Denis Dufrane

Summary

Country: Belgium

Publications

  1. ncbi request reprint The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats
    Denis Dufrane
    Faculte de Medecine, Laboratory of Experimental Surgery, Universite Catholique de Louvain, CHEX 5570, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    Biomaterials 27:3201-8. 2006
  2. ncbi request reprint Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-to-primate models
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculty of Medicine, Brussels, Belgium
    Xenotransplantation 13:204-14. 2006
  3. doi request reprint Regeneration of abdominal wall musculofascial defects by a human acellular collagen matrix
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, CHEX 5570, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    Biomaterials 29:2237-48. 2008
  4. doi request reprint Native pancreatic alpha-cell adaptation in streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation
    Denis Dufrane
    Faculte de Medecine, Laboratory of Experimental Surgery, Universite Catholique de Louvain, CHEX 5570, Avenue Hippocrate 55, Brussels, Belgium
    Xenotransplantation 16:152-63. 2009
  5. doi request reprint Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Transplantation 90:1054-62. 2010
  6. ncbi request reprint Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, and Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Transplantation 81:1345-53. 2006
  7. doi request reprint In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation
    Sophie Veriter
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Tissue Eng Part A 16:1503-13. 2010
  8. doi request reprint Galactosyl-knock-out engineered pig as a xenogenic donor source of adipose MSCs for bone regeneration
    Thomas Schubert
    Endocrine Cell Therapy Unit, Center of Tissue and Cell Therapy, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Biomaterials 34:3279-89. 2013
  9. doi request reprint Beta-5 score to evaluate pig islet graft function in a primate pre-clinical model
    Yasuhiro Igarashi
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Xenotransplantation 17:449-59. 2010
  10. doi request reprint Critical size bone defect reconstruction by an autologous 3D osteogenic-like tissue derived from differentiated adipose MSCs
    Thomas Schubert
    Endocrine Cell Therapy Unit, Center of Tissue and Cell Therapy, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Biomaterials 34:4428-38. 2013

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats
    Denis Dufrane
    Faculte de Medecine, Laboratory of Experimental Surgery, Universite Catholique de Louvain, CHEX 5570, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    Biomaterials 27:3201-8. 2006
    ..In rats, the peritoneum site seems not appropriate for promoting the engraftment of encapsulated pig islets. Kidney subcapsular and subcutaneous spaces represent an interesting alternative...
  2. ncbi request reprint Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-to-primate models
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculty of Medicine, Brussels, Belgium
    Xenotransplantation 13:204-14. 2006
    ..This experimental work was designed to provide guidelines applicable in pig pancreas procurement and islet isolation for successful islet xenotransplantation into primates...
  3. doi request reprint Regeneration of abdominal wall musculofascial defects by a human acellular collagen matrix
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, CHEX 5570, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    Biomaterials 29:2237-48. 2008
    ..In conclusion, human acellular collagen matrix, placed in an FLT position, can induce an abdominal wall reconstitution without adhesions and hernia recurrence...
  4. doi request reprint Native pancreatic alpha-cell adaptation in streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation
    Denis Dufrane
    Faculte de Medecine, Laboratory of Experimental Surgery, Universite Catholique de Louvain, CHEX 5570, Avenue Hippocrate 55, Brussels, Belgium
    Xenotransplantation 16:152-63. 2009
    ....
  5. doi request reprint Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Transplantation 90:1054-62. 2010
    ..This study assessed the capacity of alginate-encapsulated islets to reverse diabetes in a pig-to-primate model...
  6. ncbi request reprint Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, and Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Transplantation 81:1345-53. 2006
    ..The aim of this study was to assess the long-term biocompatibility of alginate encapsulated pig islets after transplantation in primates...
  7. doi request reprint In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation
    Sophie Veriter
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Tissue Eng Part A 16:1503-13. 2010
    ..A traditional alginate made of high mannuronic content (SLM3%) is an adapted material to immunoprotect islets in subcutaneous tissue. No improvement was found with lower viscosity and use of GRGDSP-peptide sequence...
  8. doi request reprint Galactosyl-knock-out engineered pig as a xenogenic donor source of adipose MSCs for bone regeneration
    Thomas Schubert
    Endocrine Cell Therapy Unit, Center of Tissue and Cell Therapy, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Biomaterials 34:3279-89. 2013
    ..No significant difference was found at POD 28. The combination of the cellular immunomodulation with the Gal-KO phenotype of AMSCs can significantly improve the cellular engraftment of pig osteogenic cells by delaying xenorejection...
  9. doi request reprint Beta-5 score to evaluate pig islet graft function in a primate pre-clinical model
    Yasuhiro Igarashi
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Xenotransplantation 17:449-59. 2010
    ..We developed a composite scoring system to accurately assess pig islet function in pre-clinical primate studies...
  10. doi request reprint Critical size bone defect reconstruction by an autologous 3D osteogenic-like tissue derived from differentiated adipose MSCs
    Thomas Schubert
    Endocrine Cell Therapy Unit, Center of Tissue and Cell Therapy, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Biomaterials 34:4428-38. 2013
    ..This custom-made 3D osteogenic AMSC autograft is a therapeutic solution for bone non-unions and for critical-size defects...
  11. doi request reprint Pig islets for clinical islet xenotransplantation
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Curr Opin Nephrol Hypertens 18:495-500. 2009
    ..Another source of insulin-producing cells, therefore, would be of major interest, and pigs represent a possible and serious source for obtaining such cells...
  12. doi request reprint Pig islet for xenotransplantation in human: structural and physiological compatibility for human clinical application
    Denis Dufrane
    Pôle de Chirurgie Expérimentale et Transplantation, Universite Catholique de Louvain, Secteur des Sciences de la Santé, Institut de Recherche Expérimentale et Clinique, B 1200 Brussels, Belgium
    Transplant Rev (Orlando) 26:183-8. 2012
    ..Therefore, in this review, we provide a summary of the present state of knowledge about pig and human islet compatibility...
  13. ncbi request reprint Streptozotocin-induced diabetes in large animals (pigs/primates): role of GLUT2 transporter and beta-cell plasticity
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Transplantation 81:36-45. 2006
    ..To induce irreversible diabetes in large animals, the efficiency of streptozotocin (STZ) was evaluated in pigs, primates and compared to the gold standard model in rats...
  14. ncbi request reprint Nutrient control of insulin secretion in isolated normal human islets
    Jean Claude Henquin
    Unité d Endocrinologie et Métabolisme, UCL 55 30, Ave Hippocrate 55, B 1200 Brussels, Belgium
    Diabetes 55:3470-7. 2006
    ....
  15. doi request reprint The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells
    Thomas Schubert
    Laboratory of Experimental Surgery IREC CHEX, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Biomaterials 32:8880-91. 2011
    ..05)) were found for osteogenic-differentiated AMSCs in comparison to BM-MSCs after 30 days of implantation. Osteogenic-differentiated AMSCs are the best candidate to improve the angio-/osteogenicity of decellularized bone allografts...
  16. ncbi request reprint A simple method using a polymethylpenten chamber for isolation of human pancreatic islets
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculty of Medicine, Brussels, Belgium
    Pancreas 30:e51-9. 2005
    ..We describe a novel method using a polymethylpenten chamber (PMPC) and compare its efficacy to the classic method using a stainless steel chamber (SSC)...
  17. doi request reprint Formalin fixation could interfere with the clinical assessment of the tumor-free margin in tumor surgery: magnetic resonance imaging-based study
    Pierre Louis Docquier
    Department of Orthopedic Surgery, Saint Luc University Hospital, Brussels, Belgium
    Oncology 78:115-24. 2010
    ..Fixation could interfere with the accuracy of the assessment of the tumor-free margin...
  18. pmc Macro- or microencapsulation of pig islets to cure type 1 diabetes
    Denis Dufrane
    Department of Health Sciences, Institute for Experimental and Clinical, Experimental Surgery and Transplantation, Catholic University of Louvain, B 1200 Brussels, Belgium
    World J Gastroenterol 18:6885-93. 2012
    ..In this review, we summarize current knowledge of encapsulated pig islets, to determine obstacles to implantation in humans and possible solutions to overcome these obstacles...