Femke Heindryckx

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. pmc Experimental mouse models for hepatocellular carcinoma research
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Exp Pathol 90:367-86. 2009
  2. doi request reprint Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Hepatology 57:1793-805. 2013
  3. doi request reprint The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 58:319-28. 2013
  4. doi request reprint Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 57:61-8. 2012
  5. doi request reprint Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor
    Bram Blomme
    Department of Hepatology and Gastroenterology, Ghent University Hospital, 9000 Ghent, Belgium
    Mol Cell Biochem 372:199-210. 2013
  6. doi request reprint Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Eur J Gastroenterol Hepatol 24:1020-32. 2012
  7. ncbi request reprint The paradox of the unfolded protein response in cancer
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 33:4683-94. 2013
  8. doi request reprint Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
  9. pmc Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Mol Cancer 9:219. 2010
  10. doi request reprint Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Cytokine 59:442-9. 2012

Collaborators

Detail Information

Publications10

  1. pmc Experimental mouse models for hepatocellular carcinoma research
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Exp Pathol 90:367-86. 2009
    ..Transgenic mice expressing viral genes, oncogenes and/or growth factors allow the identification of pathways involved in hepatocarcinogenesis...
  2. doi request reprint Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Hepatology 57:1793-805. 2013
    ..Our findings warrant further investigation of the role of angiogenesis in the pathophysiology in NASH...
  3. doi request reprint The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 58:319-28. 2013
    ..Unlike VEGF, genetic studies have shown that PlGF is specifically involved in pathologic angiogenesis, thus its inhibition would not affect healthy blood vessels, providing an attractive drug candidate with a good safety profile...
  4. doi request reprint Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Hepatol 57:61-8. 2012
    ..The effect of prolyl hydroxylase domain 2 on the pathogenesis of liver cancer has never been studied...
  5. doi request reprint Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor
    Bram Blomme
    Department of Hepatology and Gastroenterology, Ghent University Hospital, 9000 Ghent, Belgium
    Mol Cell Biochem 372:199-210. 2013
    ..On the protein level, 5D11D4-treatment had a prominent effect on the MAP kinase pathway with a significant p38 activation, yet independent of Ets-1 function...
  6. doi request reprint Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Eur J Gastroenterol Hepatol 24:1020-32. 2012
    ..PlGF is a homologue of the vascular endothelial growth factor, which is only involved in pathological angiogenesis, therefore, its inhibition does not induce adverse effects...
  7. ncbi request reprint The paradox of the unfolded protein response in cancer
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 33:4683-94. 2013
    ..In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer. ..
  8. doi request reprint Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
    ....
  9. pmc Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Mol Cancer 9:219. 2010
    ..The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC...
  10. doi request reprint Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease
    Stephanie Coulon
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Cytokine 59:442-9. 2012
    ..These data indicate the involvement of inflammatory (TNF╬▒ and IL6), angiogenic (VEGF) cytokines and sVEGFR1 in the pathophysiology of NAFLD...