F Dequiedt

Summary

Affiliation: Gembloux Agricultural University
Country: Belgium

Publications

  1. ncbi MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX
    Juraj Kopacek
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia
    Biochim Biophys Acta 1729:41-9. 2005
  2. doi Class IIa histone deacetylases: conducting development and differentiation
    Maud Martin
    Cellular and Molecular Biology Unit, FUSAGx, Gembloux, Belgium
    Int J Dev Biol 53:291-301. 2009
  3. pmc Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030 Gembloux, Belgium
    J Exp Med 201:793-804. 2005
  4. pmc Bovine leukemia virus-induced persistent lymphocytosis in cattle does not correlate with increased ex vivo survival of B lymphocytes
    F Dequiedt
    Department of Applied Biochemistry and Biology, Molecular Biology and Animal Physiology Unit, Faculty of Agronomy, B5030 Gembloux, Belgium
    J Virol 73:1127-37. 1999
  5. pmc New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030, Gembloux, Belgium
    Mol Cell Biol 26:7086-102. 2006
  6. ncbi Genetic determinants of bovine leukemia virus pathogenesis
    L Willems
    Department of Applied Biochemistry and Biology, Faculty of Agronomy, B5030 Gembloux, Belgium
    AIDS Res Hum Retroviruses 16:1787-95. 2000
  7. ncbi Nucleotide sequence of the bovine P53 tumor-suppressor cDNA
    F Dequiedt
    Faculty of Agronomy, Gembloux, Belgium
    DNA Seq 5:261-4. 1995
  8. pmc Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis
    Maud Martin
    Cellular and Molecular Biology Unit, FUSAGx, 5030 Gembloux, Belgium
    Proc Natl Acad Sci U S A 105:4727-32. 2008
  9. doi The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6
    S Legros
    Center for Molecular and Cellular Biology, Gembloux Agro Bio Tech, University of Liege ULg, Gembloux, Belgium
    Oncogene 30:4050-62. 2011
  10. pmc Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling
    Jean Claude Twizere
    Department of Cellular and Molecular Biology, Faculty of Gembloux, Belgium
    Blood 109:1051-60. 2007

Collaborators

Detail Information

Publications23

  1. ncbi MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX
    Juraj Kopacek
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia
    Biochim Biophys Acta 1729:41-9. 2005
    ..Taken together, our results suggest that besides the PI3K pathway, the MAPK cascade is involved in the regulation of CA9 gene expression under both hypoxia and high cell density...
  2. doi Class IIa histone deacetylases: conducting development and differentiation
    Maud Martin
    Cellular and Molecular Biology Unit, FUSAGx, Gembloux, Belgium
    Int J Dev Biol 53:291-301. 2009
    ..Elucidating cellular and molecular mechanisms by which functions of class IIa HDACs are modulated could potentially lead to new therapeutic opportunities for various diseases...
  3. pmc Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030 Gembloux, Belgium
    J Exp Med 201:793-804. 2005
    ..These findings indicate that PKD is likely to play a key role in the signaling pathways controlling negative selection...
  4. pmc Bovine leukemia virus-induced persistent lymphocytosis in cattle does not correlate with increased ex vivo survival of B lymphocytes
    F Dequiedt
    Department of Applied Biochemistry and Biology, Molecular Biology and Animal Physiology Unit, Faculty of Agronomy, B5030 Gembloux, Belgium
    J Virol 73:1127-37. 1999
    ..The higher levels of ex vivo apoptosis occurring in cattle might indicate a decreased susceptibility to development of leukemia in vivo...
  5. pmc New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030, Gembloux, Belgium
    Mol Cell Biol 26:7086-102. 2006
    ..e., Ser155, is a prerequisite for the phosphorylation of the nearby 14-3-3 site, Ser181. We propose that this multisite hierarchical phosphorylation by a variety of kinases allows for sophisticated regulation of class IIa HDACs function...
  6. ncbi Genetic determinants of bovine leukemia virus pathogenesis
    L Willems
    Department of Applied Biochemistry and Biology, Faculty of Agronomy, B5030 Gembloux, Belgium
    AIDS Res Hum Retroviruses 16:1787-95. 2000
    ..The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep...
  7. ncbi Nucleotide sequence of the bovine P53 tumor-suppressor cDNA
    F Dequiedt
    Faculty of Agronomy, Gembloux, Belgium
    DNA Seq 5:261-4. 1995
    ..Furthermore, the homology is not equally distributed along the molecule since the highest divergence is located within the exon 4. The bovine p53 shares 93% and 91% homology with the ovine p53 at the DNA and protein level respectively...
  8. pmc Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis
    Maud Martin
    Cellular and Molecular Biology Unit, FUSAGx, 5030 Gembloux, Belgium
    Proc Natl Acad Sci U S A 105:4727-32. 2008
    ..This study unravels a dynamic interplay among 14-3-3s, protein kinases, and PP2A and provides a model for the regulation of class IIa HDACs...
  9. doi The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6
    S Legros
    Center for Molecular and Cellular Biology, Gembloux Agro Bio Tech, University of Liege ULg, Gembloux, Belgium
    Oncogene 30:4050-62. 2011
    ..We postulate that inhibition of the stress response pathway by Tax would favor cell survival under stressful conditions and may have an important role in HTLV-1-induced cellular transformation...
  10. pmc Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling
    Jean Claude Twizere
    Department of Cellular and Molecular Biology, Faculty of Gembloux, Belgium
    Blood 109:1051-60. 2007
    ..Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies...
  11. ncbi Nucleotide sequence of the ovine P53 tumor-suppressor cDNA and its genomic organization
    F Dequiedt
    Faculty of Agronomy, Gembloux, Belgium
    DNA Seq 5:255-9. 1995
    ..We also report the structure of the ovine p53 gene that is similar to those already defined from other species...
  12. ncbi Class IIa histone deacetylases: regulating the regulators
    M Martin
    Cellular and Molecular Biology Unit, FUSAGx, Gembloux, Belgium
    Oncogene 26:5450-67. 2007
    ..Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications...
  13. ncbi HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
    Franck Dequiedt
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco 94141, USA
    Immunity 18:687-98. 2003
    ..Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes...
  14. ncbi Subtype selective substrates for histone deacetylases
    Birgit Heltweg
    Department of Pharmaceutical and Medicinal Chemistry, Westfalische Wilhelms Universitat Munster, Hittorfstrasse 58 62, 48149 Munster, Germany
    J Med Chem 47:5235-43. 2004
    ..The subtype selectivity of HDAC inhibitors could be predicted with these substrates and an easily obtainable mixture of HDAC subtypes...
  15. pmc Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function
    Fiona L Scott
    Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:19499-510. 2008
    ..Importantly, cleavage of HDAC7 alters its subcellular localization and abrogates its Nur77 repressor function. Thus we demonstrate a direct role for initiator caspase-mediated proteolysis in promoting gene transcription...
  16. ncbi Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    Wolfgang Fischle
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Mol Cell 9:45-57. 2002
    ..These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity...
  17. ncbi Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases
    Birgit Heltweg
    Department of Pharmaceutical and Medicinal Chemistry, Westfalische Wilhelms Universitat Munster, Hittorfstr 58 62, Munster 48149, Germany
    Anal Biochem 319:42-8. 2003
    ..Interestingly, MAL shows some relative preference toward class II, indicating that subtype selectivity in small-molecule HDAC substrates might be obtained...
  18. pmc Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
    J von Blume
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 26:4619-33. 2007
    ....
  19. pmc Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
    Céline Marban
    INSERM unité 575 Pathophysiology of Nervous System, Centre de Neurochimie, Strasbourg, France
    EMBO J 26:412-23. 2007
    ..Altogether, our findings uncover new therapeutic opportunities for purging latent HIV-1 viruses from their cellular reservoirs...
  20. pmc Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation
    Marjorie Pion
    INSERM U372, Unité de Pathogénie des Infections à Lentivirus, Parc Scientifique et Technologique de Luminy, 13276 Marseille, France
    J Virol 77:4025-32. 2003
    ....
  21. ncbi Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines
    Sybille Wittich
    Department of Pharmaceutical and Medicinal Chemistry, Westfalische Wilhelms Universitat Munster, Germany
    Anticancer Drugs 16:635-43. 2005
    ..The predictive value of in vitro HDAC inhibition assays for identifying anti-proliferative compounds has been emphasized...
  22. ncbi Class II histone deacetylases: versatile regulators
    Eric Verdin
    Gladstone Institute of Virology and Immunology, University of California San Francisco, PO Box 419100, San Francisco, CA 94141, USA
    Trends Genet 19:286-93. 2003
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated...
  23. ncbi Measurement of mammalian histone deacetylase activity
    Eric Verdin
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94103, USA
    Methods Enzymol 377:180-96. 2004