P Therasse

Summary

Affiliation: EORTC Data Center
Country: Belgium

Publications

  1. ncbi request reprint Update in methodology and conduct of cancer clinical trials
    P Therasse
    EORTC Data Center, Av E Mounier, 83 box11, 1200 Brussels, Belgium
    Eur J Cancer 42:1322-30. 2006
  2. ncbi request reprint RECIST revisited: a review of validation studies on tumour assessment
    P Therasse
    EORTC Data Center, avenue E Mounier, 83 Box 11, 1200 Brussels, Belgium
    Eur J Cancer 42:1031-9. 2006
  3. ncbi request reprint RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma
    P Therasse
    EORTC Data Center, Brussels, Belgium
    Eur J Cancer 41:1426-30. 2005
  4. ncbi request reprint Clinical trials design and treatment tailoring: general principles applied to breast cancer research
    P Therasse
    EORTC Data Center, Av E Mounier, Brussels, Belgium
    Crit Rev Oncol Hematol 59:98-105. 2006
  5. ncbi request reprint TuBaFrost 5: multifunctional central database application for a European tumor bank
    M Isabelle
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Eur J Cancer 42:3103-9. 2006
  6. ncbi request reprint Virtual microscopy in virtual tumor banking
    M Isabelle
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Adv Exp Med Biol 587:75-86. 2006
  7. ncbi request reprint Summary measures and statistics in the analysis of quality of life data: an example from an EORTC-NCIC-SAKK locally advanced breast cancer study
    D Curran
    European Organization for Research and Treatment of Cancer EORTC Data Center, Avenue Mounier 83, Bte 11, Brussels, Belgium
    Eur J Cancer 36:834-44. 2000
  8. ncbi request reprint Health related quality of life outcomes in cancer clinical trials
    A Bottomley
    EORTC Data Center, Quality of Life Unit, avenue E Mounier, 83, 1200 Brussels, Belgium
    Eur J Cancer 41:1697-709. 2005
  9. ncbi request reprint TuBaFrost 6: virtual microscopy in virtual tumour banking
    I Teodorovic
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Eur J Cancer 42:3110-6. 2006
  10. ncbi request reprint Cancer drug development in Europe: a selection of new agents under development at the European Drug Development Network
    D Lacombe
    European Organisation for Research and Treatment of Cancer, Assistant Director New Drug Development Program, avenue E Mounier, 83 b11, 1200 Brussels, Belgium
    Cancer Invest 21:137-47. 2003

Detail Information

Publications43

  1. ncbi request reprint Update in methodology and conduct of cancer clinical trials
    P Therasse
    EORTC Data Center, Av E Mounier, 83 box11, 1200 Brussels, Belgium
    Eur J Cancer 42:1322-30. 2006
    ..There is much less academic research conducted in Europe, there is a lot of discrepancy and inconsistency in the implementation of the directive across member states and there is no apparent direct benefit for the patients...
  2. ncbi request reprint RECIST revisited: a review of validation studies on tumour assessment
    P Therasse
    EORTC Data Center, avenue E Mounier, 83 Box 11, 1200 Brussels, Belgium
    Eur J Cancer 42:1031-9. 2006
    ..The findings of this review, together with experience acquired thus far and the results of some ongoing research projects, have paved the way for RECIST 2.0 to be hopefully announced later this year...
  3. ncbi request reprint RECIST vs. WHO: prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma
    P Therasse
    EORTC Data Center, Brussels, Belgium
    Eur J Cancer 41:1426-30. 2005
    ..In conclusion, response criteria as defined by RECIST are adequate to measure response and progression in non-GIST soft tissue sarcoma and can be used instead of the modified WHO criteria...
  4. ncbi request reprint Clinical trials design and treatment tailoring: general principles applied to breast cancer research
    P Therasse
    EORTC Data Center, Av E Mounier, Brussels, Belgium
    Crit Rev Oncol Hematol 59:98-105. 2006
    ..The real challenge of the next coming years resides in recruiting large number of patients from specific subgroups to validate tailored therapies...
  5. ncbi request reprint TuBaFrost 5: multifunctional central database application for a European tumor bank
    M Isabelle
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Eur J Cancer 42:3103-9. 2006
    ..Communication between requestor and involved collectors is started with automatically generated e-mails...
  6. ncbi request reprint Virtual microscopy in virtual tumor banking
    M Isabelle
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Adv Exp Med Biol 587:75-86. 2006
    ..A system of complete pathology review supporting biorepositories is described, based on the implementation of this technique in the European Human Frozen Tumor Tissue Bank (TuBaFrost)...
  7. ncbi request reprint Summary measures and statistics in the analysis of quality of life data: an example from an EORTC-NCIC-SAKK locally advanced breast cancer study
    D Curran
    European Organization for Research and Treatment of Cancer EORTC Data Center, Avenue Mounier 83, Bte 11, Brussels, Belgium
    Eur J Cancer 36:834-44. 2000
    ..In this paper, we show the importance of performing sensitivity or supportive analysis to support conclusions drawn from the primary analysis...
  8. ncbi request reprint Health related quality of life outcomes in cancer clinical trials
    A Bottomley
    EORTC Data Center, Quality of Life Unit, avenue E Mounier, 83, 1200 Brussels, Belgium
    Eur J Cancer 41:1697-709. 2005
    ..With more than 40 ongoing HRQOL studies in the EORTC, we expect HRQOL to play an even greater role over the coming decade in helping establish the optimal treatment and care approach for cancer patients...
  9. ncbi request reprint TuBaFrost 6: virtual microscopy in virtual tumour banking
    I Teodorovic
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Eur J Cancer 42:3110-6. 2006
    ..A system of complete pathology review supporting bio-repositories is described, based on the implementation of this technique in the European Human Frozen Tumor Tissue Bank (TuBaFrost)...
  10. ncbi request reprint Cancer drug development in Europe: a selection of new agents under development at the European Drug Development Network
    D Lacombe
    European Organisation for Research and Treatment of Cancer, Assistant Director New Drug Development Program, avenue E Mounier, 83 b11, 1200 Brussels, Belgium
    Cancer Invest 21:137-47. 2003
    ..In this paper, the most interesting drugs under development in each of the three organisations are being described and discussed...
  11. ncbi request reprint New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    P Therasse
    European Organization for Research and Treatment of Cancer, Brussels, Belgium
    J Natl Cancer Inst 92:205-16. 2000
    ..Methods of assessing tumor lesions are better codified, briefly within the guidelines and in more detail in Appendix I. All other aspects of response evaluation have been discussed, reviewed, and amended whenever appropriate...
  12. ncbi request reprint Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG)
    L Biganzoli
    Jules Bordet Institute, Brussels, Belgium
    Ann Oncol 15:207-10. 2004
    ..To collect oncologists' experience and opinion on adjuvant chemotherapy in elderly breast cancer patients...
  13. ncbi request reprint The importance of quality assurance in surgical oncology
    M L E A Landheer
    EORTC Data Centre, Brussels, Belgium
    Eur J Surg Oncol 28:571-602. 2002
    ..The aims were to review the existing methods of quality assurance in surgical oncology and to determine a relationship between surgery-related factors and the variety in outcomes in the treatment of solid cancers...
  14. ncbi request reprint Medical fellowship programme within the Gynaecological Cancer Group of the European Organisation for Research and Treatment of Cancer
    H C Wagenaar
    EORTC Data Center, Brussels, Belgium
    Gynecol Obstet Invest 57:66-71. 2004
    ..Over the past decade, 76 research fellowships have been appointed at the EORTC Data Center. This paper shows an overview of the activities of one EORTC/GCG medical fellow...
  15. ncbi request reprint Addressing the challenge of intergroup studies in oncology: the EORTC experience. European Organisation for Research and Treatment of Cancer
    A Zurlo
    EORTC Data Center, Avenue E Mounier 83, 1200, Brussels, Belgium
    Eur J Cancer 38:S169-72. 2002
    ..Recently, a specific EORTC Intergroup Office started its activity devoted to solve the issues related to the intergroup co-operation. This office will have an increasing role to promote and help in conducting intergroup studies...
  16. ncbi request reprint Human tissue research: EORTC recommendations on its practical consequences
    I Teodorovic
    EORTC Data Center, Av E Mounier, 83 11, 1200, Brussels, Belgium
    Eur J Cancer 39:2256-63. 2003
    ..Being part of the EU TubaFrost project, the EORTC will provide a common international platform for the use of tissues for research purposes, finding a balance between different laws and assuring scientific progress...
  17. ncbi request reprint Quality assurance in surgical oncology (QASO) within the European Organization for Research and Treatment of Cancer (EORTC): current status and future prospects
    M L Landheer
    EORTC Data Center, Avenue E Mounier 83 1, 1200 Brussels, Belgium
    Eur J Cancer 37:1450-62. 2001
    ..However, there has been no attempt to harmonise these initiatives across the different medical specialties. The EORTC will have to address this problem within its short-term scientific strategy...
  18. ncbi request reprint Research and quality control in surgical oncology
    P Therasse
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    Surg Oncol Clin N Am 10:763-72, viii. 2001
    ....
  19. ncbi request reprint Final results of a randomized phase III trial comparing cyclophosphamide, epirubicin, and fluorouracil with a dose-intensified epirubicin and cyclophosphamide + filgrastim as neoadjuvant treatment in locally advanced breast cancer: an EORTC-NCIC-SAKK mult
    P Therasse
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Clin Oncol 21:843-50. 2003
    ..To compare the efficacy of a standard anthracycline-based regimen to a dose-intensified anthracycline regimen in locally advanced breast cancer...
  20. ncbi request reprint Quality assurance in medical oncology within the EORTC. European Organisation for Research and Treatment of Cancer
    P Therasse
    EORTC Data Center, Av E Mounier, 83 11, 1200, Brussels, Belgium
    Eur J Cancer 38:S152-4. 2002
    ..More recently, the EORTC QA Committee proposed a minimal set of quality control procedures to be implemented by all EORTC groups...
  21. ncbi request reprint The challenges and achievements involved in implementing Quality of Life research in cancer clinical trials
    A Bottomley
    Quality of Life Unit, on behalf of the EORTC Quality of Life Group and the EORTC Data Center, EORTC Data Center, Avenue E Mounier 83 11, 1200, Brussels, Belgium
    Eur J Cancer 39:275-85. 2003
    ..In the following paper, we therefore examine past experience in EORTC QOL studies, with a focus on the challenges presented and the improved approaches that are being implemented to obtain more meaningful outcomes...
  22. ncbi request reprint Treatment outcome studies. pitfalls in current methods and practice
    C Legrand
    European Organization for Research and Treatment of Cancer, Av E Mounier 83, Box 11, B 1200 Brussels, Belgium
    Eur J Cancer 38:1173-80. 2002
    ..Most of the studies use registry data, while only a few use discharge data or data available from clinical trials...
  23. ncbi request reprint Measuring the clinical response. What does it mean?
    P Therasse
    EORTC Data Center, Av E Mounier, 83 11, 1200 Brussels, Belgium
    Eur J Cancer 38:1817-23. 2002
    ....
  24. ncbi request reprint Quality assurance within EORTC: past, present and future. Introduction. European Organisation for Research and Treatment of Cancer
    P Therasse
    EORTC Data Center, Av E Mounier, 83 11, 1200, Brussels, Belgium
    Eur J Cancer 38:S151. 2002
  25. doi request reprint Examining the relationships among health-related quality-of-life indicators in cancer patients participating in clinical trials: a pooled study of baseline EORTC QLQ-C30 data
    Francesca Martinelli
    Quality of Life Department, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 11:587-99. 2011
    ..The second objective of this study was to identify which HRQoL indicators are linked to patients' perception of overall quality of life...
  26. ncbi request reprint The EORTC Breast Cancer Group: 40 years of research contributing to improve breast cancer management
    P Therasse
    EORTC Data Center, Av E Mounier, 83 11, 1200, Brussels, Belgium
    Eur J Cancer 38:S39-43. 2002
    ..EBCG is a founding member of the Breast InterGroup (BIG)...
  27. ncbi request reprint Statistical methodology of phase III cancer clinical trials: advances and future perspectives
    R Sylvester
    EORTC Data Center, 83 avenue E Mounier, Bte 11, 1200, Brussels, Belgium
    Eur J Cancer 38:S162-8. 2002
    ..Finally, some future perspectives and topics for further statistical methodological research will be presented in order to spur statisticians to meet the challenge of efficiently designing and analysing the clinical trials of tomorrow...
  28. ncbi request reprint Evaluation of response: new and standard criteria
    P Therasse
    European Organisation for Research and Treatment of Cancer Data Center, Brussels, Belgium
    Ann Oncol 13:127-9. 2002
  29. ncbi request reprint TuBaFrost: European virtual tumor tissue banking
    P H J Riegman
    The TuBaFrost Consortium, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Adv Exp Med Biol 587:65-74. 2006
    ..Thereby, improving availability of large amounts of high quality samples of a highly specified or rare tumor types and contact opportunities for cooperation with other institutes...
  30. ncbi request reprint Impact of locoregional treatment on the early-stage breast cancer patients: a retrospective analysis
    J A van der Hage
    Department of Surgery, D6 43, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 39:2192-9. 2003
    ..Adjuvant radiotherapy in mastectomised patients was associated with both a significantly superior locoregional control and overall survival. The effect of adjuvant radiotherapy was most profound in patients who had 1-3 positive nodes...
  31. ncbi request reprint TuBaFrost 4: access rules and incentives for a European tumour bank
    J A Lopez-Guerrero
    Unit of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, C Profesor Beltran Baguena, 8 11, Valencia, Spain
    Eur J Cancer 42:2924-9. 2006
    ..With this general purpose in mind, the rules and responsibilities for collectors, requestors and central office were generated...
  32. ncbi request reprint TuBaFrost 2: Standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network
    M M Morente
    Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro, 3, E 28029 Madrid, Spain
    Eur J Cancer 42:2684-91. 2006
    ..The operational framework for TuBaFrost has drawn upon the best practice of standard workflows and operating procedures employed by members of the TuBaFrost project and key initiatives worldwide...
  33. ncbi request reprint TuBaFrost 1: Uniting local frozen tumour banks into a European network: an overview
    P H J Riegman
    Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Eur J Cancer 42:2678-83. 2006
    ..An overview of the development of the European virtual frozen tissue bank infrastructure is described in this paper. The various key aspects are described in more detail in a series of articles to appear in this Journal...
  34. ncbi request reprint Clinical outcome of breast cancer patients with liver metastases alone in the anthracycline-taxane era: a retrospective analysis of two prospective, randomised metastatic breast cancer trials
    G Atalay
    Institut Jules Bordet, Boulevard de Waterloo 125, 1000 Brussels, Belgium
    Eur J Cancer 39:2439-49. 2003
    ....
  35. ncbi request reprint Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10850 comparing modified radical mastectomy with tumorectomy plus tamoxifen
    I S Fentiman
    Hedley Atkins Breast Unit, Guy s Hospital, SE1 9RT, London, UK
    Eur J Cancer 39:300-8. 2003
    ..In contrast, there were more distant metastases in the MRM group, but with a similar overall survival in both groups. The results of this trial give cautious support for the use of WLE+T for selected older women...
  36. ncbi request reprint Locally advanced/inflammatory breast cancers treated with intensive epirubicin-based neoadjuvant chemotherapy: are there molecular markers in the primary tumour that predict for 5-year clinical outcome?
    H Bonnefoi
    Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Ann Oncol 14:406-13. 2003
    ..This paper reports the results of a study assessing the potential prognostic or predictive value of HER-2, p53, cyclinD1, MIB1, ER and PgR expression by immunohistochemistry from patients included in an EORTC-NCIC-SAKK trial...
  37. ncbi request reprint Analysis of breast cancer survival by clinical response to neoadjuvant chemoendocrine therapy
    J Bogaerts
    Ann Oncol 17:352-3; author reply 353-4. 2006
  38. ncbi request reprint Quality assurance in clinical trials
    P B Ottevanger
    Department of Internal Medicine, Division of Medical Oncology, 550, University Hospital Nijmegen, Geert Grooteplein 8, PO 9101, 6500HB Nijmegen, The Netherlands
    Crit Rev Oncol Hematol 47:213-35. 2003
    ....
  39. ncbi request reprint Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy
    I S Fentiman
    Hedley Atkins Breast Unit, Guy s Hospital, SE1 9RT, London, UK
    Eur J Cancer 39:309-16. 2003
    ..0001). Overall survival of the two groups was similar. The results indicate that tamoxifen alone leads to an unacceptably high rate of local progression or relapse...
  40. ncbi request reprint TuBaFrost 3: regulatory and ethical issues on the exchange of residual tissue for research across Europe
    E B van Veen
    Medlaw Consult, P O Box 11500, 2502 AM Den Haag, The Netherlands
    Eur J Cancer 42:2914-23. 2006
    ..This coordinating rule has a sound basis in EU law in general and will solve the problems related to diverging national regulatory regimes in the case of cross national research with residual tissue...
  41. ncbi request reprint Confirmation of response in cancer clinical trials: a meaningless exercise?
    P Therasse
    Eur J Cancer 41:1501-2. 2005
  42. ncbi request reprint The importance of quality assurance in surgical oncology in the treatment of colorectal cancer
    M L Landheer
    Department of Surgery, , Arnhem, The Netherlands
    Surg Oncol Clin N Am 10:885-914, x. 2001
    ..Consequently, these findings might imply a considerable change in cancer treatment strategies because the routine use of adjuvant therapies could be questioned...
  43. ncbi request reprint OECI TuBaFrost tumor biobanking
    Peter H J Riegman
    Department of Pathology Josephine Nefkens Institute, Erasmus Medical Center Rotterdam, The Netherlands
    Tumori 94:160-3. 2008
    ..In addition, new infrastructure plans have been developed and the first preparatory steps have been set. For biobanks the BBMRI project has started aiming for Pan-European Biobanking and Biomolecular Resources Research Infrastructure...