Jean Michel Foidart

Summary

Country: Belgium

Publications

  1. ncbi Role of ADAM and ADAMTS metalloproteinases in airway diseases
    Genevieve Paulissen
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA, University of Liege and CHU of Liege, Sart Tilman, Belgium
    Respir Res 10:127. 2009
  2. ncbi Screening for inter-hospital differences in cesarean section rates in low-risk deliveries using administrative data: an initiative to improve the quality of care
    Willem Aelvoet
    Federal Service of Health, Food Chain Safety and Environment, Brussels, Belgium
    BMC Health Serv Res 8:3. 2008
  3. ncbi [Vascular placental pathology in high-risk groups: definition and synopsis]
    Jean Michel Foidart
    maternité universitaire, CHR Citadelle, boulevard du 12e de Ligne, 1, B 4000 Liege, Belgique
    Ann Med Interne (Paris) 154:332-9. 2003
  4. ncbi Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia--a step forward but not the definitive answer
    J M Foidart
    University of Liege, Department of Obstetrics and Gynaecology, Hospital de la Citadelle, Blvd du XII eme de Ligne, 4000 Liege, Belgium
    J Reprod Immunol 82:106-11. 2009
  5. ncbi Advances in hormone replacement therapy: weight benefits of drospirenone, a 17alpha-spirolactone-derived progestogen
    Jean Michel Foidart
    Hopital de la Citadelle, Liege, Belgium
    Gynecol Endocrinol 23:692-9. 2007
  6. ncbi The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
    Laetitia Devy
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    FASEB J 16:147-54. 2002
  7. ncbi Expression of ADAMs and their inhibitors in sputum from patients with asthma
    Genevieve Paulissen
    Department of Biology of Tumours, Center for Biomedical Integrative Genoproteomics, CHU Liege, University of Liege, Belgium
    Mol Med 12:171-9. 2006
  8. ncbi Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    Christophe F Deroanne
    Research Center in Experimental Cancerology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 21:427-36. 2002
  9. ncbi Matrix metalloproteinase-9 contributes to choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    Am J Pathol 161:1247-53. 2002
  10. ncbi Estrogens reduce the expression of YKL-40 in the retina: implications for eye and joint diseases
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1740-6. 2003

Detail Information

Publications103 found, 100 shown here

  1. ncbi Role of ADAM and ADAMTS metalloproteinases in airway diseases
    Genevieve Paulissen
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA, University of Liege and CHU of Liege, Sart Tilman, Belgium
    Respir Res 10:127. 2009
    ..This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD...
  2. ncbi Screening for inter-hospital differences in cesarean section rates in low-risk deliveries using administrative data: an initiative to improve the quality of care
    Willem Aelvoet
    Federal Service of Health, Food Chain Safety and Environment, Brussels, Belgium
    BMC Health Serv Res 8:3. 2008
    ....
  3. ncbi [Vascular placental pathology in high-risk groups: definition and synopsis]
    Jean Michel Foidart
    maternité universitaire, CHR Citadelle, boulevard du 12e de Ligne, 1, B 4000 Liege, Belgique
    Ann Med Interne (Paris) 154:332-9. 2003
    ....
  4. ncbi Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia--a step forward but not the definitive answer
    J M Foidart
    University of Liege, Department of Obstetrics and Gynaecology, Hospital de la Citadelle, Blvd du XII eme de Ligne, 4000 Liege, Belgium
    J Reprod Immunol 82:106-11. 2009
    ..The purpose of this review is to critically evaluate the recent hypotheses and their possible insights on early diagnosis, prevention and treatment...
  5. ncbi Advances in hormone replacement therapy: weight benefits of drospirenone, a 17alpha-spirolactone-derived progestogen
    Jean Michel Foidart
    Hopital de la Citadelle, Liege, Belgium
    Gynecol Endocrinol 23:692-9. 2007
    ..0125). E(2)/DRSP could help maintain or even slightly decrease body weight during treatment, potentially improving HRT acceptance and compliance...
  6. ncbi The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
    Laetitia Devy
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    FASEB J 16:147-54. 2002
    ..Using specific PAI-1 mutants, we could demonstrate that PAI-1 promotes angiogenesis at physiological (nanomolar) concentrations through its antiproteolytic activity rather than by interacting with vitronectin...
  7. ncbi Expression of ADAMs and their inhibitors in sputum from patients with asthma
    Genevieve Paulissen
    Department of Biology of Tumours, Center for Biomedical Integrative Genoproteomics, CHU Liege, University of Liege, Belgium
    Mol Med 12:171-9. 2006
    ..05, and r = 0.55, P = 0.01, respectively). We conclude that expression of ADAMs and ADAMTSs and their inhibitors is modulated in airways from patients with asthma and that these molecules may play a role in the pathogenesis of asthma...
  8. ncbi Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    Christophe F Deroanne
    Research Center in Experimental Cancerology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 21:427-36. 2002
    ..These observations provide a conspicuous demonstration that HDAC inhibitors are potent anti-angiogenic factors altering VEGF signaling...
  9. ncbi Matrix metalloproteinase-9 contributes to choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    Am J Pathol 161:1247-53. 2002
    ..In mice deficient in MMP-9 expression the development of choroidal neovascularization induced by laser photocoagulation still occurred, but at a reduced level...
  10. ncbi Estrogens reduce the expression of YKL-40 in the retina: implications for eye and joint diseases
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1740-6. 2003
    ....
  11. ncbi Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment
    Sarah Berndt
    Department of Obstetrics and Gynecology, Centre Hospitalier Regional, Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    J Clin Endocrinol Metab 94:4567-74. 2009
    ..Indeed, we previously demonstrated that hCG contributes to endothelial cell recruitment and vessel formation...
  12. ncbi Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1732-9. 2003
    ..To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD)...
  13. ncbi Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment
    Sophie Lorquet
    University of Liege, Laboratory of Tumor and Developmental Biology, GIGA Cancer, Institute of Pathology, CHU B23, B 4000 Liege, Belgium
    FASEB J 24:3782-95. 2010
    ..These findings provide new insights into mechanisms regulating physiological and pathological angiogenesis and vessel stabilization...
  14. ncbi Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences
    Vassilis Tsatsaris
    Department of Obstetrics and Gynecology, Hopital de la Citadelle, B 4000 Liege, Belgium
    J Clin Endocrinol Metab 88:5555-63. 2003
    ..The second one is the down-regulation of its membrane bound form (VEGFR-1) in the placental bed, which may result in the defective uteroplacental development...
  15. ncbi Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells
    Christèle Bisson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    Int J Cancer 105:7-13. 2003
    ..Collectively, these results implicate myofibroblasts as major producer of MT1-MMP in breast cancer and emphasize the importance of stromal-epithelial cell interactions in their progression...
  16. ncbi Human breast adenocarcinoma cell lines promote angiogenesis by providing cells with uPA-PAI-1 and by enhancing their expression
    Khalid Bajou
    Laboratory of Tumor and Development Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, Liege, Belgium
    Int J Cancer 100:501-6. 2002
    ....
  17. ncbi Transient reduction of placental angiogenesis in PAI-1-deficient mice
    Soraya Labied
    Laboratory of Tumour and Development Biology, University of Liege, Tour de Pathologie B23, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, Liege, Belgium
    Physiol Genomics 43:188-98. 2011
    ..Altogether our data provide evidence for a transient impaired placental morphology in PAI-1-deficient mice that is then normalized, leading to normal embryonic development...
  18. ncbi Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:3186-93. 2003
    ..In the current study, the influence of placental growth factor (PlGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated...
  19. ncbi MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Belgium
    FASEB J 17:2290-2. 2003
    ..These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization...
  20. ncbi The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects
    Lorin Host
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, GIGA Cancer, University of Liege, Liege, Belgium
    Int J Cancer 131:1537-48. 2012
    ..It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination...
  21. ncbi Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium
    Frederic Goffin
    Departments of Tumor and Development Biology, Faculty of Medicine, University of Liege, Belgium
    Biol Reprod 69:976-84. 2003
    ..These specific patterns of MMP expression associated with each phase of the cycle may point to specific roles in the processes of menstruation, housekeeping activities, angiogenesis, tissue growth, and extracellular matrix remodeling...
  22. ncbi Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells
    Anne Brysse
    Laboratory of Developmental and Tumor Biology, GIGA Cancer, University of Liege, Sart Tilman, Liege, Belgium
    Mol Cancer Res 10:121-32. 2012
    ..Our results thus clearly show an implication of ZO-1 in CXCL8/IL-8 regulation. Because of the major implications of CXCL8/IL-8 in tumor invasion, such a regulation could play an important role in breast cancer progression...
  23. ncbi Endometrial vessel maturation in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
    Ravet Stéphanie
    Laboratory of Tumor and Development Biology, Center of Experimental Cancer Research, University de Liège, Tour de Pathologie B23, Avenue de l Hopital, GIGA R, Sart Tilman, B 4000 Liege, Belgium
    Hum Reprod 22:3084-91. 2007
    ..The area, density and maturation of endometrial vessels were quantified in 19 endometrial biopsies of women with LNG-IUS and in 10 normally ovulating patients during mid-luteal phase...
  24. ncbi Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
    Khalid Bajou
    Laboratory of Tumor and Development Biology, CRCE, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 23:6986-90. 2004
    ..Of great interest is the finding that PAI-1 produced by tumor cells, even at high concentration, did not overcome the absence of PAI-1 in the host, emphasizing the importance of the cellular source of PAI-1...
  25. ncbi Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
    Didier D Cataldo
    Department of Respiratory Diseases and Laboratory of Biology of Tumours and Development, University of Liege, Liege, Belgium
    Am J Pathol 161:491-8. 2002
    ..In contrast, the expression of tissue inhibitor of metalloproteinases-1 was enhanced after allergen exposure in both groups. We conclude that MMP-9 plays a key role in the development of airway inflammation after allergen exposure...
  26. ncbi Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice
    Maud Jost
    Laboratory of Tumor and Developmental Biology, Center for Experimental Cancer Research, Center for Biomedical Integrative Genoproteomics, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    Cancer Res 66:5234-41. 2006
    ..These data highlight the requirement to understand the individual functions of each MMP to improve anticancer strategies...
  27. ncbi Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase
    Benoit Detry
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique appliqué Recherche GIGA Cancer, University of Liege, Liege, Belgium
    Blood 119:5048-56. 2012
    ..Our findings provide new mechanistic insight into how LECs negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis...
  28. ncbi Differential expression of Vegfr-2 and its soluble form in preeclampsia
    Carine Munaut
    Laboratory of Tumor and Development Biology, CHU, GIGA Cancer, University of Liege, Liege, Belgium
    PLoS ONE 7:e33475. 2012
    ..Therefore, the aim of our study was to characterize the plasma levels of VEGFR-2 in PE patients and to perform VEGFR-2 immunolocalization in placenta...
  29. ncbi Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor
    Anne Masset
    Laboratory of Biology of Tumor and Development, Groupe Interdisciplinaire de Génoprotéomique Appliqué GIGA Cancer, Tour de Pathologie B23, Sart Tilman, Liege, University of Liege, Liege, Belgium
    Int J Cancer 128:283-93. 2011
    ....
  30. ncbi Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor
    Erik Maquoi
    Laboratory of Tumor and Development Biology, , Centre Hospitalier Universitaire, , Belgium
    Clin Cancer Res 10:4038-47. 2004
    ..In contrast to broad-spectrum inhibitors, the administration of Ro-28-2653 was not associated with the occurrence of adverse side effects that might hamper the therapeutic potential of these drugs...
  31. ncbi Digging deeper into lymphatic vessel formation in vitro and in vivo
    Benoit Detry
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique appliqué Recherche GIGA Cancer, University of Liege, B 4000 Liege, Belgium
    BMC Cell Biol 12:29. 2011
    ..Ultrastructural analyses through Transmission Electron Microscopy (TEM) were performed to investigate tube morphogenesis, an important differentiating process observed during endothelial cell organization into capillary structures...
  32. ncbi [Defective placental implantation and its effects on maternal endothelial function]
    Jean Michel Foidart
    Gynecologie Obstetrique, Universite de Liege, Hopital de la Citadelle, 1 boulevard du 12e ligne, B 4000 Liege, Belgique
    Bull Acad Natl Med 193:1059-64; discussion 1064-6, 1067-8. 2009
    ..This can hinder both trophoblast invasion and increase uteroplacental flow during preeclampsia...
  33. ncbi Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast
    Carine Munaut
    Laboratory of Tumor and Development Biology, CRCE, CHU, GIGA, University of Liege, Tour de Pathologie B23, Sart Tilman B 4000, Liege, Belgium
    Hum Reprod 23:1407-15. 2008
    ..Here, we tested the hypothesis that these altered levels of angiogenic cytokines and of the anti-angiogenic soluble forms of cytokine receptors could be the consequence of hypoxia...
  34. ncbi The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors
    Caroline Piette
    Laboratory of Tumor and Developmental Biology, GIGA R, CHU, Liege, Belgium
    J Biol Chem 284:32483-92. 2009
    ..Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy...
  35. ncbi Does plasminogen activator inhibitor-1 drive lymphangiogenesis?
    Françoise Bruyére
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué Cancer, University of Liege, Liege, Belgium
    PLoS ONE 5:e9653. 2010
    ..PAI-1 does not appear as a potential therapeutic target to counteract pathological lymphangiogenesis...
  36. ncbi Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas
    Carine Munaut
    Laboratory of Tumour and Development Biology, University of Liege, Liege, Belgium
    Int J Cancer 106:848-55. 2003
    ..Because of its dual ability to activate MMP-2 and to up-regulate VEGF, MT1-MMP might be of central importance in the growth of GBMs and represent an interesting target for anti-cancer treatments...
  37. ncbi Trophoblast invasion and placentation: molecular mechanisms and regulation
    Frédéric van den Brûle
    Laboratory of Tumor Biology and Development, Pathology B23, CHU Liege, Liege, Belgium
    Chem Immunol Allergy 88:163-80. 2005
    ..In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed...
  38. ncbi Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
    Veronique Masson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    FASEB J 19:234-6. 2005
    ..Our data demonstrate for the first time in an experimental model that MMP-2 and MMP-9 cooperate in promoting the in vivo invasive and angiogenic phenotype of malignant keratinocytes...
  39. ncbi Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases
    Erik Maquoi
    Laboratory of Tumor and Development Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    Biochem J 373:19-24. 2003
    ..This study demonstrates that the catalytic activity of MT1-MMP on the cell surface is regulated through a vacuolar H(+)-ATPase-dependent degradation process...
  40. ncbi Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases mRNA transcripts in the bronchial secretions of asthmatics
    Didier D Cataldo
    Department of Pneumology, University of Liege, CHU Sart Tilman, Liege 4000, Belgium
    Lab Invest 84:418-24. 2004
    ....
  41. ncbi Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12
    Genevieve Paulissen
    Laboratory of Tumor and Developmental Biology, Interdisciplinary Group of Applied Genoproteomics Cancer GIGA Cancer, University of Liège and University Hospital of Liège, 4000 Liege, Belgium
    J Immunol 189:4135-43. 2012
    ....
  42. ncbi Potential therapeutic target discovery by 2D-DIGE proteomic analysis in mouse models of asthma
    Florence Quesada Calvo
    GIGA Research, GIGA I3, GIGA Cancer, and GIGA Neurosciences, University of Liege, Belgium
    J Proteome Res 10:4291-301. 2011
    ..This study unveils new mediators of potential importance that are up- and down-regulated in asthma. Among up-regulated mediators, GRP-78 appears as a potential new therapeutic target worthy of further investigations...
  43. ncbi Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization
    Julie Lecomte
    Laboratory of Tumor and Developmental Biology, Tour de Pathologie, CHU B23, Groupe Interdisciplinaire de Génoprotéomique Appliquée Research GIGA Cancer, University of Liege, 4000, Liege, Belgium
    Cell Mol Life Sci 68:677-86. 2011
    ..The present study sheds light on a novel function of MMP13 during BM-dependent choroidal vascularization and provides evidence for a role for MSC in the pathogenesis of CNV...
  44. ncbi Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation
    Maud M Gueders
    Department of Pneumology, Center for Biomedical Integrative Genoproteomic, University of Liege, Belgium
    J Immunol 175:2589-97. 2005
    ....
  45. ncbi Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases
    Nor Eddine Sounni
    Laboratory of Tumor and Development Biology University of Liège, Sart Tilman, 4000 Sart Tilman, B 4000 Liege, Belgium
    J Biol Chem 279:13564-74. 2004
    ....
  46. ncbi Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells
    Melanie Mestdagt
    Laboratory of Developmental and Tumour Biology, University of Liege, Liege, Belgium
    Int J Cancer 118:35-42. 2006
    ..Our results therefore identify MCP-1 as a target of the beta-catenin/TCF/LEF pathway in breast tumour cells, a regulation which could play a key role in breast tumour progression...
  47. ncbi Delivery of granulocyte-macrophage colony-stimulating factor in bioadhesive hydrogel stimulates migration of dendritic cells in models of human papillomavirus-associated (pre)neoplastic epithelial lesions
    Pascale Hubert
    Department of Pathology B35, CHU Sart Tilman, 4000 Liege, Belgium
    Antimicrob Agents Chemother 48:4342-8. 2004
    ....
  48. ncbi Abnormal vascular architecture at the placental-maternal interface in placenta increta
    Frederic Chantraine
    Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire, Hôpital la Citadelle, Liege, Belgium
    Am J Obstet Gynecol 207:188.e1-9. 2012
    ..The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies...
  49. ncbi Nebulized anti-IL-13 monoclonal antibody Fab' fragment reduces allergen-induced asthma
    Jonathan Hacha
    Laboratory of Tumors and Developmental Biology and Department of Respiratory Diseases, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Research GIGA I and GIGA Cancer, University of Liege and Centre Hospitalier Universitaire, Liege Sart Tilman, Belgium
    Am J Respir Cell Mol Biol 47:709-17. 2012
    ..Specific neutralization of IL-13 in the lungs using an inhaled anti-IL-13 Fab' could represent a novel and effective therapy for the treatment of asthma...
  50. ncbi Effects of oral contraception with ethinylestradiol and drospirenone on oxidative stress in women 18-35 years old
    Donat de Groote
    PROBIOX SA, Campus Universitaire du Sart Tilman, Avenue de l Hopital, Tour GIGA, Bat B34, B 4000 Liege, Belgium
    Contraception 80:187-93. 2009
    ..Oral contraceptives (OCs) with estrogens and progestins may affect oxidative stress (OS) status...
  51. ncbi Transactivation of vimentin by beta-catenin in human breast cancer cells
    Christine Gilles
    Laboratory of Tumor and Developmental Biology, University of Liege, CHU Sart Tilman, B23, B 4000 Liege, Belgium
    Cancer Res 63:2658-64. 2003
    ..Our results therefore demonstrate that the vimentin promoter is a target of the beta-catenin/TCF pathway and strongly suggest an implication of this regulation in epithelial cell migration/invasion...
  52. ncbi Environmental dichlorodiphenyltrichlorethane or hexachlorobenzene exposure and breast cancer: is there a risk?
    Corinne Charlier
    Clinical Toxicology Laboratory, Sart Tilman University Hospital, University of Liege, Liege, Belgium
    Clin Chem Lab Med 42:222-7. 2004
    ..026)...
  53. ncbi Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge
    Didier D Cataldo
    Departments of Pneumology, University of Liege, Liege, Belgium
    Chest 122:1553-9. 2002
    ....
  54. ncbi Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions
    Pascale Hubert
    Department of Pathology, GIGA CANCER GIGA I3, University of Liege, B23 CHU Sart Tilman, Liege, Belgium
    Am J Reprod Immunol 64:126-36. 2010
    ....
  55. ncbi Inhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16K hPRL
    Ngoc Quynh Nhu Nguyen
    GIGA Research, Molecular Biology and Genetic Engineering Unit, University of Liege, Belgium
    Mol Ther 15:2094-100. 2007
    ..Both the number and size of metastases are reduced by 50% in 16K hPRL-treated mice. These results highlight a potential role for 16K hPRL in anticancer therapy for both primary tumors and metastases...
  56. ncbi Reduction of apoptosis and proliferation in endometriosis
    Aude Beliard
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    Fertil Steril 82:80-5. 2004
    ..To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status...
  57. ncbi Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast tumors implanted in ovariectomized nude mice
    Joëlle Desreux
    Laboratory of Biology of Tumors and Development, Pathology Tower 3, CHU Sart Tilman, Liege, Belgium
    Gynecol Obstet Invest 63:31-8. 2007
    ..Tibolone, with its in vitro documented inhibitory effects on estrogens metabolism and its selective action on breast, may be an alternative that could favorably influence the health benefit of hormone replacement therapy...
  58. ncbi Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture
    Vincent Chabottaux
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, University of Liege, Tour de Pathologie, Liege, Belgium
    J Cell Mol Med 13:4002-13. 2009
    ..On this basis, we propose that MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation...
  59. ncbi Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium
    Sarah Berndt
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Universite de Liege, Liege, Belgium
    FASEB J 20:2630-2. 2006
    ..VEGF and hCG also displayed additive activities. Altogether, these data demonstrate that peritrophoblastic angiostimulation may result from a paracrine dialogue between trophoblast, epithelial, and endothelial cells through hCG and VEGF...
  60. ncbi Isoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
    Soraya Labied
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué GIGA R, Universite de Liege, Liege, Belgium
    Transplantation 95:426-33. 2013
    ..These properties confer a significantly higher angiogenic potential to VEGF111 in comparison with the other VEGF isoforms...
  61. ncbi Evidence for cross-talk between the LH receptor and LH during implantation in mice
    Virginie Gridelet
    University of Liege, Center of Immunology, Institute of Pathology, Centre Hospitalier Universitaire B 23, 4000 Liege Sart Tilman, Belgium
    Reprod Fertil Dev 25:511-22. 2013
    ..In support of this hypothesis, we identified a bioactive LH signal at the time of murine blastocyst implantation...
  62. ncbi Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor
    Julie Lecomte
    Laboratory of Tumor and Development Biology, GIGA Cancer, University of Liege, Liege, Belgium
    Neoplasia 14:943-51. 2012
    ..Our data support the concept of fibroblast subset specialization with BM-derived α-SMA(+) cells being the main source of MMP13, a stromal mediator of cancer cell invasion...
  63. ncbi Individual decisions in placenta increta and percreta: a case series
    Frederic Chantraine
    Department of Obstetrics and Gynecology, University of Liege, Liege, Belgium
    J Perinat Med 40:265-70. 2012
    ..Its prevalence increases proportionally to the number of cesarean sections. This study analyzed the changes of our management strategy to devise treatment guidelines for this uncommon disorder...
  64. ncbi Routine fetal RHD genotyping with maternal plasma: a four-year experience in Belgium
    Jean Marc Minon
    Department of Laboratory Medicine, the University Department of Fetal Medicine, Centre Hospitalier Régional de la Citadelle, Liege, Belgium
    Transfusion 48:373-81. 2008
    ..The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium...
  65. ncbi Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions
    Marie Piette
    Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Liege, CHU, B36, B 4000 Liege 1, Belgium
    Eur J Pharm Sci 28:189-95. 2006
    ..Moreover, in vivo administration of Ro 28-2653 solutions highlighted some information about the pharmacokinetic behavior of Ro 28-2653: a long biologic half-life (about 15.5h) and a small overall volume of distribution (8l)...
  66. ncbi Management of recurrent or persistent stress urinary incontinence after TVT-O by mesh readjustment
    Laurent de Landsheere
    Department of Obstetrics and Gynecology, CHR La Citadelle, Boulevard du 12e de ligne n 1, 4000 Liege, Belgium
    Int Urogynecol J 21:1347-51. 2010
    ..The aim of this study was to evaluate, retrospectively, the place of sub-urethral mesh readjustment when treating recurrent stress urinary incontinence (SUI) after TVT-O...
  67. ncbi Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
    Maud M Gueders
    Department of Tumors and Developmental Biology, GIGA Research, University of Liege and CHU of Liege, Belgium
    Inflamm Res 58:845-54. 2009
    ..Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains...
  68. ncbi Human endometrial leukemia inhibitory factor and interleukin-6: control of secretion by transforming growth factor-beta-related members
    Sophie Perrier d'Hauterive
    University of Liege, Department of Medicine, Center of Immunology, Institute of Pathology CHU B23, Liege Sart Tilman, Belgium
    Neuroimmunomodulation 12:157-63. 2005
    ....
  69. ncbi Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials
    Vincent Lambert
    Laboratory of Tumor and Development Biology, , , Belgium
    Invest Ophthalmol Vis Sci 44:2791-7. 2003
    ..CONCLUSIONS: These observations may help to reconcile reports with opposite results regarding the effects of PAI-1 on angiogenesis and certainly warn against uncontrolled use of PAI-1-modulating drugs in clinical trials...
  70. ncbi Shunting the intervillous space: new concepts in human uteroplacental vascularization
    Jean Pierre Schaaps
    Department of Obstetrics and Gynecology, CHR de la Citadelle, Liege, Belgium
    Am J Obstet Gynecol 192:323-32. 2005
    ..We therefore attempted to provide arguments for a functional vascular anastomotic network located in the placental bed during human pregnancy...
  71. ncbi ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo
    Natacha Rocks
    Laboratory of Biology of Tumors and Development, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Research, GIGA Cancer and GIGA I, University of Liege and CHU of Liege, Liege, Belgium
    Cancer Res 68:9541-50. 2008
    ..In conclusion, we propose a new paradigm for catalytically active ADAMTS-1 contribution to tumor development, which consists of the recruitment of fibroblasts involved in tumor growth and tumor-associated stroma remodeling...
  72. ncbi Modeling lymphangiogenesis in a three-dimensional culture system
    Françoise Bruyére
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué Cancer, University of Liege, Avenue de l hôpital 3, B 4000 Liege, Belgium
    Nat Methods 5:431-7. 2008
    ....
  73. ncbi Human chorionic gonadotropin: a hormone with immunological and angiogenic properties
    Marie Tsampalas
    University of Liege, Centre of Immunology, CHU B 23, B 4000 Liege, Belgium
    J Reprod Immunol 85:93-8. 2010
    ..Our review focuses on these functions of hCG, giving new insight into the endocrine-immune dialogue that exists between the conceptus and immune cells within the receptive endometrium at the time of implantation...
  74. ncbi Prediction of maternal predisposition to preeclampsia
    Patrick Emonts
    Department of Obstetrics and Gynaecology, University of Liege, CHR Citadelle, Liege, Belgium
    Hypertens Pregnancy 27:237-45. 2008
    ..To derive a prediction index based on the most salient patient history, laboratory, and clinical parameters for identifying women at high risk for developing preeclampsia (PE)...
  75. ncbi 6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis
    Isabelle Kempen
    Drug Research Center, Laboratoire de Chimie Pharmaceutique, Universite de Liege, 1 Avenue de l Hopital, tour 4 5, Sart Tilman, B 4000 Liege, Belgium
    Eur J Med Chem 43:2735-50. 2008
    ..This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents...
  76. ncbi Differential elevation of matrix metalloproteinase expression in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
    Soraya Labied
    Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA R, Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    Hum Reprod 24:113-21. 2009
    ..Thus the objective of this study was to compare matrix metalloproteinase (MMP) expression in endometrium during luteal phase and in short-term (1 month) and long-term (> or =6 months) LNG-IUS users...
  77. ncbi Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization
    Nor Eddine Sounni
    Laboratory of Tumor and Development Biology, , CHU, , Belgium
    Int J Cancer 98:23-8. 2002
    ..Our data provide the first demonstration, in an experimental model, that MT1-MMP expression by tumor cells promotes tumor vascularization...
  78. ncbi Differential heat shock gene hsp70-1 response to toxicants revealed by in vivo study of lungs in transgenic mice
    Delphine Wirth
    Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Cell Stress Chaperones 7:387-95. 2002
    ....
  79. ncbi New asthma biomarkers: lessons from murine models of acute and chronic asthma
    Emmanuel Di Valentin
    GIGA Research Laboratory of Fundamental Virology and Immunology, Univ of Liège, B 4000 Liege, Belgium
    Am J Physiol Lung Cell Mol Physiol 296:L185-97. 2009
    ....
  80. ncbi Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I
    Maud Jost
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman B 4000 Liège, Belgium
    Am J Pathol 171:1369-80. 2007
    ..Altogether, the present study demonstrates that different cellular mechanisms contribute to PAI-1-regulated tumoral and CNV. PAI-1 contributes to BM-dependent choroidal vascularization and to BM-independent tumor growth and angiogenesis...
  81. ncbi Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: lack of relationship to infertility, but evidence of high exposure of the mothers
    Corinne J Charlier
    Clinical Toxicology Laboratory, CHU Sart Tilman, 4000 Liege, Belgium
    Reprod Toxicol 20:215-20. 2005
    ..These data suggest that male infertility could be associated with exposure of the mothers to p,p'-DDE with deleterious effects restricted to intra-uterine life and thus undetected in blood or seminal plasma of subfertile men...
  82. ncbi Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis
    Aude Beliard
    Laboratory of Biology of Tumors and Development, , Sart-Tilman, , Belgium
    Fertil Steril 79:724-9. 2003
    ..An antiadhesive hyaluronate gel used in clinics decreases the adhesion in a dose-dependent manner and reduces cytokine bioavailability...
  83. ncbi The impact of detailed explanatory leaflets on patient satisfaction with urodynamic consultation: a double-blind randomized controlled trial
    Véronique Hougardy
    CHR Site de La Citadelle, University of Liege, Liege, Belgium
    Neurourol Urodyn 28:374-9. 2009
    ....
  84. ncbi Treating gliomas with glucocorticoids: from bedside to bench
    Caroline Piette
    , , , Belgium
    Acta Neuropathol (Berl) 112:651-64. 2006
    ..We then review current guidelines on the choice of molecule, dose and duration of glucocorticoid treatment for gliomas...
  85. ncbi Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
    Sophie Hallez
    Chimie Biologique, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
    Cancer Immunol Immunother 53:642-50. 2004
    ....
  86. ncbi Reduced excision repair cross-complementing 1 expression associates with enhanced papilloma formation and fibroblast transformation after genetic disruption of secreted protein acidic and rich in cysteine
    Yasumasa Kato
    Department of Biochemistry and Molecular Biology, Kanagawa Dental College, Yokosuka 238 8580, Japan
    Int J Oncol 27:759-68. 2005
    ..These data reinforce a growing number of observations in which SPARC has shown opposite effects on different tumor types/stages...
  87. ncbi A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma
    Maud M Gueders
    Department of Pneumology, GIGA Research, Liège and Centre Hospitalier Universitaire de Liège, Belgium
    Biochem Pharmacol 75:514-26. 2008
    ..MMPs play key roles in the complex cascade of events leading to asthmatic phenotype...
  88. ncbi Advances in hormone replacement therapy with drospirenone, a unique progestogen with aldosterone receptor antagonism
    Santiago Palacios
    Instituto Palacios, Salud y Medicina de la Mujer, Madrid, Spain
    Maturitas 55:297-307. 2006
    ..This combination may therefore offer an alternative therapeutic option with additional benefits beyond current HRT agents for symptomatic post-menopausal women...
  89. ncbi Plasmin-activated doxorubicin prodrugs containing a spacer reduce tumor growth and angiogenesis without systemic toxicity
    Laetitia Devy
    Laboratory of Tumor and Developmental Biology, , Tour de Pathologie (B23, Sart-Tilman, , Belgium
    FASEB J 18:565-7. 2004
    ..These data validate both the use of elongated spacers in vivo and the concept of targeting anticancer prodrugs to tumor-associated plasmin...
  90. ncbi Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
    Vincent Chabottaux
    Laboratory of Tumor and Development Biology, , Center for Biomedical Integrative Genoproteomics, , Belgium
    Cancer Res 66:5165-72. 2006
    ..t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies...
  91. ncbi The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    Amin Hajitou
    Laboratory of Tumor and Development Biology, and, Laboratory of Connective Tissues Biology, , Sart-Tilman, , Belgium
    FASEB J 16:1802-4. 2002
    ..This work provides evidence that endostatin and angiostatin act on tumor cells themselves...
  92. ncbi Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells
    Myriam Polette
    Institut National de la Sante et de la Recherche Medicale UMRS 514, Laboratory of Histology, IFR 53, CHU Maison Blanche, Reims, France
    Cancer Res 65:7691-8. 2005
    ..Such transfections concomitantly activated the beta-catenin/TCF/LEF pathway. Our results therefore show that ZO-1, besides its structural role in TJ assembly, can intervene in signaling events promoting tumor cell invasion...
  93. ncbi Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma
    Karim Y Vermaelen
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    J Immunol 171:1016-22. 2003
    ..We conclude that the specific absence of MMP-9 activity inhibits the development of allergic airway inflammation by impairing the recruitment of DCs into the airways and the local production of DC-derived proallergic chemokines...
  94. ncbi Effect of matrigel on human extravillous trophoblasts differentiation: modulation of protease pattern gene expression
    Anne Tarrade
    INSERM 427, Laboratoire de Microscopie Electronique, , , 75006 Paris, France
    Biol Reprod 67:1628-37. 2002
    ..This in vitro model will be of interest to study the cellular mechanisms involved in abnormal trophoblast invasion observed in poor placentation and preeclampsia...
  95. ncbi Migration-stimulating factor displays HEXXH-dependent catalytic activity important for promoting tumor cell migration
    Xavier Houard
    INSERM Unite 36, College de France, Paris, France
    Int J Cancer 116:378-84. 2005
    ..These results suggest that MSF may be involved in tumor progression...
  96. ncbi E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells
    Beatrice Nawrocki-Raby
    Institut National de la Santé et de la Recherche Mèdicale INSERM Unité Mixte de Recherche Santé UMRS 514, Laboratoire Pol Bouin, Reims, France
    Am J Pathol 163:653-61. 2003
    ..These data demonstrate a direct role of E-cadherin/catenin complex organization in the regulation of MMPs and suggest an implication of this regulation in the expression of an invasive phenotype by bronchial tumor cells...
  97. ncbi Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases
    Maud M Gueders
    Department of Pneumology, Center for Biomedical Integrative Genoproteomics, , Belgium
    Eur J Pharmacol 533:133-44. 2006
    ....
  98. ncbi Upregulation of MMPs by soluble E-cadherin in human lung tumor cells
    Beatrice Nawrocki-Raby
    INSERM UMRS 514, Laboratoire Pol Bouin, IFR 53, CHU Maison Blanche, Reims, France
    Int J Cancer 105:790-5. 2003
    ..These data provide new insight into mechanisms of tumor invasion by ectodomain shedding of the cell-cell adhesion molecule E-cadherin...
  99. ncbi Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  100. ncbi Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  101. ncbi Hepatocarcinoma cell lines down-regulate matrix metalloproteinase-2 expression in human hepatic myofibroblasts
    Jean Frédéric Blanc
    Laboratoire de Biologie des Tumeurs et du Developpement, INSERM E9917, Universite Victor Segalen, Bordeaux 2, 146 rue Leo Saignat, 33076, France
    Int J Oncol 20:1129-36. 2002
    ..This was partly reproduced by their conditioned media. We conclude that hepatoma cell lines down-regulate the expression of MMP-2 by myofibroblasts...