Research Topics
Species | Klaus BacherSummaryAffiliation: Ghent University Country: Belgium Publications
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Detail Information
Publications
Image quality performance of liquid crystal display systems: influence of display resolution, magnification and window settings on contrast-detail detectionKlaus Bacher
Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
Eur J Radiol 58:471-9. 2006..If a 3-megapixel LCD is used in mammography setting, a very time-consuming magnification of the digital mammograms would be necessary...- In vitro and in vivo evaluation of direct rhenium-188-labeled anti-CD52 monoclonal antibody alemtuzumab for radioimmunotherapy of B-cell chronic lymphocytic leukemiaMario De Decker
Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Nucl Med Biol 35:599-604. 2008..Therefore, (188)Re-alemtuzumab would be an ideal candidate for radioimmunotherapy of chronic lymphocytic leukemia... - Image quality and radiation dose on digital chest imaging: comparison of amorphous silicon and amorphous selenium flat-panel systemsKlaus Bacher
Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B9000, Belgium
AJR Am J Roentgenol 187:630-7. 2006..In addition, the low-contrast performance of both systems with standard and low radiation doses was compared... - Dose reduction in patients undergoing chest imaging: digital amorphous silicon flat-panel detector radiography versus conventional film-screen radiography and phosphor-based computed radiographyKlaus Bacher
Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
AJR Am J Roentgenol 181:923-9. 2003..In addition, a contrast-detail phantom study was set up to assess the low-contrast detection of all three systems... - Accurate dosimetry: an essential step towards good clinical practice in nuclear medicineKlaus Bacher
Department of Medical Physics and Radiation Protection, Ghent University, Belgium
Nucl Med Commun 26:581-6. 2005..It is concluded that reliable dosimetry is essential in performing scientific clinical studies according to the principle of good clinical practice... - Patient-specific dose and radiation risk estimation in pediatric cardiac catheterizationKlaus Bacher
Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
Circulation 111:83-9. 2005..However, knowledge of the effective dose in pediatric interventional cardiology is very limited... - Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinomaKim De Ruyck
Department of Anatomy, Embryology, Histology, and Medical Physics, Ghent University, Gent, Belgium
J Nucl Med 45:612-8. 2004..To this end, dicentric chromosomes (DCs) were scored in metaphase spreads of peripheral blood cultures. The equivalent total-body dose was deduced from the DC yields using an in vitro dose-response curve... - In vitro screening for synergism of high-linear energy transfer 213Bi-radiotherapy with other therapeutic agents for the treatment of B-cell chronic lymphocytic leukemiaKatia Vandenbulcke
Department of Radiopharmacy, Ghent University, Ghent, Belgium
Cancer Biother Radiopharm 21:364-72. 2006..CONCLUSIONS: The results of this in vitro study highlight a potential benefit of alpha-irradiation in combination with the drugs considered in this study... - Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro studyKatia Vandenbulcke
Department of Radiopharmacy, Ghent University, Belgium
Nucl Med Commun 25:1131-6. 2004..These data are in favour of alpha-RIT in SLVL patients... - gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?Laurence Beels
Ghent University, Department of Basic Medical Sciences, Proeftuinstraat 86, 9000 Gent, Belgium
Circulation 120:1903-9. 2009..Patient-specific dose was assessed and radiation risks were estimated according to the linear-no-threshold model, commonly used in radiation protection, and the gamma-H2AX foci data... 
Dose-length product of scanners correlates with DNA damage in patients undergoing contrast CTLaurence Beels
Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000 Gent, Belgium
Eur J Radiol 81:1495-9. 2012..This study addresses the question if dose settings of scanners expressed by dose-length product (DLP) are correlated with directly measurable biological effects in patients...- Patient dosimetry in radionuclide therapy: the whys and the whereforesHubert M Thierens
Department of Medical Physics and Radiation Protection, University of Ghent, Belgium
Nucl Med Commun 26:593-9. 2005..This will allow treatment protocols based on tumour dose prescriptions as performed in external beam radiotherapy... - Patient dosimetry for 131I-lipiodol therapyMyriam A Monsieurs
Department of Anatomy, Embryology, Histology and Medical Physics, Faculty of Medicine, University of Ghent, Proeftuinstraat 86, 9000, Ghent, Belgium
Eur J Nucl Med Mol Imaging 30:554-61. 2003..Except in the case of the smaller tumours, comparable results were obtained with MCNP and MIRDOSE. Due to hypersplenism, biological dosimetry results based on the MN assay are not reliable... - TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumorsKim De Ruyck
Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, and Department of Radiation Oncology, Gent University Hospital, Belgium
Int J Radiat Oncol Biol Phys 65:1240-8. 2006..552delAGG, -800G>A, -509C>T, Leu10Pro, Arg25Pro, Thr263Ile) and the occurrence of late normal tissue reactions after gynecologic radiotherapy (RT)... - Typetesting of physical characteristics of digital mammography systems for screening within the Flemish breast cancer screening programmeHubert Thierens
Department of Medical Physics and Radiation Protection, QCC, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
Eur J Radiol 70:539-48. 2009..However, as zooming and scrolling are necessary for 3-megapixel monitors to get the full resolution capabilities of the image capture system, 5-megapixel monitors are preferred in a busy screening environment... - Correlation of contrast-detail analysis and clinical image quality assessment in chest radiography with a human cadaver studyAn De Crop
Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, B 9000 Ghent, Belgium
Radiology 262:298-304. 2012..To determine the correlation between the clinical and physical image quality of chest images by using cadavers embalmed with the Thiel technique and a contrast-detail phantom... - In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damageKatia Vandenbulcke
Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
Eur J Nucl Med Mol Imaging 30:1357-64. 2003..Long-term toxicity on healthy B and T lymphocytes was systematically higher for the alpha emitter (RBE=5 to 2)... - Biodistribution and planar gamma camera imaging of (123)I- and (131)I-labeled F(ab')(2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumorIngrid J G Burvenich
Laboratory of Radiopharmacy, University of Ghent, B 9000 Ghent, Belgium
Nucl Med Biol 34:257-65. 2007..The aim of this study was to evaluate the biodistribution and planar gamma camera imaging characteristics of radioiodinated F(ab')(2) and Fab fragments of monoclonal antibody (mAb) 14C5 in tumor-bearing mice... - Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid catKathelijne Peremans
Medical Imaging Department, Faculty of Veterinary Science, University Ghent, Merelbeke, Belgium
J Feline Med Surg 10:460-5. 2008..In this study, albeit including a small number of cats, outcome did not seem to be significantly affected... - (188)Re-HDD/lipiodol therapy for hepatocellular carcinoma: an activity escalation studyBieke Lambert
Nuclear Medicine Division, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
Eur J Nucl Med Mol Imaging 33:344-52. 2006.... - 188Re-HDD/lipiodol for treatment of hepatocellular carcinoma: a feasibility study in patients with advanced cirrhosisBieke Lambert
Nuclear Medicine Division, Ghent University Hospital, Belgium
J Nucl Med 46:1326-32. 2005..7 GBq (188)Re-4-hexadecyl-1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol/lipiodol ((188)Re-HDD/lipiodol) for treatment of hepatocellular carcinoma (HCC) in patients with moderately advanced cirrhosis... - Biodistribution and dosimetry of (99m)Tc-depreotide (P829) in patients suffering from breast carcinomaBieke Van Den Bossche
Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
Cancer Biother Radiopharm 19:776-83. 2004..This paper reports on the biodistribution and dosimetry of (99m)Tc-depreotide in patients... - 188Re-HDD/lipiodol therapy for hepatocellular carcinoma: a phase I clinical trialBieke Lambert
Nuclear Medicine Division, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Nucl Med 46:60-6. 2005..A secondary objective was to document the response... - Radiolabeling, biodistribution, and dosimetry of (123)I-mAb 14C5: a new mAb for radioimmunodetection of tumor growth and metastasis in vivoChristophe M M Lahorte
Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, Gent, Belgium
J Nucl Med 45:1065-73. 2004..This study reports on the in vitro evaluation, biodistribution, and dosimetry of (123)I-labeled monoclonal antibody (mAb) 14C5, a new antibody-based agent proposed for radioimmunodetection of tumor growth and metastasis in vivo... - Patient doses in gamma-intracoronary radiotherapy: the Radiation Burden Assessment StudyHubert Thierens
Department of Medical Physics and Radiation Protection, Ghent University, Ghent, Belgium
Int J Radiat Oncol Biol Phys 60:678-85. 2004..To determine accurately the radiation burden of both patients and staff from intracoronary radiotherapy (IRT) with (192)Ir and to investigate the importance of IRT in the patient dose compared with interventional X-rays... - Patient dosimetry for 131I-MIBG therapy for neuroendocrine tumours based on 123I-MIBG scansMyriam Monsieurs
Department of Medical Physics and Radiation Protection, Ghent University, Proeftuinstraat 86, 9000 Ghent, Belgium
Eur J Nucl Med Mol Imaging 29:1581-7. 2002..85 and the correction factor, 1.20. Our results show that it is feasible to use data from pre-therapy (123)I-MIBG scans to calculate the total body dose of the subsequent (131)I-MIBG therapy... - In vivo evaluation and dosimetry of 123I-2-iodo-D-phenylalanine, a new potential tumor-specific tracer for SPECT, in an R1M rhabdomyosarcoma athymic mouse modelVeerle Kersemans
Laboratory for Radiopharmacy, Universiteit Gent, Gent, Belgium
J Nucl Med 46:2104-11. 2005..Because of the successful results with 123/125I-2-iodo-L-phenylalanine, 123/125I-2-iodo-D-phenylalanine was developed, and its tumor-detecting characteristics were evaluated in vivo...