Francoise Foury

Summary

Country: Belgium

Publications

  1. ncbi Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain
    F Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    J Biol Chem 276:7762-8. 2001
  2. ncbi Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain
    Francoise Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    J Biol Chem 277:24475-83. 2002
  3. ncbi Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain
    F Foury
    FEBS Lett 456:281-4. 1999
  4. ncbi Mitochondrial DNA mutators
    F Foury
    Unite de Biochimie Physiologique, Croix du Sud 2 20, 1348, Louvain la Neuve, Belgium
    Cell Mol Life Sci 61:2799-811. 2004
  5. ncbi The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae
    F Foury
    Unite de Biochimie Physiologique, Louvain la Neuve, Belgium
    FEBS Lett 440:325-31. 1998
  6. ncbi Human genetic diseases: a cross-talk between man and yeast
    F Foury
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Gene 195:1-10. 1997
  7. ncbi Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria
    F Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, Louvain la Neuve, Belgium
    FEBS Lett 411:373-7. 1997
  8. ncbi Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly
    Francoise Foury
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Croix du Sud, 5 15, 1348 Louvain la Neuve, Belgium
    EMBO Rep 8:194-9. 2007
  9. ncbi Yeast mitochondrial biogenesis: a model system for humans?
    Francoise Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    Curr Opin Chem Biol 6:106-11. 2002
  10. ncbi Frataxin interacts with Isu1 through a conserved tryptophan in its beta-sheet
    Sébastien Leidgens
    Unite de Biochimie Physiologique, Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Hum Mol Genet 19:276-86. 2010

Collaborators

Detail Information

Publications25

  1. ncbi Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain
    F Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    J Biol Chem 276:7762-8. 2001
    ..Finally, no oxidative stress gene is induced...
  2. ncbi Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain
    Francoise Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    J Biol Chem 277:24475-83. 2002
    ..Moreover, 55Fe incorporation into heme by ferrochelatase is increased in an MRS4-overexpressing strain. The function of MRS4 in iron import into mitochondria is discussed...
  3. ncbi Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain
    F Foury
    FEBS Lett 456:281-4. 1999
    ..The frataxin family bears homology to a bacterial protein family which confers resistance to tellurium, a metal closely related to sulfur. Yfh1p might control the synthesis of iron-sulfur clusters in mitochondria...
  4. ncbi Mitochondrial DNA mutators
    F Foury
    Unite de Biochimie Physiologique, Croix du Sud 2 20, 1348, Louvain la Neuve, Belgium
    Cell Mol Life Sci 61:2799-811. 2004
    ..Proofreading-deficient mutator human cell lines and knockin mice have been created. They will be useful for studying the mechanisms by which mtDNA mutations accumulate in diseases, ageing, malignancy and drug therapy...
  5. ncbi The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae
    F Foury
    Unite de Biochimie Physiologique, Louvain la Neuve, Belgium
    FEBS Lett 440:325-31. 1998
    ..Our data suggest that shuffling of mobile elements plays an important role in the remodelling of the yeast mitochondrial genome...
  6. ncbi Human genetic diseases: a cross-talk between man and yeast
    F Foury
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Gene 195:1-10. 1997
    ....
  7. ncbi Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria
    F Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, Louvain la Neuve, Belgium
    FEBS Lett 411:373-7. 1997
    ..The neurodegeneration observed in Friedreich's ataxia can be well explained on the basis of a mitochondrial iron overload responsible for an increased production of highly toxic free radicals...
  8. ncbi Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly
    Francoise Foury
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Croix du Sud, 5 15, 1348 Louvain la Neuve, Belgium
    EMBO Rep 8:194-9. 2007
    ..Therefore, the acidic ridge is essential for the Yfh1 function and is likely to be involved in iron-mediated protein-protein interactions...
  9. ncbi Yeast mitochondrial biogenesis: a model system for humans?
    Francoise Foury
    Unite de Biochimie Physiologique, Place Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    Curr Opin Chem Biol 6:106-11. 2002
    ....
  10. ncbi Frataxin interacts with Isu1 through a conserved tryptophan in its beta-sheet
    Sébastien Leidgens
    Unite de Biochimie Physiologique, Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Hum Mol Genet 19:276-86. 2010
    ..Therefore, Trp-131, which is the only strictly conserved frataxin residue in all sequenced species, appears as a major contributor to the interaction with Isu1 through its surface-exposed aromatic side chain...
  11. ncbi Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae
    Anna Ramazzotti
    Unite de Biochimie Physiologique, Croix du Sud, 2 20, 1348 Louvain la Neuve, Belgium
    FEBS Lett 557:215-20. 2004
    ..Analysis of the cellular phenotypes resulting from pairwise combinations of yfh1 and isu1 mutations, and cross-linking experiments in isolated mitochondria provide evidence for a direct interaction between Yfh1p and Isu1p...
  12. ncbi A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability
    Enrico Baruffini
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Genetics 177:1227-31. 2007
    ..This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains...
  13. ncbi A cluster of pathogenic mutations in the 3'-5' exonuclease domain of DNA polymerase gamma defines a novel module coupling DNA synthesis and degradation
    Karolina Szczepanowska
    Institute of Life Sciences, Croix du Sud 4 15, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Hum Mol Genet 19:3516-29. 2010
    ....
  14. ncbi Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria
    E Van Dyck
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Mol Gen Genet 246:426-36. 1995
    ..Antibodies directed against the aminoterminus of RIM2/MRS12 detect this protein in mitochondria. The function of the RIM2/MRS12 protein and the substrates it might transport are discussed...
  15. ncbi Antimutator alleles of yeast DNA polymerase gamma modulate the balance between DNA synthesis and excision
    Francoise Foury
    Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    PLoS ONE 6:e27847. 2011
    ..These elements modulate in a subtle manner the balance between DNA polymerization and excision...
  16. ncbi Mitochondrial DNA polymerases from yeast to man: a new family of polymerases
    N Lecrenier
    Laboratoire de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Gene 185:147-52. 1997
    ....
  17. ncbi Yeast nuclear genes for mtDNA maintenance
    Francoise Foury
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Methods Mol Biol 197:139-49. 2002
  18. ncbi Disruption and basic phenotypic analysis of 18 novel genes from the yeast Saccharomyces cerevisiae
    R Wysocki
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Yeast 15:165-71. 1999
    ..YBL025w has recently been identified as RRN10, a gene that encodes an RNA polymerase I-specific transcription initiator factor. The deletion of the remaining fourteen ORFs did not reveal any mutant phenotype in our basic growth tests...
  19. ncbi Overexpression of the RNR1 gene rescues Saccharomyces cerevisiae mutants in the mitochondrial DNA polymerase-encoding MIP1 gene
    N Lecrenier
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Mol Gen Genet 249:1-7. 1995
    ..Our results show that an increased supply of dNTPs in mitochondria can stimulate the mtDNA polymerase activity and indicate that the dNTP concentration may be rate limiting for the replication of mtDNA...
  20. ncbi A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB
    E Van Dyck
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    EMBO J 11:3421-30. 1992
    ..Antibodies against this purified protein localize RIM1 to mitochondria. The SSB encoded by RIM1 is therefore an essential component of the yeast mtDNA replication apparatus...
  21. ncbi A non-essential function for yeast frataxin in iron-sulfur cluster assembly
    Geoffrey Duby
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Croix du Sud 2 20, B 1348 Louvain la Neuve, Belgium
    Hum Mol Genet 11:2635-43. 2002
    ..The large variations observed in the activity of Fe-S cluster proteins under different physiological conditions result from secondary defects in the physiology of delta YFH1 cells...
  22. ncbi Screens for mitochondrial mutants in yeast
    Francoise Foury
    Unite de Biochimie Physiologique, Louvain la Neuve, Belgium
    Methods Mol Biol 372:167-76. 2007
    ....
  23. ncbi PIF1: a DNA helicase in yeast mitochondria
    A Lahaye
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    EMBO J 10:997-1007. 1991
    ..PIF1 is a single-stranded (ss) DNA-dependent ATPase and a DNA helicase which unwinds partially DNA duplexes in a 5' to 3' direction with respect to the ss DNA on which it binds first...
  24. ncbi Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene
    R Chiari
    Cellular Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 59:5785-92. 1999
    ..The identification of these antigens suggests that point mutations could be the major cause of the strong immunogenicity of MEL.A cells...
  25. ncbi PIF1 DNA helicase from Saccharomyces cerevisiae. Biochemical characterization of the enzyme
    A Lahaye
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    J Biol Chem 268:26155-61. 1993
    ..When forked substrates are used, unwinding by PIF1 is markedly stimulated. The enzyme has a sedimentation coefficient of 6.5 S, suggesting that it exists as a monomer in solution...