Andrew Bottomley

Summary

Affiliation: EORTC Data Center
Country: Belgium

Publications

  1. ncbi request reprint Beyond the development of health-related quality-of-life (HRQOL) measures: a checklist for evaluating HRQOL outcomes in cancer clinical trials--does HRQOL evaluation in prostate cancer research inform clinical decision making?
    Fabio Efficace
    European Organization for Research and Treatment of Cancer EORTC, Quality of Life Unit and Genitourinary Unit, EORTC Data Center, Brussels, Belgium
    J Clin Oncol 21:3502-11. 2003
  2. pmc Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: the EORTC QLQ-TC26
    Bernhard Holzner
    Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
    Qual Life Res 22:369-78. 2013
  3. doi request reprint Moving the boundaries of international collaboration on clinical trials and QoL: experiences in oncology and legislation within the European Parliament
    Andrew Bottomley
    EORTC, Avenue Mounier, 83 11, 1200 Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 13:43-5. 2013
  4. pmc Differential item functioning (DIF) analyses of health-related quality of life instruments using logistic regression
    Neil W Scott
    Section of Population Health, University of Aberdeen, UK
    Health Qual Life Outcomes 8:81. 2010
  5. doi request reprint Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of Cancer
    Andrew Bottomley
    Quality of Life Department, EORTC Headquarters, Brussels, Belgium
    J Clin Oncol 27:2916-23. 2009
  6. ncbi request reprint International perspective on health-related quality-of-life research in cancer clinical trials: the European Organisation for Research and Treatment of Cancer experience
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer EORTC Quality of Life Unit and Quality of Life Group, Brussels, Belgium
    J Clin Oncol 25:5082-6. 2007
  7. doi request reprint Patient-reported outcomes: assessment and current perspectives of the guidelines of the Food and Drug Administration and the reflection paper of the European Medicines Agency
    Andrew Bottomley
    EORTC Quality of Life Department, EORTC Headquarters, Avenue E Mounierlaan, 83 11, Brussels 1200, Belgium
    Eur J Cancer 45:347-53. 2009
  8. ncbi request reprint Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer In
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer, EORTC Data Center, Brussels, Belgium
    J Clin Oncol 24:1435-42. 2006
  9. doi request reprint Symptom and quality of life results of an international randomised phase III study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer
    Andrew Bottomley
    Quality of Life Department, European Organisation for Research and Treatment of Cancer, EORTC Headquarters, AISBL IVZW, Avenue E Mounierlaan, 83 11, Brussel 1200, Bruxelles, Belgium
    Eur J Cancer 44:2178-84. 2008
  10. ncbi request reprint Symptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural
    Andrew Bottomley
    EORTC Data Center, Quality of Life Unit, avenue E Mounier, 83, 1200 Brussels, Belgium
    J Clin Oncol 25:5770-6. 2007

Detail Information

Publications60

  1. ncbi request reprint Beyond the development of health-related quality-of-life (HRQOL) measures: a checklist for evaluating HRQOL outcomes in cancer clinical trials--does HRQOL evaluation in prostate cancer research inform clinical decision making?
    Fabio Efficace
    European Organization for Research and Treatment of Cancer EORTC, Quality of Life Unit and Genitourinary Unit, EORTC Data Center, Brussels, Belgium
    J Clin Oncol 21:3502-11. 2003
    ..Materials and..
  2. pmc Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: the EORTC QLQ-TC26
    Bernhard Holzner
    Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
    Qual Life Res 22:369-78. 2013
    ..The low mortality rate makes quality of life (QOL) an important issue in this patient group. This study aimed to develop a supplementary module of the EORTC QLQ-C30 questionnaire to assess TC-specific aspects of QOL...
  3. doi request reprint Moving the boundaries of international collaboration on clinical trials and QoL: experiences in oncology and legislation within the European Parliament
    Andrew Bottomley
    EORTC, Avenue Mounier, 83 11, 1200 Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 13:43-5. 2013
    ..This meeting set the stage for future research and policy meetings to give greater visibility to quality of life as an outcome in clinical trials within the world of EU legislators...
  4. pmc Differential item functioning (DIF) analyses of health-related quality of life instruments using logistic regression
    Neil W Scott
    Section of Population Health, University of Aberdeen, UK
    Health Qual Life Outcomes 8:81. 2010
    ..This article reviews issues that arise when testing for DIF in HRQoL instruments. We focus on logistic regression methods, which are often used because of their efficiency, simplicity and ease of application...
  5. doi request reprint Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of Cancer
    Andrew Bottomley
    Quality of Life Department, EORTC Headquarters, Brussels, Belgium
    J Clin Oncol 27:2916-23. 2009
    ..Our trial examined the HRQOL effects of adjuvant pegylated IFN-alpha-2b (PEG-IFN-alpha-2b) versus observation in patients with stage III melanoma...
  6. ncbi request reprint International perspective on health-related quality-of-life research in cancer clinical trials: the European Organisation for Research and Treatment of Cancer experience
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer EORTC Quality of Life Unit and Quality of Life Group, Brussels, Belgium
    J Clin Oncol 25:5082-6. 2007
    ....
  7. doi request reprint Patient-reported outcomes: assessment and current perspectives of the guidelines of the Food and Drug Administration and the reflection paper of the European Medicines Agency
    Andrew Bottomley
    EORTC Quality of Life Department, EORTC Headquarters, Avenue E Mounierlaan, 83 11, Brussels 1200, Belgium
    Eur J Cancer 45:347-53. 2009
    ..This review paper provides an overview of the current perspectives and views on these guidelines...
  8. ncbi request reprint Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer In
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer, EORTC Data Center, Brussels, Belgium
    J Clin Oncol 24:1435-42. 2006
    ..This article compares the impact on HRQOL of first-line treatment with cisplatin versus raltitrexed and cisplatin...
  9. doi request reprint Symptom and quality of life results of an international randomised phase III study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer
    Andrew Bottomley
    Quality of Life Department, European Organisation for Research and Treatment of Cancer, EORTC Headquarters, AISBL IVZW, Avenue E Mounierlaan, 83 11, Brussel 1200, Bruxelles, Belgium
    Eur J Cancer 44:2178-84. 2008
    ..This study reports the symptom and HRQOL results in which standard treatment was compared to standard therapy plus Bec2, an anti-idiotypic antibody that mimics GD3, a ganglioside antigen...
  10. ncbi request reprint Symptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural
    Andrew Bottomley
    EORTC Data Center, Quality of Life Unit, avenue E Mounier, 83, 1200 Brussels, Belgium
    J Clin Oncol 25:5770-6. 2007
    ..This study reports an evaluation of the prognostic value of these factors using data gathered from a recent randomized controlled trial...
  11. ncbi request reprint Health-related quality of life in survivors of locally advanced breast cancer: an international randomised controlled phase III trial
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer, EORTC Data Center, Qualtiy of Life Unit, Brussels, Belgium
    Lancet Oncol 6:287-94. 2005
    ..We aimed to compare the effects of such an approach with those of standard chemotherapy on health-related quality of life (HRQOL)...
  12. ncbi request reprint A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites
    Chantal Quinten
    Quality of Life Department, European Organization for Research and Treatment of Cancer Headquarters, Brussels, Belgium
    Cancer 120:302-11. 2014
    ..The objective of this study was to examine the prognostic value of baseline health-related quality of life (HRQOL) for survival with regard to different cancer sites using 1 standardized and validated patient self-assessment tool...
  13. pmc Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival
    Chantal Quinten
    Quality of Life Department, European Organization for Research and Treatment of Cancer Headquarters, Brussels, Belgium
    J Natl Cancer Inst 103:1851-8. 2011
    ..We examined the extent to which patient and clinician symptom scoring and their agreement could contribute to the estimation of overall survival among cancer patients...
  14. doi request reprint Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials
    John T Maringwa
    Quality of Life Department, EORTC, Brussels, Belgium
    Support Care Cancer 19:1753-60. 2011
    ....
  15. doi request reprint Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials
    Chantal Quinten
    Quality of Life Department, EORTC Headquarters, Brussels, Belgium
    Lancet Oncol 10:865-71. 2009
    ..We examined whether HRQOL scores are associated with survival when pooled across a large sample of patients with different disease sites...
  16. ncbi request reprint Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: an international multicenter study
    Fabio Efficace
    European Organisation for Research and Treatment of Cancer, EORTC Data Center, Quality of Life Unit, Ave E Mounier 83, 1200 Brussels, Belgium
    J Clin Oncol 22:3381-8. 2004
    ..Although the literature highlights the important role of HRQOL parameters in predicting survival in advanced metastatic disease, little evidence exists for earlier stages...
  17. ncbi request reprint Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?
    Fabio Efficace
    European Organisation for Research and Treatment of Cancer EORTC, EORTC Data Center, Quality of Life Unit, Avenue E Mounier 83, 1200 Brussels, Belgium
    Eur J Cancer 42:42-9. 2006
    ..The results suggest that social functioning, acts as a prognostic measure of survival beyond a number of previously known biomedical parameters...
  18. ncbi request reprint Randomized, controlled trial investigating short-term health-related quality of life with doxorubicin and paclitaxel versus doxorubicin and cyclophosphamide as first-line chemotherapy in patients with metastatic breast cancer: European Organization for Re
    Andrew Bottomley
    Quality of Life Unit, European Organization for Research and Treatment of Cancer Data Center, Insitut Jules Bordet, Brussels, Belgium
    J Clin Oncol 22:2576-86. 2004
    ..To compare health-related quality of life (HRQOL) in patients with metastatic breast cancer receiving the combination of doxorubicin and paclitaxel (AT) or doxorubicin and cyclophosphamide (AC) as first-line chemotherapy treatment...
  19. doi request reprint Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials
    Efstathios Zikos
    Quality of Life Department, EORTC Headquarters, Brussels, Belgium Electronic address
    Lancet Oncol 15:e78-89. 2014
    ..Although overall reporting of health-related quality of life was acceptable, improvements are needed to optimise the use of health-related quality of life in randomised controlled trials. ..
  20. doi request reprint Examining the relationships among health-related quality-of-life indicators in cancer patients participating in clinical trials: a pooled study of baseline EORTC QLQ-C30 data
    Francesca Martinelli
    Quality of Life Department, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 11:587-99. 2011
    ..The second objective of this study was to identify which HRQoL indicators are linked to patients' perception of overall quality of life...
  21. ncbi request reprint Prognostic value of health-related quality-of-life data in predicting survival in patients with anaplastic oligodendrogliomas, from a phase III EORTC brain cancer group study
    Murielle E L Mauer
    European Organisation for Research and Treatment of Cancer Data Center, Quality of Life Unit, Ave Mounier 83 11, Brussels, Belgium 1200
    J Clin Oncol 25:5731-7. 2007
    ..This is one of a few studies that have explored the value of baseline symptoms and health-related quality of life (HRQOL) in predicting survival in patients with brain cancer...
  22. ncbi request reprint Erythropoietin improves quality of life--a response
    Andrew Bottomley
    Quality of Life Unit, EORTC Data Center, Brussels, Belgium
    Lancet Oncol 3:527. 2002
  23. ncbi request reprint Health-related quality of life in non-small-cell lung cancer: methodologic issues in randomized controlled trials
    Andrew Bottomley
    Quality of Life Unit, European Organization for Research and Treatment of Cancer Data Center, Belgium, Germany
    J Clin Oncol 21:2982-92. 2003
    ..To date, no detailed systematic review exists of HRQOL methodology in NSCLC RCTs...
  24. ncbi request reprint Assessing HRQOL: a neglected issue for high-grade glioma
    Fabio Efficace
    Quality of Life Unit, EORTC, Brussels, Belgium
    Lancet Oncol 4:11-2. 2003
  25. ncbi request reprint Is baseline quality of life useful for predicting survival with hormone-refractory prostate cancer? A pooled analysis of three studies of the European Organisation for Research and Treatment of Cancer Genitourinary Group
    Laurence Collette
    European Organisation for Research and Treatment of Cancer, Data Center Biostatistics, Ave E Mounier 83 11, B 1200 Brussels, Belgium
    J Clin Oncol 22:3877-85. 2004
    ....
  26. pmc Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials
    Lily Claassens
    Erasmus Medical Centre, Rotterdam, The Netherlands
    J Clin Oncol 29:2104-20. 2011
    ..The objective was to evaluate HRQOL methodology reporting over the last decade and its benefit for clinical decision making...
  27. pmc Net clinical benefit analysis of radiation therapy oncology group 0525: a phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma
    Terri S Armstrong
    Terri S Armstrong, University of Texas Health Science Center School of Nursing Terri S Armstrong, Jeffrey S Wefel, Mark R Gilbert, Tito R Mendoza, MD Anderson Cancer Center, Houston, TX Meihua Wang, Minhee Won, Radiation Therapy Oncology Group Statistical Center Maria Werner Wasik, Thomas Jefferson University Hospital, Philadelphia, PA Andrew Bottomley, Corneel Coens, European Organisation for Research and Treatment of Cancer, Brussels, Belgium David G Brachman, Arizona Oncology Services Foundation and Barrow Neurological Institute, Phoenix, AZ Ali K Choucair, Mayo Clinic, Jacksonville, FL Minesh Mehta, University of Maryland, Baltimore, MD
    J Clin Oncol 31:4076-84. 2013
    ....
  28. ncbi request reprint Health related quality of life in prostate carcinoma patients: a systematic review of randomized controlled trials
    Fabio Efficace
    Quality of Life Unit, European Organisation for Research and Treatment of Cancer, EORTC Data Center, Brussels, Belgium
    Cancer 97:377-88. 2003
    ..Given this, the authors undertook a systematic review to evaluate HRQOL assessment methodology and reported outcomes of randomized controlled clinical trials (RCTs) with prostate carcinoma patients...
  29. doi request reprint Evaluating health-related quality of life and symptom burden in brain tumour patients: instruments for use in experimental trials and clinical practice
    Murielle E Mauer
    European Organisation for Research and Treatment of Cancer Headquarters, Quality of Life Department, Brussels, Belgium
    Curr Opin Neurol 21:745-53. 2008
    ..This review focuses on instruments for measuring HRQOL in brain tumour patients and the recent developments in the field...
  30. ncbi request reprint The cancer patient and quality of life
    Andrew Bottomley
    European Organisation for Research and Treatment of Cancer Data Center, Brussels, Belgium
    Oncologist 7:120-5. 2002
    ..This review considers recent developments in the field of quality of life, oncological challenges and future directions...
  31. ncbi request reprint Radiotherapy in conjunction with intravenous infusion of 180 mg of disodium pamidronate in management of osteolytic metastases from breast cancer: clinical evaluation, biochemical markers, quality of life, and monitoring of recalcification using assessmen
    Vassilis Kouloulias
    Department of Radiology, Areteion University Hospital, Athens
    Int J Radiat Oncol Biol Phys 57:143-57. 2003
    ..To evaluate the clinical improvement and radiographically monitor the effect of local radiotherapy in conjunction with disodium pamidronate (DP) on metastatic osteolytic disease...
  32. doi request reprint Promoting pan-European cancer research for the benefit of all cancer patients
    John Bean
    European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 12:443-5. 2012
    ..This conference highlighted the tremendous progress that has been made over the past 50 years and pointed to the challenges that will be faced in the future...
  33. doi request reprint The journey of health-related quality of life assessment
    Andrew Bottomley
    Quality of Life Department, European Organisation for Research and Treatment of Cancer, 1200 Brussels, Belgium
    Lancet Oncol 9:906. 2008
  34. ncbi request reprint Human recombinant erythropoietin and quality of life: a wonder drug or something to wonder about?
    Andrew Bottomley
    Quality of Life Unit, EORTC Data Center, Brussels, Belgium
    Lancet Oncol 3:145-53. 2002
    ..Evidence from this review suggests that more robust designs are required to show any significant quality-of-life benefits for cancer patients undergoing epoetin treatment...
  35. ncbi request reprint Quality of life in patients undergoing systemic therapy for advanced breast cancer
    Andrew Bottomley
    Quality of Life Unit, EORTC Data Center, Brussels, Belgium
    Lancet Oncol 3:620-8. 2002
    ..We propose some approaches to overcome these limitations and improve future study designs...
  36. doi request reprint An international phase 3 trial in head and neck cancer: quality of life and symptom results: EORTC 24954 on behalf of the EORTC Head and Neck and the EORTC Radiation Oncology Group
    Andrew Bottomley
    Quality of Life Department, European Organization for Research and Treatment of Cancer, Brussels, Belgium
    Cancer 120:390-8. 2014
    ..The current study reports detailed effects of both treatment arms on health-related quality of life (HRQOL) and symptoms...
  37. ncbi request reprint Metastatic colorectal cancer: treatment challenges and quality of life
    Andrew Bottomley
    Quality of Life Unit, European Organisation for Research and Treatment of Cancer, EORTC Data Centre, 1200 Brussels, Belgium
    Lancet 359:1537-8. 2002
  38. doi request reprint Trends in translation requests and arising issues regarding cultural adaptation
    Dagmara Kuliś
    European Organisation for Research and Treatment of Cancer, E Mounierlaan 83 11, B 1200 Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 11:307-14. 2011
    ..These translation challenges have to be carefully addressed to ensure the equivalence and validity of the final questionnaires...
  39. ncbi request reprint Quality of life in breast cancer patients: measurement issues in cancer clinical trials
    Fabio Efficace
    European Organisation for Research and Treatment of Cancer, Quality of Life Unit, avenue E Mounier, 83 1200 Brussels, Belgium
    Expert Rev Pharmacoecon Outcomes Res 2:57-65. 2002
    ..We propose suggestions for selecting future measures for use in a breast cancer population of patients...
  40. ncbi request reprint Multicollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection
    Kristel Van Steen
    Limburgs Universitair Centrum, Center for Statistics, Biostatistics, Universitaire Campus, B 3590 Diepenbeek, Belgium
    Stat Med 21:3865-84. 2002
    ..The prognostic factor analysis was rerun without global QL in the model, and selected the same significant prognostic factors as before...
  41. ncbi request reprint Guidelines for the use of epoetin: have quality-of-life benefits been proven?
    Andrew Bottomley
    J Clin Oncol 21:2223; author reply 2224-5. 2003
  42. ncbi request reprint Translation procedures for standardised quality of life questionnaires: The European Organisation for Research and Treatment of Cancer (EORTC) approach
    Michael Koller
    Center for Clinical Studies, University Hospital Regensburg, D 93042 Regensburg, Germany
    Eur J Cancer 43:1810-20. 2007
    ..This report summarises the EORTC translation procedure, recent accomplishments and challenges...
  43. ncbi request reprint Quality of life in good prognosis patients with metastatic germ cell cancer: a prospective study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20)
    Sophie D Fossa
    Norwegian Radium Hospital, Oslo, Norway
    J Clin Oncol 21:1107-18. 2003
    ..To describe global quality of life (GLQL) in patients with metastatic testicular cancer (TC) treated with four different schedules of bleomycin, etoposide, and cisplatin (BEP) chemotherapy (four v three cycles given over 5 v 3 days)...
  44. ncbi request reprint Fatigue and quality of life: lessons from the real world
    Henning Flechtner
    Clinic for Psychiatry and Psychotherapy of Children and Adolescents, University of Cologne, Cologne, Germany
    Oncologist 8:5-9. 2003
    ..Investigations are essential to determine the current status of long-term survivors in more detail and to link that status to conditions observed during the treatment of acutely ill patients...
  45. ncbi request reprint Do quality-of-life randomized clinical trials support clinicians in their decision-making?
    Fabio Efficace
    J Clin Oncol 20:4126-7; author reply 4127. 2002
  46. ncbi request reprint Toward a clearer understanding of the prognostic value of health-related quality-of-life parameters in breast cancer
    Fabio Efficace
    J Clin Oncol 23:1335-6; author reply 1336. 2005
  47. ncbi request reprint Health-related quality of life in patients treated for anaplastic oligodendroglioma with adjuvant chemotherapy: results of a European Organisation for Research and Treatment of Cancer randomized clinical trial
    Martin J B Taphoorn
    Department of Neurology, Medical Center Haaglanden Westeinde Ziekenhuis, The Hague, The Netherlands
    J Clin Oncol 25:5723-30. 2007
    ....
  48. ncbi request reprint The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care
    Mogens Groenvold
    Research Unit, Department of Palliative Medicine, Bispebjerg Hospital, 23, Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    Eur J Cancer 42:55-64. 2006
    ..The resulting 15-item EORTC QLQ-C15-PAL is a 'core questionnaire' for palliative care. Depending on the research questions, it may be supplemented by additional items, modules or questionnaires...
  49. doi request reprint The relationship between overall quality of life and its subdimensions was influenced by culture: analysis of an international database
    Neil W Scott
    Department of Public Health, University of Aberdeen, UK
    J Clin Epidemiol 61:788-95. 2008
    ....
  50. doi request reprint Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and
    Fabio Efficace
    Italian Group for Adult Hematologic Diseases GIMEMA, GIMEMA Data Center, Health Outcome Research Unit, via Benevento, 6, 00161, Rome, Italy
    J Clin Oncol 26:2020-6. 2008
    ..The aim of this research is to validate this model on data from an independent sample...
  51. ncbi request reprint Palliative-care trials: how best to publish findings?
    Murielle E Mauer
    Lancet Oncol 9:411-2. 2008
  52. ncbi request reprint EORTC QLQ-C15-PAL: the new standard in the assessment of health-related quality of life in advanced cancer?
    Mogens Groenvold
    Palliat Med 20:59-61. 2006
  53. pmc An integrated psychological strategy for advanced colorectal cancer patients
    Patrizia Pugliese
    Service of Psychology, Regina Elena Cancer Institute, Via Elio Chianesi, 53, 00144 Rome, Italy
    Health Qual Life Outcomes 4:9. 2006
    ..The aim of this report is to describe an integrated approach and to evaluate its feasibility in routine clinical practice in 98 advanced colorectal cancer (ACC) patients during chronomodulated chemotherapy...
  54. ncbi request reprint Health-related quality of life in patients with glioblastoma: a randomised controlled trial
    Martin J B Taphoorn
    Medical Centre Haaglanden, The Hague, The Netherlands
    Lancet Oncol 6:937-44. 2005
    ..This paper reports the health-related quality of life (HRQOL) of the patients in this trial...
  55. ncbi request reprint Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute
    Jan P van Meerbeeck
    Thoracic Oncology Unit, University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    J Clin Oncol 23:6881-9. 2005
    ....
  56. ncbi request reprint Variability and sample size requirements for health-related quality-of-life measures: understanding the challenges facing investigators
    Corneel Coens
    J Clin Oncol 23:8541-2; author reply 8542-3. 2005
  57. ncbi request reprint What is the effect of systemic anticancer treatment on cognitive function?
    Alessandro Minisini
    Unit of Medical Oncology, University of Udine, Italy
    Lancet Oncol 5:273-82. 2004
    ..These trials should have sufficient statistical power and, importantly, should also be prospective...
  58. doi request reprint The prognostic significance of patient-reported outcomes in cancer clinical trials
    Carolyn C Gotay
    Department of Health Care and Epidemiology, University of British Columbia, 5804 Fairview Ave, Vancouver, British Columbia, V6E 1R7 Canada
    J Clin Oncol 26:1355-63. 2008
    ..This study systematically assessed the impact of PROs on patient survival after a cancer diagnosis within the context of clinical trials...
  59. ncbi request reprint Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach
    Pernilla Lagergren
    Department of Social Medicine at South Bristol, University of Bristol, Bristol, United Kingdom
    Eur J Cancer 43:2066-73. 2007
    ..To combine and test the EORTC questionnaires for assessing quality of life (HRQL) for oesophageal (QLQ-OES18) and stomach cancer (QLQ-STO22), into a single questionnaire for tumours of the oesophagus, oesophago-gastric junction or stomach...
  60. pmc Standards are needed for quality of life clinical trials
    Andrew Bottomley
    BMJ 324:1156. 2002