Research Topics
| Arne HeyerickSummaryAffiliation: Ghent University Country: Belgium Publications
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Detail Information
Publications
A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomfortsArne Heyerick
Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium
Maturitas 54:164-75. 2006..To examine the efficacy of a hop extract enriched in 8-prenylnaringenin (8-PN, the phytoestrogen in hops, Humulus lupulus L.) on relief of menopausal discomforts...
Combinatorial analysis of lupulin gland transcription factors from R2R3Myb, bHLH and WDR families indicates a complex regulation of chs_H1 genes essential for prenylflavonoid biosynthesis in hop (Humulus Lupulus L.)Jaroslav Matousek
Biology Centre ASCR vvi, Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
BMC Plant Biol 12:27. 2012....- Fate of flavins in sensitized photodegradation of isohumulones and reduced derivatives: studies on formation of radicals via EPR combined with detailed product analysesArne Heyerick
Laboratory of Pharmacognosy and Phytochemistry, Ghent University, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, B 9000, Ghent, Belgium
Photochem Photobiol Sci 4:412-9. 2005..However, no superimposed signals were observed on sensitized irradiation of dihydroisohumulones... 
Disposition of hop prenylflavonoids in human breast tissueSelin Bolca
Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
Mol Nutr Food Res 54:S284-94. 2010..6+/-118.8 fmol/g, p=0.009) and glandular (241.6+/-93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue...- Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal womenSelin Bolca
Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
J Nutr 137:2242-6. 2007..850 (1.215-2.817), P = 0.004] intake were more likely to be strong equol producers. Finally, we validated the daidzein metabolism by fecal cultures as screening assay to identify equol producers without dietary intervention... - Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalentsSelin Bolca
Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
J Nutr 139:2293-300. 2009..These findings support the importance of personalized screening when assessing the efficacy of such products and mixtures... - Disposition of soy isoflavones in normal human breast tissueSelin Bolca
Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering and the Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
Am J Clin Nutr 91:976-84. 2010..Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered... - Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian womenSelin Bolca
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
Br J Nutr 98:950-9. 2007..Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products... - Photooxidative degradation of beer bittering principles: a key step on the route to lightstruck flavor formation in beerKevin Huvaere
Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, B-9000 Ghent, Belgium
J Agric Food Chem 53:1489-94. 2005..Interaction of reduced derivatives of isohumulones with triplet-excited riboflavin furnished radical precursors of volatile aldehydes, which may lead to the development of unpleasant stale or cardboard flavors... - Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgammaMarjan Van Cleemput
Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Gent, Belgium
Mol Nutr Food Res 53:1143-55. 2009..Finally, systemic administration of HBA efficiently inhibited acute local inflammation in vivo... - The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicalsSam Possemiers
Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Gent, Belgium
Fitoterapia 82:53-66. 2011..Moreover, knowledge about intestinal processes may offer innovative strategies for targeted product development... - Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestineSam Possemiers
Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Gent, Belgium
J Nutr 138:1310-6. 2008..In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats... - Production of monoclonal antibodies against hop-derived (Humulus lupulus L.) prenylflavonoids and the development of immunoassaysCiska Wyns
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000, Ghent, Belgium
Talanta 85:197-205. 2011..13% and 1.57%, respectively for IX and 6.13% and 2.43%, respectively for 8-PN. Furthermore, the method demonstrated excellent accuracy and significant correlation with measurements by an established and validated HPLC-MS method... - Bioavailability of hop-derived iso-α-acids and reduced derivativesKo Cattoor
UGent Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B 9000 Ghent, Belgium
Food Funct 2:412-22. 2011..Bioavailability of DHIAA is mostly influenced by phase-II metabolism as shown by enzymatic hydrolysis of plasma samples upon administration of DHIAA... - Radicaloid-type oxidative decomposition of beer bittering agents revealedKevin Huvaere
Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, 9000 Ghent, Belgium
Chemistry 9:4693-9. 2003..Thus, flavor-active beer constituents may degrade oxidatively in the absence of oxygen, thereby leading to reaction products that escape UV detection... - Transport of hop bitter acids across intestinal Caco-2 cell monolayersKo Cattoor
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, UGent Ghent University, Ghent, Belgium
J Agric Food Chem 58:4132-40. 2010..It appears that alpha-acids are efficiently absorbed, whereas the permeability of beta-acids is low. Limiting factors in the absorption of beta-acids could involve P-gp and MRP-2 type efflux transporters and phase II metabolism... - Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo speciesLaura Van Hoyweghen
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, B 9000 Ghent, Belgium
Phytochem Anal 23:433-43. 2012.... - Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compoundsMarjan Van Cleemput
Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Gent, Belgium
J Nat Prod 72:1220-30. 2009..This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds... - Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serumCiska Wyns
Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, B 9000 Gent, Belgium
J Chromatogr B Analyt Technol Biomed Life Sci 878:949-56. 2010.... - Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activityVisnja Popović
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Phytochemistry 87:102-11. 2013.... - Absorption, translocation and metabolism of metamitron in Chenopodium albumJonas Aper
Weed Science Unit, Faculty of Bioscience Engineering, Department of Plant Production, Ghent University, Gent, Belgium
Pest Manag Sci 68:209-16. 2012..The objectives of this study were to clarify the absorption, translocation and metabolic fate of metamitron in C. album... - Prenylated chalcone xanthohumol associates with histones in breast cancer cells--a novel target identified by a monoclonal antibodyCiska Wyns
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Mol Nutr Food Res 56:1688-96. 2012..The intracellular fate of xanthohumol (XN) from hops is an underexplored field in the research for the molecular mechanisms causing its wide range of effects in chemoprevention and gene expression involved in hepatic metabolism... - Antioxidant flavone glycosides from the leaves of Fargesia robustaLaura Van Hoyweghen
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, B 9000 Ghent, Belgium
J Nat Prod 73:1573-7. 2010..Compounds 1, 4, and 5 exhibited potent antioxidant activity in the TEAC assay, while compounds 1, 3, and 5 showed the highest antioxidant capacity in the ORAC assay... - Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activityMary Kaileh
Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
J Biol Chem 282:4253-64. 2007.... - Distribution of soy-derived phytoestrogens in human breast tissue and biological fluidsJulie Maubach
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
Obstet Gynecol 103:892-8. 2004..The concentrations were in the low nanomolar range, whereas in the corresponding serum samples, concentrations were a hundred-fold higher... - Metabolism of the food-associated carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human intestinal microbiotaLynn Vanhaecke
Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium
J Agric Food Chem 54:3454-61. 2006..This may predict individual susceptibility to carcinogenic risk from this suspected dietary carcinogen... - The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushesJames Bowe
Division of Reproduction and Endocrinology, King's College London, 2.36D New Hunt's House, Guy's Campus, London SE1 1UL, UK
J Endocrinol 191:399-405. 2006..These observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERalpha and ERbeta... - HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotesJaroslav Matousek
Biology Centre of the ASCR, v v i Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
J Agric Food Chem 55:7767-76. 2007..These effects on heterologous transgenotes suggest that the HlMyb3 gene may influence hop morphogenesis, as well as metabolome composition during lupulin gland maturation... - A safety study of oral tangeretin and xanthohumol administration to laboratory miceBarbara W Vanhoecke
Department of Gynaecological Oncology, De Pintelaan 185, University Hospital Ghent, B 9000 Ghent, Belgium
In Vivo 19:103-7. 2005..Both tangeretin, a citrus methoxyflavone, and xanthohumol, the main prenylated chalcone present in hops (Humulus lupulus L.), act on the mitogen-activated protein kinase pathway and await further investigation for administration in vivo... - Cloning and molecular analysis of the regulatory factor HlMyb1 in hop (Humulus lupulus L.) and the potential of hop to produce bioactive prenylated flavonoidsJaroslav Matousek
Institute of Plant Molecular Biology AS CR, , , Czech Republic
J Agric Food Chem 53:4793-8. 2005.... - Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringeninSam Possemiers
Laboratory of Microbial Ecology and Technology (LabMET, Faculty of Bioscience Engineering, Gent University-UGent, Coupure Links 653, Gent, Belgium
J Agric Food Chem 53:6281-8. 2005.... - The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestineSam Possemiers
Unit on Ecology and Physiology of the Digestive Tract (UEPSD, National Institute for Agricultural Research (INRA, F-78352 Jouy-en-Josas Cedex, France
J Nutr 136:1862-7. 2006..6417, P < 0.01). These data show that intestinal conversion of IX upon moderate beer consumption can lead to 8-PN exposure values that might fall within the range of human biological activity... - Efficient extraction of high-quality total RNA from various hop tissues (Humulus lupulus L.)Jelle De Keukeleire
Department of Plant Genetics and Breeding, Agricultural Research Centre, Melle, Belgium
Prep Biochem Biotechnol 36:355-62. 2006..Furthermore, the method could provide RNA for further molecular studies, including Northern blot hybridizations and reverse transcription-polymerase chain reactions... - Sequence analysis of a "true" chalcone synthase (chs_H1) oligofamily from hop (Humulus lupulus L.) and PAP1 activation of chs_H1 in heterologous systemsJaroslav Matousek
Biological Centre AS CR, Institute of Plant Molecular Biology, Branisovska 31, , Czech Republic
J Agric Food Chem 54:7606-15. 2006..It can be expected that the PAP1 factor could significantly influence the expression of the chs_H1 oligofamily in transgenic hop and modify the hop metabolome... - Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.)Jelle De Keukeleire
Institute for Agricultural and Fisheries Research, Unit Plant, Research Domain Genetics and Breeding, Caritasstraat 21, 9090 Melle, Belgium
J Agric Food Chem 55:61-6. 2007..WC proved to be a rich source of bioactive chalcones, particularly desmethylxanthohumol... - Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantitiesAxel Schwekendiek
Institute of Plant Breeding, Seed Science, and Population Genetics, Department of Plant Breeding and Biotechnology, University of Hohenheim, 70593 Stuttgart, Germany
J Agric Food Chem 55:7002-9. 2007.... - Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.)Jelle De Keukeleire
Department of Plant Genetics and Breeding, Agricultural Research Centre, Caritasstraat 21, B-9090 Melle, Belgium
J Agric Food Chem 51:4436-41. 2003..The study demonstrated that key compounds for flavor and potential beneficial health effects associated with beer not only reside in the glandular lupulin structures but also are distributed over various parts of the hop plant...