Wim Derave

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy
    Mahir S Ozdemir
    Department of Electronics and Information Systems, MEDISIP, Ghent University IBBT IBiTech, De Pintelaan 185 block B, B 9000 Ghent, Belgium
    Phys Med Biol 52:6781-94. 2007
  2. ncbi request reprint beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
    Wim Derave
    Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 103:1736-43. 2007
  3. ncbi request reprint Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine
    Wim Derave
    Research Unit of Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
    Nutrition 22:332-3. 2006
  4. doi request reprint Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8)
    Wim Derave
    Research Center for Exercise and Health, Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Rejuvenation Res 11:641-7. 2008
  5. doi request reprint Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training
    Wim Derave
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Sports Med 40:247-63. 2010
  6. ncbi request reprint Soleus muscles of SAMP8 mice provide an accelerated model of skeletal muscle senescence
    Wim Derave
    Research Center for Excercise Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
    Exp Gerontol 40:562-72. 2005
  7. doi request reprint Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Eur J Appl Physiol 108:495-503. 2010
  8. ncbi request reprint Ergogenic effects of creatine in sports and rehabilitation
    Peter Hespel
    Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, K U Leuven, Leuven, Belgium
    Subcell Biochem 46:245-59. 2007
  9. doi request reprint Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, Ghent, Belgium
    Eur J Appl Physiol 111:2571-80. 2011
  10. doi request reprint Carnosine loading and washout in human skeletal muscles
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    J Appl Physiol (1985) 106:837-42. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy
    Mahir S Ozdemir
    Department of Electronics and Information Systems, MEDISIP, Ghent University IBBT IBiTech, De Pintelaan 185 block B, B 9000 Ghent, Belgium
    Phys Med Biol 52:6781-94. 2007
    ..These values are in agreement with previously reported biopsy-based results. Our results suggest that 1H MRS can provide an alternative method for non-invasively determining carnosine concentration in human calf muscle in vivo...
  2. ncbi request reprint beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
    Wim Derave
    Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 103:1736-43. 2007
    ....
  3. ncbi request reprint Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine
    Wim Derave
    Research Unit of Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
    Nutrition 22:332-3. 2006
    ..Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine...
  4. doi request reprint Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8)
    Wim Derave
    Research Center for Exercise and Health, Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Rejuvenation Res 11:641-7. 2008
    ..Oral creatine supplementation is able to transiently but potently increase muscle carnosine and anserine content, which coincides with improved resistance to contractile fatigue...
  5. doi request reprint Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training
    Wim Derave
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Sports Med 40:247-63. 2010
    ..However, many aspects of the supplement, such as the potential side effects and the mechanism of action, require additional and thorough investigation by the sports science community...
  6. ncbi request reprint Soleus muscles of SAMP8 mice provide an accelerated model of skeletal muscle senescence
    Wim Derave
    Research Center for Excercise Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
    Exp Gerontol 40:562-72. 2005
    ..We suggest that soleus muscles of SAMP8 mice provide a cost-effective model for muscular aging studies...
  7. doi request reprint Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Eur J Appl Physiol 108:495-503. 2010
    ..This may contribute to the ergogenic effect of the supplement found in some exercise modes...
  8. ncbi request reprint Ergogenic effects of creatine in sports and rehabilitation
    Peter Hespel
    Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, K U Leuven, Leuven, Belgium
    Subcell Biochem 46:245-59. 2007
    ..Thus, creatine may also be beneficial in sport competition and training characterized by daily glycogen depletion, as well as provide therapeutic value in the insulin-resistant state...
  9. doi request reprint Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, Ghent, Belgium
    Eur J Appl Physiol 111:2571-80. 2011
    ..517; p = 0.002) between an invasive and non-invasive method for muscle carnosine quantification. In conclusion, this study shows that 5 weeks sprint training has no effect on the muscle carnosine content and carnosine synthase mRNA...
  10. doi request reprint Carnosine loading and washout in human skeletal muscles
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    J Appl Physiol (1985) 106:837-42. 2009
    ..The present study shows that washout periods for crossover designs in supplementation studies for muscle metabolites may sometimes require months rather than weeks...
  11. doi request reprint Effect of beta-alanine and carnosine supplementation on muscle contractility in mice
    Inge Everaert
    Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    Med Sci Sports Exerc 45:43-51. 2013
    ....
  12. doi request reprint Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans
    Inge Everaert
    Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    Amino Acids 40:1221-9. 2011
    ....
  13. ncbi request reprint AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation
    Bert O Eijnde
    Exercise Physiology and Biomechanics Laboratory, Faculty of Kinesiology and Rehabilitation Sciences, Tervuursevest 101, B 3001 Leuven, Belgium
    J Appl Physiol (1985) 98:1228-33. 2005
    ..Furthermore, the present observations indicate that AMPK probably is not implicated in the previously reported beneficial effects of oral creatine supplementation on muscle during immobilization and rehabilitative weight training...
  14. ncbi request reprint No effects of lifelong creatine supplementation on sarcopenia in senescence-accelerated mice (SAMP8)
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Faculty of Kinesiology and Rehabilitation Sciences, Tervuursevest 101, B 3001 Leuven, Belgium
    Am J Physiol Endocrinol Metab 289:E272-7. 2005
    ..It is concluded that lifelong creatine supplementation is no effective strategy to prevent sarcopenia in senescence-accelerated mice...
  15. doi request reprint Important role of muscle carnosine in rowing performance
    Audrey Baguet
    Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 109:1096-101. 2010
    ....
  16. doi request reprint Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans
    Inge Everaert
    Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    Am J Physiol Renal Physiol 302:F1537-44. 2012
    ..In conclusion, low plasma carnosinase activity promotes the presence of circulating carnosine upon an oral challenge. These data may further clarify the link among CNDP1 genotype, carnosinase, and diabetic nephropathy...
  17. doi request reprint Gene expression of carnosine-related enzymes and transporters in skeletal muscle
    Inge Everaert
    Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium
    Eur J Appl Physiol 113:1169-79. 2013
    ..Collectively, these data show that muscle carnosine homeostasis is regulated by nutritional and hormonal stimuli in a complex interplay between related transporters and enzymes...
  18. doi request reprint The influence of sex, age and heritability on human skeletal muscle carnosine content
    Audrey Baguet
    Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium
    Amino Acids 43:13-20. 2012
    ..Muscle carnosine decreased mainly during early adulthood and hardly from adulthood to elderly. High intra-twin correlations were observed, but muscle-dependent differences preclude clear conclusions toward heritability...
  19. ncbi request reprint Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Physical Education and Physiotherapy, K U Leuven, B 3001, Leuven, Belgium
    Neurobiol Dis 13:264-72. 2003
    ..Furthermore, creatine intake does not exert a beneficial effect on muscle function in a transgenic mouse model of ALS...
  20. doi request reprint Meal and beta-alanine coingestion enhances muscle carnosine loading
    Sanne Stegen
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Med Sci Sports Exerc 45:1478-85. 2013
    ..We hypothesize that, by analogy with creatine supplementation, 1) an inverse relationship between urinary excretion and muscle loading is present, and 2) the latter is stimulated by carbohydrate- and protein-induced insulin action...
  21. pmc A new method for non-invasive estimation of human muscle fiber type composition
    Audrey Baguet
    Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 6:e21956. 2011
    ..Until today, the muscle biopsy method is still accepted as gold standard to measure muscle fiber type composition. Because of its invasive nature and high sampling variance, it would be useful to develop a non-invasive alternative...
  22. ncbi request reprint Creatine supplementation in health and disease: what is the evidence for long-term efficacy?
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Physical Education and Physiotherapy, Catholic University of Leuven, Leuven, Belgium
    Mol Cell Biochem 244:49-55. 2003
    ..The primary purpose of the present review article is to critically evaluate the available evidence for long-term efficacy of creatine administration and to hypothesize about ways to optimize creatine administration regimens...
  23. doi request reprint Use of β-alanine as an ergogenic aid
    Wim Derave
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Nestle Nutr Inst Workshop Ser 75:99-108. 2013
    ..This chapter aims to (1) discuss the scientific basis and physiological background of β-alanine and its synthesis product carnosine, and (2) translate these scientific findings to practical applications in sports...
  24. pmc A simple exoskeleton that assists plantarflexion can reduce the metabolic cost of human walking
    Philippe Malcolm
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 8:e56137. 2013
    ..The main research question of our study was whether it is possible to obtain a higher reduction in metabolic cost by tuning the actuation timing...
  25. doi request reprint Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exercise
    Katrien Koppo
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Med Sci Sports Exerc 41:1626-32. 2009
    ..To test the hypothesis that L-arginine (the substrate for nitric oxide synthase [NOS]) administration slows the VO2 kinetics at the onset of moderate-intensity exercise in humans...
  26. doi request reprint Genetic variations in the androgen receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men
    Hélène De Naeyer
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 9:e86235. 2014
    ..Therefore, we aim to investigate the relationship between genetic variations in the AR, circulating androgens and muscle mass and function in young healthy male siblings...
  27. doi request reprint Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise training
    Sanne Stegen
    Department Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium
    Obes Surg 21:61-70. 2011
    ..The purpose of this pilot study is to investigate the effect of gastric bypass surgery on physical fitness and to determine if an exercise program in the first 4 months is beneficial...
  28. ncbi request reprint Effects of post-absorptive and postprandial exercise on glucoregulation in metabolic syndrome
    Wim Derave
    Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, K U Leuven, Tervuursevest 101, B 3001 Leuven, Belgium
    Obesity (Silver Spring) 15:704-11. 2007
    ..It is hypothesized that post-absorptive exercise enhances fat oxidation rate during exercise and thereafter attenuates the glucose and insulin response to subsequent meals...
  29. ncbi request reprint Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Katholieke Universiteit Leuven, 3001, Belgium
    J Appl Physiol (1985) 94:1910-6. 2003
    ..Furthermore, combined protein and creatine supplementation improved oral glucose tolerance, which is supposedly unrelated to the changes in muscle GLUT-4 expression...
  30. ncbi request reprint Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans
    Wim Derave
    Laboratory of Exercise Physiology and Biomechanics, Faculty of Physical Education and Physiotherapy, Katholieke Universiteite Leuven, B 3001 Leuven, Belgium
    J Appl Physiol (1985) 97:852-7. 2004
    ..Furthermore, these data suggest that this leads to enhanced utilization of arginine as a substrate for secondary pathways...
  31. ncbi request reprint Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise
    Farah S L Thong
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Canada
    Diabetes 51:583-90. 2002
    ....
  32. ncbi request reprint Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS
    Wim Derave
    Dept of Biomedical Kinesiology, Katholieke Universiteit Leuven, B 3001 Leuven, Belgium
    Am J Physiol Endocrinol Metab 291:E1250-7. 2006
    ..The increased creatine uptake is paralleled by an increased cell surface expression of the creatine transporter...
  33. ncbi request reprint Exercise programs for older men: mode and intensity to induce the highest possible health-related benefits
    Christophe Delecluse
    Department of Kinesiology, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Belgium
    Prev Med 39:823-33. 2004
    ..Additionally, effects of moderate- and low-intensity resistance training are compared...
  34. ncbi request reprint Prior exercise increases basal and insulin-induced p38 mitogen-activated protein kinase phosphorylation in human skeletal muscle
    Farah S L Thong
    Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Appl Physiol (1985) 94:2337-41. 2003
    ..Because p38 MAPK has been suggested to play a necessary role in activation of GLUT-4 at the cell surface, the present data may suggest a putative role of p38 MAPK in the increased insulin sensitivity of skeletal muscle after exercise...
  35. doi request reprint Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation
    Bertrand Leger
    Clinique Romande de Réadaptation SuvaCare, Sion, Switzerland
    Rejuvenation Res 11:163-175B. 2008
    ..Human sarcopenia may be linked to a reduction in the activity or sensitivity of anabolic signaling proteins such as GHR, IGF-1, and Akt. TNFalpha, SOCS-3, and myostatin are potential candidates influencing this anabolic perturbation...
  36. ncbi request reprint Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1
    Bertrand Leger
    Clinique romande de réadaptation, SuvaCare, Sion, Switzerland
    FASEB J 20:583-5. 2006
    ..The transcriptional regulation of human atrogin-1 may be controlled by an Akt-mediated transcription factor other than FKHR or via another signaling pathway...