Claus Bachert

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi The WHO ARIA (allergic rhinitis and its impact on asthma) initiative
    C Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    Chem Immunol Allergy 82:119-26. 2003
  2. ncbi [Allergic rhinoconjunctivitis. Guidelines of the DGAI in association with the DDG]
    Claus Bachert
    HNO Universitätsklinik Gent, Belgien
    J Dtsch Dermatol Ges 4:264-75. 2006
  3. ncbi Regulation of proinflammatory cytokines in seasonal allergic rhinitis
    C Bachert
    ENT Department, University Hospital Ghent, Belgium
    Int Arch Allergy Immunol 118:375-9. 1999
  4. ncbi Persistent rhinitis - allergic or nonallergic?
    C Bachert
    University Hospital Ghent Belgium
    Allergy 59:11-5; discussion 15. 2004
  5. ncbi Effect of intranasal fluticasone propionate and triamcinolone acetonide on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity in healthy volunteers
    C Bachert
    University Hospital, Ghent, Belgium Institut für Atemwegsforschung GmbH, Dusseldorf, Germany
    Clin Exp Allergy 34:85-90. 2004
  6. ncbi Mediators in nasal polyposis
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, B 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 2:481-7. 2002
  7. ncbi Patient preferences and sensory comparisons of three intranasal corticosteroids for the treatment of allergic rhinitis
    Claus Bachert
    Department of Ear, Nose, and Throat, University Hospital, Ghent, Belgium
    Ann Allergy Asthma Immunol 89:292-7. 2002
  8. ncbi Staphylococcus aureus superantigens and airway disease
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
    Curr Allergy Asthma Rep 2:252-8. 2002
  9. ncbi Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
    C Bachert
    Department of Otorhinolaryngology, University Hospital of Ghent, Belgium
    Eur Arch Otorhinolaryngol 258:406-12. 2001
  10. doi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008

Detail Information

Publications100

  1. ncbi The WHO ARIA (allergic rhinitis and its impact on asthma) initiative
    C Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    Chem Immunol Allergy 82:119-26. 2003
    ..Elaborate guidelines for the diagnosis and assessment of the severity of disease are provided, and detailed recommendations for the management of rhinitis and asthma are suggested with a special focus on specific immunotherapy...
  2. ncbi [Allergic rhinoconjunctivitis. Guidelines of the DGAI in association with the DDG]
    Claus Bachert
    HNO Universitätsklinik Gent, Belgien
    J Dtsch Dermatol Ges 4:264-75. 2006
  3. ncbi Regulation of proinflammatory cytokines in seasonal allergic rhinitis
    C Bachert
    ENT Department, University Hospital Ghent, Belgium
    Int Arch Allergy Immunol 118:375-9. 1999
    ..Mediators and cytokines have been demonstrated to be released due to nasal allergen exposure in sensitized subjects, but little is known about the release of cytokines and their antagonists under natural conditions...
  4. ncbi Persistent rhinitis - allergic or nonallergic?
    C Bachert
    University Hospital Ghent Belgium
    Allergy 59:11-5; discussion 15. 2004
    ..Accordingly, from a clinical standpoint NARES, irritative-toxic, hormonal, drug-induced and idiopathic rhinitis are possibly the least difficult forms of nonallergic rhinitis to diagnose...
  5. ncbi Effect of intranasal fluticasone propionate and triamcinolone acetonide on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity in healthy volunteers
    C Bachert
    University Hospital, Ghent, Belgium Institut für Atemwegsforschung GmbH, Dusseldorf, Germany
    Clin Exp Allergy 34:85-90. 2004
    ..Most published studies show that intranasal corticosteroids have no effect on the hypothalamic-pituitary-adrenal (HPA) axis, but there have been isolated reports to the contrary, contradicting accumulated knowledge on pharmacokinetics...
  6. ncbi Mediators in nasal polyposis
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, B 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 2:481-7. 2002
    ....
  7. ncbi Patient preferences and sensory comparisons of three intranasal corticosteroids for the treatment of allergic rhinitis
    Claus Bachert
    Department of Ear, Nose, and Throat, University Hospital, Ghent, Belgium
    Ann Allergy Asthma Immunol 89:292-7. 2002
    ....
  8. ncbi Staphylococcus aureus superantigens and airway disease
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
    Curr Allergy Asthma Rep 2:252-8. 2002
    ..This circumstantial evidence is currently limited to rhinitis, sinusitis, and possibly asthma, but may, if supported, open a new understanding of pathomechanisms and therapeutic targets...
  9. ncbi Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
    C Bachert
    Department of Otorhinolaryngology, University Hospital of Ghent, Belgium
    Eur Arch Otorhinolaryngol 258:406-12. 2001
    ..All studied variables reached baseline 3 weeks after the URTI. Naturally acquired URTI represent a limited, neutrophilic inflammatory reaction, orchestrated by the release of pro-inflammatory cytokines and chemokines...
  10. doi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps...
  11. doi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    ..Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis...
  12. ncbi Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  13. ncbi Chronic rhinosinusitis with and without nasal polyps: what is the difference?
    Wouter Huvenne
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 9:213-20. 2009
    ..This disease differentiation will not only increase our knowledge of the pathophysiology of sinusitis but may lead to new diagnostic and therapeutic strategies specifically targeted and adapted to the diagnosed disease entity...
  14. doi Chronic rhinosinusitis: from one disease to different phenotypes
    Claus Bachert
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pediatr Allergy Immunol 23:2-4. 2012
    ..Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma...
  15. ncbi Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Upper Airways Research Laboratory, Gent University Hospital, Belgium
    Am J Rhinol 20:456-60. 2006
    ..We studied the possible impact of SE-induced immune responses on the eicosanoid production in nasal polyp (NP) patients...
  16. doi Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma
    Claus Bachert
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 130:376-81.e8. 2012
    ..The role of IgE in patients with severe asthma is not fully understood...
  17. doi Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization
    Marie Noëlle Corriveau
    Upper Airways Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Rhinol Allergy 23:461-5. 2009
    ....
  18. ncbi Identification of the nasal mucosa as a new target for leptin action
    Jasmien Taildeman
    Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Histopathology 56:789-98. 2010
    ..Conclusions: Leptin receptors and their biological ligand leptin are expressed in the nasal mucosa, suggesting a possible role in upper airway immunology...
  19. doi Pathophysiology of chronic rhinosinusitis
    Peter Tomassen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic Audiological Science, Ghent University, Ghent, Belgium
    Proc Am Thorac Soc 8:115-20. 2011
    ..Identification of specific disease subgroups and their etiologies is an important and challenging task for future research...
  20. ncbi Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China
    Nan Zhang
    Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium
    Am J Rhinol 20:445-50. 2006
    ..This study analyzes the impact of Staphylococcus aureus enterotoxins (SAEs) and the inflammatory pattern in polyps from China...
  21. pmc Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  22. doi RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 129:1515-21.e8. 2012
    ..RAGE is reported to play a role in diverse pathologies including lower airway conditions, but the exact mechanism of action remains poorly understood. In the upper airways, the involvement of RAGE remains completely unexplored...
  23. doi Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7. 2008
    ..The purpose of this study was to investigate the presence of S. aureus enterotoxin genes and the agr subtype in bacterial DNA of S. aureus strains isolated from the middle meatus of nasal polyp and control patients...
  24. ncbi Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 121:110-5. 2008
    ..Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis...
  25. doi T-cell regulation in chronic paranasal sinus disease
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 121:1435-41, 1441.e1-3. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without nasal polyps (CRSsNP) represents a predominant T(H)1 milieu...
  26. doi Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
    ..This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of CRS to further unravel its pathogenesis...
  27. doi Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
    ..Nasal polyps often are associated with asthma. The phenotype of these patients is unknown...
  28. ncbi TGF-beta signaling and collagen deposition in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 124:253-9, 259.e1-2. 2009
    ..Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns...
  29. pmc Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
    Wouter Huvenne
    Upper Airways Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent University, Ghent, Belgium
    Respir Res 12:69. 2011
    ..Colonization with Staphylococcus aureus results in release of virulent enterotoxins, with superantigen activity which causes T cell activation...
  30. ncbi Collection of nasal secretions for immunological analysis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Eur Arch Otorhinolaryngol 261:242-6. 2004
    ..The method is non-invasive, well standardized and reproducible and therefore may serve as a valid tool for future investigations...
  31. doi Prevalence of allergic sensitization versus allergic rhinitis symptoms in an unselected population
    Katrien Blomme
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Int Arch Allergy Immunol 160:200-7. 2013
    ..The objective of the present survey was to evaluate the prevalence of allergic sensitization and the prevalence of clinically diagnosed AR in a sample of the Belgian population, and to estimate the effect of age and gender...
  32. ncbi Local inflammation in chronic upper airway disease
    Lien Calus
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Curr Pharm Des 18:2336-46. 2012
    ..Defining and predicting response to therapy in individual CRS patients is a challenge for future research...
  33. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    ..There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps...
  34. pmc Different regulation of cigarette smoke induced inflammation in upper versus lower airways
    Wouter Huvenne
    Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent University, Belgium
    Respir Res 11:100. 2010
    ..We investigated and compared the effects of CS on upper and lower airways, in a mouse model of subacute and chronic CS exposure...
  35. doi Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3
    Feng Lan
    Division of Geriatrics, Center for Medical Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Upper Airways Research Laboratory, ENT Department, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 132:1314-21. 2013
    ..In patients with persistent upper airway inflammation, the number of forkhead box protein 3 (Foxp3)(+) regulatory T (Treg) cells is reduced, but the regulation of Foxp3 expression in Treg cells is poorly understood...
  36. pmc Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue
    Xiangdong Wang
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 7:e39875. 2012
    ..aureus are not clearly understood. The aim of this study was to investigate the interaction between S. aureus and herpes simplex virus type 1 (HSV1) in the invasion of the nasal mucosa and nasal polyp tissue...
  37. ncbi Pathogenesis of chronic rhinosinusitis
    Paul Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 6:487-94. 2006
    ..These findings question the current assumption that NP is a subgroup of CRS, but suggest that CRS and NP should probably be considered as distinct disease entities...
  38. doi Tissue remodeling in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University, Belgium
    Curr Opin Allergy Clin Immunol 11:8-11. 2011
    ..To summarize the current knowledge on remodeling in chronic sinus disease...
  39. ncbi Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolarynogy, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Allergy Clin Immunol 115:1189-96. 2005
    ....
  40. doi Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 131:110-6.e1. 2013
    ..Omalizumab is a human anti-IgE mAb with proved efficacy in patients with severe allergic asthma. Omalizumab could be a treatment option for patients with nasal polyps and asthma...
  41. doi Cytokine profiles in Japanese patients with chronic rhinosinusitis
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Allergol Int 61:115-22. 2012
    ..Studying inflammatory mediators in clearly defined disease subgroups may lead to a better differentiation of chronic sinus diseases...
  42. doi Chronic sinusitis and rhinitis: clinical terminology "Chronic Rhinosinusitis" further supported
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    Rhinology 48:54-8. 2010
    ..We therefore investigated the immunological background of the chronically inflamed nasal and sinusal mucosa...
  43. doi Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps?
    Katia Verbruggen
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 148:87-98. 2009
    ....
  44. doi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  45. ncbi Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 118:1133-41. 2006
    ..Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels...
  46. ncbi Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Belgium
    Am J Rhinol 18:267-72. 2004
    ..Transforming growth factor (TGF) beta1 plays an important role in tissue remodeling, which is poorly understood in chronic diseases of the sinuses...
  47. doi Syk-kinase inhibition prevents mast cell activation in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Rhinology 49:100-6. 2011
    ..Spleen tyrosine kinase (Syk) is positioned upstream of the IgE receptor signal transducing pathway and may represent an important target for the treatment of nasal inflammatory diseases...
  48. doi Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 128:989-95.e1-8. 2011
    ..Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival...
  49. doi Local complement activation in nasal polyposis
    Thibaut Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Laryngoscope 119:1753-8. 2009
    ....
  50. doi Pilot study using doxycycline-releasing stents to ameliorate postoperative healing quality after sinus surgery
    Wouter Huvenne
    Upper Airway Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent, Belgium
    Wound Repair Regen 16:757-67. 2008
    ....
  51. ncbi Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship
    Claudina A Pérez-Novo
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 133:255-60. 2004
    ..In this study, we therefore aimed to determine, whether aspirin sensitivity was related to an immune response to SAEs, and how both criteria would be related to eosinophilic inflammation...
  52. ncbi The role of sinus disease in asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 6:29-36. 2006
    ..This concept primarily refers to the well established link between allergic rhinitis and asthma, but it also covers a possible link between sinus disease and asthma (allergic or nonallergic) and other lower airway disease...
  53. ncbi Secretion of TGF-betal, TGF-beta2, EGF and PDGF into nasal fluid after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Eur Arch Otorhinolaryngol 259:234-8. 2002
    ..This is the first study proposing a follow-up method for nasal and sinus mucosal healing after surgery in order to determine cytokine secretion profiles...
  54. ncbi The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered
    Rogério Pezato
    Upper Airway Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, Belgium Department of Otolaryngology Head and Neck Surgery, Federal University of Sao Paulo, Brazil Electronic address
    Immunobiology 219:729-36. 2014
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized as a Th2-driven disease. Activated dendritic cells (DCs) are the main T-cell activators; their role in the chronic inflammatory process of nasal polyposis is still unclear...
  55. pmc Mixed T Helper Cell Signatures In Chronic Rhinosinusitis with and without Polyps
    Lara Derycke
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e97581. 2014
    ..The aim of this study was to characterize the intracytoplasmatic cytokines ofTcells infiltrating theinflamed sinonasal mucosa...
  56. doi Role of staphylococcal superantigens in airway disease
    Wouter Huvenne
    Upper Airways Research Laboratory, Department of Otorhinolaryngology Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 161:304-14. 2013
    ..This review outlines the current knowledge on the influence of SEs on airway inflammation. We highlight, in particular, the recent evidence on their role in asthma. ..
  57. doi Damage-associated molecular patterns and their receptors in upper airway pathologies
    Koen Van Crombruggen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Cell Mol Life Sci 70:4307-21. 2013
    ..It is, however, of importance to assess these molecules again from a point of view as a DAMP in order to further unravel the pathogenesis of CRS...
  58. doi Staphylococcus aureus enterotoxin B regulates prostaglandin E2 synthesis, growth, and migration in nasal tissue fibroblasts
    Claudina A Pérez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    J Infect Dis 197:1036-43. 2008
    ..We therefore studied the possible influence of Staphylococcus aureus enterotoxin B (SEB) on the cyclooxygenase (COX) pathway and basic functions of airway structural cells...
  59. ncbi Allergic rhinitis, rhinosinusitis, and asthma: one airway disease
    Claus Bachert
    ENT Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 24:19-43. 2004
  60. ncbi Effect of mometasone furoate nasal spray on quality of life of patients with acute rhinosinusitis
    Claus Bachert
    Ear, Nose and Throat Department, University Hospital, Ghent, Belgium
    Rhinology 45:190-6. 2007
    ..Treatment with MFNS 200 g b.i.d. is associated with a significant improvement in HRQoL compared with placebo in patients with acute, uncomplicated rhinosinusitis...
  61. doi Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, BE 9000 Ghent, Belgium
    Clin Drug Investig 30:109-22. 2010
    ....
  62. pmc Suppression of Cytokine Release by Fluticasone Furoate vs. Mometasone Furoate in Human Nasal Tissue Ex-Vivo
    Nan Zhang
    Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 9:e93754. 2014
    ..Topical glucocorticosteroids are the first line therapy for airway inflammation. Modern compounds with higher efficacy have been developed, but head-to-head comparison studies are sparse...
  63. ncbi Pharmacological management of nasal polyposis
    Claus Bachert
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Drugs 65:1537-52. 2005
    ..This review summarises current knowledge on pathogenesis as well as established and future approaches in the pharmacological management of bilateral eosinophilic nasal polyposis...
  64. ncbi Impact of RNA quality on reference gene expression stability
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Biotechniques 39:52, 54, 56. 2005
  65. ncbi Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis
    Bernd Lange
    Institut für Atemwegsforschung GmbH, Dusseldorf, Germany
    Ann Allergy Asthma Immunol 95:272-82. 2005
    ..Current guidelines recommend intranasal glucocorticosteroids as first-line therapy for seasonal allergic rhinitis...
  66. pmc Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Inflamm (Lond) 6:11. 2009
    ..We have aimed to activate mast cells within ex-vivo human nasal tissue by IgE/anti-IgE specific (epsilon chain specific) stimulations and in this respect to test the usability of nasal polyps versus inferior turbinates..
  67. ncbi Predictive and monitoring value of matrix metalloproteinase-9 for healing quality after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, B 9000 Ghent, Belgium
    Wound Repair Regen 12:412-8. 2004
    ..MMP-9 is the first objective factor suitable to predict and monitor the healing quality after sinus surgery, indicating MMP-9 as a possible therapeutic target...
  68. ncbi Superantigens and nasal polyps
    Claus Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Curr Allergy Asthma Rep 3:523-31. 2003
    ..This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis...
  69. ncbi Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st
    Claus Bachert
    University of Ghent, Ghent, Belgium
    Clin Ther 27:993-1003. 2005
    ..Both are available over the counter for use at the standard recommended doses of 500 and 1000 mg per single use...
  70. ncbi Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 114:838-44. 2004
    ..The Xyzal in Persistent Rhinitis Trial is the first large, long-term clinical trial studying patients with persistent rhinitis as defined by Allergic Rhinitis and its Impact on Asthma...
  71. ncbi Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial
    Claus Bachert
    University of Ghent, ENT Department, Ghent, Belgium
    Rhinology 47:51-8. 2009
    ..To evaluate the efficacy and safety of the herbal drug preparation from the roots of Pelargonium sidoides (EPs 7630) compared to placebo...
  72. doi Evidence-based management of nasal polyposis by intranasal corticosteroids: from the cause to the clinic
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium claus bachert ugent be
    Int Arch Allergy Immunol 155:309-21. 2011
    ..Treatment with these mainstay options has been found to improve quality of life, which, along with symptom improvement, is a key factor in disease treatment...
  73. pmc A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
    Nan Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Evid Based Complement Alternat Med 2012:673145. 2012
    ..The combination of S. baicalensis and E. senticosus may be able to significantly block allergic early-and late-phase mediators and substantially suppress the release of proinflammatory, and Th1-, Th2-, and Th17-derived cytokines...
  74. ncbi Wound healing of the nasal and paranasal mucosa: a review
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Am J Rhinol 16:77-84. 2002
    ..Only few data regarding the specific healing of the nasal or sinusal mucosa are available...
  75. doi A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 31:921-44. 2009
    ..First-generation and older second-generation antihistamines, while effective against nasal itching, sneezing, and rhinorrhea, have limited efficacy in relieving nasal congestion...
  76. ncbi Desloratadine treatment for intermittent and persistent allergic rhinitis: a review
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 29:1795-802. 2007
    ..Desloratadine has been approved by the European Medicines Evaluation Agency for the treatment of intermittent and persistent AR, as defined by the ARIA classification...
  77. doi Human mast cells express leptin and leptin receptors
    Jasmien Taildeman
    Department of Pathology, Ghent University Hospital, Ghent University, Block A, 5th Floor, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 131:703-11. 2009
    ..Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells...
  78. ncbi Nasal function in self-reported chemically intolerant individuals
    Gerhard Andreas Wiesmüller
    Institute of Hygiene and Environmental Medicine, University Hospital, Rhenish Westphalian Technological University, Aachen, Germany
    Arch Environ Health 57:247-54. 2002
    ..For these investigations, anterior rhinomanometry was usable, but acoustic rhinometry can be recommended only after sufficient standardization has occurred. Furthermore, biochemical parameters of nasal mucosa must be considered...
  79. ncbi Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD
    Gernot Rohde
    Division of Pneumology, Department of Internal Medicine, Allergology and Sleep Medicine, University Hospital Bergmannsheil, D 44789 Bochum, Germany
    Respir Med 98:858-64. 2004
    ..Our data for the first time suggest differences between healthy subjects, smokers and patients with established COPD regarding the role of bacterial products and point to a possible disease modifying role of SAEs...
  80. ncbi Staphylococcus aureus sensitization and allergic disease in early childhood: population-based birth cohort study
    Aida Semic-Jusufagic
    University of Manchester, Wythenshawe Hospital, Manchester, UK
    J Allergy Clin Immunol 119:930-6. 2007
    ..Staphylococcus aureus-secreted enterotoxins (SEs) may be involved in the pathophysiology of atopic diseases...
  81. ncbi Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
    Thibaut Van Zele
    J Allergy Clin Immunol 114:981-3. 2004
  82. ncbi Short-term use of intranasal corticosteroids: lack of systemic effects
    Claus Bachert
    J Allergy Clin Immunol 109:573-4. 2002
  83. ncbi Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, CA 92123, USA
    J Allergy Clin Immunol 116:1289-95. 2005
    ..However, the efficacy of intranasal corticosteroid monotherapy for acute, uncomplicated rhinosinusitis is not established...
  84. ncbi Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI), Allergic Rhinitis and its Impact on Asthma (ARIA)
    Jean Bousquet
    Allergy 58:192-7. 2003
  85. ncbi Rhinosinusitis: Developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center Department of Pediatrics, University of California, San Diego, San Diego, California
    Otolaryngol Head Neck Surg 135:S31-80. 2006
    ....
  86. ncbi Rhinosinusitis: developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center and Department of Pediatrics, University of California, San Diego, USA
    J Allergy Clin Immunol 118:S17-61. 2006
    ....
  87. ncbi Comparison of solutions for sublingual immunotherapy
    Claus Bachert
    Int Arch Allergy Immunol 142:89-90. 2007
  88. ncbi Mizolastine provides effective symptom relief in patients suffering from perennial allergic rhinitis: a double-blind, placebo-controlled study versus loratadine
    Charles Frèche
    hôpital Américain, Neuilly sur Seine, France
    Ann Allergy Asthma Immunol 89:304-10. 2002
    ..Mizolastine is a nonsedating H1 histamine receptor antagonist with additional antiallergic properties currently marketed in Europe for the treatment of seasonal and perennial allergic rhinitis (PAR) and urticaria...
  89. ncbi Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis
    Fenna A Ebbens
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Allergy Clin Immunol 118:1149-56. 2006
    ..On the basis of this hypothesis, intranasal treatment with amphotericin B should benefit patients with CRS. Data from 2 uncontrolled and 2 controlled trials are conflicting, however...
  90. ncbi Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Berlin, Germany
    J Allergy Clin Immunol 111:763-9. 2003
    ..This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H(1)-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period...
  91. ncbi [Value of leukotriene antagonists in bronchial asthma]
    Wolfgang Petro
    Krankenpfl J 42:257. 2004
  92. ncbi IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma
    Claus Bachert
    J Allergy Clin Immunol 111:1131-2. 2003
  93. ncbi Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, CA, USA
    Pediatr Allergy Immunol 15:253-60. 2004
    ..05). Fexofenadine, at doses of up to 60 mg b.i.d., is safe and non-sedating, and fexofenadine HCl 30 mg b.i.d. effectively reduces all seasonal allergic rhinitis symptoms in children aged 6-11 years...
  94. ncbi Judicious antibiotic use and intranasal corticosteroids in acute rhinosinusitis
    Catherine Butkus Small
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla 10595, USA
    Am J Med 120:289-94. 2007
    ..The use of intranasal corticosteroids in acute rhinosinusitis therefore might reduce the inappropriate use of antimicrobial therapy in acute rhinosinusitis...
  95. ncbi Interleukin-5, eosinophilic diseases and therapeutic intervention
    Lennart Zabeau
    VIB09 Dept Medical Protein Research, Ghent University, Belgium
    Curr Drug Targets Inflamm Allergy 2:319-28. 2003
    ..Here, we review the current status of IL-5 and IL-5 receptor research, with emphasis on strategies to interfere with IL-5 function...
  96. ncbi Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis
    G Walter Canonica
    Allergy and Respiratory Diseases Clinic, DIMI, Genoa University, Pad Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Respir Med 100:1706-15. 2006
    ..Allergic rhinitis is a chronic respiratory disorder with a detrimental impact on health-related quality of life (HRQOL) and health status. Enhancement and maintenance of patient function and well-being are therefore considered as essential...
  97. ncbi Ultra-short-course seasonal allergy vaccine (Pollinex Quattro): viewpoints
    Marel Jutek
    Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Drugs 66:939-40. 2006
  98. pmc Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA
    Claudina Pérez
    Faculty of Medicine and Health Sciences, Department of Otorhynolaringology, Ghent University Hospital De Pintelaan 185, 9000 Ghent, Belgium
    BMC Biotechnol 3:17. 2003
    ..The aim of this study was to develop a reliable and sensitive real-time quantitative PCR assay to analyse the expression level of each isoform...
  99. doi EPOS Primary Care Guidelines: European Position Paper on the Primary Care Diagnosis and Management of Rhinosinusitis and Nasal Polyps 2007 - a summary
    Mike Thomas
    Department of General Practice and Primary Care, University of Aberdeen, Aberdeen, Scotland, UK
    Prim Care Respir J 17:79-89. 2008
    ....
  100. ncbi [Health care reform leaves allergy and skin patients in the lurch]
    Petra von der Lage
    Deutsche Gesellschaft for Allergologie und klinische Immunologie DGAI
    Kinderkrankenschwester 23:414-5. 2004