Arne Heyerick

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
    Arne Heyerick
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium
    Maturitas 54:164-75. 2006
  2. pmc Combinatorial analysis of lupulin gland transcription factors from R2R3Myb, bHLH and WDR families indicates a complex regulation of chs_H1 genes essential for prenylflavonoid biosynthesis in hop (Humulus Lupulus L.)
    Jaroslav Matousek
    Biology Centre ASCR vvi, Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    BMC Plant Biol 12:27. 2012
  3. ncbi request reprint Fate of flavins in sensitized photodegradation of isohumulones and reduced derivatives: studies on formation of radicals via EPR combined with detailed product analyses
    Arne Heyerick
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, B 9000, Ghent, Belgium
    Photochem Photobiol Sci 4:412-9. 2005
  4. doi request reprint Disposition of hop prenylflavonoids in human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
    Mol Nutr Food Res 54:S284-94. 2010
  5. doi request reprint Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents
    Selin Bolca
    Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Nutr 139:2293-300. 2009
  6. ncbi request reprint Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Nutr 137:2242-6. 2007
  7. doi request reprint Disposition of soy isoflavones in normal human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering and the Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Am J Clin Nutr 91:976-84. 2010
  8. ncbi request reprint Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women
    Selin Bolca
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Br J Nutr 98:950-9. 2007
  9. ncbi request reprint Photooxidative degradation of beer bittering principles: a key step on the route to lightstruck flavor formation in beer
    Kevin Huvaere
    Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, B 9000 Ghent, Belgium
    J Agric Food Chem 53:1489-94. 2005
  10. doi request reprint Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma
    Marjan Van Cleemput
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Gent, Belgium
    Mol Nutr Food Res 53:1143-55. 2009

Collaborators

Detail Information

Publications38

  1. ncbi request reprint A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
    Arne Heyerick
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium
    Maturitas 54:164-75. 2006
    ..To examine the efficacy of a hop extract enriched in 8-prenylnaringenin (8-PN, the phytoestrogen in hops, Humulus lupulus L.) on relief of menopausal discomforts...
  2. pmc Combinatorial analysis of lupulin gland transcription factors from R2R3Myb, bHLH and WDR families indicates a complex regulation of chs_H1 genes essential for prenylflavonoid biosynthesis in hop (Humulus Lupulus L.)
    Jaroslav Matousek
    Biology Centre ASCR vvi, Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    BMC Plant Biol 12:27. 2012
    ....
  3. ncbi request reprint Fate of flavins in sensitized photodegradation of isohumulones and reduced derivatives: studies on formation of radicals via EPR combined with detailed product analyses
    Arne Heyerick
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, B 9000, Ghent, Belgium
    Photochem Photobiol Sci 4:412-9. 2005
    ..However, no superimposed signals were observed on sensitized irradiation of dihydroisohumulones...
  4. doi request reprint Disposition of hop prenylflavonoids in human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
    Mol Nutr Food Res 54:S284-94. 2010
    ..6+/-118.8 fmol/g, p=0.009) and glandular (241.6+/-93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue...
  5. doi request reprint Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents
    Selin Bolca
    Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Nutr 139:2293-300. 2009
    ..These findings support the importance of personalized screening when assessing the efficacy of such products and mixtures...
  6. ncbi request reprint Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Nutr 137:2242-6. 2007
    ..850 (1.215-2.817), P = 0.004] intake were more likely to be strong equol producers. Finally, we validated the daidzein metabolism by fecal cultures as screening assay to identify equol producers without dietary intervention...
  7. doi request reprint Disposition of soy isoflavones in normal human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering and the Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Am J Clin Nutr 91:976-84. 2010
    ..Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered...
  8. ncbi request reprint Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women
    Selin Bolca
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Br J Nutr 98:950-9. 2007
    ..Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products...
  9. ncbi request reprint Photooxidative degradation of beer bittering principles: a key step on the route to lightstruck flavor formation in beer
    Kevin Huvaere
    Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, B 9000 Ghent, Belgium
    J Agric Food Chem 53:1489-94. 2005
    ..Interaction of reduced derivatives of isohumulones with triplet-excited riboflavin furnished radical precursors of volatile aldehydes, which may lead to the development of unpleasant stale or cardboard flavors...
  10. doi request reprint Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma
    Marjan Van Cleemput
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Gent, Belgium
    Mol Nutr Food Res 53:1143-55. 2009
    ..Finally, systemic administration of HBA efficiently inhibited acute local inflammation in vivo...
  11. doi request reprint The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Gent, Belgium
    Fitoterapia 82:53-66. 2011
    ..Moreover, knowledge about intestinal processes may offer innovative strategies for targeted product development...
  12. doi request reprint Production of monoclonal antibodies against hop-derived (Humulus lupulus L.) prenylflavonoids and the development of immunoassays
    Ciska Wyns
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000, Ghent, Belgium
    Talanta 85:197-205. 2011
    ..13% and 1.57%, respectively for IX and 6.13% and 2.43%, respectively for 8-PN. Furthermore, the method demonstrated excellent accuracy and significant correlation with measurements by an established and validated HPLC-MS method...
  13. doi request reprint Bioavailability of hop-derived iso-α-acids and reduced derivatives
    Ko Cattoor
    UGent Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B 9000 Ghent, Belgium
    Food Funct 2:412-22. 2011
    ..Bioavailability of DHIAA is mostly influenced by phase-II metabolism as shown by enzymatic hydrolysis of plasma samples upon administration of DHIAA...
  14. ncbi request reprint Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Gent, Belgium
    J Nutr 138:1310-6. 2008
    ..In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats...
  15. doi request reprint Metabolism of hop-derived bitter acids
    Ko Cattoor
    Laboratory of Pharmacognosy and Phytochemistry, Laboratory of Medical Biochemistry and Clinical Analysis, Laboratory of Pharmaceutical Technology, and Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University Ugent, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Agric Food Chem 61:7916-24. 2013
    ....
  16. doi request reprint Transport of hop bitter acids across intestinal Caco-2 cell monolayers
    Ko Cattoor
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, UGent Ghent University, Ghent, Belgium
    J Agric Food Chem 58:4132-40. 2010
    ..It appears that alpha-acids are efficiently absorbed, whereas the permeability of beta-acids is low. Limiting factors in the absorption of beta-acids could involve P-gp and MRP-2 type efflux transporters and phase II metabolism...
  17. ncbi request reprint Radicaloid-type oxidative decomposition of beer bittering agents revealed
    Kevin Huvaere
    Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, Ghent University, 9000 Ghent, Belgium
    Chemistry 9:4693-9. 2003
    ..Thus, flavor-active beer constituents may degrade oxidatively in the absence of oxygen, thereby leading to reaction products that escape UV detection...
  18. doi request reprint Prenylated chalcone xanthohumol associates with histones in breast cancer cells--a novel target identified by a monoclonal antibody
    Ciska Wyns
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Mol Nutr Food Res 56:1688-96. 2012
    ..The intracellular fate of xanthohumol (XN) from hops is an underexplored field in the research for the molecular mechanisms causing its wide range of effects in chemoprevention and gene expression involved in hepatic metabolism...
  19. doi request reprint Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo species
    Laura Van Hoyweghen
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, B 9000 Ghent, Belgium
    Phytochem Anal 23:433-43. 2012
    ....
  20. doi request reprint Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds
    Marjan Van Cleemput
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Gent, Belgium
    J Nat Prod 72:1220-30. 2009
    ..This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds...
  21. doi request reprint Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serum
    Ciska Wyns
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, B 9000 Gent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 878:949-56. 2010
    ....
  22. doi request reprint Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity
    Visnja Popović
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Phytochemistry 87:102-11. 2013
    ....
  23. doi request reprint Absorption, translocation and metabolism of metamitron in Chenopodium album
    Jonas Aper
    Weed Science Unit, Faculty of Bioscience Engineering, Department of Plant Production, Ghent University, Gent, Belgium
    Pest Manag Sci 68:209-16. 2012
    ..The objectives of this study were to clarify the absorption, translocation and metabolic fate of metamitron in C. album...
  24. doi request reprint Antioxidant flavone glycosides from the leaves of Fargesia robusta
    Laura Van Hoyweghen
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, B 9000 Ghent, Belgium
    J Nat Prod 73:1573-7. 2010
    ..Compounds 1, 4, and 5 exhibited potent antioxidant activity in the TEAC assay, while compounds 1, 3, and 5 showed the highest antioxidant capacity in the ORAC assay...
  25. ncbi request reprint Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 282:4253-64. 2007
    ....
  26. ncbi request reprint Distribution of soy-derived phytoestrogens in human breast tissue and biological fluids
    Julie Maubach
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    Obstet Gynecol 103:892-8. 2004
    ..We aimed to investigate the concentrations of genistein, daidzein, and equol in human breast tissue homogenate and to compare these with the corresponding values in serum and urine...
  27. ncbi request reprint Metabolism of the food-associated carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human intestinal microbiota
    Lynn Vanhaecke
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 54:3454-61. 2006
    ..This may predict individual susceptibility to carcinogenic risk from this suspected dietary carcinogen...
  28. pmc The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes
    James Bowe
    Division of Reproduction and Endocrinology, King s College London, 2 36D New Hunt s House, Guy s Campus, London SE1 1UL, UK
    J Endocrinol 191:399-405. 2006
    ..These observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERalpha and ERbeta...
  29. ncbi request reprint A safety study of oral tangeretin and xanthohumol administration to laboratory mice
    Barbara W Vanhoecke
    Department of Gynaecological Oncology, De Pintelaan 185, University Hospital Ghent, B 9000 Ghent, Belgium
    In Vivo 19:103-7. 2005
    ..Both tangeretin, a citrus methoxyflavone, and xanthohumol, the main prenylated chalcone present in hops (Humulus lupulus L.), act on the mitogen-activated protein kinase pathway and await further investigation for administration in vivo...
  30. ncbi request reprint Cloning and molecular analysis of the regulatory factor HlMyb1 in hop (Humulus lupulus L.) and the potential of hop to produce bioactive prenylated flavonoids
    Jaroslav Matousek
    Institute of Plant Molecular Biology AS CR, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Agric Food Chem 53:4793-8. 2005
    ....
  31. ncbi request reprint Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Gent University UGent, Coupure Links 653, Gent, Belgium
    J Agric Food Chem 53:6281-8. 2005
    ....
  32. ncbi request reprint Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.)
    Jelle De Keukeleire
    Institute for Agricultural and Fisheries Research, Unit Plant, Research Domain Genetics and Breeding, Caritasstraat 21, 9090 Melle, Belgium
    J Agric Food Chem 55:61-6. 2007
    ..WC proved to be a rich source of bioactive chalcones, particularly desmethylxanthohumol...
  33. ncbi request reprint The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    Sam Possemiers
    Unit on Ecology and Physiology of the Digestive Tract UEPSD, National Institute for Agricultural Research INRA, F 78352 Jouy en Josas Cedex, France
    J Nutr 136:1862-7. 2006
    ..6417, P < 0.01). These data show that intestinal conversion of IX upon moderate beer consumption can lead to 8-PN exposure values that might fall within the range of human biological activity...
  34. ncbi request reprint Efficient extraction of high-quality total RNA from various hop tissues (Humulus lupulus L.)
    Jelle De Keukeleire
    Department of Plant Genetics and Breeding, Agricultural Research Centre, Melle, Belgium
    Prep Biochem Biotechnol 36:355-62. 2006
    ..Furthermore, the method could provide RNA for further molecular studies, including Northern blot hybridizations and reverse transcription-polymerase chain reactions...
  35. ncbi request reprint Sequence analysis of a "true" chalcone synthase (chs_H1) oligofamily from hop (Humulus lupulus L.) and PAP1 activation of chs_H1 in heterologous systems
    Jaroslav Matousek
    Biological Centre AS CR, Institute of Plant Molecular Biology, Branisovska 31, 37005 Ceske Budejovice, Czech Republic
    J Agric Food Chem 54:7606-15. 2006
    ..It can be expected that the PAP1 factor could significantly influence the expression of the chs_H1 oligofamily in transgenic hop and modify the hop metabolome...
  36. ncbi request reprint HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotes
    Jaroslav Matousek
    Biology Centre of the ASCR, v v i Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Agric Food Chem 55:7767-76. 2007
    ..These effects on heterologous transgenotes suggest that the HlMyb3 gene may influence hop morphogenesis, as well as metabolome composition during lupulin gland maturation...
  37. ncbi request reprint Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities
    Axel Schwekendiek
    Institute of Plant Breeding, Seed Science, and Population Genetics, Department of Plant Breeding and Biotechnology, University of Hohenheim, 70593 Stuttgart, Germany
    J Agric Food Chem 55:7002-9. 2007
    ....
  38. ncbi request reprint Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.)
    Jelle De Keukeleire
    Department of Plant Genetics and Breeding, Agricultural Research Centre, Caritasstraat 21, B 9090 Melle, Belgium
    J Agric Food Chem 51:4436-41. 2003
    ..The study demonstrated that key compounds for flavor and potential beneficial health effects associated with beer not only reside in the glandular lupulin structures but also are distributed over various parts of the hop plant...