Claus Bachert

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Allergic Rhinitis and its impact on asthma update (ARIA 2008). The Belgian perspective
    C Bachert
    ENT Department, URL, University Hosptial Gent, Belgium
    B-ENT 4:253-7. 2008
  2. pmc Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
    Wouter Huvenne
    Upper Airways Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent University, Ghent, Belgium
    Respir Res 12:69. 2011
  3. pmc A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
    Nan Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Evid Based Complement Alternat Med 2012:673145. 2012
  4. pmc Staphylococcus aureus and Chronic Airway Disease
    Lara Derycke
    From the Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Belgium and Centre Hospitalier Universitaire de Québec, Pavillon Saint Francois d Assise, Quebec, Canada
    World Allergy Organ J 3:223-8. 2010
  5. pmc Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa
    Leonardo Balsalobre
    Department of Otolaryngology, Head and Neck Surgery of Federal University of São Paulo, Sao Paulo, Brazil
    J Otolaryngol Head Neck Surg 42:29. 2013
  6. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  7. doi request reprint Chronic rhinosinusitis: from one disease to different phenotypes
    Claus Bachert
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pediatr Allergy Immunol 23:2-4. 2012
  8. doi request reprint Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma
    Claus Bachert
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 130:376-81.e8. 2012
  9. doi request reprint Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'
    C Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Intern Med 272:133-43. 2012
  10. pmc Diagnostic tools in Rhinology EAACI position paper
    Glenis Scadding
    Royal National Throat, Nose and Ear Institute, London, UK
    Clin Transl Allergy 1:2. 2011

Detail Information

Publications152 found, 100 shown here

  1. ncbi request reprint Allergic Rhinitis and its impact on asthma update (ARIA 2008). The Belgian perspective
    C Bachert
    ENT Department, URL, University Hosptial Gent, Belgium
    B-ENT 4:253-7. 2008
    ..This document has now been updated: ARIA 2008. In this article, it is aimed to summarize the newly updated and published version of "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008" in a Belgian perspective...
  2. pmc Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
    Wouter Huvenne
    Upper Airways Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent University, Ghent, Belgium
    Respir Res 12:69. 2011
    ..Colonization with Staphylococcus aureus results in release of virulent enterotoxins, with superantigen activity which causes T cell activation...
  3. pmc A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
    Nan Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Evid Based Complement Alternat Med 2012:673145. 2012
    ..The combination of S. baicalensis and E. senticosus may be able to significantly block allergic early-and late-phase mediators and substantially suppress the release of proinflammatory, and Th1-, Th2-, and Th17-derived cytokines...
  4. pmc Staphylococcus aureus and Chronic Airway Disease
    Lara Derycke
    From the Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Belgium and Centre Hospitalier Universitaire de Québec, Pavillon Saint Francois d Assise, Quebec, Canada
    World Allergy Organ J 3:223-8. 2010
    ..Knowing the triggers of the pathomechanisms involved will greatly help us to find new therapeutic approaches to resolve this chronic inflammatory process...
  5. pmc Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa
    Leonardo Balsalobre
    Department of Otolaryngology, Head and Neck Surgery of Federal University of São Paulo, Sao Paulo, Brazil
    J Otolaryngol Head Neck Surg 42:29. 2013
    ..To evaluate TGF-β1 expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP)...
  6. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  7. doi request reprint Chronic rhinosinusitis: from one disease to different phenotypes
    Claus Bachert
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pediatr Allergy Immunol 23:2-4. 2012
    ..Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma...
  8. doi request reprint Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma
    Claus Bachert
    Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 130:376-81.e8. 2012
    ..The role of IgE in patients with severe asthma is not fully understood...
  9. doi request reprint Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'
    C Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Intern Med 272:133-43. 2012
    ..These findings should lead to a clinically relevant endotyping of patients with upper and lower airway disease and to a new understanding of the role of IgE 'above atopy'...
  10. pmc Diagnostic tools in Rhinology EAACI position paper
    Glenis Scadding
    Royal National Throat, Nose and Ear Institute, London, UK
    Clin Transl Allergy 1:2. 2011
    ..A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology...
  11. ncbi request reprint Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 114:838-44. 2004
    ..The Xyzal in Persistent Rhinitis Trial is the first large, long-term clinical trial studying patients with persistent rhinitis as defined by Allergic Rhinitis and its Impact on Asthma...
  12. doi request reprint Treatment of respiratory allergy with allergy immunotherapy tablets
    C Bachert
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, University Hospital Ghent, Belgium
    Allergy 66:57-9. 2011
    ..Safety profiles favour AIT over SCIT. Studies suggest that tablets in all aspects are superior to sublingual drops. AITs for other allergies including house dust mite and birch and ragweed pollen are in development...
  13. doi request reprint Rhinosinusitis and asthma: a link for asthma severity
    C Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, 9000, Belgium
    Curr Allergy Asthma Rep 10:194-201. 2010
    ..Recent findings in severe asthma patients confirm the role of superantigens in lower airway disease...
  14. doi request reprint Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
    ..Nasal polyps often are associated with asthma. The phenotype of these patients is unknown...
  15. ncbi request reprint Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, BE 9000 Ghent, Belgium
    Clin Drug Investig 30:109-22. 2010
    ....
  16. ncbi request reprint Pharmacological management of nasal polyposis
    Claus Bachert
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Drugs 65:1537-52. 2005
    ..This review summarises current knowledge on pathogenesis as well as established and future approaches in the pharmacological management of bilateral eosinophilic nasal polyposis...
  17. ncbi request reprint Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st
    Claus Bachert
    University of Ghent, Ghent, Belgium
    Clin Ther 27:993-1003. 2005
    ..Both are available over the counter for use at the standard recommended doses of 500 and 1000 mg per single use...
  18. ncbi request reprint Superantigens and nasal polyps
    Claus Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Curr Allergy Asthma Rep 3:523-31. 2003
    ..This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis...
  19. ncbi request reprint Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial
    Claus Bachert
    University of Ghent, ENT Department, Ghent, Belgium
    Rhinology 47:51-8. 2009
    ..To evaluate the efficacy and safety of the herbal drug preparation from the roots of Pelargonium sidoides (EPs 7630) compared to placebo...
  20. ncbi request reprint Management of nasal polyposis
    C Bachert
    Dept of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    B-ENT . 2005
    ..Nevertheless medical therapy must be continued after surgery to prevent recurrences. Algorithms of decision are finally proposed [corrected]..
  21. doi request reprint A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 31:921-44. 2009
    ..First-generation and older second-generation antihistamines, while effective against nasal itching, sneezing, and rhinorrhea, have limited efficacy in relieving nasal congestion...
  22. ncbi request reprint Effect of mometasone furoate nasal spray on quality of life of patients with acute rhinosinusitis
    Claus Bachert
    Ear, Nose and Throat Department, University Hospital, Ghent, Belgium
    Rhinology 45:190-6. 2007
    ..Treatment with MFNS 200 g b.i.d. is associated with a significant improvement in HRQoL compared with placebo in patients with acute, uncomplicated rhinosinusitis...
  23. ncbi request reprint Desloratadine treatment for intermittent and persistent allergic rhinitis: a review
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 29:1795-802. 2007
    ..Desloratadine has been approved by the European Medicines Evaluation Agency for the treatment of intermittent and persistent AR, as defined by the ARIA classification...
  24. doi request reprint Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    ..Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis...
  25. ncbi request reprint Belgian guidelines for the treatment of acute rhinosinusitis in general practice
    C Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    B-ENT 3:175-7. 2007
    ..It is recommended to treat ARS with topical glucocorticosteroids 200 mcg BID. Antibiotics are recommended for the treatment of severe ARS, if need be, together with topical glucocorticosteroids BID...
  26. ncbi request reprint Levocetirizine: a modern H(1)-antihistamine for the treatment of allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, Univerisity Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Expert Rev Clin Immunol 1:495-510. 2005
    ..It is also reported to reduce comorbidities as well as overall treatment costs when administered continuously over the longterm...
  27. ncbi request reprint The role of sinus disease in asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 6:29-36. 2006
    ..This concept primarily refers to the well established link between allergic rhinitis and asthma, but it also covers a possible link between sinus disease and asthma (allergic or nonallergic) and other lower airway disease...
  28. doi request reprint Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    J Asthma 48:965-73. 2011
    ..The recent identification of a fourth histamine receptor has reinforced clinical interest in the pleiotropic effects of histamine and the relative roles of histamine receptors in mediating immune and inflammatory responses...
  29. doi request reprint Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps...
  30. ncbi request reprint Chronic rhinosinusitis with and without nasal polyps: what is the difference?
    Wouter Huvenne
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 9:213-20. 2009
    ..This disease differentiation will not only increase our knowledge of the pathophysiology of sinusitis but may lead to new diagnostic and therapeutic strategies specifically targeted and adapted to the diagnosed disease entity...
  31. ncbi request reprint Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  32. pmc Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  33. ncbi request reprint Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China
    Nan Zhang
    Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium
    Am J Rhinol 20:445-50. 2006
    ..This study analyzes the impact of Staphylococcus aureus enterotoxins (SAEs) and the inflammatory pattern in polyps from China...
  34. ncbi request reprint Inflammatory patterns in upper airway disease in the same geographical area may change over time
    Michael Katotomichelakis
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 27:354-60. 2013
    ....
  35. ncbi request reprint Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Upper Airways Research Laboratory, Gent University Hospital, Belgium
    Am J Rhinol 20:456-60. 2006
    ..We studied the possible impact of SE-induced immune responses on the eicosanoid production in nasal polyp (NP) patients...
  36. doi request reprint Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization
    Marie Noëlle Corriveau
    Upper Airways Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Rhinol Allergy 23:461-5. 2009
    ....
  37. ncbi request reprint Identification of the nasal mucosa as a new target for leptin action
    Jasmien Taildeman
    Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Histopathology 56:789-98. 2010
    ..The aim of this study was to examine systemic and local nasal leptin and leptin receptor expression in patients with nasal polyposis and healthy controls...
  38. doi request reprint Pathophysiology of chronic rhinosinusitis
    Peter Tomassen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic Audiological Science, Ghent University, Ghent, Belgium
    Proc Am Thorac Soc 8:115-20. 2011
    ..Identification of specific disease subgroups and their etiologies is an important and challenging task for future research...
  39. ncbi request reprint TGF-beta signaling and collagen deposition in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 124:253-9, 259.e1-2. 2009
    ..Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns...
  40. ncbi request reprint RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 129:1515-21.e8. 2012
    ..RAGE is reported to play a role in diverse pathologies including lower airway conditions, but the exact mechanism of action remains poorly understood. In the upper airways, the involvement of RAGE remains completely unexplored...
  41. ncbi request reprint Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 121:110-5. 2008
    ..Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis...
  42. doi request reprint Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
    ..This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of CRS to further unravel its pathogenesis...
  43. ncbi request reprint Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship
    Claudina A Pérez-Novo
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 133:255-60. 2004
    ..In this study, we therefore aimed to determine, whether aspirin sensitivity was related to an immune response to SAEs, and how both criteria would be related to eosinophilic inflammation...
  44. doi request reprint T-cell regulation in chronic paranasal sinus disease
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 121:1435-41, 1441.e1-3. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without nasal polyps (CRSsNP) represents a predominant T(H)1 milieu...
  45. ncbi request reprint Local inflammation in chronic upper airway disease
    Lien Calus
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Curr Pharm Des 18:2336-46. 2012
    ..Defining and predicting response to therapy in individual CRS patients is a challenge for future research...
  46. pmc Different regulation of cigarette smoke induced inflammation in upper versus lower airways
    Wouter Huvenne
    Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent University, Belgium
    Respir Res 11:100. 2010
    ..We investigated and compared the effects of CS on upper and lower airways, in a mouse model of subacute and chronic CS exposure...
  47. doi request reprint Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7. 2008
    ..The purpose of this study was to investigate the presence of S. aureus enterotoxin genes and the agr subtype in bacterial DNA of S. aureus strains isolated from the middle meatus of nasal polyp and control patients...
  48. ncbi request reprint Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Belgium
    Am J Rhinol 18:267-72. 2004
    ..Transforming growth factor (TGF) beta1 plays an important role in tissue remodeling, which is poorly understood in chronic diseases of the sinuses...
  49. doi request reprint Prevalence of allergic sensitization versus allergic rhinitis symptoms in an unselected population
    Katrien Blomme
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Int Arch Allergy Immunol 160:200-7. 2013
    ..The objective of the present survey was to evaluate the prevalence of allergic sensitization and the prevalence of clinically diagnosed AR in a sample of the Belgian population, and to estimate the effect of age and gender...
  50. pmc Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue
    Xiangdong Wang
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 7:e39875. 2012
    ..aureus are not clearly understood. The aim of this study was to investigate the interaction between S. aureus and herpes simplex virus type 1 (HSV1) in the invasion of the nasal mucosa and nasal polyp tissue...
  51. ncbi request reprint Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolarynogy, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Allergy Clin Immunol 115:1189-96. 2005
    ....
  52. ncbi request reprint Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    ..There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps...
  53. ncbi request reprint Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B
    P W Hellings
    Laboratory of Experimental Immunology, Department of Otorhinolaryngology, University Hospitals, Faculty of Medicine, University of Leuven, Belgium
    Clin Exp Allergy 36:1063-71. 2006
    ..We used a mouse model of airway allergy to study the effects of nasal or bronchial contact with SEB on bronchial allergic inflammation...
  54. doi request reprint Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3
    Feng Lan
    Division of Geriatrics, Center for Medical Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Upper Airways Research Laboratory, ENT Department, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 132:1314-21. 2013
    ..In patients with persistent upper airway inflammation, the number of forkhead box protein 3 (Foxp3)(+) regulatory T (Treg) cells is reduced, but the regulation of Foxp3 expression in Treg cells is poorly understood...
  55. ncbi request reprint Collection of nasal secretions for immunological analysis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Eur Arch Otorhinolaryngol 261:242-6. 2004
    ..The method is non-invasive, well standardized and reproducible and therefore may serve as a valid tool for future investigations...
  56. doi request reprint Chronic sinusitis and rhinitis: clinical terminology "Chronic Rhinosinusitis" further supported
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    Rhinology 48:54-8. 2010
    ..We therefore investigated the immunological background of the chronically inflamed nasal and sinusal mucosa...
  57. ncbi request reprint Pathogenesis of chronic rhinosinusitis
    Paul Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 6:487-94. 2006
    ..These findings question the current assumption that NP is a subgroup of CRS, but suggest that CRS and NP should probably be considered as distinct disease entities...
  58. doi request reprint Tissue remodeling in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University, Belgium
    Curr Opin Allergy Clin Immunol 11:8-11. 2011
    ..To summarize the current knowledge on remodeling in chronic sinus disease...
  59. ncbi request reprint Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 118:1133-41. 2006
    ..Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels...
  60. ncbi request reprint Impact of RNA quality on reference gene expression stability
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Biotechniques 39:52, 54, 56. 2005
  61. doi request reprint Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 131:110-6.e1. 2013
    ..Omalizumab is a human anti-IgE mAb with proved efficacy in patients with severe allergic asthma. Omalizumab could be a treatment option for patients with nasal polyps and asthma...
  62. ncbi request reprint Allergic rhinitis, rhinosinusitis, and asthma: one airway disease
    Claus Bachert
    ENT Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 24:19-43. 2004
  63. doi request reprint Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 128:989-95.e1-8. 2011
    ..Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival...
  64. doi request reprint Cytokine profiles in Japanese patients with chronic rhinosinusitis
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Allergol Int 61:115-22. 2012
    ..Studying inflammatory mediators in clearly defined disease subgroups may lead to a better differentiation of chronic sinus diseases...
  65. doi request reprint Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps?
    Katia Verbruggen
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 148:87-98. 2009
    ....
  66. doi request reprint The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  67. ncbi request reprint Staphylococcus aureus superantigens and airway disease
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
    Curr Allergy Asthma Rep 2:252-8. 2002
    ..This circumstantial evidence is currently limited to rhinitis, sinusitis, and possibly asthma, but may, if supported, open a new understanding of pathomechanisms and therapeutic targets...
  68. doi request reprint Syk-kinase inhibition prevents mast cell activation in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Rhinology 49:100-6. 2011
    ..Spleen tyrosine kinase (Syk) is positioned upstream of the IgE receptor signal transducing pathway and may represent an important target for the treatment of nasal inflammatory diseases...
  69. doi request reprint Pilot study using doxycycline-releasing stents to ameliorate postoperative healing quality after sinus surgery
    Wouter Huvenne
    Upper Airway Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent, Belgium
    Wound Repair Regen 16:757-67. 2008
    ....
  70. doi request reprint Staphylococcus aureus enterotoxin B regulates prostaglandin E2 synthesis, growth, and migration in nasal tissue fibroblasts
    Claudina A Pérez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    J Infect Dis 197:1036-43. 2008
    ..We therefore studied the possible influence of Staphylococcus aureus enterotoxin B (SEB) on the cyclooxygenase (COX) pathway and basic functions of airway structural cells...
  71. ncbi request reprint Secretion of TGF-betal, TGF-beta2, EGF and PDGF into nasal fluid after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Eur Arch Otorhinolaryngol 259:234-8. 2002
    ..This is the first study proposing a follow-up method for nasal and sinus mucosal healing after surgery in order to determine cytokine secretion profiles...
  72. ncbi request reprint Macrophage mannose receptor in chronic sinus disease
    S Claeys
    Department of Otorhinolaryngology, University Hospital, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    Allergy 59:606-12. 2004
    ....
  73. ncbi request reprint Local complement activation in nasal polyposis
    Thibaut Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Laryngoscope 119:1753-8. 2009
    ....
  74. ncbi request reprint Predictive and monitoring value of matrix metalloproteinase-9 for healing quality after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, B 9000 Ghent, Belgium
    Wound Repair Regen 12:412-8. 2004
    ..MMP-9 is the first objective factor suitable to predict and monitor the healing quality after sinus surgery, indicating MMP-9 as a possible therapeutic target...
  75. ncbi request reprint Wound healing of the nasal and paranasal mucosa: a review
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Am J Rhinol 16:77-84. 2002
    ..Only few data regarding the specific healing of the nasal or sinusal mucosa are available...
  76. ncbi request reprint Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis
    P Gevaert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Allergy 58:371-9. 2003
    ..Given the key role of IL-5 in eosinophil function, we investigated SOL IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP)...
  77. ncbi request reprint Effect of corticosteroids on wound healing after endoscopic sinus surgery
    M Jorissen
    ENT Department, HNS, University of Leuven, Leuven, Belgium
    Rhinology 47:280-6. 2009
    ..Approximately 20% patients with chronic rhinosinusitis undergoing Functional Endoscopic Sinus Surgery (FESS) experience impaired wound healing, leading to recurrences of sinusitis and polyps...
  78. pmc Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Inflamm (Lond) 6:11. 2009
    ..We have aimed to activate mast cells within ex-vivo human nasal tissue by IgE/anti-IgE specific (epsilon chain specific) stimulations and in this respect to test the usability of nasal polyps versus inferior turbinates..
  79. pmc Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA
    Claudina Pérez
    Faculty of Medicine and Health Sciences, Department of Otorhynolaringology, Ghent University Hospital De Pintelaan 185, 9000 Ghent, Belgium
    BMC Biotechnol 3:17. 2003
    ..The aim of this study was to develop a reliable and sensitive real-time quantitative PCR assay to analyse the expression level of each isoform...
  80. ncbi request reprint Mediators in nasal polyposis
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, B 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 2:481-7. 2002
    ....
  81. ncbi request reprint Total and specific IgE in nasal polyps is related to local eosinophilic inflammation
    C Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, B-9000 Ghent, Belgium
    J Allergy Clin Immunol 107:607-14. 2001
    ..Similarly, the presence of specific IgE to staphylococcal enterotoxins A and B also points to a possible role of bacterial superantigens...
  82. ncbi request reprint Microbiology of chronic sinusitis
    P B van Cauwenberge
    State University of Ghent, Department of Otorhinolaryngology, Belgium
    Acta Otorhinolaryngol Belg 51:239-46. 1997
    ..It is postulated that, although bacteria are very important in acute sinusitis, their role in chronic sinusitis is minimal, the bacteria being opportunistic colonisers...
  83. doi request reprint Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 64:725-32. 2009
    ....
  84. ncbi request reprint Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis
    J B Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Allergy 59:54-60. 2004
    ..Differences in histological features between CS and NP might be related to the respective expression of MMPs and their tissue inhibitors (TIMPs)...
  85. ncbi request reprint Human beta-defensins and toll-like receptors in the upper airway
    S Claeys
    Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 58:748-53. 2003
    ..In this study, the expression of human beta-defensins (HBD) 2 and 3 and toll-like receptors (TLR) 2 and 4 in various upper airway diseases was investigated...
  86. ncbi request reprint Interleukin-5, eosinophilic diseases and therapeutic intervention
    Lennart Zabeau
    VIB09 Dept Medical Protein Research, Ghent University, Belgium
    Curr Drug Targets Inflamm Allergy 2:319-28. 2003
    ..Here, we review the current status of IL-5 and IL-5 receptor research, with emphasis on strategies to interfere with IL-5 function...
  87. ncbi request reprint Evidence-based management of nasal polyposis by intranasal corticosteroids: from the cause to the clinic
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium claus bachert ugent be
    Int Arch Allergy Immunol 155:309-21. 2011
    ..Nasal polyposis is an inflammatory disorder involving the mucosa of the nose and paranasal sinuses and affecting approximately 2-4% of the general population...
  88. doi request reprint Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases
    Olga Krysko
    Department of Oto Rhino Laryngology, Ghent University Hospital, UZ Gent, MRB, Belgium
    Apoptosis 15:1137-46. 2010
    ..Finally, we will address possible therapeutic strategies, such as the use of macrolide antibiotics and statins, for modulating apoptotic cell clearance...
  89. pmc Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 6:e22160. 2011
    ..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
  90. doi request reprint Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Belgium
    Trends Immunol 32:157-64. 2011
    ..Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies...
  91. ncbi request reprint Role of staphylococcal superantigens in airway disease
    C Bachert
    Upper Airway Research Laboratory, ENT Department, University Hospital Ghent, Ghent, Belgium
    Chem Immunol Allergy 93:214-36. 2007
    ..However, therapeutic approaches are so far limited and empirical, and need further improvement to tackle this currently underestimated clinical challenge...
  92. ncbi request reprint Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators
    S Claeys
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Clin Exp Allergy 35:467-72. 2005
    ..Innate defence markers and inflammatory mediators in NP from patients with CF were compared with non-cystic fibrosis nasal polyps (non-CF-NP) to determine a possible different immunological background in macroscopically similar tissue...
  93. ncbi request reprint Staphylococcus aureus enterotoxin B facilitates allergic sensitization in experimental asthma
    W Huvenne
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 40:1079-90. 2010
    ..Staphylococcus aureus Enterotoxin B (SEB) has immunomodulatory effects in allergic airway disease. The potential contribution of SEB to the sensitization process to allergens remains obscure...
  94. ncbi request reprint Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006
    ..Studying inflammatory cells and mediators in clearly defined disease subgroups may lead to a better differentiation of chronic sinus diseases...
  95. ncbi request reprint Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 60:71-9. 2005
    ..We aimed to study the relationship between systemic and local IgE formation, nasal carriage of Staphylococcus aureus and nasal polyposis...
  96. doi request reprint Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 383:613-26. 2011
    ..These vasodilatations can be suppressed by the EP(1/3) receptor agonist sulprostone at subnanomolar concentrations...
  97. ncbi request reprint Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery
    J B Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Laryngoscope 115:56-61. 2005
    ..In this work, we aimed to explore the source of MMP-9 and the influence of inflammation on MMP-9 expression and release in nasal tissue and secretions during airway remodelling after surgery...
  98. ncbi request reprint Local immunoglobulin production in nasal polyposis is modulated by superantigens
    T Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 37:1840-7. 2007
    ..We aimed to study the systemic and local production of Igs in relation to plasma cells, B cells and specific IgE to SAEs...
  99. ncbi request reprint Wound healing after paranasal sinus surgery: neutrophilic inflammation influences the outcome
    J B Watelet
    Department of Otorhinolaryngology and Department of Pathology, Ghent University Hospital, Ghent, Belgium
    Histopathology 48:174-81. 2006
    ..The aim of this study was to explore systematically the different histomorphological processes and cell populations involved in the wound repair of the paranasal mucosa...
  100. ncbi request reprint An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis
    N Zhang
    ENT Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium
    Rhinology 43:162-8. 2005
    ..Therapeutic approaches are so far empirical, and need further study, also serving to proof the clinical relevance of the concept...
  101. doi request reprint T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation
    C A Pérez Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Clin Exp Allergy 40:1323-32. 2010
    ..Staphylococcal superantigens may modulate airway inflammatory disease...