Tom Druet

Summary

Country: Belgium

Publications

  1. doi request reprint Imputation of genotypes from different single nucleotide polymorphism panels in dairy cattle
    T Druet
    Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    J Dairy Sci 93:5443-54. 2010
  2. pmc A common reference population from four European Holstein populations increases reliability of genomic predictions
    Mogens S Lund
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, AU Foulum, PO Box 50, DK 8830 Tjele, Denmark
    Genet Sel Evol 43:43. 2011
  3. pmc Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?
    Christine Cierco-Ayrolles
    INRA, UR Unité de Biométrie et Intelligence Artificielle, Castanet Tolosan, France
    Genet Sel Evol 42:38. 2010
  4. pmc A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping
    Tom Druet
    Unit of Animal Genomics, GIGA Research and Department of Animal Production, Faculty of Veterinary Medicine, University of Liege, Belgium
    Genetics 184:789-98. 2010
  5. pmc Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors
    Tom Druet
    Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liege, Liege, Belgium
    Genetics 188:409-19. 2011
  6. pmc A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response
    Arnaud Sartelet
    Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 8:e1002581. 2012
  7. pmc Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle
    Cynthia Sandor
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 8:e1002854. 2012
  8. doi request reprint Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
  9. doi request reprint Serial translocation by means of circular intermediates underlies colour sidedness in cattle
    Keith Durkin
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, 4000 Liege Sart Tilman, Belgium
    Nature 482:81-4. 2012
  10. pmc Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle
    Wouter Coppieters
    Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, Liege, Belgium
    BMC Genomics 10:96. 2009

Collaborators

Detail Information

Publications13

  1. doi request reprint Imputation of genotypes from different single nucleotide polymorphism panels in dairy cattle
    T Druet
    Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    J Dairy Sci 93:5443-54. 2010
    ..0%. This study showed the feasibility to impute markers in dairy cattle with the current marker panels and with error rates below 1%...
  2. pmc A common reference population from four European Holstein populations increases reliability of genomic predictions
    Mogens S Lund
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, AU Foulum, PO Box 50, DK 8830 Tjele, Denmark
    Genet Sel Evol 43:43. 2011
    ..Increased accuracies of genomic predictions depend on the number of individuals added to the reference population, the reliability of their phenotypes, and the relatedness of the populations that are combined...
  3. pmc Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?
    Christine Cierco-Ayrolles
    INRA, UR Unité de Biométrie et Intelligence Artificielle, Castanet Tolosan, France
    Genet Sel Evol 42:38. 2010
    ..We simulated a wide range of scenarios adapted to animal populations and compared these two methods for each scenario...
  4. pmc A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping
    Tom Druet
    Unit of Animal Genomics, GIGA Research and Department of Animal Production, Faculty of Veterinary Medicine, University of Liege, Belgium
    Genetics 184:789-98. 2010
    ..We show that these cluster states can directly be used to fine map QTL. The method is computationally effective at handling large data sets based on high-density SNP panels...
  5. pmc Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors
    Tom Druet
    Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liege, Liege, Belgium
    Genetics 188:409-19. 2011
    ....
  6. pmc A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response
    Arnaud Sartelet
    Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 8:e1002581. 2012
    ..We provide preliminary evidence that heterozygous advantage for an as of yet unidentified phenotype may have caused a selective sweep accounting for the high frequency of the RNF11 c124-2A>G mutation in Belgian Blue Cattle...
  7. pmc Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle
    Cynthia Sandor
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 8:e1002854. 2012
    ..We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage...
  8. doi request reprint Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
    ..By performing expression QTL analyses, we identified a splice site variant in CHCHD7 and exploited this naturally occurring null allele to exclude CHCHD7 as single causative gene...
  9. doi request reprint Serial translocation by means of circular intermediates underlies colour sidedness in cattle
    Keith Durkin
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, 4000 Liege Sart Tilman, Belgium
    Nature 482:81-4. 2012
    ..This is the first example, to our knowledge, of a phenotype determined by homologous yet non-syntenic alleles that result from a novel copy-number-variant-generating mechanism...
  10. pmc Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle
    Wouter Coppieters
    Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, Liege, Belgium
    BMC Genomics 10:96. 2009
    ..Sustainable control strategies complementing anthelmintics are desired, including selective breeding for enhanced resistance...
  11. pmc A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle
    Arnaud Sartelet
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liège B34, 1 Avenue de l Hopital, 4000 Liege Sart Tilman, Belgium
    Dis Model Mech 7:119-28. 2014
    ..These data provide first evidence that accelerated ClC-7/Ostm1 gating per se is deleterious, highlighting a physiological importance of the slow voltage-activation of ClC-7/Ostm1 in lysosomal function and bone resorption. ..
  12. pmc Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle
    Corinne Fasquelle
    Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 5:e1000666. 2009
    ....
  13. doi request reprint Results of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse
    Marie Capucine Dupuis
    Unit of Animal Genetics, GIGA Research, Faculty of Veterinary Medicine, University of Liege, 1 Avenue de l Hopital, B 4000 Liege, Belgium
    Mamm Genome 22:613-20. 2011
    ..62 × 10(-6)) and 31 (p = 1.69 × 10(-5)). The two signals were driven by the enrichment of a "protective" haplotype in controls compared to cases...