Koen Deventer

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Detection of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry
    K Deventer
    Doping Control Laboratory, DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Technologiepark 30B, B 9052 Zwijnaarde, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 834:217-20. 2006
  2. doi request reprint Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatography-electrospray-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Gent University, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chem 80:1709-20. 2008
  3. doi request reprint Quantitative detection of inhaled formoterol in human urine and relevance to doping control analysis
    K Deventer
    DoCoLab, UGent, Gent, Belgium
    Drug Test Anal 4:449-54. 2012
  4. ncbi request reprint Development of a qualitative liquid chromatography/tandem mass spectrometric method for the detection of narcotics in urine relevant to doping analysis
    Koen Deventer
    Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:3015-23. 2007
  5. ncbi request reprint Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis
    K Deventer
    Department of Clinical Chemistry, DoCoLab, UGent, Zwijnaarde, Belgium
    J Chromatogr A 1216:2466-73. 2009
  6. doi request reprint Development and validation of an LC-MS/MS method for the quantification of ephedrines in urine
    K Deventer
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 877:369-74. 2009
  7. doi request reprint Interpretation of urinary concentrations of pseudoephedrine and its metabolite cathine in relation to doping control
    K Deventer
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Gent, Belgium
    Drug Test Anal 1:209-13. 2009
  8. ncbi request reprint Detection of budesonide in human urine after inhalation by liquid chromatography-mass spectrometry
    K Deventer
    Doping control laboratory DoCoLab, Ghent University, UGent, Technologiepark 30B, B 9052 Zwijnaarde, Belgium
    J Pharm Biomed Anal 42:474-9. 2006
  9. ncbi request reprint Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry
    K Deventer
    Ghent University, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 20:877-82. 2006
  10. doi request reprint Stability of selected chlorinated thiazide diuretics
    K Deventer
    Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Pharm Biomed Anal 49:519-24. 2009

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Detection of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry
    K Deventer
    Doping Control Laboratory, DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Technologiepark 30B, B 9052 Zwijnaarde, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 834:217-20. 2006
    ..The results indicate that the developed method can successfully be applied as a fast and reliable method for the detection and identification of hydroxyethylstarch...
  2. doi request reprint Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatography-electrospray-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Gent University, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chem 80:1709-20. 2008
    ..Finally, the applicability of the developed approach for the analysis of dietary supplements was checked by the analysis of a prohormone where several impurities and/or degradation products were found...
  3. doi request reprint Quantitative detection of inhaled formoterol in human urine and relevance to doping control analysis
    K Deventer
    DoCoLab, UGent, Gent, Belgium
    Drug Test Anal 4:449-54. 2012
    ..Analysis of 82 routine doping samples, declared positive for formoterol during routine analysis, did not exhibit concentrations which could be attributed to misuse...
  4. ncbi request reprint Development of a qualitative liquid chromatography/tandem mass spectrometric method for the detection of narcotics in urine relevant to doping analysis
    Koen Deventer
    Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:3015-23. 2007
    ..Finally, the described method was applied to the analysis of urine samples previously found to contain narcotics by our routine gas chromatography/mass spectrometry (GC/MS) method...
  5. ncbi request reprint Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis
    K Deventer
    Department of Clinical Chemistry, DoCoLab, UGent, Zwijnaarde, Belgium
    J Chromatogr A 1216:2466-73. 2009
    ..The study shows that 4-amino-6-chloro-1,3-benzenedisulphonamide is an important target compound for the long time detection of thiazide diuretics in urine...
  6. doi request reprint Development and validation of an LC-MS/MS method for the quantification of ephedrines in urine
    K Deventer
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 877:369-74. 2009
    ..The results were compared with those obtained with the common GC-NPD method. Results show a good correlation between both methods with correlation coefficients higher than 0.95 for all analytes...
  7. doi request reprint Interpretation of urinary concentrations of pseudoephedrine and its metabolite cathine in relation to doping control
    K Deventer
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Gent, Belgium
    Drug Test Anal 1:209-13. 2009
    ..Hence, cathine is not a good indicator to control pseudopehedrine intake. To control the (ab)use of ephedrines in sports it is recommended that WADA reintroduce a threshold for pseudoephedrine...
  8. ncbi request reprint Detection of budesonide in human urine after inhalation by liquid chromatography-mass spectrometry
    K Deventer
    Doping control laboratory DoCoLab, Ghent University, UGent, Technologiepark 30B, B 9052 Zwijnaarde, Belgium
    J Pharm Biomed Anal 42:474-9. 2006
    ..8 to 16.4% for budesonide. After administration of 200microg of budesonide to five healthy volunteers budesonide could not be detected in any urine sample whereas 16alpha-hydroxyprednisolone was detectable up to 12h post-administration...
  9. ncbi request reprint Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry
    K Deventer
    Ghent University, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 20:877-82. 2006
    ..The total run time was 15 min. All compounds were analysed in MS2 or MS3. The detection limit for all compounds was lower than 25 ng/mL except for chlorphentermine (detection limit: 250 ng/mL)...
  10. doi request reprint Stability of selected chlorinated thiazide diuretics
    K Deventer
    Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Pharm Biomed Anal 49:519-24. 2009
    ..This study confirms that thiazide degradation products can be formed in urine during transport. Hence doping control laboratories shall include them into their routine testing methods as required by WADA...
  11. doi request reprint Qualitative detection of diuretics and acidic metabolites of other doping agents in human urine by high-performance liquid chromatography-tandem mass spectrometry: comparison between liquid-liquid extraction and direct injection
    K Deventer
    Doping control laboratory DoCoLab, Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Chromatogr A 1216:5819-27. 2009
    ..With both techniques all 26 samples were found to be positive, showing the applicability of direct injection for the analysis of diuretics...
  12. ncbi request reprint Screening for anabolic steroids in doping analysis by liquid chromatography/electrospray ion trap mass spectrometry
    K Deventer
    Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Biomed Chromatogr 20:429-33. 2006
    ..The analytical run time was 11 min. The LOD for all compounds varied between 1 and 10 ng/mL. Left-over A samples, which were declared positive by GC/MS for the presence of 3'-hydroxystanozolol, were assessed using the described method...
  13. doi request reprint Prevalence of legal and illegal stimulating agents in sports
    K Deventer
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Anal Bioanal Chem 401:421-32. 2011
    ..Because stimulants are also regularly detected in nutritional (food) supplements a section on this topic is also included...
  14. ncbi request reprint Simultaneous determination of beta-blocking agents and diuretics in doping analysis by liquid chromatography/mass spectrometry with scan-to-scan polarity switching
    K Deventer
    Ghent University, Department of Clinical Biology, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 19:90-8. 2005
    ..The excretion of carvedilol was followed after intake of one tablet of Dimitone. Other doping agents including strychnine, norbuprenorphine and mesocarb hydroxysulfate could also be detected with this method...
  15. doi request reprint Detection and characterization of a new metabolite of 17alpha-methyltestosterone
    Oscar J Pozo
    DoCoLab, Ghent University, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Drug Metab Dispos 37:2153-62. 2009
    ..6-Ene-epimethyltestosterone was found in all samples, showing its applicability in the detection of methyltestosterone misuse...
  16. doi request reprint Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, Zwijnaarde, Belgium
    Drug Test Anal 1:554-67. 2009
    ..The metabolic nature of the unreported metabolites was also confirmed. A global strategy for the detection of steroid metabolites combining both human and chimeric mouse urine is proposed...
  17. ncbi request reprint Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 43:394-408. 2008
    ..The presence of these compounds has also been confirmed by the analysis of five other positive fluoxymesterone urine samples...
  18. ncbi request reprint Development and validation of a qualitative screening method for the detection of exogenous anabolic steroids in urine by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Technologiepark 30, 9052, Zwijnaarde, Belgium
    Anal Bioanal Chem 389:1209-24. 2007
    ..Limits of detection between 1 and 10 ng/ml were obtained for most analytes which fulfil current requirements. The applicability of the method was shown by analysing positive samples...
  19. doi request reprint Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chim Acta 684:98-111. 2011
    ..Additionally, the intake of methandienone was confirmed by the post-target detection of a long-term metabolite...
  20. ncbi request reprint In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200
    Nik De Brabanter
    Doping control laboratory DoCoLab, Ghent University Ugent, Technologiepark 30, B 9052, Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 27:2115-26. 2013
    ..In order to identify markers for misuse of this compound and allow for the development of adequate routine methods, the metabolism of this compound was investigated using two models...
  21. ncbi request reprint Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 22:4009-24. 2008
    ..A correlation between the steroid structure and the product ions obtained has been postulated. The application of these correlations can be useful in the elucidation of feasible structures for unknown steroids and/or their metabolites...
  22. ncbi request reprint Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:2785-96. 2007
    ..Using this approach, several endogenous interferences have been elucidated in this case study. The knowledge about the structures of these interferences has been found useful to circumvent their detection in the screening method for AS...
  23. doi request reprint Direct quantification of steroid glucuronides in human urine by liquid chromatography-electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, Zwijnaarde, Belgium
    J Chromatogr A 1183:108-18. 2008
    ..97. A slope close to 1 was obtained for all analytes except for AG possibly due to losses during the extraction process prior to GC-MS...
  24. doi request reprint Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Steroids 74:837-52. 2009
    ..Finally, a tentative structure for each detected metabolite has been proposed based on the product ion spectra measured with accurate masses using UPLC-QTOF MS...
  25. doi request reprint Doping control analysis of desmopressin in human urine by LC-ESI-MS/MS after urine delipidation
    Simone Esposito
    Doping Control Laboratory, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Zwijnaarde, Belgium
    Biomed Chromatogr 27:240-5. 2013
    ..9). The applicability of the method was proven by the analysis of real urine samples obtained after intravenous, oral and intranasal administration of desmopressin, achieving unambiguous detection of the peptide in all the cases...
  26. ncbi request reprint Ionization of anabolic steroids by adduct formation in liquid chromatography electrospray mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 42:497-516. 2007
    ..Despite the ionization limitations due to their chemical structure, most of tested anabolic steroids could be ionized using the adduct formation approach...
  27. doi request reprint Development of a sensitive GC-C-IRMS method for the analysis of androgens
    Michael Polet
    Doping Control Laboratory, Ghent University, Technologiepark 30, Zwijnaarde, Belgium
    Biomed Chromatogr 27:259-66. 2013
    ..This drastically reduces the amount of urine required. On top of that, by only changing the injection technique, the detection parameters of the IRMS are not affected and there is no loss in linearity...
  28. doi request reprint Quantitative detection of inhaled salmeterol in human urine and relevance to doping control analysis
    Koen Deventer
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, UGent, Zwijnaarde, Gent, Belgium
    Ther Drug Monit 33:627-31. 2011
    ..Analysis of 47 routine doping samples, declared to contain salmeterol during routine analysis, did not exhibit concentrations that could be considered originating from supratherapeutic doses...
  29. doi request reprint Quantification of testosterone undecanoate in human hair by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Biomed Chromatogr 23:873-80. 2009
    ..2 ng/g. The applicability of the method was checked by the analysis of three samples from patients using T-C11. A peak for the analyte was detected in all samples with concentrations between 0.4 and 8.4 ng/g...
  30. ncbi request reprint Metabolism of methylstenbolone studied with human liver microsomes and the uPA(+/+) -SCID chimeric mouse model
    Lore Geldof
    Doping Control Laboratory, Ghent University, Technologiepark 30 B, Zwijnaarde, B 9052, Belgium
    Biomed Chromatogr 28:974-85. 2014
    ..In one out of three samples, previously tested positive for methasterone, methylstenbolone and U13 were additionally detected, indicating the applicability of the method. Copyright © 2014 John Wiley & Sons, Ltd. ..
  31. doi request reprint Qualitative detection of desmopressin in plasma by liquid chromatography-tandem mass spectrometry
    Simone Esposito
    Doping Control Laboratory, Ghent University, Zwijnaarde, Belgium
    Anal Bioanal Chem 402:2789-96. 2012
    ..Only after intravenous administration could desmopressin be successfully detected...
  32. doi request reprint A fast, comprehensive screening method for doping agents in urine by gas chromatography-triple quadrupole mass spectrometry
    Peter Van Eenoo
    Doping Control Laboratory, Ghent University, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Chromatogr A 1218:3306-16. 2011
    ..Moreover, using a short capillary column and hydrogen as a carrier gas the run time of the method is less than 8min...
  33. doi request reprint Direct quantification of 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid in urine by liquid chromatography/tandem mass spectrometry in relation to doping control analysis
    C Chebbah
    Doping Control Laboratory, Department of Clinical Biology, Microbiology and Immunology, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 24:1133-41. 2010
    ..A good correlation between the two methods was obtained (r(2) > 0.98) with a slope close to 1...
  34. ncbi request reprint Results of stability studies with doping agents in urine
    P Van Eenoo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Anal Toxicol 31:543-8. 2007
    ..The study also shows that degradation can be dependent on the urinary matrix and that the results from stability studies using stabilized, filtered, or sterilized urine can underestimate degradation effects...
  35. ncbi request reprint Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry
    K Deventer
    Ghent University, Doping Control Unit, Faculty of Veterinary Medicine, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Biomed Chromatogr 16:529-35. 2002
    ..All diuretics could be detected for periods up to 96 h after the intake of therapeutic amounts...
  36. ncbi request reprint Quantitative LC-MS determination of strychnine in urine after ingestion of a Strychnos nux-vomica preparation and its consequences in doping control
    P Van Eenoo
    Doping control laboratory DoCoLab, Ghent University Ugent, Department of Clinical Biology, Microbiology and Immunology, Technologiepark 30B, B 9052 Zwijnaarde, Belgium
    Forensic Sci Int 164:159-63. 2006
    ..Maximum detected urinary concentrations ranged from 22.6 to 176 ng/mL. The results of this study show that the use of this type of preparation by athletes can lead to a positive doping case...
  37. doi request reprint Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
    Simone Esposito
    Doping control laboratory DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Drug Test Anal 4:733-8. 2012
    ..Ac-LKKTETQ was also synthesized by solid-phase peptide synthesis, and an analytical strategy for detection in plasma and urine by high-performance liquid chromatography/low resolution triple-quadrupole mass spectrometry was suggested...
  38. doi request reprint Characterization and identification of a C-terminal amidated mechano growth factor (MGF) analogue in black market products
    Simone Esposito
    Doping Control Laboratory, Ghent University Ugent, Technologiepark 30 B, 9052, Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 26:686-92. 2012
    ..In this work, two preparations from the black market containing an unknown MGF analogue were characterized...
  39. ncbi request reprint Validation of a screening method for corticosteroids in doping analysis by liquid chromatography/tandem mass spectrometry
    K Deventer
    Ghent University, Doping Control Laboratory, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Rapid Commun Mass Spectrom 17:2107-14. 2003
    ..Betamethasone could be detected for up to 12 days after administration. Validation of the chromatographic separation and mass spectrometric identification of mixtures of betamethasone and dexamethasone are also presented...
  40. doi request reprint Identification of sympathomimetic alkylamine agents in urine using liquid chromatography-mass spectrometry and comparison of derivatization methods for confirmation analyses by gas chromatography-mass spectrometry
    Vinícius F Sardela
    Universidade Federal do Rio de Janeiro, Instituto de Quimica, LAB DOP LADETEC, Avenida Athos da Silveira Ramos, 149, 21941 909 Rio de Janeiro, RJ, Brazil
    J Chromatogr A 1298:76-85. 2013
    ..The choice of the appropriated derivative for each alkylamine makes their spectra more easily interpretable, fulfills the WADA's rather strict identification criteria and enables the unequivocal identification of alkylamines in urine...
  41. ncbi request reprint Quantitative analysis of androst-4-ene-3,6,17-trione and metabolites in human urine after the administration of a food supplement by liquid chromatography/ion trap-mass spectrometry
    K Deventer
    Department of Clinical Biology, Microbiology and Immunology, Doping control laboratory DoCoLab, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 828:21-6. 2005
    ..While the parent compound is predominantly excreted in conjugated form, both metabolites are solely excreted as conjugates...
  42. ncbi request reprint Detection of androst-4-ene-3,6,17-trione (6-OXO) and its metabolites in urine by gas chromatography-mass spectrometry in relation to doping analysis
    W Van Thuyne
    Doping Control Laboratory, Department of Clinical Biology, Microbiology and Immunology, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Biomed Chromatogr 19:689-95. 2005
    ....