Research Topics
| Ingeborg GoethalsSummaryAffiliation: Ghent University Country: Belgium Publications
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Detail Information
Publications
The prefrontal cortex: insights from functional neuroimaging using cognitive activation tasksIngeborg Goethals
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, Ghent, Belgium
Eur J Nucl Med Mol Imaging 31:408-16. 2004....- Application of a neuropsychological activation probe with SPECT: the 'Tower of London' task in healthy volunteersIngeborg Goethals
Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
Nucl Med Commun 25:177-82. 2004..Hence, this study reports on the TOL task under classical neuropsychological test conditions using single photon emission computed tomography (SPECT) activation in 10 healthy subjects... - Cognitive neuroactivation using SPECT and the Stroop Colored Word Test in patients with diffuse brain injuryIngeborg Goethals
Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
J Neurotrauma 21:1059-69. 2004..This finding was associated with activation effects in posterior (mainly parietal) brain areas in addition with activation of previously observed anterior (mainly anterior cingulate) brain regions... - Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteersIngeborg Goethals
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Am J Psychiatry 161:1916-8. 2004.... - Blunted prefrontal perfusion in depressed patients performing the Tower of London taskIngeborg Goethals
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Psychiatry Res 139:31-40. 2005..This study shows that a SPECT activation procedure using the TOL task under classical test conditions is feasible in depressed patients... - Focally enhanced f-18 fluorodeoxyglucose (FDG) uptake in incidentally detected pulmonary embolism on PET/CT scanningI Goethals
Division of Nuclear Medicine, Ghent University Hospital, Gent, Belgium
Clin Nucl Med 31:497-8. 2006 - Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?Ingeborg Goethals
Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
J Psychiatr Res 41:1005-11. 2007..Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients... - Validation of a resolution-independent method for the quantification of 123I-FP-CIT SPECT scansIngeborg Goethals
Department of Nuclear Medicine, Ghent University Hospital, Belgium
Nucl Med Commun 28:771-4. 2007..To verify the applicability of a recently described resolution-independent method for the semi-quantification of 123I-FP-CIT scans... - Mismatch of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and Tc-99m pertechnetate single photon emission computed tomography (SPECT) in a euthyroid multinodular goiterIngeborg Goethals
Department of Nuclear Medicine, Ghent University Hospital, Gent
Clin Nucl Med 32:6-8. 2007..These findings, in a single patient, illustrate the wide spectrum of matched and mismatched F-18 FDG and Tc-99m pertechnetate thyroid uptake along with their variable pathologic correlates... - Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette's syndromeIngeborg Goethals
Department of Nuclear Medicine, Ghent University Hospital
J Trauma Dissociation 9:543-9. 2008..We conclude that our findings support the temporal lobe as well as the frontolimbic disconnection hypotheses of dissociation... 
The potential value of a pictorial atlas for aid in the visual diagnosis of 123I FP-CIT SPECT scansI Goethals
Department of Nuclear Medicine, Ghent University Hospital, Gent, Belgium
Nuklearmedizin 48:173-8. 2009..Hence, having a pictorial atlas available may facilitate the visual assessment of 123I FP-CIT SPECT scans...- Normal uptake of F-18 FDG in the testis as assessed by PET/CT in a pediatric study populationIngeborg Goethals
Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, Ghent, Belgium
Ann Nucl Med 23:817-20. 2009..To investigate the correlation between the F-18 FDG uptake in the normal testis as assessed by PET-CT and patient age in a pediatric study population... - Time-dependent changes in 18F-FDG activity in the thymus and bone marrow following combination chemotherapy in paediatric patients with lymphomaIngeborg Goethals
Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
Eur J Nucl Med Mol Imaging 37:462-7. 2010..To investigate the time-dependent changes in (18)F-FDG uptake by the thymus and marrow following combination chemotherapy for lymphoma in a paediatric study population... - The effect of acquisition time on visual and semi-quantitative analysis of F-18 FDG-PET studies in patients with head and neck cancerIngeborg Goethals
Department of Nuclear Medicine, Ghent University Hospital, B 9000 Ghent, Belgium
Nucl Med Commun 31:227-31. 2010..To evaluate the impact of acquisition time on F-18 fluorodeoxyglucose positron emission tomography (PET) image quality, lesion detection rate, standard uptake and lesion volume measures... - Differences of cortical 5-HT2A receptor binding index with SPECT in subtypes of anorexia nervosa: relationship with personality traits?Ingeborg Goethals
Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan, 185, B 9000 Ghent, Belgium
J Psychiatr Res 41:455-8. 2007..We also searched for associations between temperament dimensions and cortical 5-HT2) binding... - F-18 FDG-PET in children: do we have enough counts?Andre Dobbeleir
Department of Nuclear Medicine, University Hospital Ghent, 9000 Ghent, Belgium
Nucl Med Commun 31:190-4. 2010..The aim of the study was to find out whether in [F]fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG-PET) performed in children in our department, the number of counts were sufficiently high to guarantee optimal image quality... - The optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine: a dynamic positron emission tomography studyKoen Mertens
Department of aNuclear Medicine, Ghent University, Ghent, Belgium
Nucl Med Commun 33:954-9. 2012..To determine the optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine (18F-FCho) PET... - Distribution patterns of 18F-labelled fluoromethylcholine in normal structures and tumors of the head: a PET/MRI evaluationKoen Mertens
Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
Clin Nucl Med 37:e196-203. 2012..To evaluate the distribution of 18F-labelled fluoromethylcholine (FCho) in normal structures and tumors of the head region using positron emission tomography (PET) and magnetic resonance imaging... - Toward clinical application of neuropsychological activation probes with SPECT: a spatial working memory taskIngeborg Goethals
Division of Nuclear Medicine, Ghent University Hospital, Belgium
J Nucl Med 43:1426-31. 2002.... - Decreased 5-HT2a receptor binding in patients with anorexia nervosaKurt Audenaert
Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
J Nucl Med 44:163-9. 2003..It was our aim to investigate the central 5-HT(2a) receptor binding index using SPECT brain imaging... - Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imagingKoen Mertens
Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, Gent 9000, Belgium
J Clin Neurosci 19:1167-9. 2012..Thus, dual-time-point PET with F-18 FDG may not be able to differentiate between infectious and malignant brain lesions... - Standardized added metabolic activity (SAM): a partial volume independent marker of total lesion glycolysis in liver metastasesJeroen Mertens
Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Eur J Nucl Med Mol Imaging 39:1441-8. 2012..Subtracting the background activity in VOI(2)-VOI(1) from VOI(1) yields SAM. If VOI(1) is set at a reasonable distance from the tumour, PVE are avoided. Phantom and initial clinical validation data are presented... - In vitro 2-deoxy-2-[18F]fluoro-D-glucose uptake: practical considerationsKoen Mertens
Department of Nuclear Medicine, University Hospital Ghent, Belgium
Cancer Biother Radiopharm 27:183-8. 2012.... - F-18 fluorodeoxyglucose PET/CT scanning in the diagnostic work-up of a primary pericardial mesothelioma: a case reportPiet Ost
Department of Radiotherapy, Ghent University Hospital, Gent, Belgium
J Thorac Imaging 23:35-8. 2008..This is the first case describing the use of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography in the diagnostic work-up of a primary pericardial mesothelioma... - Brain perfusion SPECT in impulsivity-related personality disordersIngeborg Goethals
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
Behav Brain Res 157:187-92. 2005..CONCLUSIONS: Patients with BPD and ASPD who showed impulsive behaviour have diminished rCBF in areas of the right prefrontal and temporal cortex... - Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?Ingeborg Goethals
Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Eur J Nucl Med Mol Imaging 30:325-8. 2003..This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes... - Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistryChristophe Van de Wiele
Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
J Nucl Med 49:260-4. 2008..This study reports on the uptake of (99m)Tc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC)... - False-negative Tc-99m MIBI scintigraphy in histopathologically proved recurrent high-grade oligodendrogliomaIngeborg Goethals
Division of Nuclear Medicine, Ghent University Hospital, Belgium
Clin Nucl Med 28:299-301. 2003..However, the authors' results suggest that still other mechanisms may be involved in Tc-99m MIBI accumulation, which may account for false-negative imaging in brain tumors... - Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapySylvie Rottey
Division of Medical Oncology, Department of Internal Medicine, University Hospital Ghent, Ghent, Belgium
J Nucl Med 47:1813-8. 2006..CONCLUSION: Sequential (99m)Tc-HYNIC-annexin V imaging may allow for assessment of the response to chemotherapy within 3 d after treatment initiation... - Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS studyHarmen Reyngoudt
Department of Radiology and Nuclear Medicine, Ghent University, and Department of Psychiatry, Ghent University Hospital, Ghent, Belgium
Eur J Radiol 81:e223-31. 2012..To study age-related metabolic changes in N-acetylaspartate (NAA), total creatine (tCr), choline (Cho) and myo-inositol (Ins)... - Tumor perfusion using first-pass F-18 FDG PET imagesJeroen Mertens
Department of Nuclear Medicine, Ghent University Hospital, Gent, Belgium
Clin Nucl Med 37:166-7. 2012.... - The role of nuclear medicine in the prediction and detection of radiation-associated normal pulmonary and cardiac damageIngeborg Goethals
Division of Nuclear Medicine, University Hospital Ghent, Ghent, Belgium
J Nucl Med 44:1531-9. 2003.... - A simple test to determine the quality of your clinical PET imagesAndre Dobbeleir
Department of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium
Ann Nucl Med 24:751-7. 2010..The objective of the study was to present a simple method for comparing clinical PET images to a set of increasing quality images. Those different quality images were obtained by varying the activity concentration and the acquisition time... - Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brainJonas Claeys
Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Ann Nucl Med 24:501-5. 2010..The aim of this study was to investigate whether normoglycemic glucose concentrations interfere with cerebral F-18 FDG uptake... - Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: an ROC-based comparison of visual, semiquantitative, and voxel-based methodsKoenraad J Van Laere
Division of Nuclear Medicine, P7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Nucl Med 43:458-69. 2002..In 2 distinct clinical populations with severe traumatic brain injury and cognitive impairment, this study compared 3 widely available approaches that use normal templates to evaluate SPECT brain perfusion deficits... - Myocardial perfusion imaging in the elderly: a reviewOlivier De Winter
Nuclear Medicine Division, Ghent University Hospital, Belgium
Nucl Med Commun 27:529-34. 2006..This article briefly overviews the possible stress modalities, diagnostic accuracy and prognostic value of myocardial perfusion imaging in elderly patients... - Differentiation between peri-anastomotic inflammatory changes and local recurrence following neoadjuvant radiochemotherapy surgery for colorectal cancer using visual and semiquantitative analysis of PET-CT dataP Smeets
Department of Radiology, Ghent University Hospital, Ghent, Belgium
Q J Nucl Med Mol Imaging 54:327-32. 2010.... - FDG uptake in primary squamous cell carcinoma of the head and neck. The relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosisP Deron
Department of Head and Neck Surgery, Ghent University Hospital, De Pintelaan 185, 9000 B Gent, Belgium
Nuklearmedizin 50:15-21. 2011.... - The effect of citalopram hydrobromide on 5-HT2A receptors in the impulsive-aggressive dog, as measured with 123I-5-I-R91150 SPECTK Peremans
Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
Eur J Nucl Med Mol Imaging 32:708-16. 2005.... - Registration accuracy of 153Gd transmission images of the brainF Jacobs
Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
Eur J Nucl Med Mol Imaging 31:1495-9. 2004.... - Functional imaging, serotonin and the suicidal brainK Audenaert
Department of Psychiatry and Medical Psychology, Gent University, Gent, Belgium
Acta Neurol Belg 106:125-31. 2006..These results are in keeping with 5-HT2A binding studies in depressed patients and impulsive animal research. Interestingly, both an increase and a decrease in 5-HT2A binding index seem to normalize with SSRI treatment... - Discordant findings between Tc-99m HMPAO mixed leukocytes and Tc-99m-labeled monoclonal antibody fragments (via LeukoScan) in a patient with pulmonary aspergillosisIngeborg Goethals
Division of Nuclear Medicine, University Hospital Ghent, Ghent, Belgium
Clin Nucl Med 27:596. 2002 - Multimodality SPECT imaging of multifocal spondylodiscitisFilip Gemmel
Department of Nuclear Medicine, University Hospital Ghent, Ghent, Belgium
Clin Nucl Med 29:635-6. 2004 - Nuclear medicine imaging to predict response to radiotherapy: a reviewChristophe Van de Wiele
Division of Nuclear Medicine, University Hospital Ghent, Ghent, Belgium
Int J Radiat Oncol Biol Phys 55:5-15. 2003.... - PET with (18)F-labelled choline-based tracers for tumour imaging: a review of the literatureKoen Mertens
Department of Nuclear Medicine, University Hospital Ghent, De Pintelaan, Gent, Belgium
Eur J Nucl Med Mol Imaging 37:2188-93. 2010..To give an up-to-date overview of the potential clinical utility of (18)F-labelled choline derivatives for tumour imaging with positron emission tomography... - The classical stroop interference task as a prefrontal activation probe: a validation study using 99Tcm-ECD brain SPECTK Audenaert
Department of Nuclear Medicine, University Hospital, Gent, Belgium
Nucl Med Commun 22:135-43. 2001..It is concluded that brain SPECT activation with the Stroop Color Word Test under standard neuropsychological conditions in healthy volunteers, is both technically and practically feasible... - 99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adultsK Van Laere
Division of Nuclear Medicine, Ghent University Hospital, Belgium
Eur J Nucl Med 28:873-87. 2001.... - SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patientsKurt Audenaert
Department of Nuclear Medicine, Ghent University Hospital, Ghent University, 185 De Pintelaan, B 9000 Ghent, Belgium
Nucl Med Commun 23:907-16. 2002..Our findings indicate a blunted increase in prefrontal blood perfusion as a possible biological reason for reduced drive and loss of initiative in attempted suicide patients... - The clinical value of nuclear medicine in the assessment of irradiation-induced and anthracycline-associated cardiac damageI Goethals
Division of Nuclear Medicine, Department of Cardiology, Ghent University Hospital, Ghent, Belgium
Ann Oncol 13:1331-9. 2002.... - Leakage assessment in adjustable laparoscopic gastric banding: radiography versus (99m)Tc-pertechnetate scintigraphyB Van Den Bossche
Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Eur J Nucl Med Mol Imaging 29:1128-31. 2002..6%. Leakage from the reservoir or the connecting tube is a late complication of ALGB. The presented data suggest that (99m)Tc-pertechnetate scintigraphy is more efficient than radiography in determining the presence of such leaks... - Nuclear medicine asleep in sleep research?Andreas Otte
Eur J Nucl Med Mol Imaging 29:1417-20. 2002 - Functional imaging of the suicidal brainKurt Audenaert
Nucl Med Commun 26:391-3. 2005 - Brain SPET perfusion in early Alzheimer's disease: where to look?Ingeborg Goethals
Eur J Nucl Med Mol Imaging 29:975-8. 2002 - Serotonin transporter and dopamine transporter imaging in the canine brainKathelijne Peremans
Department of Medical Imaging, Faculty of Veterinary Sciences, Ghent University, B-9000 Ghent, Belgium
Nucl Med Biol 33:907-13. 2006..Second, we studied the effect of SSRIs (sertraline, citalopram and escitalopram) on the SERT and DAT in two dogs. The position of the canine model in the study of the SERT and DAT is discussed and compared with other animal models... - Functional neuroimaging at the 2002 APSS 16th annual meeting in SeattleAndreas Otte
Med Sci Monit 8:LE37-9. 2002