Nicolas Gillet

Summary

Affiliation: Gembloux Agricultural University
Country: Belgium

Publications

  1. ncbi request reprint Cell dynamics and immune response to BLV infection: a unifying model
    Arnaud Florins
    Molecular and Cellular Biology, FNRS FUSAG, Gembloux, Belgium
    Front Biosci 12:1520-31. 2007
  2. pmc Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
    Nicolas Gillet
    Molecular and Cellular Biology, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    Retrovirology 4:18. 2007
  3. pmc Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep
    Christophe Debacq
    Molecular and Cellular Biology, FNRS FUSAG, Gembloux, Belgium
    J Virol 80:9710-9. 2006
  4. pmc Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo
    Amine Achachi
    Molecular and Cellular Biology, Gembloux University Faculty of Agronomic Sciences, 5030 Gembloux, Belgium
    Proc Natl Acad Sci U S A 102:10309-14. 2005
  5. pmc Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep
    Arnaud Florins
    National Fund for Scientific Research, Molecular and Cellular Biology Laboratory, 13 avenue Maréchal Juin, 5030 Gembloux, Belgium
    J Virol 80:11998-2008. 2006
  6. pmc Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep
    Arnaud Florins
    Molecular and Cellular Biology Laboratory, National Fund for Scientific Research FUSAGx, 13 avenue Maréchal Juin, 5030 Gembloux, Belgium
    J Virol 81:10195-200. 2007
  7. pmc Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE)
    Becca Asquith
    Department of Immunology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Proc Biol Sci 273:1165-71. 2006
  8. ncbi request reprint Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response
    Laurence Lagneaux
    Experimental Hematology, Bordet Institute, ULB, Brussels, Belgium
    Exp Hematol 35:1527-37. 2007
  9. ncbi request reprint Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients
    Agnes Lezin
    Laboratoire de Virologie Immunologie and Jeune Equipe JE 2503, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, France
    Blood 110:3722-8. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Cell dynamics and immune response to BLV infection: a unifying model
    Arnaud Florins
    Molecular and Cellular Biology, FNRS FUSAG, Gembloux, Belgium
    Front Biosci 12:1520-31. 2007
    ..As conclusion, we propose a hypothetical model unifying all these mechanisms...
  2. pmc Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
    Nicolas Gillet
    Molecular and Cellular Biology, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    Retrovirology 4:18. 2007
    ..Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far...
  3. pmc Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep
    Christophe Debacq
    Molecular and Cellular Biology, FNRS FUSAG, Gembloux, Belgium
    J Virol 80:9710-9. 2006
    ..Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection...
  4. pmc Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo
    Amine Achachi
    Molecular and Cellular Biology, Gembloux University Faculty of Agronomic Sciences, 5030 Gembloux, Belgium
    Proc Natl Acad Sci U S A 102:10309-14. 2005
    ....
  5. pmc Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep
    Arnaud Florins
    National Fund for Scientific Research, Molecular and Cellular Biology Laboratory, 13 avenue Maréchal Juin, 5030 Gembloux, Belgium
    J Virol 80:11998-2008. 2006
    ..We show that the enhanced cell death observed in BLV-infected sheep is abrogated after splenectomy, revealing a key role of the spleen in B-lymphocyte dynamics...
  6. pmc Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep
    Arnaud Florins
    Molecular and Cellular Biology Laboratory, National Fund for Scientific Research FUSAGx, 13 avenue Maréchal Juin, 5030 Gembloux, Belgium
    J Virol 81:10195-200. 2007
    ..We conclude that the R3 and G4 genes and the TM YXXL motifs are not strictly required for pathogenesis but that their integrity contributes to disease frequency and latency...
  7. pmc Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE)
    Becca Asquith
    Department of Immunology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Proc Biol Sci 273:1165-71. 2006
    ..We illustrate this approach using in vivo CFSE labelling of B lymphocytes in sheep...
  8. ncbi request reprint Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response
    Laurence Lagneaux
    Experimental Hematology, Bordet Institute, ULB, Brussels, Belgium
    Exp Hematol 35:1527-37. 2007
    ..The effects of valproic acid (VPA), an antiepileptic drug with histone deacetylase inhibitory activity, on mononuclear cells isolated from 40 CLL patients were evaluated...
  9. ncbi request reprint Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients
    Agnes Lezin
    Laboratoire de Virologie Immunologie and Jeune Equipe JE 2503, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, France
    Blood 110:3722-8. 2007
    ..This trial is registered at http://clinicaltrials.gov/as no. NCT00519181...