W P Ceelen

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence
    Wim P Ceelen
    Department of Surgery, University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Nat Rev Clin Oncol 7:108-15. 2010
  2. ncbi request reprint Neoadjuvant Chemotherapy with Bevacizumab May Improve Outcome after Cytoreduction and Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Colorectal Carcinomatosis
    Wim Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Ann Surg Oncol 21:3023-8. 2014
  3. pmc The low-molecular-weight heparin, nadroparin, inhibits tumour angiogenesis in a rodent dorsal skinfold chamber model
    I Debergh
    Department of Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Br J Cancer 102:837-43. 2010
  4. pmc Progress in rectal cancer treatment
    Wim P Ceelen
    Department of Surgery, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    ISRN Gastroenterol 2012:648183. 2012
  5. ncbi request reprint Surgery, wound healing, and metastasis: recent insights and clinical implications
    Wim Ceelen
    Department of of Surgery, Ghent University Hospital, B 9000 Ghent, Belgium Electronic address
    Crit Rev Oncol Hematol 89:16-26. 2014
  6. pmc Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members
    Sarah Pringels
    Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde, 9052, Belgium
    BMC Cancer 12:515. 2012
  7. doi request reprint Effect of perfusion temperature on glucose and electrolyte transport during hyperthermic intraperitoneal chemoperfusion (HIPEC) with oxaliplatin
    W Ceelen
    Department of Gastrointestinal Surgery, Ghent University Hospital 2K12 IC, UZ Gent, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Surg Oncol 39:754-9. 2013
  8. ncbi request reprint Current management of peritoneal carcinomatosis from colorectal cancer
    W P Ceelen
    Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium
    Minerva Chir 68:77-86. 2013
  9. doi request reprint Cytoreduction and hyperthermic intraperitoneal chemoperfusion in women with heavily pretreated recurrent ovarian cancer
    Wim P Ceelen
    Department of Surgery, University Hospital, Ghent, Belgium
    Ann Surg Oncol 19:2352-9. 2012
  10. doi request reprint Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review
    W Ceelen
    Department of Gastrointestinal Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Ann Surg Oncol 17:2847-55. 2010

Collaborators

Detail Information

Publications27

  1. doi request reprint Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence
    Wim P Ceelen
    Department of Surgery, University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Nat Rev Clin Oncol 7:108-15. 2010
    ..Several randomized controlled trials addressing these uncertainties have been initiated...
  2. ncbi request reprint Neoadjuvant Chemotherapy with Bevacizumab May Improve Outcome after Cytoreduction and Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Colorectal Carcinomatosis
    Wim Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Ann Surg Oncol 21:3023-8. 2014
    ..We aimed to assess whether neoadjuvant chemotherapy with or without bevacizumab is indicated in this patient population...
  3. pmc The low-molecular-weight heparin, nadroparin, inhibits tumour angiogenesis in a rodent dorsal skinfold chamber model
    I Debergh
    Department of Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Br J Cancer 102:837-43. 2010
    ..We aimed to examine the effects of nadroparin on tumour angiogenesis using a dorsal skinfold window chamber model in the Syrian hamster...
  4. pmc Progress in rectal cancer treatment
    Wim P Ceelen
    Department of Surgery, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    ISRN Gastroenterol 2012:648183. 2012
    ..The results of ongoing trials will help to establish the ideal tailored approach in resectable rectal cancer...
  5. ncbi request reprint Surgery, wound healing, and metastasis: recent insights and clinical implications
    Wim Ceelen
    Department of of Surgery, Ghent University Hospital, B 9000 Ghent, Belgium Electronic address
    Crit Rev Oncol Hematol 89:16-26. 2014
    ..Surgery-induced acceleration of tumour growth has been observed since several centuries...
  6. pmc Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members
    Sarah Pringels
    Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde, 9052, Belgium
    BMC Cancer 12:515. 2012
    ..These studies, which used specimens obtained by surgical resection or colonoscopic biopsy, yielded contradictory results. We studied the effect of the sampling method on the marker accuracy of VEGF family members...
  7. doi request reprint Effect of perfusion temperature on glucose and electrolyte transport during hyperthermic intraperitoneal chemoperfusion (HIPEC) with oxaliplatin
    W Ceelen
    Department of Gastrointestinal Surgery, Ghent University Hospital 2K12 IC, UZ Gent, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Surg Oncol 39:754-9. 2013
    ..Here, we examined the influence of perfusion temperature on glucose and electrolyte transport, metabolic shifts, and surgical morbidity...
  8. ncbi request reprint Current management of peritoneal carcinomatosis from colorectal cancer
    W P Ceelen
    Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium
    Minerva Chir 68:77-86. 2013
    ..Several questions remain, such as the specific role of HIPEC versus surgery alone, and the results of ongoing randomized trials are expected to provide important answers...
  9. doi request reprint Cytoreduction and hyperthermic intraperitoneal chemoperfusion in women with heavily pretreated recurrent ovarian cancer
    Wim P Ceelen
    Department of Surgery, University Hospital, Ghent, Belgium
    Ann Surg Oncol 19:2352-9. 2012
    ..Limited data are available on the use of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC) in patients with recurrent stage III ovarian cancer...
  10. doi request reprint Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review
    W Ceelen
    Department of Gastrointestinal Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Ann Surg Oncol 17:2847-55. 2010
    ..Recently, the lymph node ratio (LNR), defined as the ratio of the number of positive nodes over the total number of examined nodes, was proposed to stratify outcome in stage III patients...
  11. ncbi request reprint Hola trial: ventral hernia open versus laparoscopic repair. A call for participants
    W Ceelen
    Department of Surgery, Ghent University Hospital
    Acta Chir Belg 105:679-82. 2005
  12. ncbi request reprint Looking beyond the surface: a beginner's guide to the surgical literature
    W Ceelen
    Dept of Surgery, University Hospital Ghent
    Acta Chir Belg 105:427-35. 2005
  13. ncbi request reprint Surgery and intracavitary chemotherapy for peritoneal carcinomatosis from colorectal origin
    W Ceelen
    Dept of Surgery, Ghent University Hospital, Ghent, Belgium
    Acta Gastroenterol Belg 71:373-8. 2008
    ..In this review, we discuss the biological rationale, clinical methods, and oncological outcomes associated with cytoreduction and intracavitary chemotherapy in CRC patients suffering from peritoneal disease spread...
  14. doi request reprint Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer: a systematic review and meta-analysis
    Wim Ceelen
    Department of Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Int J Cancer 124:2966-72. 2009
    ..The addition of chemotherapy does not benefit sphincter preservation rate or long-term survival. Future trials should address improvements in the rate of distant metastasis and overall survival by incorporating more active chemotherapy...
  15. ncbi request reprint Pre-operative combined modality therapy in the management of locally advanced rectal cancer
    W Ceelen
    Department of Surgery, University Hospital, 2K12 IC, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Surg Oncol 32:259-68. 2006
    ..To review the use of pre-operative combined modality therapy (CMT, chemotherapy with radiotherapy) in the management of resectable rectal cancer...
  16. ncbi request reprint Surgery for peritoneal carcinomatosis from colorectal origin: techniques and limitations
    W P Ceelen
    Surgical Oncology, University Hospital Gent, Dept of Surgery 2K12, Ghent, Belgium
    Acta Chir Belg 106:276-82. 2006
  17. ncbi request reprint Neoadjuvant chemoradiation versus hyperfractionated accelerated radiotherapy in locally advanced rectal cancer
    Wim Ceelen
    Department of Surgical Oncology, University Hospital, De Pintelaan 185, B 9000, Ghent, Belgium
    Ann Surg Oncol 14:424-31. 2007
    ..The exact role of the addition of chemotherapy is not established. We compared neoadjuvant therapy using chemoradiation (CRT) or hyperfractionated accelerated radiotherapy (HART)...
  18. pmc Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels
    W Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Br J Cancer 96:692-700. 2007
    ..Direct effects of rhEPO on neoplastic endothelium are likely to explain these findings in addition to indirect effects induced by increased oxygenation...
  19. ncbi request reprint Surgical trauma, minimal residual disease and locoregional cancer recurrence
    W P Ceelen
    Department of Surgery, University Hospital, Ghent, Belgium
    Cancer Treat Res 134:51-69. 2007
    ..Specific targeted therapy aimed at inhibiting the inflammatory response, tumour cell adhesion, or the metastatic phenotype of dormant cells appears promising in preclinical models and needs to be addressed in future clinical trials...
  20. ncbi request reprint Pharmacodynamic aspects of intraperitoneal cytotoxic therapy
    W P Ceelen
    Department of Surgery, University Hospital, Ghent, Belgium
    Cancer Treat Res 134:195-214. 2007
    ..Ultimately, however, randomised trials of ip chemotherapy with surgery will have to provide the evidence base to further build upon...
  21. ncbi request reprint Safety and efficacy of hyperthermic intraperitoneal chemoperfusion with high-dose oxaliplatin in patients with peritoneal carcinomatosis
    Wim P Ceelen
    Department of Surgery, Ghent University Hospital, B 9000 Ghent, Belgium
    Ann Surg Oncol 15:535-41. 2008
    ..We analyzed the safety and efficacy of HIPEC using high-dose oxaliplatin, a cytotoxic agent commonly used in metastatic colorectal cancer and showing promising activity in ovarian cancer and mesothelioma...
  22. ncbi request reprint Noninvasive monitoring of radiotherapy-induced microvascular changes using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in a colorectal tumor model
    Wim Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 64:1188-96. 2006
    ..To examine dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with a macromolecular contrast agent (P792) to visualize effects of radiotherapy (RT) on microvascular leakage in a colorectal cancer model...
  23. doi request reprint Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI
    Dieter De Naeyer
    Department of Civil Engineering, Institute Biomedical Technology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    MAGMA 24:51-66. 2011
    ..This work proposes a theoretical framework describing how finite signal-noise-ratio (SNR) in the MR images is propagated throughout the measurement protocol to uncertainty on the kinetic parameter estimates...
  24. ncbi request reprint Use of hyperthermic intraperitoneal chemotherapy (HIPEC) in management of peritoneal carcinomatosis from colorectal origin
    Wim P Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Surg Technol Int 14:125-30. 2005
    ..Future trials are needed to provide more solid evidence in favor of surgery in PC originating from CRC in the era of modern chemotherapy and to better define the role of HIPEC as an adjunct to surgery...
  25. doi request reprint Peritoneal minimal residual disease in colorectal cancer: mechanisms, prevention, and treatment
    Wim P Ceelen
    Department of Surgical Oncology, Ghent University Hospital, Ghent, Belgium
    Lancet Oncol 10:72-9. 2009
    ..In this Review, we summarise the molecular mechanisms and potential preventive measures associated with each step of the peritoneal metastatic cascade...
  26. ncbi request reprint Gastric banding for clinically severe obesity: results with the Swedish band
    Wim P Ceelen
    Department of Surgery, Ghent University Hospital, Ghent, Belgium
    Surg Technol Int 12:103-9. 2004
    ..This chapter is a review of our experience with the SAGB and provides an overview of current controversies regarding its place in management of severe obesity...
  27. ncbi request reprint Use of laparoscopy for rectal cancer: a word of caution
    Wim P Ceelen
    J Clin Oncol 25:5040; author reply 5040-1. 2007