Peter Geldhof

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. pmc Microarray analysis of the intestinal host response in Giardia duodenalis assemblage E infected calves
    Leentje Dreesen
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 7:e40985. 2012
  2. pmc A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae
    Dries Masure
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 7:e2138. 2013
  3. pmc Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection
    Belgacem Mihi
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 44:121. 2013
  4. pmc Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora
    Esley Heizer
    The Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA
    BMC Genomics 14:118. 2013
  5. pmc Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum
    Manuela Rinaldi
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 42:61. 2011
  6. ncbi request reprint Recombinant expression systems: the obstacle to helminth vaccines?
    Peter Geldhof
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Trends Parasitol 23:527-32. 2007
  7. ncbi request reprint Vaccine testing of a recombinant activation-associated secreted protein (ASP1) from Ostertagia ostertagi
    P Geldhof
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan, Merelbeke, Belgium
    Parasite Immunol 30:57-60. 2008
  8. ncbi request reprint RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects
    P Geldhof
    Faculty of Veterinary Medicine, Department of Virology, Parasitology and Immunology, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Parasitology 134:609-19. 2007
  9. pmc Granule exocytosis of granulysin and granzyme B as a potential key mechanism in vaccine-induced immunity in cattle against the nematode Ostertagia ostertagi
    Frederik Van Meulder
    Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Infect Immun 81:1798-809. 2013
  10. pmc Vaccination with an Ostertagia ostertagi polyprotein allergen protects calves against homologous challenge infection
    Isabel Vercauteren
    Department of Morphology, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Ghent, Belgium
    Infect Immun 72:2995-3001. 2004

Collaborators

Detail Information

Publications49

  1. pmc Microarray analysis of the intestinal host response in Giardia duodenalis assemblage E infected calves
    Leentje Dreesen
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 7:e40985. 2012
    ....
  2. pmc A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae
    Dries Masure
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 7:e2138. 2013
    ..suum specific antibodies are required for efficient elimination of the larvae. Together, these results indicate an important role for eosinophils in the intestinal defense against invading A. suum larvae...
  3. pmc Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection
    Belgacem Mihi
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 44:121. 2013
    ..In conclusion, this study shows that the emergence of adult O. ostertagi worms is associated with marked cellular changes that can be partly triggered by the worm's Excretory/secretory antigens. ..
  4. pmc Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora
    Esley Heizer
    The Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA
    BMC Genomics 14:118. 2013
    ..New methods of control and alternative drug targets are necessary. In-depth analysis of transcriptomic data can help provide these targets...
  5. pmc Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum
    Manuela Rinaldi
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 42:61. 2011
    ....
  6. ncbi request reprint Recombinant expression systems: the obstacle to helminth vaccines?
    Peter Geldhof
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Trends Parasitol 23:527-32. 2007
    ..So, in addition to testing more expression systems, it should be considered that prior evaluation and characterization of the native antigens might help the development of recombinant vaccines against helminths in the long term...
  7. ncbi request reprint Vaccine testing of a recombinant activation-associated secreted protein (ASP1) from Ostertagia ostertagi
    P Geldhof
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan, Merelbeke, Belgium
    Parasite Immunol 30:57-60. 2008
    ..Further analysis of the structure of the native ASPs and their glycosylations is being done...
  8. ncbi request reprint RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects
    P Geldhof
    Faculty of Veterinary Medicine, Department of Virology, Parasitology and Immunology, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Parasitology 134:609-19. 2007
    ..The future application of RNAi in parasite functional genomics will greatly depend on how we can overcome these difficulties. Optimization of the dsRNA delivery methods and in vitro culture conditions will be the major challenges...
  9. pmc Granule exocytosis of granulysin and granzyme B as a potential key mechanism in vaccine-induced immunity in cattle against the nematode Ostertagia ostertagi
    Frederik Van Meulder
    Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Infect Immun 81:1798-809. 2013
    ..Overall, the results suggest a potential role for granule exocytosis by globule leukocytes, potentially IgE mediated, in vaccine-induced protection against O. ostertagi...
  10. pmc Vaccination with an Ostertagia ostertagi polyprotein allergen protects calves against homologous challenge infection
    Isabel Vercauteren
    Department of Morphology, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Ghent, Belgium
    Infect Immun 72:2995-3001. 2004
    ..In contrast to the native antigen, recombinant OPA expressed in Escherichia coli did not stimulate any protection...
  11. pmc the intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time
    Dries Masure
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 7:e2588. 2013
    ..Taken together, these results shed new light on the mechanisms of self-cure that occur during A. suum infections. ..
  12. ncbi request reprint Validation of the protective Ostertagia ostertagi ES-thiol antigens with different adjuvantia
    P Geldhof
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Belgium
    Parasite Immunol 26:37-43. 2004
    ..Although the protective immune mechanism against O. ostertagi remains unknown, protection in the ES-thiol QuilA group was associated with high levels of parasite-specific antibodies in the abomasal mucosa...
  13. doi request reprint Analysis of the translationally controlled tumour protein in the nematodes Ostertagia ostertagi and Caenorhabditis elegans suggests a pivotal role in egg production
    Yves Meyvis
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Parasitol 39:1205-13. 2009
    ..elegans. Knock-down of C. elegans tctp (tct-1) transcription reduced the numbers of eggs laid by the hermaphrodite in the F(0) and F(1) generations by 90% and 72%, respectively, indicating a pivotal role of TCTP in reproduction...
  14. doi request reprint Structure of Ostertagia ostertagi ASP-1: insights into disulfide-mediated cyclization and dimerization
    Jimmy Borloo
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Acta Crystallogr D Biol Crystallogr 69:493-503. 2013
    ....
  15. pmc Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile
    Prisca R Hoorens
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    BMC Genomics 12:140. 2011
    ..The aim of the current study was to identify all members of the bovine mucin family by genome mining and subsequently investigate the transcription pattern of these mucins in the GI tract...
  16. ncbi request reprint Vaccination of calves against Ostertagia ostertagi with cysteine proteinase enriched protein fractions
    P Geldhof
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Parasite Immunol 24:263-70. 2002
    ..However, these correlations were quite weak and did not appear to be isotype-specific...
  17. doi request reprint Effect of an Ostertagia ostertagi infection on the transcriptional stability of housekeeping genes in the bovine abomasum
    Belgacem Mihi
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Parasitol 181:354-9. 2011
    ..The potential for HKG selection to impact candidate transcript levels is therefore an important consideration for studies of parasite infected tissue...
  18. ncbi request reprint Hybrid N-glycans on the host protective activation-associated secreted proteins of Ostertagia ostertagi and their importance in immunogenicity
    Yves Meyvis
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Mol Biochem Parasitol 161:67-71. 2008
    ..While removal of these glycans had little effect on antibody recognition by vaccinated animals, denaturing and reducing the proteins dramatically reduced recognition, suggesting the importance of conformational protein backbone epitopes...
  19. ncbi request reprint Identification and characterization of a novel specific secreted protein family for selected members of the subfamily Ostertagiinae (Nematoda)
    H Saverwyns
    Laboratory for Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Parasitology 135:63-70. 2008
    ..An analysis of the nematode genome and EST databases indicated that these novel ES proteins are unique to O. ostertagi and its relative, Teladorsagia circumcincta, suggesting a key function in these abomasal parasites...
  20. pmc Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases
    Tao Wang
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    PLoS Negl Trop Dis 7:e2467. 2013
    ....
  21. pmc In-depth proteomic and glycomic analysis of the adult-stage Cooperia oncophora excretome/secretome
    Jimmy Borloo
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B 9820, Belgium
    J Proteome Res 12:3900-11. 2013
    ..The predominance of the nonglycosylated double-domain ASP in the high-molecular weight fraction renders it ideal for advancement toward vaccine trials and development. ..
  22. ncbi request reprint Experimental selection for ivermectin resistance in Ostertagia ostertagi in cattle
    A M Van Zeveren
    Laboratory for Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Parasitol 150:104-10. 2007
    ..2 mg/kg BW) only reduced the faecal egg counts by 57% and 65% on days 7 and 14 after treatment, respectively. In contrast, the therapeutic IVM dose was 100% effective at eliminating the parental IVM-susceptible isolate...
  23. ncbi request reprint Activation-associated secreted proteins are the most abundant antigens in a host protective fraction from Ostertagia ostertagi
    P Geldhof
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B9820, Belgium
    Mol Biochem Parasitol 128:111-4. 2003
  24. pmc Digital dermatitis in cattle is associated with an excessive innate immune response triggered by the keratinocytes
    Walid Refaai
    Department of Reproduction, Obstetrics, and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    BMC Vet Res 9:193. 2013
    ..Twenty four samples representing the 5 different clinical stages of DD (M0-M4) were collected from slaughtered cattle for histopathological and immunological analyses...
  25. ncbi request reprint A Bayesian approach for the evaluation of six diagnostic assays and the estimation of Cryptosporidium prevalence in dairy calves
    Thomas Geurden
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 37:671-82. 2006
    ....
  26. doi request reprint Evaluation of a serodiagnostic test using Ascaris suum haemoglobin for the detection of roundworm infections in pig populations
    Johnny Vlaminck
    Department of Virology, Parasitology and Immunology, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Parasitol 189:267-73. 2012
    ..The results of this study suggest that the AsHb ELISA could provide pig farmers and veterinarians with an easier and more sensitive way to estimate the overall prevalence of A. suum on their farm...
  27. pmc Molecular identification of Entamoeba spp. in captive nonhuman primates
    B Levecke
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Clin Microbiol 48:2988-90. 2010
    ..The results revealed the presence of Entamoeba histolytica (NHP variant only), E. dispar, E. moshkovskii, E. hartmanni, E. coli, and E. polecki-like organisms...
  28. ncbi request reprint Identification of excretory-secretory products of larval and adult Ostertagia ostertagi by immunoscreening of cDNA libraries
    Isabel Vercauteren
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B 9820, Belgium
    Mol Biochem Parasitol 126:201-8. 2003
    ..In this manner it could be proven that 15 cDNAs code for genuine secreted proteins. The identification of these ES antigens allows to select proteins with potential protective capacities, which are targets for vaccine development...
  29. ncbi request reprint Molecular characterisation of Giardiaduodenalis in captive non-human primates reveals mixed assemblage A and B infections and novel polymorphisms
    Bruno Levecke
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Parasitol 39:1595-601. 2009
    ....
  30. ncbi request reprint Proteinases released in vitro by the parasitic stages of the bovine abomasal nematode Ostertagia ostertagi
    P Geldhof
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Parasitology 121:639-47. 2000
    ..The specificity of the L3, L4 and adult Ostertagia ostertagi proteinases against the different substrates indicates variable functional requirements...
  31. ncbi request reprint Protein disulphide isomerase of Ostertagia ostertagi: an excretory-secretory product of L4 and adult worms?
    P Geldhof
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Int J Parasitol 33:129-36. 2003
    ..Two-dimensional Western blot analysis indicated that Ost-PDI2 is recognised by calves during a natural O. ostertagi infection, which suggests that Ost-PDI2 could be used for immunological control of ostertagiosis...
  32. ncbi request reprint Different Sarcocystis spp. are present in bovine eosinophilic myositis
    Lieve Vangeel
    Laboratory of Veterinary Pathology, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Parasitol 197:543-8. 2013
    ..hominis. However S. cruzi and S. hirsuta were also found, as well as an unidentified species. It can be concluded that Sarcocystis species present in lesions of BEM are not restricted to one species. ..
  33. doi request reprint Monitoring macrocyclic lactone resistance in Cooperia oncophora on a Belgian cattle farm during four consecutive years
    A El-Abdellati
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium
    Vet Parasitol 171:167-71. 2010
    ..However, the test should be further optimized, e.g. more isolates with different susceptibility to ivermectin and mixtures of species, in order to use the test in field conditions...
  34. ncbi request reprint Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi
    V De Maere
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Belgium
    Parasitology 130:89-98. 2005
    ..The protein MET-1 was expressed in insect cells using the baculovirus expression system but the immunization of calves with this molecule did not lead to protection against challenge infection...
  35. ncbi request reprint Protection studies with a globin-enriched protein fraction of Ostertagia ostertagi
    E Claerebout
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Vet Parasitol 128:299-307. 2005
    ..In conclusion, vaccination of calves with O. ostertagi globin resulted in highly variable protection levels after challenge infection...
  36. ncbi request reprint Cytokine responses in immunized and non-immunized calves after Ostertagia ostertagi infection
    E Claerebout
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Parasite Immunol 27:325-31. 2005
    ..No significant association was observed in the abomasal mucosa between any examined cytokine mRNA level and immune effector responses such as parasite-specific antibodies or the number of mucosal mast cells or eosinophils...
  37. ncbi request reprint Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi
    A Visser
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Int J Parasitol 38:455-65. 2008
    ..Oo-ASP1 and Oo-ASP2 on the other hand were localised in the reproductive tract of both male and female worms, suggesting a role in reproduction or in the development of the reproductive tract...
  38. ncbi request reprint Efficacy and specificity of RNA interference in larval life-stages of Ostertagia ostertagi
    A Visser
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Parasitology 133:777-83. 2006
    ..In conclusion, the results indicate that the RNAi pathway is probably present in O. ostertagi but that the current RNAi techniques can not be used as a reliable screening method...
  39. ncbi request reprint Evaluation of reference genes for quantitative real-time PCR in Ostertagia ostertagi by the coefficient of variation and geNorm approach
    A M Van Zeveren
    Laboratory for Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Mol Biochem Parasitol 153:224-7. 2007
  40. ncbi request reprint Vaccination against Ostertagia ostertagi with subfractions of the protective ES-thiol fraction
    Y Meyvis
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Parasitol 149:239-45. 2007
    ..05), except for male worms from the ES-thiol group. These results suggest the protective capacity of ASPs and the presence of other protective antigens in the ES-thiol fraction...
  41. doi request reprint The use of a simplified faecal egg count reduction test for assessing anthelmintic efficacy on Belgian and German cattle farms
    A El-Abdellati
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium
    Vet Parasitol 169:352-7. 2010
    ....
  42. ncbi request reprint Mixed Giardia duodenalis assemblage A and E infections in calves
    T Geurden
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Parasitol 38:259-64. 2008
    ..duodenalis assemblage E, are frequently infected with the zoonotic assemblage A, either as a mixed or mono-infection, suggesting that calves might be underestimated as a potential zoonotic reservoir for human infections...
  43. ncbi request reprint Giardia muris Infection in Mice Is Associated with a Protective Interleukin 17A Response and Induction of Peroxisome Proliferator-Activated Receptor Alpha
    Leentje Dreesen
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Infect Immun 82:3333-40. 2014
    ..In conclusion, this study shows for the first time the importance of IL-17 production in the clearance of a G. muris infection together with an early induction of PPARα. The effect of the latter, however, is still unclear. ..
  44. ncbi request reprint Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans
    Linda Murray
    Division of Veterinary Infection and Immunity, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Int J Parasitol 37:1117-25. 2007
    ..This study provides proof of principle that active, post-translationally modified parasitic nematode proteases can be expressed in C. elegans and this approach can be extended for expression of known protective antigens...
  45. ncbi request reprint Evaluation of Caenorhabditis elegans glycoproteins as protective immunogens against Haemonchus contortus challenge in sheep
    Diane L Redmond
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, Scotland, UK
    Int J Parasitol 34:1347-53. 2004
    ..Qualitative differences were also determined between the glycan epitopes of the C. elegans ConA-binding proteins and those of H-gal-GP, suggesting the presence of H. contortus-specific patterns of glycosylation...
  46. ncbi request reprint Characterisation of a DM domain-containing transcription factor from Trichostrongylus vitrinus (Nematoda: Strongylida)
    Alasdair J Nisbet
    Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, United Kingdom
    Parasitol Int 55:155-7. 2006
    ..vitrinus. The highest levels of expression in fourth stage larvae coincide with the period in which profound gender-specific alterations in physiology occur in both the parasitic and free-living nematodes...
  47. ncbi request reprint Testing the efficacy of RNA interference in Haemonchus contortus
    Peter Geldhof
    Moredun Research Institute, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, UK
    Int J Parasitol 36:801-10. 2006
    ..elegans and other nematodes have limited efficacy in H. contortus. This may reflect differences between nematode species in dsRNA uptake and transport into cells and between cells...
  48. doi request reprint ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics
    Anne Lespine
    Laboratoire de Pharmacologie Toxicologie, INRA, 180 chemin de Tournefeuille, 31931 Toulouse, France
    Trends Parasitol 24:293-8. 2008
    ..This opinion article will discuss the recent findings in this research field and assess the possibilities of this approach being used in the field...
  49. ncbi request reprint RNA interference in parasitic nematodes of animals: a reality check?
    David P Knox
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Trends Parasitol 23:105-7. 2007
    ..elegans) is fully functional in some parasitic nematodes...