Norbert De Kimpe

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Daphnane-type diterpene orthoesters and their biological activities
    Weidong He
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, B 9000, Belgium
    Mini Rev Med Chem 2:185-200. 2002
  2. doi Solvent-controlled selective transformation of 2-bromomethyl-2-methylaziridines to functionalized aziridines and azetidines
    Sonja Stanković
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:3181-90. 2012
  3. doi Nucleophile-directed selective transformation of cis-1-tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines
    Sara Kenis
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Chemistry 19:5966-71. 2013
  4. doi Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study
    Hannelore Goossens
    Center for Molecular Modeling, Ghent University, Member of QCMM Alliance Ghent Brussels, Technologiepark 903, B 9052 Zwijnaarde, Belgium
    J Org Chem 76:8698-709. 2011
  5. doi Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH₄-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines and evaluation of their antimalarial activity
    Matthias D'hooghe
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Bioorg Med Chem Lett 23:1507-10. 2013
  6. doi Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines
    Gert Callebaut
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 10:2326-38. 2012
  7. doi Opposite regiospecific ring opening of 2-(cyanomethyl)aziridines by hydrogen bromide and benzyl bromide: experimental study and theoretical rationalization
    Saron Catak
    Center for Molecular Modeling, Ghent University, Technologiepark 903, B 9052 Zwijnaarde, Belgium
    J Org Chem 75:4530-41. 2010
  8. doi Diastereoselective aldol reaction of zincated 3-chloro-3-methyl-1-azaallylic anions as key step in the synthesis of 1,2,3,4-tetrasubstituted 3-chloroazetidines
    Sven Mangelinckx
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:3415-25. 2012
  9. doi Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines
    Karen Mollet
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:8364-75. 2011
  10. ncbi Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Med Chem 52:4058-62. 2009

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi Daphnane-type diterpene orthoesters and their biological activities
    Weidong He
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, B 9000, Belgium
    Mini Rev Med Chem 2:185-200. 2002
    ..The occurrence, biological activity, and molecular pharmacology of these compounds will be reviewed...
  2. doi Solvent-controlled selective transformation of 2-bromomethyl-2-methylaziridines to functionalized aziridines and azetidines
    Sonja Stanković
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:3181-90. 2012
    ..In addition, the experimentally observed solvent-dependent behavior of 2-bromomethyl-2-methylaziridines was further supported by means of DFT calculations...
  3. doi Nucleophile-directed selective transformation of cis-1-tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines
    Sara Kenis
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Chemistry 19:5966-71. 2013
    ....
  4. doi Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study
    Hannelore Goossens
    Center for Molecular Modeling, Ghent University, Member of QCMM Alliance Ghent Brussels, Technologiepark 903, B 9052 Zwijnaarde, Belgium
    J Org Chem 76:8698-709. 2011
    ....
  5. doi Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH₄-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines and evaluation of their antimalarial activity
    Matthias D'hooghe
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Bioorg Med Chem Lett 23:1507-10. 2013
    ..Furthermore, the proposed mode of action was supported by ligand docking studies, pointing to a strong binding interaction with the enzyme plasmepsin II...
  6. doi Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines
    Gert Callebaut
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 10:2326-38. 2012
    ....
  7. doi Opposite regiospecific ring opening of 2-(cyanomethyl)aziridines by hydrogen bromide and benzyl bromide: experimental study and theoretical rationalization
    Saron Catak
    Center for Molecular Modeling, Ghent University, Technologiepark 903, B 9052 Zwijnaarde, Belgium
    J Org Chem 75:4530-41. 2010
    ....
  8. doi Diastereoselective aldol reaction of zincated 3-chloro-3-methyl-1-azaallylic anions as key step in the synthesis of 1,2,3,4-tetrasubstituted 3-chloroazetidines
    Sven Mangelinckx
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:3415-25. 2012
    ..DFT calculations revealed that chelation of both zinc and lithium cations in the transition state structure leads to the experimentally observed high syn diastereoselectivity of aldol reactions...
  9. doi Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines
    Karen Mollet
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:8364-75. 2011
    ..Furthermore, cis-4-bromo-3-(phenoxy or benzyloxy)piperidines were elaborated into the piperidin-3-one framework via dehydrobromination followed by acid hydrolysis...
  10. ncbi Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, B 9000 Ghent, Belgium
    J Med Chem 52:4058-62. 2009
    ..Eleven compounds exhibited antimalarial activity with IC(50) values of <or=30 microM, and the majority of these compounds did not show cytotoxicity at the concentrations tested...
  11. ncbi Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity
    Karen Mollet
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Chemistry 19:3383-96. 2013
    ..Furthermore, additional insights into the mechanism and the factors governing this new ring-expansion reaction were provided by means of density functional theory calculations...
  12. doi Synthesis of 4-substituted 3,3-difluoropiperidines
    Riccardo Surmont
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    J Org Chem 75:929-32. 2010
    ..4-Benzyloxy-3,3-difluoropiperidine was prepared using an analogous methodology and was converted to N-protected 3,3-difluoro-4,4-dihydroxypiperidine, a compound with high potential as a building block in medicinal chemistry...
  13. ncbi Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes
    Karel Vervisch
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 75:7734-44. 2010
    ..3.1]nonanes. ..
  14. ncbi Identification of volatile markers for indoor fungal growth and chemotaxonomic classification of Aspergillus species
    Viviana Polizzi
    Department of Sustainable Organic Chemistry and Technology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Fungal Biol 116:941-53. 2012
    ..These results are useful in the chemotaxonomic discrimination of fungal species, in aid to the classical morphological and molecular identification techniques...
  15. doi Synthesis of new functionalized aziridine-2- and azetidine-3-carboxylic acid derivatives of potential interest for biological and foldameric applications
    Asta Zukauskaitė
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
    Amino Acids 41:541-58. 2011
    ....
  16. doi Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic acid
    Eva Van Hende
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 74:2250-3. 2009
    ..Changing the N-protecting group to a Boc-group allows further oxidation to 1-Boc-3-fluoroazetidine-3-carboxylic acid, a new fluorinated heterocyclic amino acid...
  17. doi A new entry into cis-3-amino-2-methylpyrrolidines via ring expansion of 2-(2-hydroxyethyl)-3-methylaziridines
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000, Ghent, Belgium
    Org Biomol Chem 7:135-41. 2009
    ..Thus, a new formal synthesis of the antipsychotic emonapride was developed through preparation and further aroylation of cis-3-amino-1-benzyl-2-methylpyrrolidine...
  18. ncbi JEM Spotlight: Fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings
    Viviana Polizzi
    Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Food Analysis, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Environ Monit 11:1849-58. 2009
    ..and Cladosporium spp. In addition, one hundred and seventeen (M)VOCs were identified, especially linear alkanes (C(9)-C(17)), aldehydes, aromatic compounds and monoterpenes...
  19. doi Asymmetric synthesis of new chiral N-sulfinyl 2,2-disubstituted aziridines by Grignard additions across alpha-chloro N-sulfinyl ketimines
    Filip Colpaert
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 8:3251-8. 2010
    ..The stereoselectivity obtained in the Grignard addition is rationalized by the coordinating ability of the alpha-chloro atom resulting in the opposite stereochemical outcome as observed for nonfunctionalized N-sulfinyl ketimines...
  20. doi Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines
    Stéphanie Vandekerckhove
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Bioorg Med Chem Lett 23:318-22. 2013
    ..falciparum with IC(50)-values ranging between 150 and 680 nM...
  21. doi Influence of various growth parameters on fungal growth and volatile metabolite production by indoor molds
    Viviana Polizzi
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Sci Total Environ 414:277-86. 2012
    ..Results show that, even at suboptimal conditions for growth, production of fungal volatiles can be significant...
  22. doi Regioselectivity in the ring opening of non-activated aziridines
    Sonja Stanković
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Chem Soc Rev 41:643-65. 2012
    ..This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references)...
  23. ncbi A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran
    Karel Vervisch
    Dep of Organic Chemistry, Fac of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000, Ghent, Belgium
    Org Biomol Chem 7:3271-9. 2009
    ....
  24. ncbi Stereoselective synthesis of trans- and cis-2-aryl-3-(hydroxymethyl)aziridines through transformation of 4-aryl-3-chloro-beta-lactams and study of their ring opening
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 8:607-15. 2010
    ..cis-2-Aryl-3-(hydroxymethyl)aziridines were shown to be highly reluctant to undergo ring opening by LiAlH(4) and MeOH under similar reaction conditions...
  25. ncbi Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines
    Guido Verniest
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 8:2509-12. 2010
    ..The key step of the synthetic pathway involves the regioselective bromofluorination of N-Boc-4-methylenepiperidine and 3-methylenepyrrolidine using Et(3)N.3HF and NBS...
  26. doi Synthesis of the natural products 3-hydroxymollugin and 3-methoxymollugin
    Mudiganti Naga Venkata Sastry
    Department of Organic Chemistry, Faculty of Bioscience Engineering Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 75:2274-80. 2010
    ..The latter oxidation process results in 3-hydroxymollugin 2 along with the rearranged furomollugin 4, which is a ring-contracted analogue of the natural product mollugin 1...
  27. doi Furan formation from lipids in starch-based model systems, as influenced by interactions with antioxidants and proteins
    Agnieszka Owczarek-Fendor
    Department of Food Safety and Food Quality, NutriFOODchem Unit, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 59:2368-76. 2011
    ..This was also the case when fresh oils were applied, shown previously to be nearly unable to generate furan. This observation can be explained by an intensified ascorbic acid degradation stimulated by the presence of lipids...
  28. doi Asymmetric synthesis of chiral N-sulfinyl 3-alkyl- and 3-arylpiperidines by α-alkylation of N-sulfinyl imidates with 1-chloro-3-iodopropane
    Filip Colpaert
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:234-44. 2011
    ..Finally, the N-tert-butanesulfinylpiperidines could be efficiently deprotected to enantiomerically pure 3-alkyl- and 3-arylpiperidine hydrochlorides...
  29. doi Stereoselective synthesis of chiral 4-(1-chloroalkyl)-beta-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines
    Stijn Dekeukeleire
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 75:5934-40. 2010
    ....
  30. doi Palladium(II)-catalyzed synthesis of 2H,3'H-spiro[benzofuran-3,2'-naphthoquinones]
    Pieter Claes
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 78:8330-9. 2013
    ..Unsubstituted or ortho-substituted 2-aryloxymethyl-1,4-quinones were found to rearrange toward the corresponding 2-(4-hydroxyaryl)-1,4-quinones upon treatment with trifluoroacetic acid. ..
  31. doi Impact of the N-terminal amino acid on the formation of pyrazines from peptides in Maillard model systems
    Fien Van Lancker
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 60:4697-708. 2012
    ..It is clear that different mechanisms must be responsible for this observation. This study clearly illustrates the capability of peptides to produce flavor compounds such as pyrazines...
  32. doi Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones
    Karel Vervisch
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Lett 14:106-9. 2012
    ....
  33. doi Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates
    Karel Vervisch
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 10:3308-14. 2012
    ..Furthermore, these 2-(cyanomethyl)piperidines were shown to be eligible substrates for the preparation of methyl cis-(1-arylmethyl-4-piperidin-2-yl)acetates through a Pinner reaction using gaseous HCl in methanol...
  34. doi Amino acid catalysis of 2-alkylfuran formation from lipid oxidation-derived α,β-unsaturated aldehydes
    An Adams
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 59:11058-62. 2011
    ....
  35. doi Synthesis of 3-methoxyazetidines via an aziridine to azetidine rearrangement and theoretical rationalization of the reaction mechanism
    Sonja Stanković
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:2157-67. 2011
    ..A thorough insight into the reaction mechanism was provided by both experimental study and theoretical rationalization...
  36. doi Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone
    Sara Kenis
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000, Ghent, Belgium
    Org Biomol Chem 9:7217-23. 2011
    ....
  37. doi Asymmetric synthesis of 2-arylpyrrolidines starting from gamma-chloro N-(tert-butanesulfinyl)ketimines
    Erika Leemans
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Chem Commun (Camb) 46:3122-4. 2010
    ....
  38. doi Model studies on the pattern of volatiles generated in mixtures of amino acids, lipid-oxidation-derived aldehydes, and glucose
    An Adams
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 59:1449-56. 2011
    ..These results suggest that amino-acid-induced degradations and further reactions of lipid oxidation products may be of considerable importance in thermally processed foods...
  39. ncbi Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride
    Sonja Stanković
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 8:4266-73. 2010
    ..Additionally, 2-(methoxymethyl)- and 2-(phenoxymethyl)aziridines were treated with LiAlH(4) under microwave irradiation, giving rise to either isopropylamines or 1-methoxypropan-2-amines depending on the reaction conditions...
  40. ncbi Asymmetric synthesis of chloroisothreonine derivatives via syn-stereoselective Mannich-type additions across N-sulfinyl-α-chloroimines
    Gert Callebaut
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 12:3393-405. 2014
    ..These novel chloroisothreonine derivatives proved to be excellent building blocks in asymmetric synthesis of novel syn-β,γ-aziridino-α-hydroxy esters and biologically relevant trans-oxazolidinone carboxylic esters. ..
  41. ncbi 2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis
    Pieter Claes
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Eur J Med Chem 77:409-21. 2014
    ..tb. The study was further extended with a comet assay and a VITOTOX™ assay to investigate the possibility of observable genotoxic effects caused by these compounds. ..
  42. doi Highly stereoselective synthesis of beta-lactams utilizing alpha-chloroimines as new and powerful chiral inductors
    Matthias D'hooghe
    Department of Organic Chemistry, Ghent University, Coupure Links 653, Ghent, Belgium
    Chemistry 14:6336-40. 2008
  43. doi Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts
    Sara Kenis
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:5982-92. 2012
    ....
  44. doi On-fiber furan formation from volatile precursors: a critical example of artefact formation during Solid-Phase Microextraction
    An Adams
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 897:37-41. 2012
    ..Especially when performing precursor studies, static headspace sampling should preferably be applied for furan analysis...
  45. doi Autoregulatory properties of (+)-thujopsene and influence of environmental conditions on its production by Penicillium decumbens
    Viviana Polizzi
    Faculty of Bioscience Engineering, Department of Sustainable Organic Chemistry and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Microb Ecol 62:838-52. 2011
    ..Few data are present in the literature about chemical communication between fungi. The present research could, therefore, contribute to understanding fungal metabolism and behaviour in indoor environments...
  46. pmc Use of medicinal plants and pharmaceuticals by indigenous communities in the Bolivian Andes and Amazon
    Ina Vandebroek
    Research Associate, Ghent University, Laboratory of Tropical and Subtropical Agriculture and Ethnobotany, Coupure Links 653, B 9000 Ghent, Belgium
    Bull World Health Organ 82:243-50. 2004
    ....
  47. doi Formation of pyrazines in Maillard model systems of lysine-containing dipeptides
    Fien Van Lancker
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 58:2470-8. 2010
    ..This study clearly illustrates the capability of peptides to produce flavor compounds that can differ from those obtained from the corresponding reactions with free amino acids...
  48. doi New synthesis of 3-fluoropyrroles
    Riccardo Surmont
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 74:1377-80. 2009
    ..2.2]octane bistetrafluoroborate) and subsequent aromatization by dehydrofluorination. This methodology provides a new and easy entry toward various new 3-fluorinated pyrroles...
  49. doi Asymmetric synthesis of α-chloro-β-amino-N-sulfinyl imidates as chiral building blocks
    Filip Colpaert
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:2204-13. 2011
    ..The obtained absolute anti-diastereoselectivity is the opposite of the stereochemical outcome observed for α-methyl-substituted imidates...
  50. doi Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines
    Riccardo Surmont
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 8:4514-7. 2010
    ..In a second strategy, iodolactonization of 2,2-difluoro-4-pentenoic acid gave the corresponding γ-lactone, which was transformed into 5-hydroxy-3,3-difluoropiperidine...
  51. doi Intramolecular pi-pi stacking interactions in 2-substituted N,N-dibenzylaziridinium ions and their regioselectivity in nucleophilic ring-opening reactions
    Saron Catak
    Center for Molecular Modeling, Ghent University, Technologiepark 903, B 9052 Zwijnaarde, Belgium
    J Org Chem 75:885-96. 2010
    ....
  52. pmc Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity
    Matthias D'hooghe
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Beilstein J Org Chem 7:1745-52. 2011
    ....
  53. ncbi Four-membered heterocycles with a carbon-heteroatom exocyclic double bond at the 3-position: puckering potential and thermodynamic properties
    Peter Vansteenkiste
    Center of Molecular Modeling, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
    J Phys Chem A 111:2797-803. 2007
    ..Moreover, the correct description of the puckering potential with the hindered rotor treatment leads to substantial corrections on the thermodynamic properties in the harmonic oscillator approximation...
  54. doi Diastereoselective synthesis of bicyclic gamma-lactams via ring expansion of monocyclic beta-lactams
    Stijn Dekeukeleire
    Department of Organic Chemistry, Faculty of Bioscience Engineering, UGhent University, Coupure Links 653, B 9000 UGhent, Belgium
    J Org Chem 74:1644-9. 2009
    ..The intermediate N-acyliminium ions were formed by ring expansion of the starting beta-lactams through generation of a transient silver(I)-induced carbenium ion...
  55. doi Novel diastereoselective synthesis of bicyclic beta-lactams through radical cyclization and their reduction toward 2-(1-alkoxy-2-hydroxyethyl)piperidines and 2-(1-alkoxy-2-hydroxyethyl)azepanes
    Erika Leemans
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 73:1422-8. 2008
    ..2.0]octane-8-ones and 1-azabicyclo[5.2.0]nonan-9-ones with lithium aluminum hydride resulted in novel 2-(1-alkoxy-2-hydroxyethyl)piperidines and -azepanes, which were isolated as single isomers...
  56. doi Transformation of trans-4-aryl-3-chloro-1-(2-chloroethyl)azetidin-2-ones into 3-aryl-2-(ethylamino)propan-1-ols via intermediate 1-(1-aryl-2-chloro-3-hydroxypropyl)aziridines and trans-2-aryl-3-(hydroxymethyl)aziridines
    Karen Mollet
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 76:264-9. 2011
    ....
  57. doi Theoretical study on the structural properties of various solvated metalated 3-halo-1-azaallylic anions
    Bart De Sterck
    Center for Molecular Modeling, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
    J Phys Chem A 113:6375-80. 2009
    ..Calculations on dimerization energies show that coordination with THF is energetically preferred over aggregation...
  58. ncbi Gold-catalyzed synthesis of 2-aryl-3-fluoropyrroles
    Riccardo Surmont
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Lett 11:2920-3. 2009
    ..Difluorinated homopropargylamines are prepared by the addition of gem-difluoropropargyllithium reagents to arylated N-tosylimines...
  59. ncbi Convenient synthesis of trans-beta-amino carboxylic esters with an azetidine skeleton via rearrangement of beta,gamma-aziridino alpha-amino esters
    Lorand Kiss
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Lett 9:4399-402. 2007
    ....
  60. doi Formation of pyrazines and a novel pyrrole in Maillard model systems of 1,3-dihydroxyacetone and 2-oxopropanal
    An Adams
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 56:2147-53. 2008
    ..These results underscore the importance of the ratio of the different reagents and the presence of water in the resulting flavor formation in the Maillard reaction...
  61. ncbi Impact of lipid oxidation-derived aldehydes and ascorbic acid on the antioxidant activity of model melanoidins
    Vaida Kitryté
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Food Chem 135:1273-83. 2012
    ..Water-soluble high molecular weight (>12kDa) and nonsoluble fractions comprised the major part of the antioxidants derived from amino acid/lipid oxidation product model systems, with or without glucose or ascorbic acid...
  62. doi Rearrangement of N-tert-butanesulfinyl α-halo imines with alkoxides to N-tert-butanesulfinyl 2-amino acetals as precursors of N-protected and N-unprotected α-amino carbonyl compounds
    Filip Colpaert
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 77:6023-32. 2012
    ..Via this method, an asymmetric synthesis of (S)-cathinone hydrochloride (er 94:6) was achieved...
  63. doi Synthesis of 3-amino-4-fluoropyrazoles
    Riccardo Surmont
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    J Org Chem 76:4105-11. 2011
    ..2.2]octane bis(tetrafluoroborate) (Selectfluor) toward the corresponding monofluorinated enaminoketones, followed by condensation with different hydrazines...
  64. doi New general synthesis of α-alkoxyketones via α'-alkylation, α-alkylation and α,α'-dialkylation of α-alkoxyketimines
    Filip Colpaert
    Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Biomol Chem 9:549-58. 2011
    ..Hydrolysis of the imino function led to the desired substituted α-alkoxyketones. The ratio of α-, α'-, and α,α'-(di)alkylated compounds depended on the amount of base used and on the nature of the alkylating reagent...
  65. doi Mechanistic insights into furan formation in Maillard model systems
    Fien Van Lancker
    Department of Sustainable Organic Chemistry and Technology, Ghent University, Ghent, Belgium
    J Agric Food Chem 59:229-35. 2011
    ....
  66. ncbi Asymmetric synthesis of aziridines by reduction of N-tert-butanesulfinyl alpha-chloro imines
    Bram Denolf
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 72:3211-7. 2007
    ..All chiral aziridines were obtained as a single diastereomer after recrystallization (overall yield up to 91%) or after flash chromatography...
  67. ncbi Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams
    Willem Van Brabandt
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 71:7083-6. 2006
    ..Especially the hydride reduction of 4-imidoyl-1-(2- and 3-haloalkyl)azetidin-2-ones turned out to be an efficient and straightforward method for the preparation 2-substituted piperazines and 1,4-diazepanes...
  68. doi New entries toward 3,3-difluoropiperidines
    Guido Verniest
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 73:5458-61. 2008
    ..In addition, this methodology was applied to establish the first synthesis of N-protected 3,3-difluoropipecolic acid, a new fluorinated amino acid...
  69. ncbi An easy stereoselective access to beta,gamma-aziridino alpha-amino ester derivatives via mannich reaction of benzophenone imines of glycine esters with N-sulfonyl alpha-chloroaldimines
    Lorand Kiss
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 72:7199-206. 2007
    ....
  70. doi Use of headspace SPME-GC-MS for the analysis of the volatiles produced by indoor molds grown on different substrates
    Fien Van Lancker
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Environ Monit 10:1127-33. 2008
    ..and are potentially interesting for the monitoring of this fungal genus. Further experiments will be performed with other Penicillium spp. to study the possibility that these two compounds are specific for this group of molds...
  71. doi Asymmetric synthesis of alpha-alkylated N-sulfinyl imidates as new chiral building blocks
    Filip Colpaert
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 74:3792-7. 2009
    ..Hydrolysis of the alpha-benzylated imidate hydrochlorides afforded the corresponding chiral esters with >95% ee...
  72. doi Electrophile-induced bromocyclization of gamma,delta-unsaturated ketimines to intermediate 1-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Belgium
    Org Biomol Chem 6:3667-9. 2008
    ....
  73. doi Asymmetric synthesis of new chiral beta-amino acid derivatives by Mannich-type reactions of chiral N-sulfinyl imidates with N-tosyl aldimines
    Filip Colpaert
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Org Lett 12:1904-7. 2010
    ..Hydrolysis of the imidate hydrochlorides afforded the corresponding chiral beta-sulfonylamino esters with >98% ee as new chiral beta-amino acid derivatives...
  74. ncbi Thermal degradation studies of food melanoidins
    An Adams
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 53:4136-42. 2005
    ....
  75. ncbi Synthesis of 3-fluoroazetidines
    Willem Van Brabandt
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 71:7100-2. 2006
    ..N-(Alkylidene or 1-arylmethylidene)-2-propenylamines were regiospecifically functionalized to novel N-(alkylidene or 1-arylmethylidene)-3-bromo-2-fluoropropylamines, which were proven to be excellent precursors for 3-fluoroazetidines...
  76. ncbi Novel synthesis of 3,4-diaminobutanenitriles and 4-amino-2-butenenitriles from 2-(cyanomethyl)aziridines through intermediate aziridinium salts: an experimental and theoretical approach
    Veronique van Speybroeck
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 72:4733-40. 2007
    ..The results were rationalized on the basis of ab initio calculations...
  77. ncbi Synthesis of 2-chloro-2-imidoylaziridines via aza-Darzens-type reaction of 3,3-dichloro-1-azaallylic anions and N-(arylsulfonyl)imines
    Nicola Giubellina
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 71:5881-7. 2006
    ..The latter 2-(aminomethyl)aziridines 27 represent stereochemically defined small azaheterocyclic rings which were scarcely reported in the literature...
  78. ncbi Synthesis and reactivity of 1-substituted 2-fluoro- and 2,2-difluoroaziridines
    Guido Verniest
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 72:8569-72. 2007
    ..These reactions point to the divergent reactive behavior of monofluoro- and difluoroaziridines...
  79. ncbi Heteroaryl cross-coupling as an entry toward the synthesis of lavendamycin analogues: a model study
    Guido Verniest
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    J Org Chem 75:424-33. 2010
    ....
  80. doi Impact of various food ingredients on the retention of furan in foods
    Fien Van Lancker
    Department of Organic Chemistry, Ghent University, Belgium
    Mol Nutr Food Res 53:1505-11. 2009
    ..In addition, in this case, the highest retention was found in baby foods with added oils. Baby food containing spinach showed the highest furan concentration (172 ppb) as well as the highest furan retention...
  81. doi Experimental and computational study of the conrotatory ring opening of various 3-chloro-2-azetines
    Sven Mangelinckx
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Org Chem 73:5481-8. 2008
    ....
  82. doi Efficient synthesis of cis- and trans-3,4-dihydroxy-3,4-dihydromollugin
    Naga Venkata Sastry Mudiganti
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Org Chem 73:3867-74. 2008
    ..The synthesis of trans-3,4-dihydroxy-3,4-dihydromollugin was achieved using Oxone in good yield. A mechanism for the formation of cis-3,4-dihydroxymollugin acetonide from the reaction of mollugin with Oxone is proposed...
  83. doi Reactivity of N-(omega-haloalkyl)-beta-lactams with regard to lithium aluminium hydride: novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridines and 3-aryl-3-(N-propylamino)propan-1-ols
    Matthias D'hooghe
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000, Ghent, Belgium
    Org Biomol Chem 6:1190-6. 2008
    ....
  84. ncbi Flavour analysis of Greek white wine by solid-phase microextraction-capillary gas chromatography-mass spectrometry
    Jan C R Demyttenaere
    Department of Organic Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4, B 9000 Ghent, Belgium
    J Chromatogr A 985:233-46. 2003
    ..The optimised SPME method was then applied to investigate the qualitative aroma composition of three other Greek wines, namely Zitsa, Limnos and Filoni...
  85. ncbi Analysis of volatiles of malt whisky by solid-phase microextraction and stir bar sorptive extraction
    Jan C R Demyttenaere
    Deparment of Organic Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4, B 9000 Ghent, Belgium
    J Chromatogr A 985:221-32. 2003
    ..An optimum SPME method was developed. Finally a more recent sample preparation technique, namely SBSE was evaluated to extract whisky volatiles...
  86. ncbi De novo production of (+)-aristolochene by sporulated surface cultures of Penicillium roqueforti
    Jan C R Demyttenaere
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Phytochemistry 59:597-602. 2002
    ..04 mg/ml of culture) was obtained with the latter medium. The biosynthesis of (+)-aristolochene showed a maximum during the fourth day after inoculation...
  87. ncbi Use of headspace solid-phase microextraction and headspace sorptive extraction for the detection of the volatile metabolites produced by toxigenic Fusarium species
    Jan C R Demyttenaere
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent B 9000, Belgium
    J Chromatogr A 1027:147-54. 2004
    ....
  88. ncbi A comparison of traditional healers' medicinal plant knowledge in the Bolivian Andes and Amazon
    Ina Vandebroek
    Faculty of Agriculture and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent B 9000, Belgium
    Soc Sci Med 59:837-49. 2004
    ..It is hypothesised that social factors underlying traditional medical practices (background of extensive family in traditional medicine) play an important role in transmission--and hence survival of knowledge on medicinal plants...
  89. ncbi Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii
    Weidong He
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, Belgium
    Bioorg Med Chem 10:3245-55. 2002
    ..Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays...
  90. ncbi Thermal degradation studies of glucose/glycine melanoidins
    Kourosch Abbaspour Tehrani
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 50:4062-8. 2002
    ..These results demonstrate the possibility of producing some flavor-significant volatiles from heated standard melanoidins at temperatures relevant to food preparation and contribute to the flavor aspects originating from melanoidins...
  91. ncbi Characterization of model melanoidins by the thermal degradation profile
    An Adams
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 51:4338-43. 2003
    ..Nonsoluble glucose/glycine melanoidins were also subjected to an oxidation. The results indicate that the thermal degradation profile is a useful tool in the characterization of different types of melanoidins...
  92. ncbi New pyranonaphthoquinone and pyranonaphthohydroquinone from the roots of Pentas longiflora
    Samir El-Hady
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Belgium
    J Nat Prod 65:1377-9. 2002
    ....
  93. ncbi A benzochromene from the roots of Pentas bussei
    Jacques F Bukuru
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Nat Prod 65:783-5. 2002
    ..The structure of this new compound was determined by spectroscopic data interpretation...
  94. ncbi Biotransformation of (R)-(+)- and (S)-(-)-citronellol by Aspergillus sp. and Penicillium sp., and the use of solid-phase microextraction for screening
    Jan C R Demyttenaere
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Chromatogr A 1027:137-46. 2004
    ..5 and when heat treatment (steam distillation solvent extraction) was applied...
  95. ncbi Chemistry of 2-acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine, 2-acetyl-2-thiazoline, and 5-acetyl-2,3-dihydro-4H-thiazine: extraordinary Maillard flavor compounds
    An Adams
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Chem Rev 106:2299-319. 2006
  96. doi Modification of casein by the lipid oxidation product malondialdehyde
    An Adams
    Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Agric Food Chem 56:1713-9. 2008
    ..Clearly, the contribution of lipid oxidation products, such as malondialdehyde, to protein modification (both in food and in vivo) can be substantial and needs to be taken into account in future studies...
  97. ncbi Investigating the safety of plants used in South African traditional medicine: testing for genotoxicity in the micronucleus and alkaline comet assays
    Joslyn L S Taylor
    Flemish Institute of Technological Research VITO, Environmental Toxicology, Mol, Belgium
    Environ Mol Mutagen 42:144-54. 2003
    ..Although a number of these plants are recognised as toxic by traditional healers, several plants that are used in common remedies were found to be genotoxic and potentially dangerous. Environ...
  98. ncbi Screening of medicinal plants used in South African traditional medicine for genotoxic effects
    Esameldin E Elgorashi
    Division of Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400, Mol, Belgium
    Toxicol Lett 143:195-207. 2003
    ..The only 90% methanol extracts that were mutagenic in strain TA98 were from the leaves of C. roseus and Ziziphus mucronata in the presence of metabolic activation. No genotoxic effects were found in strain TA100 or in the VITOTOX test...
  99. pmc In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species
    Louis Maes
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 48:130-6. 2004
    ..This study concludes that triterpenoid saponins from M. balansae show promising in vitro and in vivo antileishmanial potential and can be considered as new lead structures in the search for novel antileishmanial drugs...
  100. ncbi In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives
    Nils Germonprez
    Tibotec nv, Generaal De Wittelaan 11 bus 4, B 2800 Mechelen, Belgium
    J Med Chem 48:32-7. 2005
    ..2-0.4 mg/kg was administered. Several chemical derivatives of maesabalides I-VI were prepared in order to study the structure-activity relationship...
  101. ncbi Genotoxicity of melanoidin fractions derived from a standard glucose/glycine model
    Joslyn L S Taylor
    Vlaamse Instelling voor Technologisch Onderzoek, Environmental Toxicology, Boeretang 200, B 2400 Mol, Belgium
    J Agric Food Chem 52:318-23. 2004
    ..The LMW fraction, however, showed toxicity at these high concentrations. The volatile fraction produced in this reaction showed genotoxicity only in the Vitotox test, at high concentrations...