Jean Francois Focant

Summary

Country: Belgium

Publications

  1. ncbi request reprint High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum
    Jean Francois Focant
    CART, Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1130:97-107. 2006
  2. pmc Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS)
    Jessica Dekeirsschieter
    Department of Functional and Evolutionary Entomology, Gembloux Agro Bio Tech, University of Liege, Gembloux, Belgium
    PLoS ONE 7:e39005. 2012
  3. doi request reprint Levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in human milk from different regions of France
    Jean Francois Focant
    CART Mass Spectrometry Laboratory, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Sci Total Environ 452:155-62. 2013
  4. doi request reprint Improvement of ylang-ylang essential oil characterization by GC×GC-TOFMS
    Michał Brokl
    Chemistry Department CART, Organic and Biological Analytical Chemistry, University of Liege, Allée du 6 Août B6c, Liège B 4000, Belgium
    Molecules 18:1783-97. 2013
  5. ncbi request reprint Optimisation and use of tandem-in-time mass spectrometry in comparison with immunoassay and HRGC/HRMS for PCDD/F screening
    J F Focant
    Chemistry Department, University of Liege, Belgium
    Chemosphere 43:417-24. 2001
  6. ncbi request reprint Comprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs. Comparison with other methods
    Jean Francois Focant
    CART Mass Spectrometry Laboratory, Chemistry Department, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1086:45-60. 2005
  7. ncbi request reprint Recent advances in mass spectrometric measurement of dioxins
    Jean Francois Focant
    Mass Spectrometry Laboratory, Dioxin Laboratory, University of Liege, Allee de la Chimie 3, Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1067:265-75. 2005
  8. ncbi request reprint Measurement of selected polybrominated diphenyl ethers, polybrominated and polychlorinated biphenyls, and organochlorine pesticides in human serum and milk using comprehensive two-dimensional gas chromatography isotope dilution time-of-flight mass spectro
    Jean Francois Focant
    Organic Analytical Toxicology OAT, Division of Laboratory Sciences DLS, National Center for Environmental Health NCEH, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30341, USA
    Anal Chem 76:6313-20. 2004
  9. ncbi request reprint Improved separation of the 209 polychlorinated biphenyl congeners using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry
    Jean Francois Focant
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, 4770 Buford Hwy NE, Mail Stop F 17, Atlanta, GA 30341, USA
    J Chromatogr A 1040:227-38. 2004
  10. ncbi request reprint Fast clean-up for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis of high-fat-content biological samples
    J F Focant
    Mass Spectrometry Laboratory, University of Liege, Belgium
    J Chromatogr A 925:207-21. 2001

Collaborators

Detail Information

Publications30

  1. ncbi request reprint High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum
    Jean Francois Focant
    CART, Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1130:97-107. 2006
    ..Data related to quality control and limit of quantification (LOQ) calculations are also presented and discussed...
  2. pmc Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS)
    Jessica Dekeirsschieter
    Department of Functional and Evolutionary Entomology, Gembloux Agro Bio Tech, University of Liege, Gembloux, Belgium
    PLoS ONE 7:e39005. 2012
    ..The use of GCxGC-TOFMS in study of postmortem volatile compounds instead of conventional GC-MS was successful...
  3. doi request reprint Levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in human milk from different regions of France
    Jean Francois Focant
    CART Mass Spectrometry Laboratory, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Sci Total Environ 452:155-62. 2013
    ..3 pg TEQ(WHO05)/kg body weight per day (85.0 pg TEQ(WHO98)/kg body weight per day) for a baby of 5 kg of body weight fed daily with 700 ml of maternal milk containing 25 g/l of lipids...
  4. doi request reprint Improvement of ylang-ylang essential oil characterization by GC×GC-TOFMS
    Michał Brokl
    Chemistry Department CART, Organic and Biological Analytical Chemistry, University of Liege, Allée du 6 Août B6c, Liège B 4000, Belgium
    Molecules 18:1783-97. 2013
    ..Compared to the most recent full GC-MS characterization, this represents 75 new compounds, essentially consisting of terpenes, terpenoid esters, and alcohols...
  5. ncbi request reprint Optimisation and use of tandem-in-time mass spectrometry in comparison with immunoassay and HRGC/HRMS for PCDD/F screening
    J F Focant
    Chemistry Department, University of Liege, Belgium
    Chemosphere 43:417-24. 2001
    ..The analysis of fly ashes from a municipal waste incinerator contaminated at different levels has then been realised. Results obtained using QISTMS, HRMS and immunoassay are compared...
  6. ncbi request reprint Comprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs. Comparison with other methods
    Jean Francois Focant
    CART Mass Spectrometry Laboratory, Chemistry Department, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1086:45-60. 2005
    ..On a toxic equivalent (TEQ) basis, all methods, including the dioxin-responsive chemically activated luciferase gene expression (DR-CALUX) assay, produced similar responses. A cost comparison is also presented...
  7. ncbi request reprint Recent advances in mass spectrometric measurement of dioxins
    Jean Francois Focant
    Mass Spectrometry Laboratory, Dioxin Laboratory, University of Liege, Allee de la Chimie 3, Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1067:265-75. 2005
    ..We report herein some of the advances we achieved in the past years in our laboratory on the development of alternative measurement methods for those compounds...
  8. ncbi request reprint Measurement of selected polybrominated diphenyl ethers, polybrominated and polychlorinated biphenyls, and organochlorine pesticides in human serum and milk using comprehensive two-dimensional gas chromatography isotope dilution time-of-flight mass spectro
    Jean Francois Focant
    Organic Analytical Toxicology OAT, Division of Laboratory Sciences DLS, National Center for Environmental Health NCEH, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30341, USA
    Anal Chem 76:6313-20. 2004
    ..OCP, PBDE, and PCB levels measured using the two methods were highly correlated, and the deviations between the two methods were below 20% for most analytes with concentrations above 1 ng/g milk lipids...
  9. ncbi request reprint Improved separation of the 209 polychlorinated biphenyl congeners using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry
    Jean Francois Focant
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, 4770 Buford Hwy NE, Mail Stop F 17, Atlanta, GA 30341, USA
    J Chromatogr A 1040:227-38. 2004
    ..This was not the case for the other investigated column sets...
  10. ncbi request reprint Fast clean-up for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis of high-fat-content biological samples
    J F Focant
    Mass Spectrometry Laboratory, University of Liege, Belgium
    J Chromatogr A 925:207-21. 2001
    ....
  11. ncbi request reprint Fast automated extraction and clean-up of biological fluids for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis
    Jean Francois Focant
    Mass Spectrometry Laboratory, Dioxin Laboratory, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 776:199-212. 2002
    ..As a result, this new approach appears to be suitable for the fast sample preparation often required for such fluids in case of emergency foodstuffs analysis or during large epidemiological studies...
  12. ncbi request reprint Levels and profiles of PCDDs, PCDFs and cPCBs in Belgian breast milk. Estimation of infant intake
    J F Focant
    Mass Spectrometry Laboratory, University of Liege, Belgium
    Chemosphere 48:763-70. 2002
    ..This value is almost 20 times higher than the World Health Organization tolerable daily intake. A value of 103 pg TEQ/kg bw/day represents the intake of PCDDs, PCDFs and cPCBs (no mono-ortho PCBs included)...
  13. ncbi request reprint Survey of commercial pasteurised cows' milk in Wallonia (Belgium) for the occurrence of polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls
    J F Focant
    Mass Spectrometry Laboratory, Dioxin Laboratory, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    Chemosphere 52:725-33. 2003
    ..Estimated daily intake (EDI) due to consumption of such milks was 0.34 pg TEQ/kg of body weight/day for PCDD/Fs and 0.69 pg TEQ/kg of body weight/day when cPCBs were included...
  14. ncbi request reprint Levels and congener distributions of PCDDs, PCDFs and non-ortho PCBs in Belgian foodstuffs--assessment of dietary intake
    J F Focant
    Mass Spectrometry Laboratory, University of Liege, Sart Tilman, Belgium
    Chemosphere 48:167-79. 2002
    ..00 pg WHO-TEQ/kg bw/day, for a 65 kg person) and 132.9 pg WHO-TEQ/day if cPCBs were included (2.04 pg WHO-TEQ/kg bw/day, for a 65 kg person). Meat (mainly beef), dairy products, and fish each account for roughly one third of the intake...
  15. ncbi request reprint Levels of PCDDs, PCDFs and PCBs in Belgian and international fast food samples
    J F Focant
    Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    Chemosphere 54:137-42. 2004
    ..7 pg WHO-TEQ/kg bw/month, including consumption of all types of analyzed meals, representing 9.5% of the PTMI. For child, a value of 14.5 pg WHO-TEQ/kg bw/month was obtained, representing 20.6% of the PTMI...
  16. ncbi request reprint An improved clean-up strategy for simultaneous analysis of polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and polychlorinated biphenyls (PCB) in fatty food samples
    Catherine Pirard
    Mass Spectrometry Laboratory, University of Liege, Belgium
    Anal Bioanal Chem 372:373-81. 2002
    ..On the basis of this simultaneous clean-up, a rapid simplified strategy for PCDD/F and selected PCB analysis determination is proposed for fatty food samples...
  17. ncbi request reprint Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers, polybrominated biphenyls, and polychlorinated biphenyls in human serum
    Andreas Sjodin
    Organic Analytical Toxicology, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway N E, Mail Stop F 17, Atlanta, GA 30341, USA
    Anal Chem 76:1921-7. 2004
    ..Mean recoveries of the (13)C-labeled internal standards ranged from 69 to 95% for the seven monitored PBDEs; 76 and 98% were recovered for BB-153 and CB-153, respectively...
  18. ncbi request reprint Environmental and human impact of an old-timer incinerator in terms of dioxin and PCB level: a case study
    Catherine Pirard
    Mass Spectrometry Laboratory, C A R T, University of Liege, Liege, Belgium
    Environ Sci Technol 39:4721-8. 2005
    ..When adjusted for age, PCB and PCDD/F blood levels were higher than general European populations and comparable to a similarly exposed Belgian population...
  19. pmc Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States
    Andreas Sjodin
    Organic Analytical Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Environ Health Perspect 112:654-8. 2004
    ..In contrast, PCB and PBB levels were negatively correlated with sample collection year, indicating that the levels of these compounds have been decreasing since their phaseout in the 1970s...
  20. ncbi request reprint Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
    ..Mean recoveries of the (13)C-labeled internal standards ranged from 60 to 89% for the eight PBDE congeners; 74 and 113% were recovered for BB-153 and CB-153, respectively...
  21. ncbi request reprint High-throughput analysis of human serum for selected polychlorinated biphenyls (PCBs) by gas chromatography-isotope dilution time-of-flight mass spectrometry (GC-IDTOFMS)
    Jean Francois Focant
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia 30341, USA
    Analyst 129:331-6. 2004
    ..The comparison with the high resolution mass spectrometry (HRMS) reference method (28 min) was good and some separation improvements have been observed. This method allows the analysis of 100 samples per day per instrument...
  22. doi request reprint Levels of dechloranes and polybrominated diphenyl ethers (PBDEs) in human serum from France
    Catherine Brasseur
    CART, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liege, Allee du 6 Aout, B6c, Sart Tilman, B 4000 Liege, Belgium CART, Mass Spectrometry Laboratory, Chemistry Department, University of Liege, Allee du 6 Aout, B6c, Sart Tilman, B 4000 Liege, Belgium
    Environ Int 65:33-40. 2014
    ..24±4.16ng/g lw). These results indicate that the attention to dechloranes should be continued if research indicates toxicological concerns. ..
  23. ncbi request reprint Suitability of tandem-in-time mass spectrometry for polybrominated diphenylether measurement in fish and shellfish samples: comparison with high resolution mass spectrometry
    Catherine Pirard
    CART, Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, Bat B6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1115:125-32. 2006
    ..An analytical procedure based on rapid automated sample preparation and QISTMS/MS appeared to be suitable for the measurement of PBDEs in fish and shellfish speciment under quality assurance/quality control (QA/QC) criteria...
  24. doi request reprint Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the forensic study of cadaveric volatile organic compounds released in soil by buried decaying pig carcasses
    Catherine Brasseur
    CART, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liege, Allee du 6 Aout, B6c, Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1255:163-70. 2012
    ..Such screening of soil samples for cadaveric decomposition signature was successfully applied on two gravesoil sites and clearly differentiates soils at proximity of buried decaying pig carcasses from control soils...
  25. ncbi request reprint New strategy for comprehensive analysis of polybrominated diphenyl ethers, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls by gas chromatography coupled with mass spectrometry
    Catherine Pirard
    Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, Bat B6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 998:169-81. 2003
    ..The whole method has been evaluated on standard solution and quality control samples consisting of fortified beef fat. Sensitivity, selectivity, accuracy and repeatability were tested with satisfactory results...
  26. doi request reprint Effects of a sublethal pesticide exposure on locomotor behavior: a video-tracking analysis in larval amphibians
    Mathieu Denoël
    Laboratory of Fish and Amphibian Ethology, Behavioural Biology Unit, Department of Biology, Ecology, and Evolution, University of Liege, 22 Quai Van Beneden, 4020 Liege, Belgium
    Chemosphere 90:945-51. 2013
    ..By highlighting effects before mortality markers, video-tracking systems also show their potential as sentinels of sublethal effects of pesticides...
  27. ncbi request reprint Qualitative evaluation of thermal desorption-programmable temperature vaporization-comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the analysis of selected halogenated contaminants
    Jean Francois Focant
    Centers for Disease Control and Prevention, National Centerfor Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, 4770 Buford Hwy NE, Mail Stop F 17, Atlanta, GA 30341, USA
    J Chromatogr A 1019:143-56. 2003
    ..Of the 58 compounds investigated, only one pair of PCBs was not resolved. All other analytes were either baseline separated into the chromatographic plane or were virtually separated using the deconvolution capability of the TOFMS...
  28. ncbi request reprint Concentration of polybrominated diphenyl ethers (PBDEs) in household dust from various countries
    Andreas Sjodin
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division for Laboratory Sciences, 4770 Buford Hwy, Atlanta, GA 30341, USA
    Chemosphere 73:S131-6. 2008
    ..We conclude that further studies are required to investigate human indoor exposure to PBDEs across countries and to determine the risk factors related to indoor design factors...
  29. ncbi request reprint Development of an absolute quantification method targeting growth hormone biomarkers using liquid chromatography coupled to isotope dilution mass spectrometry
    Stephanie Kirsch
    University of Liege, Chemistry Department, Mass Spectrometry Laboratory, Allee de la Chimie 3, B 6c Sart Tilman, B 4000 Liege, Belgium
    J Chromatogr A 1153:300-6. 2007
    ..Preliminary data regarding repeatability show that relative standard deviations (RSDs) range between 13 and 32% for IGFBP-3 and between 7 and 29% for IGF-1...
  30. ncbi request reprint MALDI-TOF MS Analysis of Cellodextrins and Xylo-oligosaccharides Produced by Hindgut Homogenates of Reticulitermes santonensis
    Catherine Brasseur
    Mass Spectrometry Laboratory, Department of Chemistry, University of Liege, allée du Six Août, B6c, Sart Tilman, B 4000 Liege, Belgium
    Molecules 19:4578-94. 2014
    ..These results are of interest for lignocellulose biomass valorization and demonstrated the potential of termites and their symbiotic microbiota as a source of interesting enzymes for oligosaccharides production. ..