Olivier Feron

Summary

Country: Belgium

Publications

  1. pmc Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Invest 118:3930-42. 2008
  2. doi request reprint Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    Olivier Feron
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Radiother Oncol 92:329-33. 2009
  3. pmc Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    Nihed Draoui
    Universite Catholique de Louvain, Pole of Pharmacology and Therapeutics, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Dis Model Mech 4:727-32. 2011
  4. pmc Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase
    Laetitia Moreno Y Banuls
    Laboratoire de Toxicologie, Faculte de Pharmacie, Universite Libre de Bruxelles, Brussels 1050, Belgium
    Mol Cancer 12:33. 2013
  5. ncbi request reprint Tumor-penetrating peptides: a shift from magic bullets to magic guns
    Olivier Feron
    Universite Catholique de Louvain, Institute of Experimental and Clinical Research, Pole of Pharmacology and Therapeutics, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Sci Transl Med 2:34ps26. 2010
  6. doi request reprint Control of blood pressure variability in caveolin-1-deficient mice: role of nitric oxide identified in vivo through spectral analysis
    Fanny Desjardins
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, UCL FATH 5349, Vésale 5, 52 Avenue Mounier, 1200 Brussels, Belgium
    Cardiovasc Res 79:527-36. 2008
  7. ncbi request reprint Mechanism of reoxygenation after antiangiogenic therapy using SU5416 and its importance for guiding combined antitumor therapy
    Reginald Ansiaux
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 66:9698-704. 2006
  8. ncbi request reprint Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption
    Nathalie Crokart
    Laboratories of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Clin Cancer Res 13:630-5. 2007
  9. ncbi request reprint Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Université Catholique de Louvain Medical School, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 67:1155-62. 2007
  10. ncbi request reprint Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery
    Philippe Martinive
    Unit of Pharmacology and Therapeutics, UCL Medical School, 53 Ave E Mounier, B 1200 Brussels, Belgium
    Mol Cancer Ther 5:1620-7. 2006

Collaborators

Detail Information

Publications83

  1. pmc Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Invest 118:3930-42. 2008
    ..As MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential...
  2. doi request reprint Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    Olivier Feron
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Radiother Oncol 92:329-33. 2009
    ..Combination with radiotherapy renders remaining cells more sensitive to irradiation, emphasizing how interference with tumor cell metabolism may complement current anticancer modalities...
  3. pmc Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    Nihed Draoui
    Universite Catholique de Louvain, Pole of Pharmacology and Therapeutics, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Dis Model Mech 4:727-32. 2011
    ..Translating knowledge of lactate shuttles to the cancer field offers new perspectives to therapeutically target the hypoxic tumor microenvironment and to tackle tumor angiogenesis...
  4. pmc Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase
    Laetitia Moreno Y Banuls
    Laboratoire de Toxicologie, Faculte de Pharmacie, Universite Libre de Bruxelles, Brussels 1050, Belgium
    Mol Cancer 12:33. 2013
    ..By contrast, the current study establishes a clear correlation between the IC50in vitro growth inhibitory concentration in human cancer cells and the Ki for the inhibition of activity of purified human α1β1 NaK...
  5. ncbi request reprint Tumor-penetrating peptides: a shift from magic bullets to magic guns
    Olivier Feron
    Universite Catholique de Louvain, Institute of Experimental and Clinical Research, Pole of Pharmacology and Therapeutics, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Sci Transl Med 2:34ps26. 2010
    ..Remarkably, this penetrating peptide works not only when it is conjugated to the payload, but also when it is coadministered with small molecules, nanoparticles, or monoclonal antibodies...
  6. doi request reprint Control of blood pressure variability in caveolin-1-deficient mice: role of nitric oxide identified in vivo through spectral analysis
    Fanny Desjardins
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, UCL FATH 5349, Vésale 5, 52 Avenue Mounier, 1200 Brussels, Belgium
    Cardiovasc Res 79:527-36. 2008
    ..However, the impact of genetic alteration of cav-1 on vascular nitric oxide (NO) production and BP homeostasis in vivo is unknown...
  7. ncbi request reprint Mechanism of reoxygenation after antiangiogenic therapy using SU5416 and its importance for guiding combined antitumor therapy
    Reginald Ansiaux
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 66:9698-704. 2006
    ....
  8. ncbi request reprint Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption
    Nathalie Crokart
    Laboratories of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Clin Cancer Res 13:630-5. 2007
    ..We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO(2)) through inhibition of mitochondrial respiration...
  9. ncbi request reprint Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Université Catholique de Louvain Medical School, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 67:1155-62. 2007
    ..To determine whether radiation-induced increases in nitric oxide (NO) production can influence tumor blood flow and improve delivery of Akt-targeting therapeutic DNA lipocomplexes to the tumor...
  10. ncbi request reprint Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery
    Philippe Martinive
    Unit of Pharmacology and Therapeutics, UCL Medical School, 53 Ave E Mounier, B 1200 Brussels, Belgium
    Mol Cancer Ther 5:1620-7. 2006
    ..ET(A) antagonist administration may wipe out such heterogeneities, thus representing an adjuvant strategy that could improve the delivery of conventional chemotherapy to tumors...
  11. doi request reprint Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier 73 20, 1200 Brussels, Belgium
    J Control Release 140:166-73. 2009
    ..Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach...
  12. ncbi request reprint Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions
    Nathalie Crokart
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 63:901-10. 2005
    ..To characterize changes in the tumor microenvironment early after irradiation and determine the factors responsible for early reoxygenation...
  13. pmc Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment
    Julie DeWever
    Unit of Pharmacology and Therapeutics UCL FATH 5349, Universite Catholique de Louvain, Brussels, Belgium
    Am J Pathol 171:1619-28. 2007
    ..Caveolin-1 therefore has the potential to be a marker of tumor vasculature maturity that may help adjusting anticancer therapies...
  14. ncbi request reprint Caveolin plays a central role in endothelial progenitor cell mobilization and homing in SDF-1-driven postischemic vasculogenesis
    Elhem Sbaa
    Unit of Pharmacology and Therapeutics, University of Louvain Medical School, Brussels, Belgium
    Circ Res 98:1219-27. 2006
    ..In particular, a transient reduction in caveolin expression was shown to therapeutically increase the engraftment of progenitor cells...
  15. doi request reprint Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells--new insights for anti-tumor treatments
    Philippe Martinive
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    FEBS J 276:509-18. 2009
    ..These observations also indicate the potential of combining Akt-targeting drugs with anti-angiogenic drugs, in particular those interfering with the NO pathway...
  16. pmc Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis
    Pierre Sonveaux
    Pole of Pharmacology, Institute of Experimental and Clinical Research, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 7:e33418. 2012
    ....
  17. ncbi request reprint Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide
    Agnes Brouet
    University of Louvain Medical School, Brussels, Belgium
    FASEB J 19:602-4. 2005
    ....
  18. pmc Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells
    Christophe J De Saedeleer
    Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques IREC, Universite Catholique de Louvain UCL, Brussels, Belgium
    PLoS ONE 7:e46571. 2012
    ....
  19. ncbi request reprint Tumor radiosensitization by antiinflammatory drugs: evidence for a new mechanism involving the oxygen effect
    Nathalie Crokart
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 65:7911-6. 2005
    ..These results also provide a new rationale for the treatment schedule when combining NSAIDs and radiotherapy...
  20. doi request reprint Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles
    Fabienne Danhier
    Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Universite Catholique de Louvain, Brussels, Belgium
    Methods Enzymol 508:157-75. 2012
    ..We also illustrate how RGD-nanoparticles may be more suited than nontargeted modalities for the tumor delivery of poorly soluble and/or highly cytotoxic drugs, using different mouse tumor xenograft models...
  21. doi request reprint The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy
    Françoise Frérart
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, UCL FATH, Brussels, Belgium
    Clin Cancer Res 14:2768-74. 2008
    ..Because hypoxia and acidity are characteristics of the tumor microenvironment, we examined whether nitrite injection could preferentially lead to NO production in tumors and influence response to treatments...
  22. ncbi request reprint Botulinum toxin potentiates cancer radiotherapy and chemotherapy
    Reginald Ansiaux
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, Brussels, Belgium
    Clin Cancer Res 12:1276-83. 2006
    ....
  23. ncbi request reprint Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment
    Reginald Ansiaux
    Laboratories of Biomedical Magnetic Resonance, Universite Catholique de Louvain, Avenue E Mounier 73 40, B 1200 Brussels, Belgium
    Clin Cancer Res 11:743-50. 2005
    ....
  24. pmc Influence of cell detachment on the respiration rate of tumor and endothelial cells
    Pierre Danhier
    Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Universite Catholique de Louvain UCL, Brussels, Belgium
    PLoS ONE 8:e53324. 2013
    ..These findings highlight the important influence exerted by cell adhesion/detachment on cell respiration, which can be probed with the unprecedented experimental assay that was developed and validated in this study...
  25. doi request reprint Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors
    Romain Boidot
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Pharmacology, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Cancer Res 72:939-48. 2012
    ....
  26. ncbi request reprint Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells
    Irina Lobysheva
    Pole of Pharmacology and Therapeutics FATH 5349, Institute of Clinical and Experimental Research, Universite Catholique de Louvain, Brussels, Belgium
    Arterioscler Thromb Vasc Biol 31:2098-105. 2011
    ..We analyzed the role of caveolin-1 (Cav-1) in the cross-talk between NADPH oxidase and endothelial nitric oxide synthase (eNOS) signaling in endothelial caveolae...
  27. doi request reprint Vascular caveolin deficiency supports the angiogenic effects of nitrite, a major end product of nitric oxide metabolism in tumors
    Françoise Frérart
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, UCL FATH 5349, Brussels, Belgium
    Mol Cancer Res 7:1056-63. 2009
    ..This work also strengthens the therapeutic value of the modulation of caveolin expression to interfere with tumor angiogenesis...
  28. doi request reprint Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing
    Heng Jiang
    Vrije Universiteit Brussel, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 76:1520-7. 2010
    ..This study examined whether activation of iNOS (a) directly in tumor cells or (b) in bystander macrophages may improve radioresponse through sparing of oxygen...
  29. doi request reprint Potentiation of radiotherapy by a localized antiangiogenic gene therapy
    Nathalie Crokart
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Brussels, Belgium
    Radiother Oncol 107:252-8. 2013
    ..We hypothesized that electrotransfer of a plasmid encoding an antiangiogenic factor, the recombinant disintegrin domain of ADAM-15, (pRDD) could modify the tumor microenvironment and radiosensitize tumor...
  30. ncbi request reprint The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors
    Christine Baudelet
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, Avenue E Mounier 73 40, B 1200 Brussels, Belgium
    NMR Biomed 19:69-76. 2006
    ..Functionality and maturation are not required for signal fluctuations, however, because a large fraction of fluctuations could still occur in non-perfused and/or immature vessels...
  31. ncbi request reprint 19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy
    Greg O Cron
    Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, UCL, Brussels, Belgium
    Magn Reson Med 59:19-27. 2008
    ..19)F NMR is a promising tool for preclinical evaluation of such vascular modifiers and may ultimately be used in the clinic to monitor how these modifiers affect chemotherapy...
  32. doi request reprint Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication
    Geraldine Rath
    Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School, 52, Avenue Mounier, B 1200 Brussels, Belgium
    Arterioscler Thromb Vasc Biol 32:2241-9. 2012
    ....
  33. pmc Nitric oxide synthase isoforms play distinct roles during acute peritonitis
    Jie Ni
    Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 25:86-96. 2010
    ..Increased nitric oxide (NO) release by NO synthase (NOS) isoforms has been implicated in acute peritonitis, but the role played by the NOS isoforms expressed in the peritoneum is unknown...
  34. doi request reprint Comparison of methods for measuring oxygen consumption in tumor cells in vitro
    Caroline Diepart
    Laboratory of Biomedical Magnetic Resonance, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Anal Biochem 396:250-6. 2010
    ..Finally, the MitoXpress fluorescent assay has the advantage of a high-sample throughput and low bulk requirements but at the cost of a lower sensitivity...
  35. doi request reprint Nitric oxide delivery to cancer: why and how?
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain UCL, Avenue E Mounier 52, B 1200 Brussels, Belgium
    Eur J Cancer 45:1352-69. 2009
    ..The development of techniques to monitor how and to which extent NO delivery influences the phenotype of a given tumour in a given patient is also discussed...
  36. pmc Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers
    Marie Grandjean
    UCLouvain, Institut de Recherche Expérimentale et Clinique IREC, Pole of Pharmacology and Therapeutics FATH, Brussels, Belgium
    PLoS ONE 8:e76508. 2013
    ....
  37. ncbi request reprint Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies
    Philippe Martinive
    Unit of Pharmacology and Therapeutics FATH 5349, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cancer Res 66:11736-44. 2006
    ..Our observations also underscore the potential of drugs targeting HIF-1alpha to resensitize the tumor vasculature to anticancer treatments...
  38. pmc Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker
    Florence Defresne
    Angiogenesis and Cancer Research Laboratory, Pole of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Neoplasia 12:562-70. 2010
    ..However, the multiple influences of anticancer treatments on the humoral immune system calls for caution when exploiting such auto-Ab as markers of the tumor response...
  39. doi request reprint Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy
    Reginald Ansiaux
    Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Radiat Res 172:584-91. 2009
    ..The observation that vandetanib causes an early increase in tumor oxygenation has implications for the timing and sequencing of treatment with VEGF signaling inhibitors in combination with radiation...
  40. ncbi request reprint Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis
    Pierre Sonveaux
    University of Louvain Medical School, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    Circ Res 95:154-61. 2004
    ..This study also provides new insights to understand the paradoxical roles of caveolin (eg, repressing basal enzyme activity but facilitating activation on agonist stimulation) in cardiovascular pathophysiology...
  41. doi request reprint Identification of cyclooxygenase-2 as a major actor of the transcriptomic adaptation of endothelial and tumor cells to cyclic hypoxia: effect on angiogenesis and metastases
    Géraldine Daneau
    Universite Catholique de Louvain, Unit of Pharmacology and Therapeutics UCL FATH 5349, Brussels, Belgium
    Clin Cancer Res 16:410-9. 2010
    ..Whether pO(2) fluctuations, particularly transient reoxygenation periods, alter the well-known hypoxia-inducible factor (HIF)-dependent gene program is largely unknown...
  42. ncbi request reprint Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption
    Benedicte F Jordan
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Avenue Mounier 73 40, B 1200 Brussels, Belgium
    Int J Cancer 109:768-73. 2004
    ..These data strongly suggest that NO is a complementary factor additive to oxygen in determining the sensitivity to irradiation and we therefore propose that NO acts as an intrinsic radiosensitizer in vivo...
  43. doi request reprint A new method combining sequential immunoaffinity depletion and differential in gel electrophoresis to identify autoantibodies as cancer biomarkers
    Marie Grandjean
    UCLouvain, Institut de Recherche Expérimentale et Clinique IREC, Pole of Pharmacology and Therapeutics FATH, Brussels, Belgium
    J Immunol Methods 396:23-32. 2013
    ..Overall, the developed methodology allowed efficient screening of sera for the identification of aAbs as potential biomarkers. ..
  44. ncbi request reprint Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment
    Pierre Sonveaux
    University of Louvain Medical School, Unit of Pharmacology and Therapeutics FATH 5349, Brussels, Belgium
    Cancer Res 64:3209-14. 2004
    ..Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy...
  45. doi request reprint Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis
    Florence Defresne
    Universite Catholique de Louvain, IREC, Pole of Pharmacology and Therapeutics UCL FATH, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Cancer Res 71:4748-57. 2011
    ..Our findings unravel the influence of tumor cells on EPC phenotypes through a SPARC-driven accentuation of macrophagic capacity associated with limitations to metastatic spread...
  46. doi request reprint Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence
    Pierre Danhier
    Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Contrast Media Mol Imaging 9:143-53. 2014
    ..BLI remains the most suitable technique for long-term monitoring of metastatic cells...
  47. doi request reprint Delivery of soluble VEGF receptor 1 (sFlt1) by gene electrotransfer as a new antiangiogenic cancer therapy
    Julien Verrax
    Angiogenesis and Cancer Research Laboratory, Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
    Mol Pharm 8:701-8. 2011
    ..In conclusion, our data support sFlt1 gene electrotransfer as a novel and safe modality to target VEGF-driven tumor angiogenesis and to maintain unaltered the recovery potential of ischemic tissues...
  48. ncbi request reprint Contribution of oxygenation to BOLD contrast in exercising muscle
    Benedicte F Jordan
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Magn Reson Med 52:391-6. 2004
    ..However, T'2 remained high for a prolonged time after stimulation. We therefore concluded that the maintenance of BOLD SI in moderately exercising skeletal muscle depends mainly on changes in pO2, rather than on blood flow or T2 effects...
  49. doi request reprint Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors
    Caroline Diepart
    Biomedical Magnetic Resonance Group, Louvain Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 72:482-90. 2012
    ..Together, our findings show that As(2)O(3) acutely increases oxygen consumption and radiosensitizes tumors, providing a new rationale for clinical investigations of As(2)O(3) in irradiation protocols to treat solid tumors...
  50. doi request reprint Antitumoral and antimetastatic effect of antiangiogenic plasmids in B16 melanoma: Higher efficiency of the recombinant disintegrin domain of ADAM 15
    Liévin Daugimont
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unite de Pharmacie Galenique, Brussels, Belgium
    Eur J Pharm Biopharm 78:314-9. 2011
    ..We investigated whether intra-tumoral electrotransfer of three angiogenic plasmids could inhibit tumor growth and metastasis...
  51. ncbi request reprint Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol
    Chantal Dessy
    Université Catholique de Louvain Medical School, Brussels, Belgium
    Circulation 112:1198-205. 2005
    ..We identified endothelial beta3-adrenoreceptors in human coronary microarteries that mediate endothelium- and NO-dependent relaxation and hypothesized that nebivolol activates these beta3-adrenoreceptors...
  52. ncbi request reprint Thyroid status is a key modulator of tumor oxygenation: implication for radiation therapy
    Benedicte F Jordan
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Radiat Res 168:428-32. 2007
    ..This study provides unique insights into the impact of modulating tumor oxygen consumption and could have implications in the management of cancer patients with thyroid disorders...
  53. ncbi request reprint Caveolins and the regulation of endothelial nitric oxide synthase in the heart
    Olivier Feron
    Unit of Pharmacology and Therapeutics, FATH 5349, Department of Medicine, Universite Catholique de Louvain, 53 avenue Mounier, 1200 Brussels, Belgium
    Cardiovasc Res 69:788-97. 2006
    ....
  54. ncbi request reprint Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: importance of optimal scheduling to exploit the 'normalization' window of the tumor vasculature
    Jérome Segers
    Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cancer Lett 244:129-35. 2006
    ..In conclusion, the present study demonstrates that the benefit of combined therapy using an anti-angiogenic agent with a cytotoxic agent requires knowledge of the time window during which the vessels initially become normalized...
  55. ncbi request reprint Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction
    Paul B Massion
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Circulation 110:2666-72. 2004
    ..Defective NO production by NOS3 (endothelial NOS [eNOS]) in the failing heart may precipitate cardiac failure, which could be reversed by overexpression of NOS3 in the myocardium...
  56. doi request reprint Multimodal imaging of tumor response to sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18F-FLT PET imaging
    Oussama Karroum
    Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Belgium, Avenue Mounier 73, B 1200 Brussels, Belgium
    Contrast Media Mol Imaging 8:274-80. 2013
    ....
  57. ncbi request reprint Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy
    Caroline Bouzin
    Université Catholique de Louvain Medical School, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    J Immunol 178:1505-11. 2007
    ..In conclusion, this study provides new insights on the mechanisms leading to the tumor EC anergy vs immune cells and opens new perspectives for the use of antiangiogenic strategies as adjuvant approaches to cancer immunotherapy...
  58. doi request reprint To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unit of Pharmaceutics, UCL FARG 7320, avenue E Mounier, B 1200, Brussels, Belgium
    J Control Release 148:135-46. 2010
    ..Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed...
  59. doi request reprint Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis
    Frederique Vegran
    Universite Catholique de Louvain, Pole of Pharmacology and Therapeutics UCL FATH, Angiogenesis and Cancer Research Laboratory, Institute of Experimental and Clinical Research IREC, Brussels, Belgium
    Cancer Res 71:2550-60. 2011
    ..In conclusion, our findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-κB/IL-8 pathway as an important link between tumor metabolism and angiogenesis...
  60. ncbi request reprint The calcium channel blocker amlodipine promotes the unclamping of eNOS from caveolin in endothelial cells
    Suzan Batova
    Unit of Pharmacology and Therapeutics, University of Louvain Medical School, UCL FATH5349, 53 Avenue E Mounier, Brussels B 1200, Belgium
    Cardiovasc Res 71:478-85. 2006
    ..g., caveolae and rafts), amlodipine could interfere with this specific locale of the enzyme and thereby modulate NO production in endothelial cells...
  61. ncbi request reprint The double regulation of endothelial nitric oxide synthase by caveolae and caveolin: a paradox solved through the study of angiogenesis
    Elhem Sbaa
    Unit of Pharmacology and Therapeutics, University of Louvain Medical School, UCL FATH 5349, B 1200 Brussels, Belgium
    Trends Cardiovasc Med 15:157-62. 2005
    ....
  62. doi request reprint Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice
    Linda Karmani
    Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue Mounier 73, 1200, Brussels, Belgium
    Contrast Media Mol Imaging 8:402-8. 2013
    ..The (89)Zr-labeled cetuximab-targeted gold nanoparticles could be a valuable tool for theranostic purposes...
  63. doi request reprint Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
    Paolo E Porporato
    Pole of Pharmacology, Universite Catholique de Louvain UCL, Avenue Emmanuel Mounier 53 box B1 53 09, 1200, Brussels, Belgium
    Angiogenesis 15:581-92. 2012
    ..This polymer is FDA-approved for other applications, emphasizing the possibility of exploiting PLGA therapeutically to improve wound healing...
  64. pmc The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action
    Laurie Hamtiaux
    Medicinal Chemistry, Cannabinoid and Endocannabinoid Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    BMC Cancer 12:92. 2012
    ..Additionally, the implication of the endocannabinoid system in malignancy is actively investigated...
  65. doi request reprint Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging
    Quentin Godechal
    Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Universite Catholique de Louvain, Avenue Mounier 73, B 1200 Brussels, Belgium
    Contrast Media Mol Imaging 6:282-8. 2011
    ..Another tumor model (KHT sarcoma), non-pigmented but expressing luciferase, was used to confirm that the EPR signal was directly linked to the melanin pigment present in the tumors...
  66. doi request reprint Both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model
    Anne Sophie Van Eyck
    Department of Gynecology, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Fertil Steril 93:1676-85. 2010
    ..To characterize the human ovarian xenograft revascularization process...
  67. doi request reprint The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the 'endothelium-derived hyperpolarizing factor'
    Chantal Dessy
    Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Universite Catholique de Louvain, UCL FATH 5349, 52 Avenue E Mounier, B 1200, Brussels, Belgium
    Pflugers Arch 459:817-27. 2010
    ..In this review, we will first focus on the current understanding of the caveolin/eNOS paradigm and will then detail the most recent findings on the role of caveolae in driving EDHF-signaling pathways...
  68. doi request reprint 3D systems delivering VEGF to promote angiogenesis for tissue engineering
    Anne des Rieux
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unite de Pharmacie Galenique, 1200 Brussels, Belgium
    J Control Release 150:272-8. 2011
    ..Encapsulation and incorporation of VEGF into 3D implants that, in addition to sustaining cell infiltration and organization, will stimulate blood vessel are a promising approach for tissue regeneration engineering...
  69. doi request reprint Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 133:11-7. 2009
    ..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  70. doi request reprint Galectin-1 in melanoma biology and related neo-angiogenesis processes
    Véronique Mathieu
    Laboratoire de Toxicologie, Faculte de Pharmacie, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Invest Dermatol 132:2245-54. 2012
    ..Altogether, these data point to gal-1 as a potential target to combat melanomas...
  71. doi request reprint Molecular electron paramagnetic resonance imaging of melanin in melanomas: a proof-of-concept
    Emilia Vanea
    Biomedical Magnetic Resonance Unit, Universite Catholique de Louvain, UCL, Brussels, Belgium
    NMR Biomed 21:296-300. 2008
    ..In addition to the proof-of-concept and the achievement of providing the first non-invasive image of an endogenous radical, this technology may represent a key advance in improving the diagnosis of suspected melanoma lesions...
  72. ncbi request reprint Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery
    Pierre Sonveaux
    Universite Catholique de Louvain UCL, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    Physiology (Bethesda) 22:97-112. 2007
    ..Delivery of SNOs by the RBC can be harnessed for therapeutic gain, and early results support the logic of this approach in the treatment of diseases as varied as cancer and neonatal pulmonary hypertension...
  73. ncbi request reprint Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice
    Maximin Senou
    Unité de Morphologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 297:E438-51. 2009
    ..Because the expression and subcellular localization of caveolin-1 were similar between normal human and murine thyroids, our findings in caveolin-1 knockout mice may have direct relevance to the human counterpart...
  74. pmc Bone marrow microenvironment and tumor progression
    Christophe F Chantrain
    Division of Hematology Oncology, Department of Pediatrics, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Microenviron 1:23-35. 2008
    ..In this article, the reciprocal relationship between the bone marrow microenvironment and tumor cells is reviewed, and its potential impact on cancer therapy is discussed...
  75. ncbi request reprint Mice that lack endothelial nitric oxide synthase are protected against functional and structural modifications induced by acute peritonitis
    Jie Ni
    Divisions of Nephrology, Pathology, Experimental Surgery, and Pharmacotherapy, Université Catholique de Louvain Medical School, Brussels, Belgium
    J Am Soc Nephrol 14:3205-16. 2003
    ..The characterization of this mouse model suggests that genetically modified mice represent useful tools to investigate the molecular bases of the peritoneal changes during peritoneal dialysis...
  76. ncbi request reprint Targeting the tumor vascular compartment to improve conventional cancer therapy
    Olivier Feron
    University of Louvain Medical School, Unit of Pharmacology and Therapeutics, UCL FATH 5349, 53 Avenue E Mounier, B 1200 Brussels, Belgium
    Trends Pharmacol Sci 25:536-42. 2004
    ..In addition, we will review recent data documenting that both mature and immature vessels coexist within tumors and, importantly, that their relative density responds to a dynamic process that evolves with time and treatments...
  77. ncbi request reprint Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases
    Christophe F Chantrain
    Department of Paediatrics, Division of Haematology Oncology, School of Medicine, Catholic University of Louvain, Brussels, Belgium
    Eur J Cancer 42:310-8. 2006
    ....
  78. ncbi request reprint Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses
    Benedicte F Jordan
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 55:1066-73. 2003
    ..We tested the hypothesis that electrical stimulation of the sciatic nerve could modify the oxygenation status and the blood flow of tumors implanted in the thigh of mice...
  79. doi request reprint Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
    Raphael Beck
    Unité de Pharmacocinétique, Metabolisme, Nutrition, et Toxicologie, département des sciences pharmaceutiques, Universite Catholique de Louvain, Avenue E Mounier 73, 1200 Brussels, Belgium
    Biochem Pharmacol 77:375-83. 2009
    ..Due to the major role of Hsp90 in stabilizing oncogenic and mutated proteins, these results may have potential clinical applications...
  80. ncbi request reprint Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo
    Michel Pelat
    Department of Medicine, Unit of Pharmacology and Therapeutics, University of Louvain, School of Medicine, Ave Mounier 53, 1200 Brussels, Belgium
    Circulation 107:2480-6. 2003
    ....
  81. ncbi request reprint Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption
    Benedicte F Jordan
    Laboratory of Medicinal Chemistry and Radiopharmacy, Laboratory of Biomedical Magnetic Resonance, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cancer Res 62:3555-61. 2002
    ....
  82. ncbi request reprint Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats
    Alina Piech
    Unit of Pharmacology and Therapeutics, FATH 5349, Universite Catholique de Louvain, 53 avenue Mounier, B 1200 Brussels, Belgium
    Cardiovasc Res 57:456-67. 2003
    ..However, changes in the expression of these regulators with the development of hypertrophic cardiomyopathy are unknown...