S Bekaert

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Telomere attrition as ageing biomarker
    Sofie Bekaert
    Department of Molecular Biotechnology, Faculty for Bioscience Engineering, Ghent University, Belgium
    Anticancer Res 25:3011-21. 2005
  2. pmc Molecular diagnostics for congenital hearing loss including 15 deafness genes using a next generation sequencing platform
    Sarah De Keulenaer
    NXTGNT, Ghent University, Ghent, Belgium
    BMC Med Genomics 5:17. 2012
  3. pmc Analysing 454 amplicon resequencing experiments using the modular and database oriented Variant Identification Pipeline
    Joachim M De Schrijver
    Laboratory for Bioinformatics and Computational Genomics, Department of Molecular Biotechnology, Ghent University, 9000 Ghent, Belgium
    BMC Bioinformatics 11:269. 2010
  4. ncbi request reprint Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease
    Sofie Bekaert
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Aging Cell 6:639-47. 2007
  5. ncbi request reprint Telomere length versus hormonal and bone mineral status in healthy elderly men
    S Bekaert
    Department for Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Mech Ageing Dev 126:1115-22. 2005
  6. ncbi request reprint Rationale, design, methods and baseline characteristics of the Asklepios Study
    Ernst R Rietzschel
    Department of Cardiovascular Diseases, Ghent University Hospital, Ghent, Belgium
    Eur J Cardiovasc Prev Rehabil 14:179-91. 2007
  7. ncbi request reprint Relation between telomerase activity, hTERT and telomere length for intracranial tumours
    L Maes
    Department of Anatomy, Embryology, Histology and Medical Physics, Section of Histology, Ghent University, B 9000 Ghent, Belgium
    Oncol Rep 18:1571-6. 2007
  8. doi request reprint Systemic telomere length and preclinical atherosclerosis: the Asklepios Study
    Tim De Meyer
    Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Eur Heart J 30:3074-81. 2009
  9. doi request reprint Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra
    Tim De Meyer
    Laboratory for Bioinformatics and Computational Genomics, Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Anal Bioanal Chem 398:1781-90. 2010
  10. doi request reprint Amplification of the pressure pulse in the upper limb in healthy, middle-aged men and women
    Patrick Segers
    Ghent University, Institute Biomedical Technology, De Pintelaan 185, B 9000 Gent, Belgium
    Hypertension 54:414-20. 2009

Detail Information

Publications24

  1. ncbi request reprint Telomere attrition as ageing biomarker
    Sofie Bekaert
    Department of Molecular Biotechnology, Faculty for Bioscience Engineering, Ghent University, Belgium
    Anticancer Res 25:3011-21. 2005
    ..Within this review, current evidence and knowledge on telomere length and telomere erosion rates reported, are summarised...
  2. pmc Molecular diagnostics for congenital hearing loss including 15 deafness genes using a next generation sequencing platform
    Sarah De Keulenaer
    NXTGNT, Ghent University, Ghent, Belgium
    BMC Med Genomics 5:17. 2012
    ..In this study we used a semi-automated PCR amplification and NGS in order to combine high sensitivity, speed and cost efficiency...
  3. pmc Analysing 454 amplicon resequencing experiments using the modular and database oriented Variant Identification Pipeline
    Joachim M De Schrijver
    Laboratory for Bioinformatics and Computational Genomics, Department of Molecular Biotechnology, Ghent University, 9000 Ghent, Belgium
    BMC Bioinformatics 11:269. 2010
    ..Currently, no open-source out-of-the-box software solution exists that reliably reports detected genetic variations and that can be used to improve future sequencing effectiveness by analyzing the PCR reactions...
  4. ncbi request reprint Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease
    Sofie Bekaert
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Aging Cell 6:639-47. 2007
    ..This further clarifies the added value of TL as a biomarker for biological aging and might improve our understanding of how TL is associated with CVD...
  5. ncbi request reprint Telomere length versus hormonal and bone mineral status in healthy elderly men
    S Bekaert
    Department for Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Mech Ageing Dev 126:1115-22. 2005
    ..Further studies are required to confirm our results, yet in this study, the predictive value of telomere length for bone loss appears to be substantial, hence underscoring the role of telomere length as a biomarker of ageing phenotypes...
  6. ncbi request reprint Rationale, design, methods and baseline characteristics of the Asklepios Study
    Ernst R Rietzschel
    Department of Cardiovascular Diseases, Ghent University Hospital, Ghent, Belgium
    Eur J Cardiovasc Prev Rehabil 14:179-91. 2007
    ..Within these broader goals, a constant will be to strive towards more fundamental mechanistic-haemodynamic insights into cardiovascular disease processes...
  7. ncbi request reprint Relation between telomerase activity, hTERT and telomere length for intracranial tumours
    L Maes
    Department of Anatomy, Embryology, Histology and Medical Physics, Section of Histology, Ghent University, B 9000 Ghent, Belgium
    Oncol Rep 18:1571-6. 2007
    ..000 kb. These results indicate that telomere shortening may be a critical step in pathogenesis of atypical and malignant meningiomas and gliomas. Critical telomere shortening in vitro was shown to activate telomerase...
  8. doi request reprint Systemic telomere length and preclinical atherosclerosis: the Asklepios Study
    Tim De Meyer
    Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Eur Heart J 30:3074-81. 2009
    ..We aimed at providing an explanation for this association by the evaluation of the biomarker value of PBL-TL in preclinical atherosclerosis...
  9. doi request reprint Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra
    Tim De Meyer
    Laboratory for Bioinformatics and Computational Genomics, Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Anal Bioanal Chem 398:1781-90. 2010
    ..Additional optimization of the normalization procedure might further improve the analyses...
  10. doi request reprint Amplification of the pressure pulse in the upper limb in healthy, middle-aged men and women
    Patrick Segers
    Ghent University, Institute Biomedical Technology, De Pintelaan 185, B 9000 Gent, Belgium
    Hypertension 54:414-20. 2009
    ..Amplification is higher in men than in women, decreases with age, and is primarily associated with the carotid augmentation index...
  11. doi request reprint Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption
    Joke Werbrouck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Ghent University Hospital, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 656:74-81. 2008
    ..The protective effect seen for the Rad51 c.-3429 and polymorphism was most prominent among the group of heavy smokers (>25 PY). No associations with risk for HNSCC were found for the other SNPs in genes of the DNA DSB repair pathways...
  12. doi request reprint Lower red blood cell counts in middle-aged subjects with shorter peripheral blood leukocyte telomere length
    Tim De Meyer
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, Belgium
    Aging Cell 7:700-5. 2008
    ..While negligible in a middle-aged population, the clinical consequences might be important in the elderly (e.g. in anemia of chronic disease). Further studies are required to confirm the impact of our results...
  13. doi request reprint NMR-based characterization of metabolic alterations in hypertension using an adaptive, intelligent binning algorithm
    Tim De Meyer
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Anal Chem 80:3783-90. 2008
    ..This enables the detection of relevant, low-intensity metabolites. These results demonstrate the power of AI-Binning and suggest the involvement of alpha-1 acid glycoproteins and choline biochemistry in hypertension...
  14. ncbi request reprint Studying telomeres in a longitudinal population based study
    Tim De Meyer
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Front Biosci 13:2960-70. 2008
    ..In this review we present different models for the biomarker value of TL and discuss the theoretical and methodological considerations of studying TL in a longitudinal population study with a special emphasis on cardiovascular disease...
  15. pmc PubMeth: a cancer methylation database combining text-mining and expert annotation
    Maté Ongenaert
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Laboratory for Bioinformatics and Computational Genomics, Ghent University, B 9000 Ghent, Belgium
    Nucleic Acids Res 36:D842-6. 2008
    ..The summarized overview of the results is very useful in case more genes or cancer types are searched at the same time...
  16. ncbi request reprint Paternal age at birth is an important determinant of offspring telomere length
    Tim De Meyer
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Hum Mol Genet 16:3097-102. 2007
    ..In conclusion, paternal age is an important determinant for TL, with substantial consequences for future studies...
  17. doi request reprint Telomere length and cardiovascular aging: the means to the ends?
    Tim De Meyer
    Dept of Molecular Biotechnology, FBE, Ghent University, Belgium
    Ageing Res Rev 10:297-303. 2011
    ..We conclude that the most promising theory is based on an acceleration of the telomere attrition rate due to cardiovascular aging related factors, possibly complemented by telomere mediated hematopoietic senescence...
  18. doi request reprint Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men
    J B Ruige
    Department of Endocrinology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Int J Androl 34:e587-93. 2011
    ..The finding provides a partial explanation for the overall neutral effect on CVD of testosterone in healthy middle-aged men...
  19. ncbi request reprint Comparing telomere length of sister chromatids in human lymphocytes using three-dimensional confocal microscopy
    Sofie Bekaert
    Laboratory for Biochemistry and Molecular Cytology, Dept of Molecular Biotechnology, Faculty for Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Cytometry 48:34-44. 2002
    ..We extended this method using confocal microscopy for the acquisition of three-dimensional (3D) images. Consequently, variations in measured signal intensities due to erroneous focusing are avoided...
  20. ncbi request reprint Telomere biology in mammalian germ cells and during development
    Sofie Bekaert
    Laboratory for Biochemistry and Molecular Cytology, Department for Molecular Biotechnology, FLTBW Ghent University, Belgium
    Dev Biol 274:15-30. 2004
    ....
  21. ncbi request reprint Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development
    Sofie Bekaert
    Laboratory for Biochemistry and Molecular Cytology, Department for Molecular Biotechnology, Faculty of Bioscience Engineering FBE, Ghent University, Belgium
    DNA Repair (Amst) 4:1028-37. 2005
    ....
  22. doi request reprint Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations
    Ernst R Rietzschel
    Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium
    Hypertension 52:535-41. 2008
    ..Our data suggest that ox-LDL is a risk marker for early ventricular remodelling. However, the effect size in the general population is small...
  23. ncbi request reprint Comparison of different protocols for telomere length estimation by combination of quantitative fluorescence in situ hybridization (Q-FISH) and flow cytometry in human cancer cell lines
    Hanane Derradji
    Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium
    Anticancer Res 25:1039-50. 2005
    ..They insure several functions including capping the end of the chromosomes, ensuring their stability and protecting them from end-to-end fusion and preventing the activation of the DNA damage checkpoints...
  24. doi request reprint Femoral plaques confound the association of circulating oxidized low-density lipoprotein with carotid atherosclerosis in a general population aged 35 to 55 years: the Asklepios Study
    Michel R Langlois
    Department of Clinical Chemistry, AZ St Jan Hospital, Ruddershove 10, B 8000, Bruges, Belgium
    Arterioscler Thromb Vasc Biol 28:1563-8. 2008
    ..In the Asklepios Study cohort of asymptomatic subjects aged 35 to 55 years, we evaluated the relationship of circulating oxLDL with subclinical atherosclerosis in the carotid and femoral arteries...