Bart P Braeckman

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Neurobiol Aging 26:689-96. 2005
  2. pmc Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
    Kristel Brys
    Department of Biology, Ghent University, K L Ledeganckstraat 35, Ghent B 9000, Belgium
    BMC Biol 8:91. 2010
  3. pmc ROS in aging Caenorhabditis elegans: damage or signaling?
    Patricia Back
    Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Oxid Med Cell Longev 2012:608478. 2012
  4. ncbi request reprint The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?
    Bart P Braeckman
    Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium
    Biogerontology 7:127-33. 2006
  5. ncbi request reprint Genetic control of longevity in C. elegans
    Bart P Braeckman
    Biology Department, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 42:90-8. 2007
  6. ncbi request reprint Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 37:1371-8. 2002
  7. ncbi request reprint No reduction of metabolic rate in food restricted Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 37:1359-69. 2002
  8. ncbi request reprint No reduction of energy metabolism in Clk mutants
    Bart P Braeckman
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000, Ghent, Belgium
    Mech Ageing Dev 123:1447-56. 2002
  9. ncbi request reprint Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, 9000 Ghent, Belgium
    Aging Cell 4:87-95. 2005
  10. ncbi request reprint Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans
    Kristel Brys
    Biology Department, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 42:845-51. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Neurobiol Aging 26:689-96. 2005
    ..In addition, we provide evidence that DAF-2 signaling controls mitochondrial bioenergetics by adjusting the rate of ATP synthesis to the rate of ATP utilization and by regulating the heat-producing proton leak pathway...
  2. pmc Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
    Kristel Brys
    Department of Biology, Ghent University, K L Ledeganckstraat 35, Ghent B 9000, Belgium
    BMC Biol 8:91. 2010
    ..The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan...
  3. pmc ROS in aging Caenorhabditis elegans: damage or signaling?
    Patricia Back
    Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Oxid Med Cell Longev 2012:608478. 2012
    ..Therefore, we comment on some methods of ROS and redox detection with emphasis on the implementation of genetically encoded biosensors in C. elegans...
  4. ncbi request reprint The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?
    Bart P Braeckman
    Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium
    Biogerontology 7:127-33. 2006
    ..Empirical studies using C. elegans (an opportunistic species) and computational studies on human populations (an equilibrium species) are shown to be consistent with these predictions...
  5. ncbi request reprint Genetic control of longevity in C. elegans
    Bart P Braeckman
    Biology Department, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 42:90-8. 2007
    ..However, their high antioxidant capacity may result in lower oxidative damage. Enhanced molecular turnover rates may also play a role in their longevity phenotype...
  6. ncbi request reprint Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 37:1371-8. 2002
    ....
  7. ncbi request reprint No reduction of metabolic rate in food restricted Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 37:1359-69. 2002
    ..These results indicate that the effects imparted by DR and the eat-2 mutation are not identical, and they contradict, at least in C. elegans, the widespread belief that CR acts by lowering the rate of metabolism...
  8. ncbi request reprint No reduction of energy metabolism in Clk mutants
    Bart P Braeckman
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000, Ghent, Belgium
    Mech Ageing Dev 123:1447-56. 2002
    ..Thus we conclude that the prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD...
  9. ncbi request reprint Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, 9000 Ghent, Belgium
    Aging Cell 4:87-95. 2005
    ..We also observed that heat production is lower in these mutants, although the respiration rate was similar or higher compared with wild-type individuals, suggesting a metabolic shift in these mutants...
  10. ncbi request reprint Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans
    Kristel Brys
    Biology Department, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 42:845-51. 2007
    ..The apparent contradiction between increased ROS generation and long lifespan in daf-2(e1370) is reconciled by an enhanced stress defense, acknowledging oxidative damage as a probable cause of aging...
  11. ncbi request reprint Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans
    Patricia Back
    Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K L Ledeganckstraat 35, Ghent, Belgium
    Exp Gerontol 45:603-10. 2010
    ..Overall, our results suggest that sod gene manipulation causes complex, combinatorial regulation of expression of individual targets of stress sensitive transcription factors...
  12. ncbi request reprint Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans
    Natascha Castelein
    Department of Biology, Ghent University, Ghent, Belgium
    Biotechnol J 3:803-12. 2008
    ..We conclude that growth in axenic culture is marked by a general up-regulation of replenishing pathways...
  13. ncbi request reprint Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans
    Koen Houthoofd
    Department of Biology, Ghent University, KL Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 38:947-54. 2003
    ..Moreover, these effects are not dependent on daf-16, which is known to suppress other mutations that act through the IIF pathway. We conclude that DR extends life span by mechanisms distinct from those specified by the IIF pathway...
  14. ncbi request reprint Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 37:1015-21. 2002
    ..Possible determinants of the enhanced life maintenance include increased resistance to oxidative stress provided by enhanced superoxide dismutase and catalase activities, and a shift to a highly reducing redox status...
  15. doi request reprint Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans
    Patricia Back
    Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, Ghent, Belgium
    Free Radic Biol Med 52:850-9. 2012
    ..Our findings demonstrate that genetically encoded biosensors can reveal previously unknown details of in vivo redox biology in multicellular organisms...
  16. ncbi request reprint LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism
    Geert Depuydt
    Biology Department, Ghent University, Proeftuinstraat 86 N1, B 9000 Ghent, Belgium
    J Proteome Res 13:1938-56. 2014
    ....
  17. ncbi request reprint Rebuttal to Van Voorhies: 'the influence of metabolic rate on longevity in the nematode Caenorhabditis elegans'
    Bart P Braeckman
    Department of Biology, Ghent Universty, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Aging Cell 1:89-90. 2002
  18. doi request reprint Lack of metabolic ageing in the long-lived flatworm Schmidtea polychroa
    Stijn Mouton
    Laboratory for Ageing Physiology and Molecular Evolution, Biology Department, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Exp Gerontol 46:755-61. 2011
    ..86 while later in life, it increased to an unusually large value of 1.17, indicating that mass-specific metabolic rate increases with size in adult S. polychroa...
  19. doi request reprint A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria
    Patricia Back
    Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium
    Anal Biochem 423:147-51. 2012
    ..We established a method for the quantification of superoxide production in isolated mitochondria without the need for acetone extraction and purification chromatography as described in previous studies...
  20. doi request reprint Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells
    Filip Matthijssens
    Department of Biology, Ghent University, Ledeganckstraat 35, B 9000 Ghent, Belgium
    Free Radic Biol Med 45:708-15. 2008
    ..coli cells...
  21. doi request reprint The free-living flatworm Macrostomum lignano: a new model organism for ageing research
    Stijn Mouton
    Department of Biology, Ghent University, Ghent, Belgium
    Exp Gerontol 44:243-9. 2009
    ..We also give an overview of the available experimental tools that allow a multidisciplinary approach for studying ageing in M. lignano...
  22. ncbi request reprint Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies
    Bart P Braeckman
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Aging Cell 1:82-8; discussion 102-3. 2002
    ..In contrast, the metabolic rate profiles point to a metabolic shift toward enhanced efficiency of oxidative phosphorylation in the daf-2 worms...
  23. ncbi request reprint Protein metabolism and lifespan in Caenorhabditis elegans
    Geert Depuydt
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Adv Exp Med Biol 694:81-107. 2010
    ..In mammals, protein homeostasis is also implicated in several neurodegenerative diseases, many of which can be modeled in C. elegans...
  24. ncbi request reprint Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans
    Natascha Castelein
    Department of Biology, Ghent University, Proeftuinstraat 86, 9000 Gent, Belgium
    Exp Gerontol 56:26-36. 2014
    ..This might be mediated by combination of a limited increase in supercomplex abundance and decreased individual CIV abundance, facilitating electron transport and ultimately leading to increased mitochondrial efficiency. ..
  25. ncbi request reprint Assaying metabolic activity in ageing Caenorhabditis elegans
    Bart P Braeckman
    Department of Biology, Ghent University, Ledeganckstraat 35, B 9000, Ghent, Belgium
    Mech Ageing Dev 123:105-19. 2002
    ..A protein quantification protocol for normalising all data for quantitative comparisons is presented. We illustrate how these methods can validate or disprove models of gene action inferred from molecular identification...
  26. pmc Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans
    Geert Depuydt
    Biology Department, Ghent University, Proeftuinstraat 86 N1, B 9000 Ghent, Belgium
    Mol Cell Proteomics 12:3624-39. 2013
    ....
  27. pmc Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano
    Stijn Mouton
    Nematology Unit, Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium
    Front Zool 6:15. 2009
    ....
  28. ncbi request reprint Extending life-span in C. elegans
    Koen Houthoofd
    Science 305:1238-9. 2004
  29. ncbi request reprint Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Gerontol 39:1137-43. 2004
    ..Thus, individual variation in lifespan in wild-type flies, and life extension by dietary-restriction and reduced insulin/IGF-1 signalling is not attributable to differences in metabolic rate...
  30. ncbi request reprint The hunt for the record life span in Caenorhabditis elegans
    Koen Houthoofd
    J Gerontol A Biol Sci Med Sci 59:408-10. 2004