Research Topics
Species | Wim DeraveSummaryAffiliation: Ghent University Country: Belgium Publications
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Detail Information
Publications
Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopyMahir S Ozdemir
Department of Electronics and Information Systems, MEDISIP, Ghent University IBBT IBiTech, De Pintelaan 185 block B, B 9000 Ghent, Belgium
Phys Med Biol 52:6781-94. 2007..These values are in agreement with previously reported biopsy-based results. Our results suggest that 1H MRS can provide an alternative method for non-invasively determining carnosine concentration in human calf muscle in vivo...
Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and trainingWim Derave
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Sports Med 40:247-63. 2010..However, many aspects of the supplement, such as the potential side effects and the mechanism of action, require additional and thorough investigation by the sports science community...- Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosineWim Derave
Research Unit of Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
Nutrition 22:332-3. 2006..Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine... - beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersWim Derave
Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
J Appl Physiol 103:1736-43. 2007.... - Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8)Wim Derave
Research Center for Exercise and Health, Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium
Rejuvenation Res 11:641-7. 2008..Oral creatine supplementation is able to transiently but potently increase muscle carnosine and anserine content, which coincides with improved resistance to contractile fatigue... - Soleus muscles of SAMP8 mice provide an accelerated model of skeletal muscle senescenceWim Derave
Research Center for Excercise Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
Exp Gerontol 40:562-72. 2005..We suggest that soleus muscles of SAMP8 mice provide a cost-effective model for muscular aging studies... - Ergogenic effects of creatine in sports and rehabilitationPeter Hespel
Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, K U Leuven, Leuven, Belgium
Subcell Biochem 46:245-59. 2007..Thus, creatine may also be beneficial in sport competition and training characterized by daily glycogen depletion, as well as provide therapeutic value in the insulin-resistant state... - Carnosine loading and washout in human skeletal musclesAudrey Baguet
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
J Appl Physiol 106:837-42. 2009..The present study shows that washout periods for crossover designs in supplementation studies for muscle metabolites may sometimes require months rather than weeks... - Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacityAudrey Baguet
Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, Ghent, Belgium
Eur J Appl Physiol 111:2571-80. 2011..517; p = 0.002) between an invasive and non-invasive method for muscle carnosine quantification. In conclusion, this study shows that 5 weeks sprint training has no effect on the muscle carnosine content and carnosine synthase mRNA... - Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exerciseAudrey Baguet
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Eur J Appl Physiol 108:495-503. 2010..This may contribute to the ergogenic effect of the supplement found in some exercise modes... - Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humansInge Everaert
Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
Amino Acids 40:1221-9. 2011.... - No effects of lifelong creatine supplementation on sarcopenia in senescence-accelerated mice (SAMP8)Wim Derave
Exercise Physiology and Biomechanics Laboratory, Faculty of Kinesiology and Rehabilitation Sciences, Tervuursevest 101, B 3001 Leuven, Belgium
Am J Physiol Endocrinol Metab 289:E272-7. 2005..It is concluded that lifelong creatine supplementation is no effective strategy to prevent sarcopenia in senescence-accelerated mice... - AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementationBert O Eijnde
Exercise Physiology and Biomechanics Laboratory, Faculty of Kinesiology and Rehabilitation Sciences, Tervuursevest 101, B 3001 Leuven, Belgium
J Appl Physiol 98:1228-33. 2005..Furthermore, the present observations indicate that AMPK probably is not implicated in the previously reported beneficial effects of oral creatine supplementation on muscle during immobilization and rehabilitative weight training... - Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humansInge Everaert
Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
Am J Physiol Renal Physiol 302:F1537-44. 2012..In conclusion, low plasma carnosinase activity promotes the presence of circulating carnosine upon an oral challenge. These data may further clarify the link among CNDP1 genotype, carnosinase, and diabetic nephropathy... - Important role of muscle carnosine in rowing performanceAudrey Baguet
Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
J Appl Physiol 109:1096-101. 2010.... - The influence of sex, age and heritability on human skeletal muscle carnosine contentAudrey Baguet
Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium
Amino Acids 43:13-20. 2012..Muscle carnosine decreased mainly during early adulthood and hardly from adulthood to elderly. High intra-twin correlations were observed, but muscle-dependent differences preclude clear conclusions toward heritability... - Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatmentWim Derave
Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Physical Education and Physiotherapy, K U Leuven, B 3001, Leuven, Belgium
Neurobiol Dis 13:264-72. 2003..Furthermore, creatine intake does not exert a beneficial effect on muscle function in a transgenic mouse model of ALS... - Creatine supplementation in health and disease: what is the evidence for long-term efficacy?Wim Derave
Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Physical Education and Physiotherapy, Catholic University of Leuven, Leuven, Belgium
Mol Cell Biochem 244:49-55. 2003..The primary purpose of the present review article is to critically evaluate the available evidence for long-term efficacy of creatine administration and to hypothesize about ways to optimize creatine administration regimens... 
A new method for non-invasive estimation of human muscle fiber type compositionAudrey Baguet
Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
PLoS ONE 6:e21956. 2011..Until today, the muscle biopsy method is still accepted as gold standard to measure muscle fiber type composition. Because of its invasive nature and high sampling variance, it would be useful to develop a non-invasive alternative...- Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exerciseKatrien Koppo
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Med Sci Sports Exerc 41:1626-32. 2009..To test the hypothesis that L-arginine (the substrate for nitric oxide synthase [NOS]) administration slows the VO2 kinetics at the onset of moderate-intensity exercise in humans... - Gene expression of carnosine-related enzymes and transporters in skeletal muscleInge Everaert
Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium
Eur J Appl Physiol 113:1169-79. 2013..Collectively, these data show that muscle carnosine homeostasis is regulated by nutritional and hormonal stimuli in a complex interplay between related transporters and enzymes... - Effect of beta-alanine and carnosine supplementation on muscle contractility in miceInge Everaert
Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
Med Sci Sports Exerc 45:43-51. 2013.... - Effects of post-absorptive and postprandial exercise on glucoregulation in metabolic syndromeWim Derave
Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, K U Leuven, Tervuursevest 101, B 3001 Leuven, Belgium
Obesity (Silver Spring) 15:704-11. 2007..It is hypothesized that post-absorptive exercise enhances fat oxidation rate during exercise and thereafter attenuates the glucose and insulin response to subsequent meals... - Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise trainingSanne Stegen
Department Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium
Obes Surg 21:61-70. 2011..The purpose of this pilot study is to investigate the effect of gastric bypass surgery on physical fitness and to determine if an exercise program in the first 4 months is beneficial... - Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exerciseFarah S L Thong
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Canada
Diabetes 51:583-90. 2002.... - Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROSWim Derave
Dept. of Biomedical Kinesiology, Katholieke Universiteit Leuven, B-3001 Leuven, Belgium
Am J Physiol Endocrinol Metab 291:E1250-7. 2006..The increased creatine uptake is paralleled by an increased cell surface expression of the creatine transporter... - Plasma guanidino compounds are altered by oral creatine supplementation in healthy humansWim Derave
Laboratory of Exercise Physiology and Biomechanics, Faculty of Physical Education and Physiotherapy, Katholieke Universiteite Leuven, B 3001 Leuven, Belgium
J Appl Physiol 97:852-7. 2004..Furthermore, these data suggest that this leads to enhanced utilization of arginine as a substrate for secondary pathways... - Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humansWim Derave
Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Katholieke Universiteit Leuven, 3001, Belgium
J Appl Physiol 94:1910-6. 2003..Furthermore, combined protein and creatine supplementation improved oral glucose tolerance, which is supposedly unrelated to the changes in muscle GLUT-4 expression... - Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1Bertrand Leger
Clinique romande de réadaptation, SuvaCare, Sion, Switzerland
FASEB J 20:583-5. 2006..The transcriptional regulation of human atrogin-1 may be controlled by an Akt-mediated transcription factor other than FKHR or via another signaling pathway... - Exercise programs for older men: mode and intensity to induce the highest possible health-related benefitsChristophe Delecluse
Department of Kinesiology, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Belgium
Prev Med 39:823-33. 2004..Additionally, effects of moderate- and low-intensity resistance training are compared... - Prior exercise increases basal and insulin-induced p38 mitogen-activated protein kinase phosphorylation in human skeletal muscleFarah S L Thong
Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Appl Physiol 94:2337-41. 2003..Because p38 MAPK has been suggested to play a necessary role in activation of GLUT-4 at the cell surface, the present data may suggest a putative role of p38 MAPK in the increased insulin sensitivity of skeletal muscle after exercise... - Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylationBertrand Leger
Clinique Romande de Réadaptation SuvaCare, Sion, Switzerland
Rejuvenation Res 11:163-175B. 2008..Human sarcopenia may be linked to a reduction in the activity or sensitivity of anabolic signaling proteins such as GHR, IGF-1, and Akt. TNFalpha, SOCS-3, and myostatin are potential candidates influencing this anabolic perturbation...