Guy Haegeman

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
  2. pmc A fully dissociated compound of plant origin for inflammatory gene repression
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Proc Natl Acad Sci U S A 102:15827-32. 2005
  3. pmc Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Gent University, Gent, Belgium
    EMBO J 27:1682-93. 2008
  4. doi RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation
    Anne Matthys
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University Ugent, K L Ledeganckstraat 35, Gent 9000, Belgium
    Cell Signal 24:1053-63. 2012
  5. ncbi Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Gent, Belgium
    Cancer Res 66:4852-62. 2006
  6. ncbi Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 282:4253-64. 2007
  7. doi Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation
    Anneleen Spooren
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Cell Signal 22:600-9. 2010
  8. doi Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain
    Evelien Gellynck
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Gene 426:23-31. 2008
  9. doi The versatile role of MSKs in transcriptional regulation
    Linda Vermeulen
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Trends Biochem Sci 34:311-8. 2009
  10. ncbi Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Ethnopharmacol 113:510-6. 2007

Collaborators

Detail Information

Publications50

  1. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression...
  2. pmc A fully dissociated compound of plant origin for inflammatory gene repression
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Proc Natl Acad Sci U S A 102:15827-32. 2005
    ..Taken together, this compound may be a lead compound of a class of antiinflammatory agents with fully dissociated properties and might thus hold great potential for therapeutic use...
  3. pmc Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Gent University, Gent, Belgium
    EMBO J 27:1682-93. 2008
    ..These findings unveil a novel aspect within the GR-mediated NF-kappaB-targeting anti-inflammatory mechanism...
  4. doi RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation
    Anne Matthys
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University Ugent, K L Ledeganckstraat 35, Gent 9000, Belgium
    Cell Signal 24:1053-63. 2012
    ..Instead, we demonstrate that RhoBTB3 strongly inhibits proteasomal degradation of the 5-HT7a receptor...
  5. ncbi Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Gent, Belgium
    Cancer Res 66:4852-62. 2006
    ..As constitutive NF-kappaB and MSK activity are hallmarks of aggressive metastatic ER-deficient breast cancer, the MSK signaling pathway may become an attractive target for chemotherapy...
  6. ncbi Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 282:4253-64. 2007
    ....
  7. doi Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation
    Anneleen Spooren
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Cell Signal 22:600-9. 2010
    ..Data from neuronal cell lines, which have been reported to show low endogenous D4 receptor expression, such as the hippocampal cell line HT22 and primary rat hippocampal cells, further support these observations...
  8. doi Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain
    Evelien Gellynck
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Gene 426:23-31. 2008
    ..This is in analogy with previous reports comparing either the rat or the human variants...
  9. doi The versatile role of MSKs in transcriptional regulation
    Linda Vermeulen
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Trends Biochem Sci 34:311-8. 2009
    ..Here, we review the current knowledge on MSK activation and its molecular targets, focusing on recent insights into the role of MSKs at multiple levels of transcriptional regulation...
  10. ncbi Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Ethnopharmacol 113:510-6. 2007
    ..Umbiliferrae) also revealed immunomodulatory NFkappaB activities. These species are good candidates for further activity-monitored fractionation to identify active constituents...
  11. pmc Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Endocr Rev 30:830-82. 2009
    ....
  12. doi Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner
    Ilse M Beck
    Laboratory of Experimental Cancer Research, Department of Radiation Therapy and Experimental Cancer Research, Ghent University, UZ 1P7, De Pintelaan 185, B 9000 Gent, Belgium
    Eur J Pharmacol 715:1-9. 2013
    ....
  13. doi KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation
    Pieter Rondou
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Physiology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Cell Signal 22:900-13. 2010
    ..Interestingly, KLHL12 does also interact with beta-arrestin2 but this has no effect on the ubiquitination or localization of beta-arrestin2 nor on the internalization of the D4 receptor...
  14. ncbi Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Biochem Pharmacol 72:1114-31. 2006
    ..We will therefore discuss in this review the multilayered interplay of NF-kappaB signaling and epigenome dynamics, in achieving appropriate gene expression responses and transcriptional activity...
  15. pmc Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells
    Matladi N Ndlovu
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Physiology, University of Ghent, K L Ledeganckstraat 35, Ghent, Belgium
    Mol Cell Biol 29:5488-504. 2009
    ....
  16. doi Interleukin-6, a mental cytokine
    Anneleen Spooren
    Laboratory of Eukaryotic Signal Transduction and Gene Expression, University of Ghent, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Brain Res Rev 67:157-83. 2011
    ..In this perspective, it is not surprising that 'well-meant' actions of IL-6 are often causing harm instead of leading to recovery...
  17. ncbi Structure of the human 5-HT7 receptor gene and characterization of its promoter region
    Koen Laenen
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, UGent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Gene 391:252-63. 2007
    ..Taken together these results support the essential role of Sp factors in regulating 5-HT(7) promoter activity...
  18. ncbi Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk
    Valerie Gossye
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Front Biosci 13:4122-43. 2008
    ..Strategies that are explored at the moment and that may hold great potential for the future are extensively reviewed...
  19. doi Targeting inflammation using selective glucocorticoid receptor modulators
    Karolien De Bosscher
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Curr Opin Pharmacol 10:497-504. 2010
    ..In this review we provide an overview of recent progress in understanding the mode of action of glucocorticoids and novel strategies to dissociate anti-inflammatory from metabolic side effects...
  20. pmc Hunting for serine 276-phosphorylated p65
    Anneleen Spooren
    Laboratory of Eukaryotic Gene Expression LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    J Biomed Biotechnol 2010:275892. 2010
    ..As PKA is one of the main kinases responsible for phosphorylation of p65 at Ser276, this observation warrants cautious interpretation of data generated using the tested antibodies...
  21. ncbi Role of glucocorticoids in dopamine-related neuropsychiatric disorders
    Kathleen Van Craenenbroeck
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Mol Cell Endocrinol 245:10-22. 2005
    ..In this review, molecular and mechanistic aspects of glucocorticoid effects on brain function and behavior will be discussed with specific reference to dopamine signaling...
  22. ncbi Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Biochem Pharmacol 64:963-70. 2002
    ..Additionally, we describe how other posttranslational modifications, such as acetylation and methylation of transcription factors or of the chromatin environment, may also affect NF-kappaB transcriptional activity...
  23. ncbi Regulation of NF-kappaB transcriptional activity
    Linda Vermeulen
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Cancer Treat Res 130:89-102. 2006
    ..Here, we review current knowledge of NF-kappaB signal transduction, focusing on the regulation of its transcriptional activity by post-translational modification of the NF-kappaB subunits...
  24. ncbi A paradigm for gene regulation: inflammation, NF-kappaB and PPAR
    Wim Vanden Berghe
    University of Gent, Department of Molecular Biology, KL Ledeganckstraat 35, 9000 Gent, Belgium
    Adv Exp Med Biol 544:181-96. 2003
    ....
  25. pmc BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase
    Pieter Rondou
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 283:11083-96. 2008
    ....
  26. doi Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders
    Katarzyna Szarc vel Szic
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Biochem Pharmacol 80:1816-32. 2010
    ..This may allow to improve healthy aging by reversing disease prone epimutations involved in chronic inflammatory and metabolic disorders...
  27. doi IL-1β potently stabilizes IL-6 mRNA in human astrocytes
    Anneleen Spooren
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, University of Ghent, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Biochem Pharmacol 81:1004-15. 2011
    ..Our data using pharmacological inhibitors suggest PKC is an important modulator of IL-6 expression in the central nervous system and this might have therapeutic implications...
  28. ncbi Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?
    Wim Vanden Berghe
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Curr Drug Metab 11:436-50. 2010
    ....
  29. doi Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Eur J Pharmacol 583:290-302. 2008
    ..The aim of this review is to discuss the mechanistic basis and applicability of different glucocorticoid receptor modulators in various affections, ranging from immune disorders to mental dysfunctions...
  30. ncbi The dopamine D4 receptor: biochemical and signalling properties
    Pieter Rondou
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University Ugent, K L Ledeganckstraat 35, 9000, Ghent, Belgium
    Cell Mol Life Sci 67:1971-86. 2010
    ..We provide an overview of the structure, signalling properties and regulation of dopamine D4 receptors, and briefly discuss their physiological and pathophysiological role in the brain...
  31. ncbi Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor
    Kathleen Van Craenenbroeck
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Life Sci 80:74-81. 2006
    ..The fact that ligands can also act as pharmacological chaperones is a fairly new additional element in the regulation of receptor expression levels with potential great impact in drug treatment...
  32. ncbi The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
    Karolien De Bosscher
    Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Endocr Rev 24:488-522. 2003
    ..The various molecular pathways proposed so far are discussed in more detail...
  33. ncbi Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k
    Kim De Martelaere
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Cell Signal 19:278-88. 2007
    ..These observations suggest that PLAC-24 may play a role in the transport and the stabilisation of newly synthesised 5-HT(7) receptor towards the plasma membrane...
  34. ncbi Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy
    Nathalie Dijsselbloem
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, KL Ledeganckstraat 35, B 9000, Belgium
    Biochem Pharmacol 68:1171-85. 2004
    ....
  35. doi Glucocorticoid receptor mutants: man-made tools for functional research
    Ilse M Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Trends Endocrinol Metab 22:295-310. 2011
    ..In this review we analyze the characteristics of GR mutants with the aim of assisting the design and interpretation of GR mutant-based experiments...
  36. doi Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Brain Behav Immun 24:1035-42. 2010
    ..The current work reviews recent advances on the characterization of a generation of novel non-steroidal GR ligands...
  37. ncbi Orientation-dependent gene expression with Epstein-Barr virus-derived vectors
    Kathleen Van Craenenbroeck
    Department for Molecular Biology, Ghent University VIB, K L Ledeganckstraat 35, 9000, Gent, Belgium
    FEBS Lett 555:489-94. 2003
    ..Northern analysis revealed a transcriptional read-through from the thymidine kinase promoter on the episomal vector, which interfered with the transcription of the heterologous gene in the less favored orientation...
  38. ncbi Involvement of GSK-3beta in TWEAK-mediated NF-kappaB activation
    Adelheid De Ketelaere
    Enabling Technologies, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B 2340 Beerse, Belgium
    FEBS Lett 566:60-4. 2004
    ..We demonstrate that the induction of IL-8 expression by TWEAK can be counteracted by LiCl. Taken together, these data suggest that GSK-3beta plays an important role in the signal transduction pathway between TWEAK and NF-kappaB...
  39. ncbi Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}
    Vladimir T Todorov
    Institute of Physiology, Institute of Pathology, and Department of Immunology, Regensburg University, D 93040 Regensburg, Germany
    J Biol Chem 280:24356-62. 2005
    ..Our results suggest that TNFalpha inhibits renin gene expression by decreasing the transactivating capacity of NFkappaB-p65 and partially by attenuating CREB1 binding to CRE...
  40. ncbi Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha
    Julie Horion
    Laboratory of Virology and Immunology, GIGA R, University of Liege, 4000 Liege, Belgium
    J Biol Chem 282:15383-93. 2007
    ..This indicates that one overall histone deacetylase role is to inhibit NF-kappaB activation by molecular mechanisms specific of the stimulus and the promoter...
  41. ncbi Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding
    Mathias Laga
    VIB Department of Medical Protein Research, Molecular and Metabolic Signaling Unit, VIB, 9000 Ghent, Belgium
    Biochem Pharmacol 74:579-89. 2007
    ....
  42. ncbi Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4
    Ezra Aksoy
    Institute for Medical Immunology, Universite Libre de Bruxelles, Charleroi, Belgium
    Eur J Immunol 35:2200-9. 2005
    ..We conclude that inhibition of PI3K activity enhances TRIF-dependent NF-kappaB activity, and thereby increases IFN-beta synthesis elicited by TLR3 or TLR4 ligands...
  43. ncbi DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha
    Philippe Delerive
    Institut National de la Santé et de la Recherche Médicale U 545, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 16:1029-39. 2002
    ....
  44. ncbi NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase
    Simone de Haij
    Department of Nephrology, Leiden University Medical Center, Building 1, C3P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Am Soc Nephrol 16:1603-11. 2005
    ..The data rather suggest that the JNK pathway may interfere with other signaling pathways, involving NF-kappaB and possibly ERK...
  45. ncbi Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets
    Sabrina Devos
    Pharmacology Department FARC, Medical School, Vrije Universiteit Brussel, 103 Laarbeeklaan, B 1090 Brussel, Belgium
    Biochem Pharmacol 65:303-8. 2003
    ..Finally, no binding of atrazine to the AR was observed. In conclusion, the effects of atrazine-type herbicides most probably do not result from interaction with the above-mentioned nuclear receptors...
  46. ncbi A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein
    Nathalie Dijsselbloem
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Molecular Biology, Ghent University, Ghent, Belgium
    J Immunol 178:5048-57. 2007
    ..Moreover, analysis of IL-6 mRNA levels in bone marrow-derived p53 null vs wild-type dendritic cells confirms a role for p53 in the reduction of NF-kappaB-dependent gene expression, mediated by genistein...
  47. ncbi Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens
    An De Naeyer
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Nat Prod 67:1829-32. 2004
    ..6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay...
  48. pmc Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production
    Greet Brouckaert
    Molecular Signalling and Cell Death Unit, Department of Molecular Biomedical Research, VIB, Ghent University, Ghent Belgium
    Mol Biol Cell 15:1089-100. 2004
    ..Uptake of neither apoptotic nor necrotic L929 cells by macrophages modulated the expression of proinflammatory cytokines by the phagocytes...
  49. pmc Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression
    Cristina Aguilera
    Centre Oncologia Molecular, Institut d Investigació Biomèdica de Bellvitge Institut de Recerca Oncologica, Barcelona 08907, Spain
    Proc Natl Acad Sci U S A 101:16537-42. 2004
    ..These findings provide additional insight in the cross-talk between NF-kappaB and other signaling pathways...
  50. ncbi Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells
    Dominique Koubovec
    Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Mol Cell Endocrinol 221:75-85. 2004
    ..The MPA-induced nuclear translocation of the glucocorticoid receptor (GR), as well as the antagonistic effects of RU486, strongly suggest that the actions of MPA in these cells are mediated at least in part via the GR...