F M Belpaire

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors
    F M Belpaire
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Clin Pharmacol 54:261-4. 1998
  2. ncbi request reprint Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat
    M E Laethem
    Heymans Institute of Pharmacology, University of Ghent Medical School, Belgium
    Chirality 6:405-10. 1994
  3. ncbi request reprint Relationship between etomidate plasma concentration and EEG effect in the rat
    P De Paepe
    Heymans Institute of Pharmacology, University of Gent, Medical School, Belgium
    Pharm Res 16:924-9. 1999
  4. ncbi request reprint Dog alpha-1-acid glycoprotein: purification and biochemical characterization
    C P Dello
    Heymans Institute of Pharmacology, Medical School, Univeristy of Ghent, Belgium
    J Pharmacol Methods 18:335-45. 1987
  5. ncbi request reprint Chiral high-performance liquid chromatographic determination of oxprenolol in plasma
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    J Chromatogr 621:225-9. 1993
  6. ncbi request reprint Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Chirality 7:616-22. 1995
  7. ncbi request reprint Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat
    P De Paepe
    Heymans Institute of Pharmacology, Electroencephalography Laboratory, Department of Neurology, University of Ghent, Medical School, Ghent, Belgium
    J Pharmacol Exp Ther 290:1048-53. 1999
  8. ncbi request reprint Influence of naloxone on the increased sensitivity to propofol during hypovolemia in the rat
    P De Paepe
    Heymans Institute of Pharmacology, Ghent University, Belgium
    Crit Care Med 29:997-9. 2001
  9. ncbi request reprint Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Pharm Res 12:1964-7. 1995
  10. ncbi request reprint Influence of continuous ambulatory peritoneal dialysis on serum alpha 1-acid glycoprotein concentration and drug binding
    F M Belpaire
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Clin Pharmacol 35:339-43. 1988

Collaborators

  • M T Rosseel
  • R A Lefebvre
  • A Hemeryck
  • B B Rasmussen
  • P De Paepe
  • M E Laethem
  • D K Van Sassenbroeck
  • W A Buylaert
  • P A Boon
  • M G Bogaert
  • C A De Vriendt
  • G Van Hoey
  • P Wijnant
  • A G Verstraete
  • E J van de Velde
  • P Martens
  • Y Vander Heyden
  • H L Vanhoe
  • C P Dello
  • N H Fraeyman
  • B Chindavijak
  • N F Fraeyman
  • A de Rick
  • C D Dello
  • J A Kint

Detail Information

Publications18

  1. ncbi request reprint The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors
    F M Belpaire
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Clin Pharmacol 54:261-4. 1998
    ..The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation...
  2. ncbi request reprint Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat
    M E Laethem
    Heymans Institute of Pharmacology, University of Ghent Medical School, Belgium
    Chirality 6:405-10. 1994
    ..The enantioselective effect of endotoxin on the plasma concentrations of the drugs studied seems mainly due to the enantioselective increase in binding to alpha 1-acid glycoprotein...
  3. ncbi request reprint Relationship between etomidate plasma concentration and EEG effect in the rat
    P De Paepe
    Heymans Institute of Pharmacology, University of Gent, Medical School, Belgium
    Pharm Res 16:924-9. 1999
    ..The effect-plasma concentration relationship of etomidate was studied in the rat using electroencephalographic changes as a pharmacodynamic parameter...
  4. ncbi request reprint Dog alpha-1-acid glycoprotein: purification and biochemical characterization
    C P Dello
    Heymans Institute of Pharmacology, Medical School, Univeristy of Ghent, Belgium
    J Pharmacol Methods 18:335-45. 1987
    ..Up to seven molecular forms with different isoelectric points were found, whereas only a single con A-dependent molecular form was detected...
  5. ncbi request reprint Chiral high-performance liquid chromatographic determination of oxprenolol in plasma
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    J Chromatogr 621:225-9. 1993
    ..5% for both enantiomers at all concentrations used. Preliminary experiments in the rat demonstrate that the method is sufficiently sensitive for pharmacokinetic studies in that species...
  6. ncbi request reprint Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Chirality 7:616-22. 1995
    ..In rabbits and in dogs, the influence of endotoxin on the disposition of the three drugs is less enantioselective than was previously observed in the rat...
  7. ncbi request reprint Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat
    P De Paepe
    Heymans Institute of Pharmacology, Electroencephalography Laboratory, Department of Neurology, University of Ghent, Medical School, Ghent, Belgium
    J Pharmacol Exp Ther 290:1048-53. 1999
    ..Our data also suggest a small increase in central nervous system sensitivity for etomidate in hypovolemic animals...
  8. ncbi request reprint Influence of naloxone on the increased sensitivity to propofol during hypovolemia in the rat
    P De Paepe
    Heymans Institute of Pharmacology, Ghent University, Belgium
    Crit Care Med 29:997-9. 2001
    ..We used the opioid blocking agent naloxone to test the hypothesis that endogenous opioids may be involved in this increased sensitivity...
  9. ncbi request reprint Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Pharm Res 12:1964-7. 1995
    ..To study the effect of probenecid on the stereoselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit...
  10. ncbi request reprint Influence of continuous ambulatory peritoneal dialysis on serum alpha 1-acid glycoprotein concentration and drug binding
    F M Belpaire
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Clin Pharmacol 35:339-43. 1988
    ..The binding of phenytoin showed little change. The concentration of alpha 1-AGP in dialysate was 2 to 5% of that in serum...
  11. ncbi request reprint Stereoselective pharmacokinetics of oxprenolol and its glucuronides in humans
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Clin Pharmacol Ther 57:419-24. 1995
    ..To study the pharmacokinetics of R(+)- and S(-)-oxprenolol and their corresponding glucuronide conjugates in healthy subjects...
  12. ncbi request reprint Direct high-performance liquid chromatography determination of diastereomeric oxprenolol glucuronides
    M E Laethem
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    J Chromatogr B Biomed Appl 675:251-5. 1996
    ..The assay is sensitive, accurate and reproducible. The method is suitable for the assay of glucuronides in liver microsomal incubates and plasma...
  13. ncbi request reprint Influence of inflammation on serum concentration, molecular heterogeneity and drug binding properties of canine alpha-1-acid glycoprotein
    C P Dello
    Heymans Institute of Pharmacology, Medical School, University of Ghent, Belgium
    J Vet Pharmacol Ther 11:71-6. 1988
    ..Changes in serum binding of oxprenolol during inflammation result from a change in the serum concentration of alpha-1-AGP rather than a change of molecular heterogeneity...
  14. pmc Alpha 1-acid glycoprotein concentration and molecular heterogeneity: relationship to oxprenolol binding in serum from healthy volunteers and patients with lung carcinoma or cirrhosis
    N F Fraeyman
    Heymans Institute of Pharmacology, Medical School, University of Ghent, Belgium
    Br J Clin Pharmacol 25:733-40. 1988
    ..There was no change in binding affinity and oxprenolol binding was significantly correlated to total AAG serum concentration and to the concentration of each of the conA dependent subtypes, in controls as well as in both patients groups...
  15. ncbi request reprint Metoprolol-paroxetine interaction in human liver microsomes: stereoselective aspects and prediction of the in vivo interaction
    A Hemeryck
    Heymans Institute of Pharmacology, Ghent University Medical School, 9000 Ghent, Belgium
    Drug Metab Dispos 29:656-63. 2001
    ..Furthermore, the extent of the in vivo metoprolol-paroxetine interaction was substantially underestimated by either one of the two in vitro approaches used when a competitive mechanism was assumed...
  16. ncbi request reprint Development and validation of a high-performance liquid chromatographic method for the determination of gamma-hydroxybutyric acid in rat plasma
    C A De Vriendt
    Heymans Institute of Pharmacology, Ghent University, Faculty of Medicine and Health Sciences, Belgium
    J Chromatogr B Biomed Sci Appl 752:85-90. 2001
    ..A good correlation was observed and a t-test indicated no significant differences from 0 and 1 for the intercept and slope, respectively...
  17. ncbi request reprint In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation
    B Chindavijak
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    J Pharm Pharmacol 39:883-6. 1987
    ..The changes in drug disposition seen after turpentine-induced inflammation, could therefore be due in part to a change in hepatic enzymatic activity...
  18. ncbi request reprint Relationship between gamma-hydroxybutyrate plasma concentrations and its electroencephalographic effects in the rat
    D K Van Sassenbroeck
    Heymans Institute of Pharmacology, Ghent University, Faculty of Medicine and Health Sciences, Belgium
    J Pharm Pharmacol 53:1687-96. 2001
    ..This study showed that the concentration-effect relationship of GHB could be characterized in individual rats using aperiodic analysis in the 15.5-30 Hz frequency band...