Decio L Eizirik

Summary

Country: Belgium

Publications

  1. ncbi New approaches for in silico identification of cytokine-modified beta cell gene networks
    Burak Kutlu
    Laboratory of Experimental Medicine, ULB, 808 Route de Lennik, B 1070 Brussels, Belgium
    Ann N Y Acad Sci 1037:41-58. 2004
  2. pmc PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim
    Izortze Santin
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 60:3279-88. 2011
  3. pmc Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance
    Maikel L Colli
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Pathog 7:e1002267. 2011
  4. pmc GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim
    Tatiane C Nogueira
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Genet 9:e1003532. 2013
  5. pmc MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA
    Maikel L Colli
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Hum Mol Genet 19:135-46. 2010
  6. pmc Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells
    Fernanda Ortis
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 59:358-74. 2010
  7. pmc Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
    M Miani
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Cell Death Dis 4:e701. 2013
  8. doi Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    D L Eizirik
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles ULB, CP 618, Route de Lennik 808, Brussels, Belgium
    Diabetologia 56:234-41. 2013
  9. pmc The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    PLoS Genet 8:e1002552. 2012
  10. doi Mining genes in type 2 diabetic islets and finding gold
    Decio L Eizirik
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles ULB, 1000 Brussels, Belgium Electronic address
    Cell Metab 16:555-7. 2012

Detail Information

Publications61

  1. ncbi New approaches for in silico identification of cytokine-modified beta cell gene networks
    Burak Kutlu
    Laboratory of Experimental Medicine, ULB, 808 Route de Lennik, B 1070 Brussels, Belgium
    Ann N Y Acad Sci 1037:41-58. 2004
    ....
  2. pmc PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim
    Izortze Santin
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 60:3279-88. 2011
    ..We presently evaluated the mechanisms by which PTPN2, a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D...
  3. pmc Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance
    Maikel L Colli
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Pathog 7:e1002267. 2011
    ..These observations indicate that the balance between Mcl-1 and Bim is a key factor regulating beta cell survival during diabetogenic viral infections...
  4. pmc GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim
    Tatiane C Nogueira
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Genet 9:e1003532. 2013
    ..This is mediated by alternative splicing of the pro-apoptotic protein Bim and exacerbated formation of the most pro-apoptotic variant BimS...
  5. pmc MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA
    Maikel L Colli
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Hum Mol Genet 19:135-46. 2010
    ..These two candidate genes for T1D may thus modulate beta-cell apoptosis and/or local release of inflammatory mediators in the course of a viral infection by acting, at least in part, at the pancreatic beta-cell level...
  6. pmc Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells
    Fernanda Ortis
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 59:358-74. 2010
    ....
  7. pmc Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
    M Miani
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Cell Death Dis 4:e701. 2013
    ..These findings link ER stress to exacerbated apoptosis during islet inflammation and provide potential mechanistic targets for beta cell protection, namely downregulation of Bim and upregulation of A1. ..
  8. doi Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    D L Eizirik
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles ULB, CP 618, Route de Lennik 808, Brussels, Belgium
    Diabetologia 56:234-41. 2013
    ..The dialogue between the UPR and inflammation may provide an explanation for the parallel increase in the prevalence of childhood obesity and type 1 diabetes...
  9. pmc The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    PLoS Genet 8:e1002552. 2012
    ..This dialog is modulated by candidate genes for the disease at both the immune system and beta cell level...
  10. doi Mining genes in type 2 diabetic islets and finding gold
    Decio L Eizirik
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles ULB, 1000 Brussels, Belgium Electronic address
    Cell Metab 16:555-7. 2012
    ..Mahdi and colleagues (2012) couple global evaluation of gene expression with coexpression network analysis of human islets from T2D patients to identify SFRP4 as an early mediator of β cell dysfunction in T2D...
  11. pmc Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
    Nils E Magnusson
    Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
    BMC Bioinformatics 6:311. 2005
    ..g. double stranded RNA (dsRNA) and cytokines), we have developed a spotted rat oligonucleotide microarray, the APOCHIP, containing 60-mer probes for 574 genes selected for the study of beta-cell apoptosis...
  12. ncbi The role for endoplasmic reticulum stress in diabetes mellitus
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Endocr Rev 29:42-61. 2008
    ..A better understanding of the pathways regulating ER stress in beta-cells may be instrumental for the design of novel therapies to prevent beta-cell loss in diabetes...
  13. doi The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
    Decio L Eizirik
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, 808 Route de Lennik, Brussels, Belgium
    Nat Rev Endocrinol 5:219-26. 2009
    ..These stages, and their progression or resolution, might depend on a patient's genetic background, which contributes to disease heterogeneity...
  14. doi Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, 808 Route de Lennik, B 1070, Brussels, Belgium
    Biochem Soc Trans 36:321-7. 2008
    ..This will hopefully allow the search for a cure for T1DM to move from a 'trial-and-error' approach to one that is really mechanistically driven...
  15. ncbi Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Ann N Y Acad Sci 1005:55-74. 2003
    ..These accumulating evidences may finally unveil the molecular mechanisms regulating the beta cell "decision" to undergo or not apoptosis in early T1DM...
  16. doi ER stress in pancreatic beta cells: the thin red line between adaptation and failure
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, 1070 Brussels, Belgium
    Sci Signal 3:pe7. 2010
    ..These and other findings provide a first glimpse on how different signals trigger diverging UPR outcomes...
  17. ncbi Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
    Ilham Kharroubi
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, B 1070 Brussels, Belgium
    Endocrinology 145:5087-96. 2004
    ..Our results argue against a unifying hypothesis for the mechanisms of beta-cell death in T1DM and T2DM...
  18. pmc Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 58:2851-62. 2009
    ..Here, we evaluated the molecular mechanisms involved in the protection of beta-cells from lipotoxic ER stress by glucagon-like peptide (GLP)-1 agonists utilized in the treatment of type 2 diabetes...
  19. pmc p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress
    Esteban N Gurzov
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, 1070 Brussels, Belgium
    J Biol Chem 285:19910-20. 2010
    ..Our data support a hierarchical activation of BH3-only proteins controlling the intrinsic pathway of beta-cell apoptosis in the context of inflammation and type 1 diabetes...
  20. pmc PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
    Fabrice Moore
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 58:1283-91. 2009
    ..We hypothesized that PTPN2 plays a direct role in beta-cell demise and assessed PTPN2 expression in human islets and rat primary and clonal beta-cells, besides evaluating its role in cytokine-induced signaling and beta-cell apoptosis...
  21. doi Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets
    Laurence Ladriere
    Laboratory of Experimental Medicine, Université Libre de Bruxelles CP 618, Route de Lennik 808, 1070 Brussels, Belgium
    J Clin Endocrinol Metab 95:1442-9. 2010
    ..This should be taken into consideration when designing approaches to pharmacologically modulate the beta-cell ER stress response in type 2 diabetes...
  22. ncbi Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells
    Monica Garcia
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Biochim Biophys Acta 1793:1768-75. 2009
    ..Our results suggest that the RIG-I pathway is present and active in beta cells and could contribute to the induction of insulitis by viral RNA intermediates...
  23. ncbi Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
    Burak Kutlu
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 52:2701-19. 2003
    ..These data provide novel and detailed insights into the gene networks activated in beta-cells facing a prolonged immune assault...
  24. pmc Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation
    Jenny Barthson
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, 1070 Brussels, Belgium
    J Biol Chem 286:39632-43. 2011
    ..Our data support a highly regulated and context-dependent modulation of specific Bcl-2 members controlling the mitochondrial pathway of β-cell apoptosis during insulitis...
  25. pmc Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Cell Sci 121:2308-18. 2008
    ..In conclusion, saturated FFA induce ER stress via ER Ca(2+) depletion. The IRE1 and resulting JNK activation contribute to beta-cell apoptosis. PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP...
  26. doi Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways
    Zeynep Dogusan
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, B 1070 Brussels, Belgium
    Diabetes 57:1236-45. 2008
    ..We presently investigated the mediators and downstream effectors of dsRNA-induced beta-cell death...
  27. pmc Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 61:2763-75. 2012
    ..This study elucidates the crosstalk between lipotoxic ER stress and the mitochondrial pathway of apoptosis that causes β-cell death in diabetes...
  28. ncbi Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation
    Fernanda Ortis
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Endocrinol 20:1867-79. 2006
    ....
  29. ncbi Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
    Miriam Cnop
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Biol Chem 282:3989-97. 2007
    ..This modifies the present paradigm regarding the beneficial role of eIF2alpha phosphorylation in beta-cells and must be taken into consideration when designing therapies to protect beta-cells in type 2 diabetes...
  30. doi Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells
    Fabrice Moore
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, BE 1070, Belgium
    Methods Mol Biol 820:179-94. 2012
    ..This chapter details the methods and settings used to achieve efficient and nontoxic transfection of small interfering RNA in immortal and primary beta cells...
  31. ncbi Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
    Pierre Pirot
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Diabetes 56:1069-77. 2007
    ..These results suggest a differential response of beta-cells to diverse endoplasmic reticulum stress inducers, leading to a differential regulation of Chop transcription...
  32. ncbi Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
    Alessandra K Cardozo
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Diabetes 54:452-61. 2005
    ....
  33. doi The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses
    Mariana Igoillo-Esteve
    Laboratory of Experimental Medicine, Erasmus Hospital, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    Endocrinology 152:447-56. 2011
    ..Further understanding of these pathways may open new possibilities to improve β-cell survival in early type 1 diabetes or after transplantation...
  34. pmc STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
    Fabrice Moore
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    J Biol Chem 286:929-41. 2011
    ..The present study elucidates the transcriptional networks through which the IFN-γ/STAT1/IRF-1 axis controls β-cell function/differentiation, demise, and islet inflammation...
  35. pmc The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells
    Fabrice Moore
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 7:e31062. 2012
    ..These observations identify a novel function of C/EBPδ as a modulatory transcription factor that inhibits the pro-apoptotic and pro-inflammatory gene networks activated by cytokines in pancreatic β-cells...
  36. ncbi Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse
    Mark de Ridder
    Academic Hospital, Free University Brussels, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 60:598-606. 2004
    ..This study examines whether activated macrophages may radiosensitize tumor cells through the release of proinflammatory mediators...
  37. doi Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes
    Miriam Cnop
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Ann Neurol 72:971-82. 2012
    ..FRDA patients have a high prevalence of diabetes, the pathogenesis of which is not known. We aimed to evaluate the relative contribution of insulin resistance and β-cell failure and the pathogenic mechanisms involved in FRDA diabetes...
  38. doi An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells
    Miriam Cnop
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Biochem Soc Trans 36:909-15. 2008
    ..In the present mini-review, we focus on recent progress in the field of ER stress in pancreatic beta-cells. Recent advances in the understanding of lipotoxic ER stress and beta-cell recovery from ER stress are discussed...
  39. doi Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway
    Michela Miani
    Laboratory of Experimental Medicine, Erasmus Hospital, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Endocrinology 153:3017-28. 2012
    ..These observations link β-cell ER stress to the triggering of exacerbated local inflammation...
  40. pmc Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells
    Lin Jiang
    Laboratoire de Pharmacodynamie et de Thérapeutique, Universite Libre de Bruxelles, Faculté deMédecine, Bâtiment GE, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Biol Chem 285:30634-43. 2010
    ..These data open the way to new strategies to control cellular Ca(2+) homeostasis that could decrease β-cell apoptosis in diabetes...
  41. ncbi Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
    Pierre Pirot
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Arq Bras Endocrinol Metabol 52:156-65. 2008
    ..This review discusses the potential mediators and mechanisms leading to beta-cell destruction in T1D...
  42. ncbi Notch signaling: a mediator of beta-cell de-differentiation in diabetes?
    Martine I Darville
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 339:1063-8. 2006
    ..Thus, activation of the Notch pathway inhibits differentiated functions in dividing but not in terminally differentiated beta-cells...
  43. ncbi Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells
    Joanne Rasschaert
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, B 1070 Brussels, Belgium
    J Biol Chem 280:33984-91. 2005
    ..This study suggests that dsRNA plus IFN-gamma triggers beta-cell apoptosis by two complementary pathways, namely TLR3-TRIF-NF-kappaB and STAT-1...
  44. pmc JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells
    Esteban N Gurzov
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    PLoS ONE 3:e3030. 2008
    ..These findings demonstrate a novel and unexpected role for JunB as a regulator of defense mechanisms against cytokine- and ER stress-mediated apoptosis...
  45. ncbi RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
    Miriam Cnop
    Laboratory of Experimental Medicine, ULB Center for Diabetes Research, Universite Libre de Bruxelles, Brussels, BelgiumDivision of Endocrinology, Erasmus Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 63:1978-93. 2014
    ..This human islet transcriptome study identified novel mechanisms of palmitate-induced β-cell dysfunction and death. The data point to cross talk between metabolic stress and candidate genes at the β-cell level...
  46. ncbi Expression of adiponectin receptors in pancreatic beta cells
    Ilham Kharroubi
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Biochem Biophys Res Commun 312:1118-22. 2003
    ..Regulated adiponectin receptor expression on pancreatic beta cells might be a novel mechanism modulating the effects of circulating adiponectin...
  47. pmc In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
    Najib Naamane
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, B 1070 Brussels, Belgium
    BMC Bioinformatics 8:55. 2007
    ..To identify NF-kappaB-regulated gene networks in beta-cells we presently used a discriminant analysis-based approach to predict NF-kappaB responding genes on the basis of putative regulatory elements...
  48. pmc Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass
    Evrard Nguidjoe
    Laboratory of Pharmacology, Universite Libre de Bruxelles, Faculte de Medecine, Brussels, Belgium
    Diabetes 60:2076-85. 2011
    ..To further characterize the role of NCX1 in β-cells under in vivo conditions, we developed and characterized mice deficient for NCX1...
  49. ncbi Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities
    Miriam Cnop
    Laboratory of Experimental Medicine, Faculty of Medicine, Erasmus Hospital, Universite Libre de Bruxelles ULB, Route de Lennik 808, CP 618, 1070 Brussels, Belgium
    Diabetes 54:S97-107. 2005
    ..This argues against a unifying hypothesis for the mechanisms of beta-cell death in type 1 and type 2 diabetes and suggests that different approaches will be required to prevent beta-cell death in type 1 and type 2 diabetes...
  50. ncbi An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells
    Martine I Darville
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Endocrinology 145:1130-6. 2004
    ..These results suggest that Oct1, NF-kappa B, and HMG-I(Y) cooperate for transactivation of the iNOS promoter in pancreatic beta-cells...
  51. ncbi Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells
    Burak Kutlu
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Belgium
    Diabetes 52:348-55. 2003
    ..We conclude that NF-kappaB plays an important role for MCP-1 expression in beta-cells. This transcription factor may be an interesting target for ex vivo gene therapy before islet transplantation...
  52. ncbi Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach
    Thomas Bouckenooghe
    Laboratory of Experimental Medicine Université Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Curr Pharm Des 16:1609-18. 2010
    ..The present review briefly describes the "state-of-the-art" in the field, and then proposes a step-by-step systems biology approach for the identification and initial testing of novel candidates for beta cell imaging...
  53. pmc DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
    Michael Volkmar
    Laboratory of Cancer Epigenetics, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    EMBO J 31:1405-26. 2012
    ..Together, our findings offer new insights into the intricate mechanisms of T2D pathogenesis, underscore the important involvement of epigenetic dysregulation in diabetic islets and may advance our understanding of T2D aetiology...
  54. doi Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
    Esteban N Gurzov
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, 1070, Brussels, Belgium
    Trends Cell Biol 21:424-31. 2011
    ....
  55. ncbi BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2
    Laura Marroquí
    Laboratory of Experimental Medicine, Université Libre de Bruxelles Center for Diabetes Research, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 63:2516-27. 2014
    ..This clarifies an unexpected and relevant mechanism by which BACH2 may contribute to diabetes. ..
  56. ncbi Cell-permeable peptides induce dose- and length-dependent cytotoxic effects
    Alessandra K Cardozo
    The Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Biochim Biophys Acta 1768:2222-34. 2007
    ....
  57. ncbi Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference
    Miguel Lopes
    Machine Learning Group, Computer Science Department, Universite Libre de Bruxelles, Brussels, Belgium Interuniversity Institute of Bioinformatics in Brussels IB 2, Brussels, Belgium Electronic address
    Genomics 103:264-75. 2014
    ..The inferred regulatory network is thus supported by the experimental validation, providing a proof-of-concept for the proposed statistical inference approach...
  58. doi IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
    Fabio A Grieco
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Route de Lennik, 808 CP618, 1070, Brussels, Belgium
    Diabetologia 57:502-11. 2014
    ..Here, we studied whether IL-17A upregulates the production of chemokines by human pancreatic islets, thus contributing to the build-up of insulitis...
  59. ncbi High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells
    David Vermijlen
    Laboratory for Cell Biology and Histology, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Eur J Immunol 34:2529-40. 2004
    ..Moreover, it appears that redirection of cytotoxic granules and increase in intracellular Ca2+ are convergence points of several of these genes...
  60. pmc tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans
    Mariana Igoillo-Esteve
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Genet 9:e1003888. 2013
    ..In light of the recent report that the type 2 diabetes candidate gene CDKAL1 is a tRNA methylthiotransferase, the findings in this family suggest broader relevance of tRNA methyltransferases in the pathogenesis of type 2 diabetes. ..