Petra De Sutter
Affiliation: Ghent University
Taelman J, Popovic M, Bialecka M, Tilleman L, Warrier S, Van der Jeught M, et al
. WNT inhibition and increased FGF signalling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation. Stem Cells Dev. 2019;: pubmed publisher
..Overall, DhiFI hESCs retained advantages of both primed and naive pluripotency and may ultimately represent a more favourable starting point for differentiation towards clinically desired cell types. ..
Heindryckx B, Neupane J, Vandewoestyne M, Christodoulou C, Jackers Y, Gerris J, et al
. Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis. Mitochondrion. 2014;18:12-7 pubmed publisher
..95). This is the first case of mutation-free baby born from a MELAS patient after TE biopsy and supports the applicability of blastocyst PGD for patients with mtDNA disorders to establish healthy offspring. ..
Neupane J, Vandewoestyne M, Ghimire S, Lu Y, Qian C, Van Coster R, et al
. Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice. Mitochondrion. 2014;18:27-33 pubmed publisher
..We show that NT in the germ line is potent to prevent transmission of heritable mtDNA disorders with the applicability for patients attempting reproduction. ..
Heras S, De Coninck D, Van Poucke M, Goossens K, Bogado Pascottini O, Van Nieuwerburgh F, et al
. Suboptimal culture conditions induce more deviations in gene expression in male than female bovine blastocysts. BMC Genomics. 2016;17:72 pubmed publisher
..Male embryos appeared to be most affected by suboptimal in vitro culture, i.e. in the presence of serum. ..
De Sutter P, Bontinck J, Schutysers V, Van Der Elst J, Gerris J, Dhont M. First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction. Hum Reprod. 2006;21:1907-11 pubmed
..It is unknown whether first-trimester bleeding, if not ending in a spontaneous abortion, negatively influences further pregnancy outcome in ART in singletons...
De Sutter P. Considerations for clinics and practitioners treating foreign patients with assisted reproductive technology: lessons from experiences at Ghent University Hospital, Belgium. Reprod Biomed Online. 2011;23:652-6 pubmed publisher
..All should be done to avoid that cross-border patients compromise the local care system. Special arrangements should be taken to manage possible complications following treatment...