Luc Dirix

Summary

Country: Belgium

Publications

  1. pmc Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
    Luc Y Dirix
    Oncology Center, AZ St Augustinus Oosterveldlaan 24, 2610 Wilrijk, Belgium
    Br J Cancer 86:389-95. 2002
  2. ncbi request reprint Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
    Gert G Van den Eynden
    Translational Cancer Research Group Antwerp, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Breast Cancer Res Treat 95:219-28. 2006
  3. ncbi request reprint Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding
    Steven J Van Laere
    Translational Cancer Research Group Laboratory of Pathology, University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 12:3249-56. 2006
  4. ncbi request reprint Inflammatory breast cancer: current understanding
    Luc Y Dirix
    Oncology Center, Multidisciplinary Breast Clinic, AZ Algemeen Ziekenhuis Sint Augustinus, Antwerp, Belgium
    Curr Opin Oncol 18:563-71. 2006
  5. pmc Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
    Aki Morikawa
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Breast Cancer Res 7:R1051-7. 2005
  6. pmc Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer
    Ina H Benoy
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Breast Cancer Res 7:R210-9. 2005
  7. ncbi request reprint Gene-expression profiling to classify soft-tissue sarcomas
    Luc Y Dirix
    AZ St Augustinus, 2610, Wilrijk, Belgium
    Lancet 359:1263-4. 2002
  8. ncbi request reprint Genomics and circulating tumor cells: promising tools for choosing and monitoring adjuvant therapy in patients with early breast cancer?
    Luc Dirix
    Oncology Center, Algemeen Ziekenhuis Sint Augustinus, Antwerp, Belgium
    Curr Opin Oncol 17:551-8. 2005
  9. doi request reprint Relapse-free survival in breast cancer patients is associated with a gene expression signature characteristic for inflammatory breast cancer
    Steven Van Laere
    Translational Cancer Research Group, Laboratory of Pathology, University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 14:7452-60. 2008
  10. doi request reprint Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer
    Maurice P H M Jansen
    Authors Affiliations Department of Medical Oncology, Erasmus University Medical Center, Cancer Institute, Rotterdam Departments of Molecular Carcinogenesis and Molecular Pathology, Central Genomic Facility, the Netherlands Cancer Institute Agendia NV, Amsterdam, the Netherlands and Translational Cancer Research Unit, Laboratory of Pathology, Antwerp University Oncology Centre, GZA Hospitals St Augustinus, Antwerp, Belgium
    Cancer Res 73:6632-41. 2013

Collaborators

Detail Information

Publications31

  1. pmc Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
    Luc Y Dirix
    Oncology Center, AZ St Augustinus Oosterveldlaan 24, 2610 Wilrijk, Belgium
    Br J Cancer 86:389-95. 2002
    ..A role of interleukin-6, by influencing both angiogenesis and haemostasis, is suggested by these observations...
  2. ncbi request reprint Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
    Gert G Van den Eynden
    Translational Cancer Research Group Antwerp, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Breast Cancer Res Treat 95:219-28. 2006
    ..In this study we sought to investigate the role of caveolin-1 and -2 in IBC cell lines and in human IBC samples...
  3. ncbi request reprint Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding
    Steven J Van Laere
    Translational Cancer Research Group Laboratory of Pathology, University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 12:3249-56. 2006
    ..This led to the hypothesis that NF-kappaB contributes to the phenotype of IBC. The aim of the present study was to further investigate the role of NF-kappaB in IBC...
  4. ncbi request reprint Inflammatory breast cancer: current understanding
    Luc Y Dirix
    Oncology Center, Multidisciplinary Breast Clinic, AZ Algemeen Ziekenhuis Sint Augustinus, Antwerp, Belgium
    Curr Opin Oncol 18:563-71. 2006
    ..The purpose of this review is to highlight recent advances in the molecular modus operandi of this particular form of breast cancer...
  5. pmc Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
    Aki Morikawa
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Breast Cancer Res 7:R1051-7. 2005
    ..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
  6. pmc Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer
    Ina H Benoy
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Breast Cancer Res 7:R210-9. 2005
    ....
  7. ncbi request reprint Gene-expression profiling to classify soft-tissue sarcomas
    Luc Y Dirix
    AZ St Augustinus, 2610, Wilrijk, Belgium
    Lancet 359:1263-4. 2002
  8. ncbi request reprint Genomics and circulating tumor cells: promising tools for choosing and monitoring adjuvant therapy in patients with early breast cancer?
    Luc Dirix
    Oncology Center, Algemeen Ziekenhuis Sint Augustinus, Antwerp, Belgium
    Curr Opin Oncol 17:551-8. 2005
    ..The purpose of this review is to highlight the recent data emerging from both approaches as a means of assessing prognosis and tailoring therapy in patients with early breast cancer...
  9. doi request reprint Relapse-free survival in breast cancer patients is associated with a gene expression signature characteristic for inflammatory breast cancer
    Steven Van Laere
    Translational Cancer Research Group, Laboratory of Pathology, University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 14:7452-60. 2008
    ....
  10. doi request reprint Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer
    Maurice P H M Jansen
    Authors Affiliations Department of Medical Oncology, Erasmus University Medical Center, Cancer Institute, Rotterdam Departments of Molecular Carcinogenesis and Molecular Pathology, Central Genomic Facility, the Netherlands Cancer Institute Agendia NV, Amsterdam, the Netherlands and Translational Cancer Research Unit, Laboratory of Pathology, Antwerp University Oncology Centre, GZA Hospitals St Augustinus, Antwerp, Belgium
    Cancer Res 73:6632-41. 2013
    ..The classification potential of these genes was only partially preserved in a cohort of 101 patients who received first-line tamoxifen treatment, suggesting some treatment selectivity in patient classification...
  11. pmc A dynamic clinical pathway for the treatment of patients with early breast cancer is a tool for better cancer care: implementation and prospective analysis between 2002-2010
    Peter A van Dam
    Breast Unit, Department of Gynecology, Sint Augustinus Hospital, Wilrijk, Belgium
    World J Surg Oncol 11:70. 2013
    ..They also aim to re-centre the focus on the patient's overall journey, rather than the contribution of each specialty or caring function independently...
  12. ncbi request reprint Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling
    Steven J Van Laere
    Translational Cancer Research Group, Lab Pathology University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Breast Cancer Res Treat 95:243-55. 2006
    ....
  13. ncbi request reprint Detection of circulating tumour cells in blood by quantitative real-time RT-PCR: effect of pre-analytical time
    Ina H Benoy
    Translational Cancer Research Group Antwerp, Pathology Laboratory, University of Antwerp University Hospital Antwerp, Edegem, and Oncology Centre, General Hospital St Augustinus, Wilrijk, Belgium
    Clin Chem Lab Med 44:1082-7. 2006
    ..The copy number of mRNA can change during storage and transport at room temperature and this may hamper accurate quantitative measurements of specific transcripts, especially when working with small numbers of target mRNAs...
  14. ncbi request reprint Sentinel node metastasis in the groin detected by technetium-labeled nannocolloid in a patient with cervical cancer
    Jan Hauspy
    Department of Obstetrics and Gynecology, Sint Augustinus Hospital, Antwerp, Belgium
    Gynecol Oncol 86:358-60. 2002
    ..The aim of this study was to describe the first sentinel groin node metastasis detected by technetium-labeled nanocolloid in a patient with cervical carcinoma...
  15. ncbi request reprint Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer
    Gert G Van den Eynden
    Translational Cancer Research Group Lab Pathology, University of Antwerp University Hospital Antwerp, Oncology Center, General Hospital, St Augustinus, Wilrijk, Antwerp 2610, Belgium
    Clin Exp Metastasis 24:13-23. 2007
    ..The aim of this study was to compare expression of hypoxia and (lymph)angiogenesis-related genes between primary breast tumors and metastases in different tissues...
  16. ncbi request reprint Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node
    Gert G Van den Eynden
    Translational Cancer Research Group Lab Pathology, University of Antwerp University Hospital Antwerp, Wilrijk Oncology Center, General Hospital St Augustinus, Wilrijk, Belgium, Antwerp, Belgium
    Clin Cancer Res 13:5391-7. 2007
    ....
  17. ncbi request reprint Robotic-assisted laparoscopic cytoreductive surgery for lobular carcinoma of the breast metastatic to the ovaries
    Peter A van Dam
    Department of Obstetrics and Gynecology, Sint Augustinus Hospital Antwerp, Belgium
    J Minim Invasive Gynecol 14:746-9. 2007
    ..She was further treated with adjuvant exemestane and is currently doing well. It is possible to treat selected patients with malignant ovarian tumors by robotic-assisted laparoscopy...
  18. doi request reprint Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer
    Gert G Van den Eynden
    Translational Cancer Research Group Lab Pathology University of Antwerp University Hospital Antwerp, Wilrijk, Belgium
    Clin Cancer Res 14:2944-52. 2008
    ..Little is known about the molecular pathways involved...
  19. pmc Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    Robert J Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4883-90. 2008
    ....
  20. ncbi request reprint Serum interleukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients
    Ina Benoy
    Angiogenesis Group, Oncology Center, St Augustinus Hospital, Wilrijk Antwerp, Belgium
    Clin Breast Cancer 2:311-5. 2002
    ..These results suggest a role for tumor-derived IL-6 in regulating VEGF expression in platelets and their precursors and also confirm the role of circulating platelets in the storage of VEGF...
  21. ncbi request reprint Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer
    Ina H Benoy
    Translational Cancer Research Group Antwerp, Wilrijk, Belgium
    Clin Breast Cancer 7:146-52. 2006
    ..Bone marrow samples from a large cohort of patients with breast cancer were analyzed for the presence of DTC by immunocytochemistry (ICC) or a molecular-based method...
  22. ncbi request reprint Circulating interleukin-6 predicts survival in patients with metastatic breast cancer
    Roberto Salgado
    Angiogenesis Group, Oncological Centre, A Z St Augustinus, Wilrijk Antwerp, Belgium
    Int J Cancer 103:642-6. 2003
    ..We conclude that circulating IL-6 is associated with worse survival in patients with metastatic breast cancer and is correlated with the extent of disease...
  23. ncbi request reprint Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study
    Ilse Van der Auwera
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Clin Cancer Res 11:7637-42. 2005
    ..The objective of this study was twofold: (a) to determine which is the most suitable marker of lymph vessels in primary breast tumors and (b) to compare histomorphometric lymph vessel variables in IBC and non-IBC...
  24. ncbi request reprint Commentary re: N. J. McCarthy et al., microvessel density, expression of estrogen receptor alpha, MIB-1, p53 and c-erbB-2 in inflammatory breast cancer. Clin. Cancer Res., 8: 3857-3862, 2002
    Cecile G Colpaert
    Clin Cancer Res 9:3815-6; author reply 3816. 2003
  25. ncbi request reprint Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    Ina H Benoy
    Translational Cancer Research Group Antwerp, University of Antwerp, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 10:7157-62. 2004
    ..The predictive value of serum IL-8 for the presence of occult metastatic tumor cells in bone marrow aspirates was evaluated in patients with operable and metastatic breast cancer...
  26. ncbi request reprint Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification
    Ilse Van der Auwera
    Translational Cancer Research Group Antwerp Lab Pathology University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Clin Cancer Res 10:7965-71. 2004
    ..The aim of this study was to confirm the angiogenic phenotype of inflammatory breast cancer and to investigate its potential to induce lymphangiogenesis...
  27. ncbi request reprint Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis
    Steven Van Laere
    Translational Cancer Research Group, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem and General Hospital, Sint Augustinus, Wilrijk, Belgium
    Breast Cancer Res Treat 93:237-46. 2005
    ..The results of our study provide potential targets for the treatment of patients with IBC...
  28. ncbi request reprint Sentinel node detection in patients with vaginal carcinoma
    Peter Van Dam
    Department of Obstetrics and Gynecology, Sint Augustinus Hospital, Antwerp, Belgium
    Gynecol Oncol 92:89-92. 2004
    ..The objective was to describe sentinel ode detection in patients with primary and recurrent vaginal carcinoma...
  29. ncbi request reprint The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis
    Cecile G Colpaert
    Department of Pathology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium
    Breast Cancer Res Treat 81:137-47. 2003
    ..FF is useful as a surrogate marker of hypoxia-driven ongoing angiogenesis and is associated with a higher relapse rate and a worse overall survival...
  30. ncbi request reprint Letter to the editor: Lymphangiogenesis in primary breast cancer
    Gert G Van den Eynden
    Cancer Lett 256:279-81; author reply 283-4. 2007
  31. ncbi request reprint Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma
    Roberto Salgado
    Cancer 101:431-2; author reply 432-3. 2004