K Audenaert

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Decreased 5-HT2a receptor binding in patients with anorexia nervosa
    Kurt Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
    J Nucl Med 44:163-9. 2003
  2. ncbi request reprint SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients
    Kurt Audenaert
    Department of Nuclear Medicine, Ghent University Hospital, Ghent University, 185 De Pintelaan, B 9000 Ghent, Belgium
    Nucl Med Commun 23:907-16. 2002
  3. ncbi request reprint Decreased frontal serotonin 5-HT 2a receptor binding index in deliberate self-harm patients
    K Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Belgium
    Eur J Nucl Med 28:175-82. 2001
  4. ncbi request reprint The classical stroop interference task as a prefrontal activation probe: a validation study using 99Tcm-ECD brain SPECT
    K Audenaert
    Department of Nuclear Medicine, University Hospital, Gent, Belgium
    Nucl Med Commun 22:135-43. 2001
  5. ncbi request reprint Regional binding index of the radiolabeled selective 5-HT2A antagonist 123I-5-I-R91150 in the normal canine brain imaged with single photon emission computed tomography
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 44:344-51. 2003
  6. ncbi request reprint Regional brain perfusion in 10 normal dogs measured using Technetium-99m ethyl cysteinate dimer spect
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Vet Radiol Ultrasound 42:562-8. 2001
  7. ncbi request reprint 99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults
    K Van Laere
    Division of Nuclear Medicine, Ghent University Hospital, Belgium
    Eur J Nucl Med 28:873-87. 2001
  8. doi request reprint Effects of medetomidine and ketamine on the regional cerebral blood flow in cats: a SPECT study
    T Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet J 192:81-8. 2012
  9. ncbi request reprint The effect of citalopram hydrobromide on 5-HT2A receptors in the impulsive-aggressive dog, as measured with 123I-5-I-R91150 SPECT
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 32:708-16. 2005
  10. ncbi request reprint In vivo evaluation of 4-[123I]iodo-N-[2[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl]benzamide, a potential SPECT radioligand for the 5-HT1A receptor
    M Vandecapelle
    Department of Radiopharmacy, Ghent University, Harelbekestraat 72, B 9000, Ghent, Belgium
    Nucl Med Biol 28:639-43. 2001

Detail Information

Publications51

  1. ncbi request reprint Decreased 5-HT2a receptor binding in patients with anorexia nervosa
    Kurt Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
    J Nucl Med 44:163-9. 2003
    ..It was our aim to investigate the central 5-HT(2a) receptor binding index using SPECT brain imaging...
  2. ncbi request reprint SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients
    Kurt Audenaert
    Department of Nuclear Medicine, Ghent University Hospital, Ghent University, 185 De Pintelaan, B 9000 Ghent, Belgium
    Nucl Med Commun 23:907-16. 2002
    ..Our findings indicate a blunted increase in prefrontal blood perfusion as a possible biological reason for reduced drive and loss of initiative in attempted suicide patients...
  3. ncbi request reprint Decreased frontal serotonin 5-HT 2a receptor binding index in deliberate self-harm patients
    K Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Belgium
    Eur J Nucl Med 28:175-82. 2001
    ....
  4. ncbi request reprint The classical stroop interference task as a prefrontal activation probe: a validation study using 99Tcm-ECD brain SPECT
    K Audenaert
    Department of Nuclear Medicine, University Hospital, Gent, Belgium
    Nucl Med Commun 22:135-43. 2001
    ..It is concluded that brain SPECT activation with the Stroop Color Word Test under standard neuropsychological conditions in healthy volunteers, is both technically and practically feasible...
  5. ncbi request reprint Regional binding index of the radiolabeled selective 5-HT2A antagonist 123I-5-I-R91150 in the normal canine brain imaged with single photon emission computed tomography
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 44:344-51. 2003
    ..This normative data can be used to compare regional brain uptake of the 123I-radioligand to dogs with behavioral disorders related to the serotonergic system, in future studies...
  6. ncbi request reprint Regional brain perfusion in 10 normal dogs measured using Technetium-99m ethyl cysteinate dimer spect
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Vet Radiol Ultrasound 42:562-8. 2001
    ..No significant left/right count differences were found, but a rostro-caudal gradient (+12-13%) was present. In this group, age and gender did not influence the perfusion pattern...
  7. ncbi request reprint 99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults
    K Van Laere
    Division of Nuclear Medicine, Ghent University Hospital, Belgium
    Eur J Nucl Med 28:873-87. 2001
    ....
  8. doi request reprint Effects of medetomidine and ketamine on the regional cerebral blood flow in cats: a SPECT study
    T Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet J 192:81-8. 2012
    ..This study showed that caution is needed when quantifying brain perfusion indices when using sedative or anaesthetic agents that may affect rCBF...
  9. ncbi request reprint The effect of citalopram hydrobromide on 5-HT2A receptors in the impulsive-aggressive dog, as measured with 123I-5-I-R91150 SPECT
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 32:708-16. 2005
    ....
  10. ncbi request reprint In vivo evaluation of 4-[123I]iodo-N-[2[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl]benzamide, a potential SPECT radioligand for the 5-HT1A receptor
    M Vandecapelle
    Department of Radiopharmacy, Ghent University, Harelbekestraat 72, B 9000, Ghent, Belgium
    Nucl Med Biol 28:639-43. 2001
    ..These data suggest that uptake in the brain does not represent binding of 1.123I to the 5-HT(1A) receptor...
  11. doi request reprint The effect of medetomidine on the regional cerebral blood flow in dogs measured using Technetium-99m-Ethyl Cysteinate Dimer SPECT
    T Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Res Vet Sci 91:138-43. 2011
    ..This study shows that caution is needed when quantifying the brain perfusion indices under medetomidine sedation...
  12. ncbi request reprint Biodistribution and displacement studies of the selective 5-HT2A receptor antagonist 123I-5-I-R91150 in the normal dog
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    Nucl Med Commun 23:1019-27. 2002
    ..This study demonstrates that the specific 5-HT(2A) iodinated ligand can be used for imaging and semi-quantification of the 5-HT(2A) receptors in the canine brain in vivo by using SPET...
  13. ncbi request reprint Depression and anxiety during isolation and radionuclide therapy
    B Brans
    Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Nucl Med Commun 24:881-6. 2003
    ..Screening for trait anxiety before admission can be easily done and may guide interventions aimed at increasing patient comfort and acceptability...
  14. ncbi request reprint Cortisol in violent suicidal behaviour: association with personality and monoaminergic activity
    K Van Heeringen
    Department of Psychiatry, University Hospital Gent, De Pintelaan 185, B 9000, Gent, Belgium
    J Affect Disord 60:181-9. 2000
    ..Delineation of such trait-like characteristics may increase the specificity in the prediction of suicidal behaviour and thus lead to new approaches to the treatment and prevention of suicidal behaviour...
  15. ncbi request reprint Functional imaging, serotonin and the suicidal brain
    K Audenaert
    Department of Psychiatry and Medical Psychology, Gent University, Gent, Belgium
    Acta Neurol Belg 106:125-31. 2006
    ..These results are in keeping with 5-HT2A binding studies in depressed patients and impulsive animal research. Interestingly, both an increase and a decrease in 5-HT2A binding index seem to normalize with SSRI treatment...
  16. ncbi request reprint 57Co SPECT, 99mTc-ECD SPECT, MRI and neuropsychological testing in senile dementia of the Alzheimer type
    J Versijpt
    Department of Biological Psychiatry, Groningen University Hospital, The Netherlands
    Nucl Med Commun 22:713-9. 2001
    ..Using visual analysis, 57Co SPECT scans were unable to show any regional raised uptake, irrespective of the disorder, depth or extent of the perfusion defects, presence of atrophy on MRI or the results of NPT...
  17. ncbi request reprint Variability study of a non-invasive approach to the absolute quantification of cerebral blood flow with 99Tcm-ECD using aortic activity as the arterial input estimate
    K Van Laere
    Division of Nuclear Medicine, University Hospital Gent, Belgium
    Nucl Med Commun 20:33-40. 1999
    ..6%. Determination of absolute hemispheric blood flow can be performed in a precise manner by means of a dynamic scan during the first 2 min after tracer injection after careful optimization of the processing parameters...
  18. ncbi request reprint Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings
    J Versijpt
    Department of Biological Psychiatry, Groningen University Hospital, Groningen, The Netherlands
    Neurobiol Aging 24:553-61. 2003
    ..The fact that the 5-HT(2A) receptor is differentially affected in AD patients has implications for both the etiological basis and therapeutic management of AD...
  19. ncbi request reprint Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide
    C Van Heeringen
    Unit for Suicide Research, Department of Psychiatry, University Hospital Gent, De Pintelaan 185, 9000 Gent, Belgium
    J Affect Disord 74:149-58. 2003
    ..g. the serotonergic system. Recently, functional neuroimaging techniques with radioligands allow direct in vivo assessment of the neurobiological status of the central nervous system...
  20. ncbi request reprint Personality-related characteristics in restricting versus binging and purging eating disordered patients
    M Vervaet
    Centre for Eating Disorders, University Department of Psychiatry, Ghent University Hospital, Belgium
    Compr Psychiatry 45:37-43. 2004
    ..The higher the scores on novelty seeking, the lower the scores on several character scales, which has important implications for the reinforcement of behavior and the treatment of eating disorders...
  21. ncbi request reprint Olanzapine in Gilles de la Tourette syndrome: beyond tics
    F van den Eynde
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Belgium
    Acta Neurol Belg 105:206-11. 2005
    ..Treatment with olanzapine (20 mg) resulted not only in a fast reduction of tic severity and frequency, but also in a reduction of obsessive-compulsive behaviours...
  22. doi request reprint Structural and functional neuroimaging studies of the suicidal brain
    S Desmyter
    University Department of Psychiatry, University Hospital Ghent, Belgium, De Pintelaan 185, 9000 Ghent, Belgium
    Prog Neuropsychopharmacol Biol Psychiatry 35:796-808. 2011
    ....
  23. ncbi request reprint Cognitive neuroactivation using SPECT and the Stroop Colored Word Test in patients with diffuse brain injury
    Ingeborg Goethals
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    J Neurotrauma 21:1059-69. 2004
    ..This finding was associated with activation effects in posterior (mainly parietal) brain areas in addition with activation of previously observed anterior (mainly anterior cingulate) brain regions...
  24. ncbi request reprint Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers
    Ingeborg Goethals
    Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Psychiatry 161:1916-8. 2004
    ....
  25. doi request reprint Efficacy of quetiapine for impulsivity and affective symptoms in borderline personality disorder
    Frederique van den Eynde
    Department of Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium
    J Clin Psychopharmacol 28:147-55. 2008
    ..These results suggest that quetiapine may be efficacious in the treatment of impulsivity and affective symptoms in BPD...
  26. ncbi request reprint Brain perfusion SPECT in impulsivity-related personality disorders
    Ingeborg Goethals
    Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Behav Brain Res 157:187-92. 2005
    ....
  27. ncbi request reprint 5-HT2A: its role in frontally mediated executive function and related psychopathology
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:512-6. 2007
    ..Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders...
  28. ncbi request reprint Application of a neuropsychological activation probe with SPECT: the 'Tower of London' task in healthy volunteers
    Ingeborg Goethals
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Nucl Med Commun 25:177-82. 2004
    ..Hence, this study reports on the TOL task under classical neuropsychological test conditions using single photon emission computed tomography (SPECT) activation in 10 healthy subjects...
  29. ncbi request reprint The dilemma of being a physician-patient
    Andreas Otte
    Ghent University, Faculty of Economics and Business Administration, Gent, Belgium
    Med Sci Monit 9:SR20-2. 2003
    ..Others are mainly based on the peer situation of the two parties involved. Awareness of the special physician-patient situation in the treating physician could be one step out of the dilemma...
  30. ncbi request reprint Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 30:1538-46. 2003
    ..This study supports a role for the serotonergic system in canine impulsive aggression...
  31. ncbi request reprint Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: an ROC-based comparison of visual, semiquantitative, and voxel-based methods
    Koenraad J Van Laere
    Division of Nuclear Medicine, P7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Nucl Med 43:458-69. 2002
    ..In 2 distinct clinical populations with severe traumatic brain injury and cognitive impairment, this study compared 3 widely available approaches that use normal templates to evaluate SPECT brain perfusion deficits...
  32. ncbi request reprint Did Maurice Ravel have a whiplash syndrome?
    Andreas Otte
    Med Sci Monit 9:LE9. 2003
  33. ncbi request reprint The exceptional brain of Maurice Ravel
    Andreas Otte
    Department of Nuclear Medicine, Ghent University Hospital, Gent, Belgium
    Med Sci Monit 9:RA134-9. 2003
    ..In addition, the influence of Ravel's disease on his musical style is evaluated. Although some authors see a link, we try to explain why there is no clear evidence for this...
  34. ncbi request reprint Toward clinical application of neuropsychological activation probes with SPECT: a spatial working memory task
    Ingeborg Goethals
    Division of Nuclear Medicine, Ghent University Hospital, Belgium
    J Nucl Med 43:1426-31. 2002
    ....
  35. ncbi request reprint Nuclear medicine asleep in sleep research?
    Andreas Otte
    Eur J Nucl Med Mol Imaging 29:1417-20. 2002
  36. ncbi request reprint Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study
    Jan J Versijpt
    Department of Biological Psychiatry, University Hospital Groningen, Groningen, The Netherlands
    Eur Neurol 50:39-47. 2003
    ..The objectives were to assess AD inflammation by detecting [(123)I]iodo-PK11195 uptake changes and investigate how uptake values relate with perfusion SPECT and neuropsychological findings...
  37. ncbi request reprint Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University Salisburylaan 133, B 9820 Merelbeke, Belgium
    Prog Neuropsychopharmacol Biol Psychiatry 26:1393-404. 2002
    ..These results suggest that age related effects should be considered in functional canine brain imaging...
  38. ncbi request reprint Alzheimer's disease-related changes in diseases characterized by elevation of intracranial or intraocular pressure
    Peter Wostyn
    Department of Psychiatry, PC Sint Amandus, Reigerlostraat 10, 8730 Beernem, Belgium
    Clin Neurol Neurosurg 110:101-9. 2008
    ..Further studies are warranted, however, especially to elucidate the role of elevated mechanical forces in Alzheimer's disease neuropathogenesis...
  39. ncbi request reprint An abnormal high trans-lamina cribrosa pressure difference: a missing link between Alzheimer's disease and glaucoma?
    Peter Wostyn
    Clin Neurol Neurosurg 110:753-4. 2008
  40. doi request reprint Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain
    Kathelijne Peremans
    Medical Imaging Department, Faculty of Veterinary Medicine, Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium
    Nucl Med Commun 29:724-9. 2008
    ..To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities...
  41. ncbi request reprint Brain SPECT in sleep research
    Andreas Otte
    Sleep 26:227. 2003
  42. ncbi request reprint Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?
    Ingeborg Goethals
    Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
    J Psychiatr Res 41:1005-11. 2007
    ..Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients...
  43. ncbi request reprint Serotonin transporter and dopamine transporter imaging in the canine brain
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Sciences, Ghent University, B 9000 Ghent, Belgium
    Nucl Med Biol 33:907-13. 2006
    ..Second, we studied the effect of SSRIs (sertraline, citalopram and escitalopram) on the SERT and DAT in two dogs. The position of the canine model in the study of the SERT and DAT is discussed and compared with other animal models...
  44. ncbi request reprint The prefrontal cortex: insights from functional neuroimaging using cognitive activation tasks
    Ingeborg Goethals
    Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 31:408-16. 2004
    ....
  45. ncbi request reprint Blunted prefrontal perfusion in depressed patients performing the Tower of London task
    Ingeborg Goethals
    Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Psychiatry Res 139:31-40. 2005
    ..This study shows that a SPECT activation procedure using the TOL task under classical test conditions is feasible in depressed patients...
  46. ncbi request reprint Differences of cortical 5-HT2A receptor binding index with SPECT in subtypes of anorexia nervosa: relationship with personality traits?
    Ingeborg Goethals
    Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan, 185, B 9000 Ghent, Belgium
    J Psychiatr Res 41:455-8. 2007
    ..We also searched for associations between temperament dimensions and cortical 5-HT2) binding...
  47. ncbi request reprint Effect of repetitive transcranial magnetic stimulation on saccades in depression: a pilot study
    Luc Crevits
    Department of Neurology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Psychiatry Res 135:113-9. 2005
    ..These results suggest the intriguing possibility that rTMS might differentially affect specific aspects of saccade behavior...
  48. ncbi request reprint A review of small animal imaging planar and pinhole spect Gamma camera imaging
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 46:162-70. 2005
    ..Current research is focusing on refining PH SPECT methodology, so specific regarding technical aspects and applications of PH SPECT will be reviewed...
  49. ncbi request reprint Functional imaging of the suicidal brain
    Kurt Audenaert
    Nucl Med Commun 26:391-3. 2005
  50. ncbi request reprint Imaging of mild traumatic brain injury using 57Co and 99mTc HMPAO SPECT as compared to other diagnostic procedures
    Kurt Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
    Med Sci Monit 9:MT112-7. 2003
    ..This study was undertaken to compare the applicability of SPECT using 57Co as a Ca-tracer in patients with mild traumatic brain injury...
  51. ncbi request reprint Adjustment disorder and the course of the suicidal process in adolescents
    Gwendolyn Portzky
    Unit for Suicide Research, Department of Psychiatry, University Hospital Gent, De Pintelaan 185, 9000 Gent, Belgium
    J Affect Disord 87:265-70. 2005
    ..The authors' goal was to investigate the association of adjustment disorders (with depressed mood) and suicide in adolescents by means of a psychological autopsy study...