Sandra Verstraelen

Summary

Affiliation: Flemish Institute for Technological Research
Country: Belgium

Publications

  1. doi request reprint Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test
    Sandra Verstraelen
    Flemish Institute for Technological Research, VITO NV, Environmental Risk and Health Unit, Mol, Belgium
    Toxicol In Vitro 27:1298-311. 2013
  2. ncbi request reprint Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, B 2400 Mol, Belgium
    Toxicol In Vitro 19:903-7. 2005
  3. doi request reprint Gene profiles of THP-1 macrophages after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO NV, Boeretang 200, 2400 Mol, Belgium
    Toxicol In Vitro 23:1151-62. 2009
  4. doi request reprint Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO N V, BE 2400 Mol, Belgium
    Toxicol Lett 185:16-22. 2009
  5. doi request reprint Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO N V, Boeretang 200, BE 2400 Mol, Belgium
    Toxicology 255:151-9. 2009
  6. doi request reprint Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research, Boeretang 200, Mol, Belgium
    Toxicol In Vitro 22:1419-31. 2008
  7. doi request reprint Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO NV, Boeretang 200, 2400 Mol, Belgium
    Toxicol In Vitro 22:1107-14. 2008
  8. doi request reprint THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers
    Nathalie Lambrechts
    Flemish Institute for Technological Research VITO N V, Centre of Expertise in Environmental Toxicology, Mol, Belgium
    Toxicol Appl Pharmacol 236:221-30. 2009
  9. doi request reprint Gene expressions changes in bronchial epithelial cells: Markers for respiratory sensitizers and exploration of the NRF2 pathway
    Sylvie Remy
    Flemish Institute for Technological Research VITO, Unit Environmental Risk and Health, Boeretang 200, Mol, Belgium Department of Biomedical Sciences, Antwerp University, Universiteitsplein 1, Antwerp, Belgium Electronic address
    Toxicol In Vitro 28:209-17. 2014
  10. ncbi request reprint The allergic cascade: review of the most important molecules in the asthmatic lung
    Karolien Bloemen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Immunol Lett 113:6-18. 2007

Collaborators

Detail Information

Publications11

  1. doi request reprint Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test
    Sandra Verstraelen
    Flemish Institute for Technological Research, VITO NV, Environmental Risk and Health Unit, Mol, Belgium
    Toxicol In Vitro 27:1298-311. 2013
    ..This 3-year research project was sponsored by the Stavros Niarchos Foundation (Greece)...
  2. ncbi request reprint Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, B 2400 Mol, Belgium
    Toxicol In Vitro 19:903-7. 2005
    ..2 (p=0.018), 20 (p=0.010) and 200 ng/ml (p=0.047) DEP combined with LPS in the group of responders. We conclude that DEP has an adjuvant effect on LPS-induced maturation of Mo-DC...
  3. doi request reprint Gene profiles of THP-1 macrophages after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO NV, Boeretang 200, 2400 Mol, Belgium
    Toxicol In Vitro 23:1151-62. 2009
    ..Using a pathway analysis tool, platelet-derived growth factor signaling was observed to be activated in THP-1 macrophages in the context of respiratory sensitization...
  4. doi request reprint Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO N V, BE 2400 Mol, Belgium
    Toxicol Lett 185:16-22. 2009
    ..Using a pathway analysis tool to identify possible underlying mechanisms of respiratory sensitization, no known canonical signaling pathway was observed to be activated in the A549 cell line...
  5. doi request reprint Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO N V, Boeretang 200, BE 2400 Mol, Belgium
    Toxicology 255:151-9. 2009
    ..Results are indicative that the BEAS-2B cell line can be used as an alternative cell model to screen chemical compounds for their respiratory sensitizing potential...
  6. doi request reprint Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research, Boeretang 200, Mol, Belgium
    Toxicol In Vitro 22:1419-31. 2008
    ..In order to develop a good in vitro model for respiratory allergy, the choice of appropriate cell types is important. Epithelial cells, macrophages and DCs are currently the most used models in this field of research...
  7. doi request reprint Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate
    S Verstraelen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO NV, Boeretang 200, 2400 Mol, Belgium
    Toxicol In Vitro 22:1107-14. 2008
    ..These genes are possible markers for respiratory sensitization caused by isocyanates...
  8. doi request reprint THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers
    Nathalie Lambrechts
    Flemish Institute for Technological Research VITO N V, Centre of Expertise in Environmental Toxicology, Mol, Belgium
    Toxicol Appl Pharmacol 236:221-30. 2009
    ..However, the DC model was superior to the monocyte model for discrimination of (non-)sensitizing chemicals...
  9. doi request reprint Gene expressions changes in bronchial epithelial cells: Markers for respiratory sensitizers and exploration of the NRF2 pathway
    Sylvie Remy
    Flemish Institute for Technological Research VITO, Unit Environmental Risk and Health, Boeretang 200, Mol, Belgium Department of Biomedical Sciences, Antwerp University, Universiteitsplein 1, Antwerp, Belgium Electronic address
    Toxicol In Vitro 28:209-17. 2014
    ....
  10. ncbi request reprint The allergic cascade: review of the most important molecules in the asthmatic lung
    Karolien Bloemen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Immunol Lett 113:6-18. 2007
    ..Chronical inflammation leads to structural changes of the airway architecture. In this review, the most important mediators involved in the induction phase, the early-phase and late-phase asthmatic reaction are discussed...
  11. doi request reprint Chemical sensitization and allergotoxicology
    Rosette L Van Den Heuvel
    Environmental Risk and Health Unit Toxicology, Flemish Institute for Technological Research VITO N V, Centre for Advanced R and D on Alternative Methods CARDAM, Boeretang 200, 2400, Mol, Belgium
    EXS 101:289-314. 2012
    ..A state of the art of the different in vitro approaches to identify contact and respiratory capacity of chemicals is covered in this chapter...