Femke Heindryckx

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. pmc Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Mol Cancer 9:219. 2010
  2. pmc Experimental mouse models for hepatocellular carcinoma research
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Exp Pathol 90:367-86. 2009
  3. ncbi Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Hepatology 57:1793-805. 2013
  4. doi The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 58:319-28. 2013
  5. doi Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 57:61-8. 2012
  6. doi Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor
    Bram Blomme
    Department of Hepatology and Gastroenterology, Ghent University Hospital, 9000 Ghent, Belgium
    Mol Cell Biochem 372:199-210. 2013
  7. doi Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Eur J Gastroenterol Hepatol 24:1020-32. 2012
  8. doi Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Cytokine 59:442-9. 2012
  9. doi Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
  10. doi Angiogenesis in chronic liver disease and its complications
    Stephanie Coulon
    Department of Hepatology and Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Liver Int 31:146-62. 2011

Collaborators

Detail Information

Publications12

  1. pmc Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Mol Cancer 9:219. 2010
    ..The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC...
  2. pmc Experimental mouse models for hepatocellular carcinoma research
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Exp Pathol 90:367-86. 2009
    ..Transgenic mice expressing viral genes, oncogenes and/or growth factors allow the identification of pathways involved in hepatocarcinogenesis...
  3. ncbi Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Hepatology 57:1793-805. 2013
    ..Treatment with αVEGFR2 showed an improvement of the liver vasculature. Moreover, fat-laden primary hepatocytes treated with αVEGFR2 stored significantly less lipids...
  4. doi The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 58:319-28. 2013
    ..Unlike VEGF, genetic studies have shown that PlGF is specifically involved in pathologic angiogenesis, thus its inhibition would not affect healthy blood vessels, providing an attractive drug candidate with a good safety profile...
  5. doi Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 57:61-8. 2012
    ..The effect of prolyl hydroxylase domain 2 on the pathogenesis of liver cancer has never been studied...
  6. doi Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor
    Bram Blomme
    Department of Hepatology and Gastroenterology, Ghent University Hospital, 9000 Ghent, Belgium
    Mol Cell Biochem 372:199-210. 2013
    ..On the protein level, 5D11D4-treatment had a prominent effect on the MAP kinase pathway with a significant p38 activation, yet independent of Ets-1 function...
  7. doi Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Eur J Gastroenterol Hepatol 24:1020-32. 2012
    ..PlGF is a homologue of the vascular endothelial growth factor, which is only involved in pathological angiogenesis, therefore, its inhibition does not induce adverse effects...
  8. doi Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Cytokine 59:442-9. 2012
    ..These data indicate the involvement of inflammatory (TNFα and IL6), angiogenic (VEGF) cytokines and sVEGFR1 in the pathophysiology of NAFLD...
  9. doi Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
    ....
  10. doi Angiogenesis in chronic liver disease and its complications
    Stephanie Coulon
    Department of Hepatology and Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Liver Int 31:146-62. 2011
    ..The fact that angiogenesis plays a pivotal role in CLDs gives rise to new opportunities for treating CLDs and its complications...
  11. pmc The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review)
    Eliene Bogaerts
    Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 9000 Gent, Belgium
    Int J Oncol 44:1015-22. 2014
    ..In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis. ..
  12. ncbi The paradox of the unfolded protein response in cancer
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 33:4683-94. 2013
    ..In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer. ..