Els Adriaens

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. doi request reprint Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay
    Els Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
    Sex Transm Dis 35:512-6. 2008
  2. ncbi request reprint Evaluation of an alternative mucosal irritation test using slugs
    E Adriaens
    Laboratory of Pharmaceutical Technology, University of Gent, Harelbekestraat 72, Belgium
    Toxicol Appl Pharmacol 182:169-75. 2002
  3. ncbi request reprint Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals
    E Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    Toxicol In Vitro 22:1285-96. 2008
  4. ncbi request reprint Slug species- and population-specific effects on the end points of the Slug Mucosal Irritation test
    Marijke M M Dhondt
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Toxicol In Vitro 20:448-57. 2006
  5. ncbi request reprint Self-medication in persistent rhinitis: overuse of decongestants in half of the patients
    Els Mehuys
    Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium Electronic address
    J Allergy Clin Immunol Pract 2:313-9. 2014
  6. ncbi request reprint The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the rabbit vaginal irritation test
    Marijke M M Dhondt
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Eur J Pharm Biopharm 60:419-25. 2005
  7. ncbi request reprint Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonary disease (PHARMACOP): a randomized controlled trial
    Eline Tommelein
    Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Br J Clin Pharmacol 77:756-66. 2014
  8. doi request reprint The slug mucosal irritation (SMI) assay: development of a screening tool for the evaluation of ocular discomfort caused by shampoos
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, and Department of Ophthalmology, Ghent University Hospital, Harelbekestraat 72, B 9000 Ghent, Belgium
    Toxicol In Vitro 25:1919-25. 2011
  9. doi request reprint The Slug Mucosal Irritation (SMI) assay: a tool for the evaluation of nasal discomfort
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Toxicol In Vitro 27:1954-61. 2013
  10. doi request reprint New aspects of the Slug Mucosal Irritation assay: predicting nasal stinging, itching and burning sensations
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Appl Toxicol 31:640-8. 2011

Collaborators

Detail Information

Publications23

  1. doi request reprint Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay
    Els Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
    Sex Transm Dis 35:512-6. 2008
    ..In the current study, it was determined whether musosal irritation potency of personal lubricants is related to varying product osmolalities...
  2. ncbi request reprint Evaluation of an alternative mucosal irritation test using slugs
    E Adriaens
    Laboratory of Pharmaceutical Technology, University of Gent, Harelbekestraat 72, Belgium
    Toxicol Appl Pharmacol 182:169-75. 2002
    ....
  3. ncbi request reprint Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals
    E Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    Toxicol In Vitro 22:1285-96. 2008
    ..We can conclude that the SMI assay is a relevant, easily transferable and reproducible alternative to predict the eye irritation potency of chemicals...
  4. ncbi request reprint Slug species- and population-specific effects on the end points of the Slug Mucosal Irritation test
    Marijke M M Dhondt
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Toxicol In Vitro 20:448-57. 2006
    ..Therefore, the results indicated that the test procedure and prediction model have to be optimised and validated, if other slug species are used instead of A. lusitanicus...
  5. ncbi request reprint Self-medication in persistent rhinitis: overuse of decongestants in half of the patients
    Els Mehuys
    Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium Electronic address
    J Allergy Clin Immunol Pract 2:313-9. 2014
    ..Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied...
  6. ncbi request reprint The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the rabbit vaginal irritation test
    Marijke M M Dhondt
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Eur J Pharm Biopharm 60:419-25. 2005
    ..The results obtained with the Slug Mucosal Irritation test were comparable to those of the rabbit vaginal irritation test...
  7. ncbi request reprint Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonary disease (PHARMACOP): a randomized controlled trial
    Eline Tommelein
    Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Br J Clin Pharmacol 77:756-66. 2014
    ..We assessed the effectiveness of a pharmaceutical care programme for patients with COPD...
  8. doi request reprint The slug mucosal irritation (SMI) assay: development of a screening tool for the evaluation of ocular discomfort caused by shampoos
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, and Department of Ophthalmology, Ghent University Hospital, Harelbekestraat 72, B 9000 Ghent, Belgium
    Toxicol In Vitro 25:1919-25. 2011
    ..The SMI assay is a promising evaluation method for discomfort in the human eye. Screening prototype (eye) formulations with this assay allows formula optimization prior to a HEIT...
  9. doi request reprint The Slug Mucosal Irritation (SMI) assay: a tool for the evaluation of nasal discomfort
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Toxicol In Vitro 27:1954-61. 2013
    ..In conclusion, the SMI assay is a promising evaluation method for clinical nasal discomfort. Screening (prototype) formulations with this assay allows formula optimization prior to a clinical trial. ..
  10. doi request reprint New aspects of the Slug Mucosal Irritation assay: predicting nasal stinging, itching and burning sensations
    Joke Lenoir
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Appl Toxicol 31:640-8. 2011
    ..For the most part results agreed with clinical data found in literature. It was concluded that the SMI assay, and the new 1-day protocol in particular, is a good tool to predict nasal clinical discomfort...
  11. doi request reprint COPD management in primary care: an observational, community pharmacy-based study
    Els Mehuys
    Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Ann Pharmacother 44:257-66. 2010
    ..However, data regarding the primary care management of COPD are scarce. Such observational data are necessary to detect problem areas and to develop targeted interventions for improvement of COPD management...
  12. doi request reprint Mucosal irritation potential of polyelectrolyte multilayer capsules
    Liesbeth J De Cock
    Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Biomaterials 32:1967-77. 2011
    ..These findings put polyelectrolyte multilayer capsules further en route towards drug delivery applications...
  13. doi request reprint Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?
    Huub P C van Kuringen
    Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium
    Macromol Biosci 12:1114-23. 2012
    ..Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications...
  14. ncbi request reprint The evaluation of the local tolerance of vaginal formulations, with or without nonoxynol-9, using the slug mucosal irritation test
    Marijke M M Dhondt
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat, Ghent, Belgium
    Sex Transm Dis 31:229-35. 2004
    ..Frequent use of some vaginal formulations can induce mucosal irritation. Therefore, it is important to evaluate their vaginal tolerance...
  15. doi request reprint Influence of reaction medium during synthesis of Gantrez AN 119 nanoparticles for oral vaccination
    Katrien Vandamme
    Laboratory of Pharmaceutical Technology, Ghent University, Belgium
    Eur J Pharm Biopharm 74:202-8. 2010
    ..Moreover, the mucosal irritation capacity was evaluated upon nanoparticle hydrolysis using a slug mucosal irritation assay. Herein, hydrolysed NP of the 44% acetone method were classified as mild irritative...
  16. ncbi request reprint Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation
    E Adriaens
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, University of Ghent, Ghent, Belgium
    Toxicol In Vitro 19:79-89. 2005
    ..Repeated testing of the chemicals revealed a good intra-laboratory reproducibility. The test seems to be a promising method for screening the eye irritating potential of chemicals...
  17. ncbi request reprint The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs
    E Adriaens
    Laboratory of Pharmaceutical Technology, University of Gent, Belgium
    Pharm Res 18:937-42. 2001
    ..CONCLUSIONS: The toxicity and activity of BAC analogues depend on the alkyl chain length. The use of BAC-C14 as a conservative agent in pharmaceutical preparations instead of the BAC-mix should be considered...
  18. doi request reprint Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose
    Thomas Quinten
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Eur J Pharm Sci 37:207-16. 2009
    ..The hydration front in the tablets during dissolution was visualized by dynamic X-ray tomography, this technique also revealed an anisotropic pore structure through the tablet...
  19. ncbi request reprint Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs
    E Adriaens
    Laboratory of Pharmaceutical Technology, University of Gent, Belgium
    Pharm Res 16:1240-4. 1999
    ..The objective of this study was to develop a simple alternative test using naked snails (slugs) for screening the irritating potency of chemicals on mucosal surfaces...
  20. doi request reprint Home medication cabinets and self-medication: a source of potential health threats?
    Leen De Bolle
    Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Ann Pharmacother 42:572-9. 2008
    ..Data regarding the contents of home medication cabinets (HMCs), the management of leftover medications, and the inclination of patients toward self-initiated treatment using nonprescription drugs are scarce...
  21. ncbi request reprint Evaluation of the mucosal irritation potency of co-spray dried Amioca/poly(acrylic acid) and Amioca/Carbopol 974P mixtures
    E Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Control Release 88:393-9. 2003
    ..By co-spray drying up to 20% Carbopol 974P could be incorporated without showing a distinct sign of irritation. These mixtures can be considered as potentially safe bioadhesive carriers...
  22. ncbi request reprint Toxicological evaluation of a bioadhesive nasal powder containing a starch and Carbopol 974 P on rabbit nasal mucosa and slug mucosa
    C Callens
    Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Ghent, Harelbekestraat 72, B-9000, Gent, Belgium
    J Control Release 76:81-91. 2001
    ..No enzymes were released from the body wall. The results indicate that the effect of the bioadhesive powder consisting of DDWM/Carbopol 974 P (90:10, w/w) on the mucosa was negligible...
  23. ncbi request reprint Ocular bioerodible minitablets as strategy for the management of microbial keratitis
    Wim Weyenberg
    Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp, Antwerp, Belgium
    Invest Ophthalmol Vis Sci 45:3229-33. 2004
    ..Evaluation in volunteers of ciprofloxacin-containing ocular gelling minitablets with prolonged release properties...