Klaus Bacher

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Image quality performance of liquid crystal display systems: influence of display resolution, magnification and window settings on contrast-detail detection
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Eur J Radiol 58:471-9. 2006
  2. doi request reprint In vitro and in vivo evaluation of direct rhenium-188-labeled anti-CD52 monoclonal antibody alemtuzumab for radioimmunotherapy of B-cell chronic lymphocytic leukemia
    Mario De Decker
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Nucl Med Biol 35:599-604. 2008
  3. ncbi request reprint Image quality and radiation dose on digital chest imaging: comparison of amorphous silicon and amorphous selenium flat-panel systems
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B9000, Belgium
    AJR Am J Roentgenol 187:630-7. 2006
  4. ncbi request reprint Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Circulation 111:83-9. 2005
  5. ncbi request reprint Accurate dosimetry: an essential step towards good clinical practice in nuclear medicine
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Belgium
    Nucl Med Commun 26:581-6. 2005
  6. ncbi request reprint Dose reduction in patients undergoing chest imaging: digital amorphous silicon flat-panel detector radiography versus conventional film-screen radiography and phosphor-based computed radiography
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
    AJR Am J Roentgenol 181:923-9. 2003
  7. ncbi request reprint Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinoma
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology, and Medical Physics, Ghent University, Gent, Belgium
    J Nucl Med 45:612-8. 2004
  8. ncbi request reprint In vitro screening for synergism of high-linear energy transfer 213Bi-radiotherapy with other therapeutic agents for the treatment of B-cell chronic lymphocytic leukemia
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 21:364-72. 2006
  9. ncbi request reprint Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro study
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Belgium
    Nucl Med Commun 25:1131-6. 2004
  10. doi request reprint gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?
    Laurence Beels
    Ghent University, Department of Basic Medical Sciences, Proeftuinstraat 86, 9000 Gent, Belgium
    Circulation 120:1903-9. 2009

Detail Information

Publications29

  1. ncbi request reprint Image quality performance of liquid crystal display systems: influence of display resolution, magnification and window settings on contrast-detail detection
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Eur J Radiol 58:471-9. 2006
    ..If a 3-megapixel LCD is used in mammography setting, a very time-consuming magnification of the digital mammograms would be necessary...
  2. doi request reprint In vitro and in vivo evaluation of direct rhenium-188-labeled anti-CD52 monoclonal antibody alemtuzumab for radioimmunotherapy of B-cell chronic lymphocytic leukemia
    Mario De Decker
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Nucl Med Biol 35:599-604. 2008
    ..Therefore, (188)Re-alemtuzumab would be an ideal candidate for radioimmunotherapy of chronic lymphocytic leukemia...
  3. ncbi request reprint Image quality and radiation dose on digital chest imaging: comparison of amorphous silicon and amorphous selenium flat-panel systems
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B9000, Belgium
    AJR Am J Roentgenol 187:630-7. 2006
    ..In addition, the low-contrast performance of both systems with standard and low radiation doses was compared...
  4. ncbi request reprint Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Circulation 111:83-9. 2005
    ..However, knowledge of the effective dose in pediatric interventional cardiology is very limited...
  5. ncbi request reprint Accurate dosimetry: an essential step towards good clinical practice in nuclear medicine
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Belgium
    Nucl Med Commun 26:581-6. 2005
    ..It is concluded that reliable dosimetry is essential in performing scientific clinical studies according to the principle of good clinical practice...
  6. ncbi request reprint Dose reduction in patients undergoing chest imaging: digital amorphous silicon flat-panel detector radiography versus conventional film-screen radiography and phosphor-based computed radiography
    Klaus Bacher
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
    AJR Am J Roentgenol 181:923-9. 2003
    ..In addition, a contrast-detail phantom study was set up to assess the low-contrast detection of all three systems...
  7. ncbi request reprint Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinoma
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology, and Medical Physics, Ghent University, Gent, Belgium
    J Nucl Med 45:612-8. 2004
    ..To this end, dicentric chromosomes (DCs) were scored in metaphase spreads of peripheral blood cultures. The equivalent total-body dose was deduced from the DC yields using an in vitro dose-response curve...
  8. ncbi request reprint In vitro screening for synergism of high-linear energy transfer 213Bi-radiotherapy with other therapeutic agents for the treatment of B-cell chronic lymphocytic leukemia
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 21:364-72. 2006
    ..The development of RIT with alpha-emitters is attractive, owing to the high (LET) nature and short path length of alpha particles allowing for higher tumor cell kill and lower toxicity to healthy tissues...
  9. ncbi request reprint Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro study
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Belgium
    Nucl Med Commun 25:1131-6. 2004
    ..The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues...
  10. doi request reprint gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?
    Laurence Beels
    Ghent University, Department of Basic Medical Sciences, Proeftuinstraat 86, 9000 Gent, Belgium
    Circulation 120:1903-9. 2009
    ..Patient-specific dose was assessed and radiation risks were estimated according to the linear-no-threshold model, commonly used in radiation protection, and the gamma-H2AX foci data...
  11. doi request reprint Dose-length product of scanners correlates with DNA damage in patients undergoing contrast CT
    Laurence Beels
    Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000 Gent, Belgium
    Eur J Radiol 81:1495-9. 2012
    ..This study addresses the question if dose settings of scanners expressed by dose-length product (DLP) are correlated with directly measurable biological effects in patients...
  12. ncbi request reprint Patient dosimetry in radionuclide therapy: the whys and the wherefores
    Hubert M Thierens
    Department of Medical Physics and Radiation Protection, University of Ghent, Belgium
    Nucl Med Commun 26:593-9. 2005
    ..This will allow treatment protocols based on tumour dose prescriptions as performed in external beam radiotherapy...
  13. doi request reprint Early biomarkers related to secondary primary cancer risk in radiotherapy treated prostate cancer patients: IMRT versus IMAT
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Gent, Belgium
    Radiother Oncol 107:377-81. 2013
    ....
  14. ncbi request reprint Patient dosimetry for 131I-lipiodol therapy
    Myriam A Monsieurs
    Department of Anatomy, Embryology, Histology and Medical Physics, Faculty of Medicine, University of Ghent, Proeftuinstraat 86, 9000, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 30:554-61. 2003
    ..Except in the case of the smaller tumours, comparable results were obtained with MCNP and MIRDOSE. Due to hypersplenism, biological dosimetry results based on the MN assay are not reliable...
  15. ncbi request reprint TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Gent University Hospital, Belgium
    Int J Radiat Oncol Biol Phys 65:1240-8. 2006
    ..552delAGG, -800G>A, -509C>T, Leu10Pro, Arg25Pro, Thr263Ile) and the occurrence of late normal tissue reactions after gynecologic radiotherapy (RT)...
  16. doi request reprint Typetesting of physical characteristics of digital mammography systems for screening within the Flemish breast cancer screening programme
    Hubert Thierens
    Department of Medical Physics and Radiation Protection, QCC, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
    Eur J Radiol 70:539-48. 2009
    ..However, as zooming and scrolling are necessary for 3-megapixel monitors to get the full resolution capabilities of the image capture system, 5-megapixel monitors are preferred in a busy screening environment...
  17. doi request reprint Correlation of contrast-detail analysis and clinical image quality assessment in chest radiography with a human cadaver study
    An De Crop
    Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
    Radiology 262:298-304. 2012
    ..To determine the correlation between the clinical and physical image quality of chest images by using cadavers embalmed with the Thiel technique and a contrast-detail phantom...
  18. ncbi request reprint In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage
    Katia Vandenbulcke
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Eur J Nucl Med Mol Imaging 30:1357-64. 2003
    ..Long-term toxicity on healthy B and T lymphocytes was systematically higher for the alpha emitter (RBE=5 to 2)...
  19. ncbi request reprint Biodistribution and dosimetry of (99m)Tc-depreotide (P829) in patients suffering from breast carcinoma
    Bieke Van Den Bossche
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Cancer Biother Radiopharm 19:776-83. 2004
    ..This paper reports on the biodistribution and dosimetry of (99m)Tc-depreotide in patients...
  20. doi request reprint Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat
    Kathelijne Peremans
    Medical Imaging Department, Faculty of Veterinary Science, University Ghent, Merelbeke, Belgium
    J Feline Med Surg 10:460-5. 2008
    ..In this study, albeit including a small number of cats, outcome did not seem to be significantly affected...
  21. ncbi request reprint Biodistribution and planar gamma camera imaging of (123)I- and (131)I-labeled F(ab')(2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor
    Ingrid J G Burvenich
    Laboratory of Radiopharmacy, University of Ghent, B 9000 Ghent, Belgium
    Nucl Med Biol 34:257-65. 2007
    ..The aim of this study was to evaluate the biodistribution and planar gamma camera imaging characteristics of radioiodinated F(ab')(2) and Fab fragments of monoclonal antibody (mAb) 14C5 in tumor-bearing mice...
  22. ncbi request reprint Radiolabeling, biodistribution, and dosimetry of (123)I-mAb 14C5: a new mAb for radioimmunodetection of tumor growth and metastasis in vivo
    Christophe M M Lahorte
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
    J Nucl Med 45:1065-73. 2004
    ..This study reports on the in vitro evaluation, biodistribution, and dosimetry of (123)I-labeled monoclonal antibody (mAb) 14C5, a new antibody-based agent proposed for radioimmunodetection of tumor growth and metastasis in vivo...
  23. ncbi request reprint 188Re-HDD/lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial
    Bieke Lambert
    Nuclear Medicine Division, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Nucl Med 46:60-6. 2005
    ..A secondary objective was to document the response...
  24. ncbi request reprint (188)Re-HDD/lipiodol therapy for hepatocellular carcinoma: an activity escalation study
    Bieke Lambert
    Nuclear Medicine Division, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Eur J Nucl Med Mol Imaging 33:344-52. 2006
    ....
  25. ncbi request reprint 188Re-HDD/lipiodol for treatment of hepatocellular carcinoma: a feasibility study in patients with advanced cirrhosis
    Bieke Lambert
    Nuclear Medicine Division, Ghent University Hospital, Belgium
    J Nucl Med 46:1326-32. 2005
    ..7 GBq (188)Re-4-hexadecyl-1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol/lipiodol ((188)Re-HDD/lipiodol) for treatment of hepatocellular carcinoma (HCC) in patients with moderately advanced cirrhosis...
  26. ncbi request reprint Patient doses in gamma-intracoronary radiotherapy: the Radiation Burden Assessment Study
    Hubert Thierens
    Department of Medical Physics and Radiation Protection, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 60:678-85. 2004
    ..To determine accurately the radiation burden of both patients and staff from intracoronary radiotherapy (IRT) with (192)Ir and to investigate the importance of IRT in the patient dose compared with interventional X-rays...
  27. ncbi request reprint Patient dosimetry for 131I-MIBG therapy for neuroendocrine tumours based on 123I-MIBG scans
    Myriam Monsieurs
    Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, 9000 Ghent, Belgium
    Eur J Nucl Med Mol Imaging 29:1581-7. 2002
    ..85 and the correction factor, 1.20. Our results show that it is feasible to use data from pre-therapy (123)I-MIBG scans to calculate the total body dose of the subsequent (131)I-MIBG therapy...
  28. doi request reprint Virtual electron microscopy in cell biology
    Sylvia Mione
    Department of Basic Medical Sciences, Ghent University, De Pintelaan 185, Gent B 9000, Belgium
    Microsc Res Tech 74:251-6. 2011
    ..Virtual electron microscopy is innovative and offers new perspectives to interpret cytological pictures and to teach cell biology in an interactive and unique way. Microsc. Res. Tech., 2010. © 2010 Wiley-Liss, Inc. ..
  29. ncbi request reprint In vivo evaluation and dosimetry of 123I-2-iodo-D-phenylalanine, a new potential tumor-specific tracer for SPECT, in an R1M rhabdomyosarcoma athymic mouse model
    Veerle Kersemans
    Laboratory for Radiopharmacy, Universiteit Gent, Gent, Belgium
    J Nucl Med 46:2104-11. 2005
    ..Because of the successful results with 123/125I-2-iodo-L-phenylalanine, 123/125I-2-iodo-D-phenylalanine was developed, and its tumor-detecting characteristics were evaluated in vivo...