework to understand how environmental stress reduces plant growth...
  35. ncbi request reprint The Arabidopsis leaf as a model system for investigating the role of cell cycle regulation in organ growth
    Gerrit T S Beemster
    Department of Plant Systems Biology, University of Ghent Flanders Interuniversity Institute for Biotechnology VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium
    J Plant Res 119:43-50. 2006
    ..This may point to a difference in the nature of the expansion process during the proliferating and non-dividing phase of leaf development...
  36. pmc Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes
    Joanna Boruc
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Plant Physiol 152:553-65. 2010
    ..Thus, we identified unknown spatiotemporal territories where functional cell cycle protein interactions are most likely to occur...
  37. ncbi request reprint The DP-E2F-like gene DEL1 controls the endocycle in Arabidopsis thaliana
    Kobe Vlieghe
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, Gent B 9052, Belgium
    Curr Biol 15:59-63. 2005
    ....
  38. doi request reprint Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root
    Ive De Smet
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, B 9052 Ghent, Belgium
    Science 322:594-7. 2008
    ..Thus, ACR4 function reveals a common mechanism of formative cell division control in the main root tip meristem and during lateral root initiation...
  39. pmc The role of the cell cycle machinery in resumption of postembryonic development
    Rosa Maria Barroco
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 137:127-40. 2005
    ..Mitotic divisions are observed only after the radicle has protruded and presumably rely on the de novo production of other cell cycle regulators...
  40. pmc Transcriptome analysis during cell division in plants
    Peter Breyne
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, Belgium
    Proc Natl Acad Sci U S A 99:14825-30. 2002
    ..Many of the genes encode novel or uncharacterized proteins, indicating that several processes underlying cell division are still largely unknown...
  41. ncbi request reprint Conditional, recombinase-mediated expression of genes in plant cell cultures
    Jérôme Joubès
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Plant J 37:889-96. 2004
    ....
  42. ncbi request reprint Molecular dissection of plant cytokinesis and phragmoplast structure: a survey of GFP-tagged proteins
    Daniel Van Damme
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Plant J 40:386-98. 2004
    ..EB1 and Aurora, in addition to other regulatory proteins (homologs of Mob1, Sid1, and Sid2), were targeted to the nucleus, suggesting that this organelle operates as a coordinating hub for cytokinesis...
  43. pmc Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoreduplication in Arabidopsis
    Roel Sterken
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 109:4678-83. 2012
    ..In accordance, both the overexpression and silencing of CYCD5;1 were effective in changing DNA ploidy levels, confirming CYCD5;1 to be a previously undescribed quantitative trait gene underlying endoreduplication in Arabidopsis...
  44. pmc The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth
    Hilde Nelissen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Proc Natl Acad Sci U S A 102:7754-9. 2005
    ..Our data indicate that the Elongator complex is evolutionarily conserved in structure and function but reveal that the mechanism by which it stimulates cell proliferation is different in yeast and plants...
  45. pmc Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset
    Tim Lammens
    Department of Plant Systems Biology, Flanders Institute for Biotechnology and Department of Molecular Genetics, Ghent University, 9052 Gent, Belgium
    Proc Natl Acad Sci U S A 105:14721-6. 2008
    ..Analogously, the atypical mammalian E2F7 protein was associated with the promoter of the APC/C-activating CDH1 gene, indicating that the transcriptional control of APC/C activator genes by atypical E2Fs might be evolutionarily conserved...
  46. pmc Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint
    Kristof De Schutter
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 19:211-25. 2007
    ....
  47. pmc Genome-wide analysis of core cell cycle genes in Arabidopsis
    Klaas Vandepoele
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Plant Cell 14:903-16. 2002
    ..This genome-wide analysis illustrates the complexity of the plant cell cycle machinery and provides a tool for elucidating the function of new family members in the future...
  48. ncbi request reprint Changes in hydrogen peroxide homeostasis trigger an active cell death process in tobacco
    James F Dat
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant J 33:621-32. 2003
    ..This oxidase-dependent oxidative burst is essential for cell death, but it is not required for the accumulation of defense proteins, suggesting a more prominent role for the oxidative burst in abiotic stress-induced cell death...
  49. pmc Cell cycle modulation in the response of the primary root of Arabidopsis to salt stress
    Gerrit West
    Department of Plant Systems Biology, University of Ghent Vlaams Interuniversitair Instituut voor Biotechnologie VIB, 9052 Ghent, Belgium
    Plant Physiol 135:1050-8. 2004
    ..When the meristem reaches the appropriate size for the given conditions, cell cycle duration returns to its default...
  50. pmc AUREOCHROME1a-mediated induction of the diatom-specific cyclin dsCYC2 controls the onset of cell division in diatoms (Phaeodactylum tricornutum)
    Marie J J Huysman
    Protistology and Aquatic Ecology, Department of Biology, Ghent University, B 9000 Gent, Belgium
    Plant Cell 25:215-28. 2013
    ....
  51. doi request reprint A local maximum in gibberellin levels regulates maize leaf growth by spatial control of cell division
    Hilde Nelissen
    Department of Plant Systems Biology, VIB, B 9052 Gent, Belgium
    Curr Biol 22:1183-7. 2012
    ..This work thereby provides a novel molecular mechanism for the regulation of the transition from cell division to expansion that controls organ growth and size...
  52. doi request reprint A comparative study of seed yield parameters in Arabidopsis thaliana mutants and transgenics
    Inge Van Daele
    Department of Plant Systems Biology, VIB, Gent, Belgium
    Plant Biotechnol J 10:488-500. 2012
    ..In addition, this study highlights the need for more thorough analysis of genes affecting seed yield...
  53. pmc Transcriptional analysis of cell growth and morphogenesis in the unicellular green alga Micrasterias (Streptophyta), with emphasis on the role of expansin
    Katrijn Vannerum
    Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent, Belgium
    BMC Plant Biol 11:128. 2011
    ....
  54. pmc The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1
    Naoki Takahashi
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Gent, Belgium
    EMBO J 27:1840-51. 2008
    ....
  55. pmc The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair
    Naoki Takahashi
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Gent, Belgium
    PLoS Genet 6:e1000817. 2010
    ..Cohesion defects observed upon knockdown of its human counterpart suggest an equally important developmental role for the orthologous mammalian ETG1 protein...
  56. doi request reprint Quantitative RNA expression analysis with Affymetrix Tiling 1.0R arrays identifies new E2F target genes
    Naira Naouar
    Department of Plant Systems Biology, VIB, Technologiepark 927, Ghent, Belgium
    Plant J 57:184-94. 2009
    ..The latter groups increase the number of excellent candidates for new, direct E2F targets by almost twofold, from 181 to 334...
  57. pmc Adaptin-like protein TPLATE and clathrin recruitment during plant somatic cytokinesis occurs via two distinct pathways
    Daniel Van Damme
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 108:615-20. 2011
    ..These data provide evidence that the plasma membrane is subject to localized endocytosis or membrane remodeling processes that are required for the fusion of the cell plate with a predefined region of the plasma membrane...
  58. pmc Somatic cytokinesis and pollen maturation in Arabidopsis depend on TPLATE, which has domains similar to coat proteins
    Daniel Van Damme
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnologie, Ghent University, B 9052 Gent, Belgium
    Plant Cell 18:3502-18. 2006
    ..These data suggest that TPLATE functions in vesicle-trafficking events required for site-specific cell wall modifications during pollen germination and for anchoring of the cell plate to the mother wall at the correct cortical position...
  59. pmc Expression of the Arabidopsis jasmonate signalling repressor JAZ1/TIFY10A is stimulated by auxin
    Wim Grunewald
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, Ghent, Belgium
    EMBO Rep 10:923-8. 2009
    ..Our results provide evidence for the existence of at least two different input signals regarding JAZ1/TIFY10A expression and thus support the idea of an intimate molecular interplay between auxin and JA signalling...
  60. ncbi request reprint Lateral root initiation or the birth of a new meristem
    Ive De Smet
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052, Gent, Belgium
    Plant Mol Biol 60:871-87. 2006
    ..Based on the current knowledge derived from recent genetic and developmental studies, we propose here a hypothetical model for LRI...
  61. pmc The cyclin-dependent kinase inhibitor Orysa;KRP1 plays an important role in seed development of rice
    Rosa Maria Barroco
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 142:1053-64. 2006
    ..Also, spatial and temporal transcript detection in developing seeds suggests that Orysa;KRP1 plays an important role in the exit from the mitotic cell cycle during rice grain formation...
  62. pmc Transcript profiling of early lateral root initiation
    Kristiina Himanen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 101:5146-51. 2004
    ..These results indicate that this lateral root induction system represents a unique synchronized system that allows the systematic study of the developmental program upstream of the cell cycle activation during lateral root initiation...
  63. doi request reprint CORNET 2.0: integrating plant coexpression, protein-protein interactions, regulatory interactions, gene associations and functional annotations
    Stefanie De Bodt
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    New Phytol 195:707-20. 2012
    ..Networks and associated evidence of the majority of currently available data types are visualized in Cytoscape. CORNET is available at https://bioinformatics.psb.ugent.be/cornet...
  64. ncbi request reprint Cell cycle: the key to plant growth control?
    Gerrit T S Beemster
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Belgium
    Trends Plant Sci 8:154-8. 2003
    ..This model can serve as a basis for future research, and prompts experimental approaches to encompass both measurements of cell growth and division parameters...
  65. pmc Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling
    Marie J J Huysman
    Protistology and Aquatic Ecology, Department of Biology, Ghent University, Krijgslaan 281 S8, 9000 Gent, Belgium
    Genome Biol 11:R17. 2010
    ..The recent genome sequencing of Thalassiosira pseudonana and Phaeodactylum tricornutum allows us to explore the molecular conservation of cell cycle regulation in diatoms...
  66. pmc NINJA connects the co-repressor TOPLESS to jasmonate signalling
    Laurens Pauwels
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Technologiepark 927, B 9052 Gent, Belgium
    Nature 464:788-91. 2010
    ..This new insight reveals how stress-related and growth-related signalling cascades use common molecular mechanisms to regulate gene expression in plants...
  67. pmc Mass spectrometry-based sequencing of lignin oligomers
    Kris Morreel
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Plant Physiol 153:1464-78. 2010
    ..Interestingly, based on molecular mass data of the unknown monomeric and dimeric substructures, at least 10 unknown monomeric units or interunit linkage types were observed, one of which was identified as an arylglycerol end unit...
  68. doi request reprint Cyclin-dependent kinase activity maintains the shoot apical meristem cells in an undifferentiated state
    Tarik Gaamouche
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Plant J 64:26-37. 2010
    ..Therefore, we propose a threshold model in which the effect of the cell-cycle machinery on meristem organization is determined by the level of CDK activity...
  69. ncbi request reprint Metacaspase activity of Arabidopsis thaliana is regulated by S-nitrosylation of a critical cysteine residue
    Beatrice Belenghi
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    J Biol Chem 282:1352-8. 2007
    ..This cysteine is absent in caspases and paracaspases but is conserved in all reported metacaspases...
  70. ncbi request reprint Cell cycle-dependent targeting of a kinesin at the plasma membrane demarcates the division site in plant cells
    Marleen Vanstraelen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Curr Biol 16:308-14. 2006
    ..Cell divisions in the absence of a KDZ resulted in misplaced cell plates, suggesting that the PPB transmits a signal to the plasma membrane required for correct cell plate guidance and vesicular targeting to the cortical division site...
  71. pmc Combining enhanced root and shoot growth reveals cross talk between pathways that control plant organ size in Arabidopsis
    Liesbeth Vercruyssen
    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium
    Plant Physiol 155:1339-52. 2011
    ..Our results show new interactions and contribute to the molecular and physiological understanding of biomass production at the whole plant level...
  72. pmc Comprehensive analysis of gene expression in Nicotiana tabacum leaves acclimated to oxidative stress
    Eva Vranová
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Proc Natl Acad Sci U S A 99:10870-5. 2002
    ..Moreover, our data indicate that in addition to defense gene induction, sensitization of plants for potentiated gene expression might be an important factor in oxidative stress acclimation...
  73. pmc Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells
    Laurens Pauwels
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 105:1380-5. 2008
    ....
  74. pmc SHORT-ROOT and SCARECROW regulate leaf growth in Arabidopsis by stimulating S-phase progression of the cell cycle
    Stijn Dhondt
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent, Belgium
    Plant Physiol 154:1183-95. 2010
    ..Therefore, we conclude that, in contrast to their specific roles in cortex/endodermis differentiation and stem cell maintenance in the root, SHR and SCR primarily function as general regulators of cell proliferation in leaves...
  75. pmc Developmental stage specificity and the role of mitochondrial metabolism in the response of Arabidopsis leaves to prolonged mild osmotic stress
    Aleksandra Skirycz
    Department of Plant Biotechnology and Genetics, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 152:226-44. 2010
    ..Taken together, our data underline the value of analyzing stress responses in development and demonstrate the importance of mitochondrial respiration for sustaining cell proliferation under osmotic stress conditions...
  76. doi request reprint A novel aux/IAA28 signaling cascade activates GATA23-dependent specification of lateral root founder cell identity
    Bert De Rybel
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Ghent, Belgium
    Curr Biol 20:1697-706. 2010
    ..Lateral roots are formed at regular intervals along the main root by recurrent specification of founder cells. To date, the mechanism by which branching of the root system is controlled and founder cells become specified remains unknown...
  77. pmc A role for the root cap in root branching revealed by the non-auxin probe naxillin
    Bert De Rybel
    Department of Plant Systems Biology, VIB, Gent, Belgium
    Nat Chem Biol 8:798-805. 2012
    ..Delivery of an auxin precursor in peripheral tissues such as the root cap might represent an important mechanism shaping root architecture...
  78. pmc Perturbation of indole-3-butyric acid homeostasis by the UDP-glucosyltransferase UGT74E2 modulates Arabidopsis architecture and water stress tolerance
    Vanesa B Tognetti
    Department of Plant Systems Biology, VIB, Ghent University, 9052 Gent, Belgium
    Plant Cell 22:2660-79. 2010
    ....
  79. ncbi request reprint What if higher plants lack a CDC25 phosphatase?
    Véronique Boudolf
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Trends Plant Sci 11:474-9. 2006
    ....
  80. doi request reprint A reciprocal 15N-labeling proteomic analysis of expanding Arabidopsis leaves subjected to osmotic stress indicates importance of mitochondria in preserving plastid functions
    Aleksandra Skirycz
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    J Proteome Res 10:1018-29. 2011
    ..In conclusion, proteomics using the (15)N labeling helped understand the mechanisms underlying growth adaptation to osmotic stress and allowed the identification of candidate genes to improve plant growth under limited water...
  81. pmc B1-type cyclin-dependent kinases are essential for the formation of stomatal complexes in Arabidopsis thaliana
    Véronique Boudolf
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 16:945-55. 2004
    ..Although division of stomatal precursors was inhibited, cells still acquired stomatal identity, illustrating that stomatal cell differentiation is independent of cellular and nuclear division...
  82. ncbi request reprint A Temperature-sensitive mutation in the Arabidopsis thaliana phosphomannomutase gene disrupts protein glycosylation and triggers cell death
    Frank A Hoeberichts
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Ghent University, 9052 Gent, Belgium
    J Biol Chem 283:5708-18. 2008
    ....
  83. pmc A population genomics study of the Arabidopsis core cell cycle genes shows the signature of natural selection
    Roel Sterken
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Plant Cell 21:2987-98. 2009
    ..Our data suggest that within Arabidopsis, the genetic robustness of cell cycle-related processes is more due to functional redundancy than high selective constraint...
  84. ncbi request reprint Microarray analysis of E2Fa-DPa-overexpressing plants uncovers a cross-talking genetic network between DNA replication and nitrogen assimilation
    Kobe Vlieghe
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    J Cell Sci 116:4249-59. 2003
    ....
  85. pmc Cold nights impair leaf growth and cell cycle progression in maize through transcriptional changes of cell cycle genes
    Bart Rymen
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Belgium
    Plant Physiol 143:1429-38. 2007
    ....
  86. doi request reprint Hydrogen peroxide-induced gene expression across kingdoms: a comparative analysis
    Korneel Vandenbroucke
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent, Belgium
    Mol Biol Evol 25:507-16. 2008
    ....
  87. doi request reprint Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants
    Lies Maes
    Department of Plant Systems Biology, VIB, Gent, Belgium
    New Phytol 189:176-89. 2011
    ..annua plants. Analysis of phytohormone-modulated transcriptional regulons provides clues to dissect the concerted regulation of metabolism and development of plant trichomes...
  88. ncbi request reprint Plant cell cycle transitions
    Lieven De Veylder
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Curr Opin Plant Biol 6:536-43. 2003
    ..These fluctuations trigger transitions between the different stages of the cell cycle...
  89. doi request reprint Quantitative analysis of venation patterns of Arabidopsis leaves by supervised image analysis
    Stijn Dhondt
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Plant J 69:553-63. 2012
    ..These findings indicate that development of LIMANI improves understanding of the interaction between vascular patterning and leaf growth...
  90. pmc A role for AtWRKY23 in feeding site establishment of plant-parasitic nematodes
    Wim Grunewald
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 148:358-68. 2008
    ..Although auxin is known to be involved in feeding site formation, our results suggest that, during early stages, auxin-independent signals might be at play to activate the initial expression of WRKY23...
  91. ncbi request reprint Canalization without flux sensors: a traveling-wave hypothesis
    Roeland M H Merks
    Department of Plant Systems Biology, VIB, Technologiepark 927, 9052 Ghent, Belgium
    Trends Plant Sci 12:384-90. 2007
    ..We propose an alternative mechanism for polar auxin channeling, which is more consistent with recent molecular observations...
  92. pmc In vivo dynamics and differential microtubule-binding activities of MAP65 proteins
    Daniel Van Damme
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 136:3956-67. 2004
    ..The expression of AtMAP65-4 peaked at mitosis, in agreement with a function related to spindle formation, whereas AtMAP65-1 and AtMAP65-5 were expressed throughout the cell cycle...
  93. doi request reprint Jasmonate-inducible gene: What does it mean?
    Laurens Pauwels
    Department of Plant Systems Biology, Flanders Institute for Biotechnology and Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Trends Plant Sci 14:87-91. 2009
    ..This emphasizes that JA signal transduction is integrated into an elaborate signalling network...
  94. pmc CORNET: a user-friendly tool for data mining and integration
    Stefanie De Bodt
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Plant Physiol 152:1167-79. 2010
    ..Moreover, networks and associated evidence are visualized in Cytoscape. Localization is visualized in pie charts, thereby allowing multiple localizations per protein. CORNET is available at http://bioinformatics.psb.ugent.be/cornet...
  95. doi request reprint Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling
    Bert De Rybel
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Gent, Belgium
    Chem Biol 16:594-604. 2009
    ..The opportunity to generate multiple and conditional knockouts in key regulators in the BR signaling pathway by bikinin represents a useful tool to further unravel regulatory mechanisms...
  96. ncbi request reprint The ins and outs of the plant cell cycle
    Lieven De Veylder
    Department of Plant Systems Biology, VIB, Technologiepark 927, 9052 Gent, Belgium
    Nat Rev Mol Cell Biol 8:655-65. 2007
    ..Here, we discuss how intrinsic developmental signals and environmental cues affect cell-cycle entry and exit...
  97. pmc Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves
    Lies Maes
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Plant Physiol 148:1453-64. 2008
    ..This hitherto unknown role for TT8 in trichome formation further underscored the functional redundancy between the three TTG1-dependent bHLH proteins...
  98. pmc The Arabidopsis locus RCB mediates upstream regulation of mitotic gene expression
    Kristiina Himanen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Plant Physiol 133:1862-72. 2003
    ..Based on the altered CYCB1;1::uidA expression patterns in rcb root meristem, a model is proposed for RCB that mediates the tissue specificity of CYCB1;1 promoter activity...
  99. pmc DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants
    Hilde Nelissen
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9000 Gent, Belgium
    Plant Cell 15:639-54. 2003
    ..Upregulation of the ANGUSTIFOLIA transcript in the strong drl1-2 allele supports this model...
  100. pmc Green light for the cell cycle
    Dirk Inze
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Gent, Belgium
    EMBO J 24:657-62. 2005
    ..The review discusses recent developments in our understanding of the plant cell cycle machinery and highlights the role of the cell cycle in plant development...
  101. pmc Physiological and transcriptomic evidence for a close coupling between chloroplast ontogeny and cell cycle progression in the pennate diatom Seminavis robusta
    Jeroen Gillard
    Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, B 9000 Gent, Belgium
    Plant Physiol 148:1394-411. 2008
    ..robusta is tightly regulated...