Olivier Devuyst

Summary

Country: Belgium

Publications

  1. ncbi request reprint Chloride channels and endocytosis: new insights from Dent's disease and ClC-5 knockout mice
    Olivier Devuyst
    Division of Nephrology, CELL Unit, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephron Physiol 99:p69-73. 2005
  2. doi request reprint Mutations in RPGRIP1L: extending the clinical spectrum of ciliopathies
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 23:1500-3. 2008
  3. ncbi request reprint Aquaporin-1 in the peritoneal membrane: Implications for water transport across capillaries and peritoneal dialysis
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Biochim Biophys Acta 1758:1078-84. 2006
  4. ncbi request reprint Variable renal disease progression in autosomal dominant polycystic kidney disease: a role for nitric oxide?
    Olivier Devuyst
    Department of Nephrology, Catholic University of Louvain Medical School, Brussels, Belgium
    J Nephrol 16:449-52. 2003
  5. ncbi request reprint Aquaporin-1 in the peritoneal membrane: implications for peritoneal dialysis and endothelial cell function
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Biol Cell 97:667-73. 2005
  6. ncbi request reprint Molecular mechanisms involved in the peritoneal membrane exposed to peritoneal dialysis
    O Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Nefrologia 23:32-7. 2003
  7. ncbi request reprint Genetics of hypercalciuric stone forming diseases
    O Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 72:1065-72. 2007
  8. ncbi request reprint Expression of CFTR in human and bovine thyroid epithelium
    O Devuyst
    Department of Physiology, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA
    Am J Physiol 272:C1299-308. 1997
  9. ncbi request reprint [Variable progression of autosomal dominant polycystic kidney disease: genetic and molecular counterparts]
    Olivier Devuyst
    Service de Nephrologie, Cliniques Universitaires Saint Luc, Faculte de Medecine, Universite Catholique de Louvain, 10, Avenue Hippocrate, 1200 Bruxelles, Belgique
    Nephrol Ther 2:S104-8. 2006
  10. ncbi request reprint The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland
    Marie France van den Hove
    Cell Biology Unit ICP UCL 7541, 75 av Hippocrate, B 1200 Brussels, Belgium
    Endocrinology 147:1287-96. 2006

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Chloride channels and endocytosis: new insights from Dent's disease and ClC-5 knockout mice
    Olivier Devuyst
    Division of Nephrology, CELL Unit, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephron Physiol 99:p69-73. 2005
    ..These studies also provided insights into important functions such as apical endocytosis, handling of proteins by renal tubular cells, calcium metabolism, and urinary acidification...
  2. doi request reprint Mutations in RPGRIP1L: extending the clinical spectrum of ciliopathies
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 23:1500-3. 2008
  3. ncbi request reprint Aquaporin-1 in the peritoneal membrane: Implications for water transport across capillaries and peritoneal dialysis
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Biochim Biophys Acta 1758:1078-84. 2006
    ..They also emphasize the critical role of AQP1 during peritoneal dialysis and suggest that manipulating AQP1 expression may be used to increase water permeability across the peritoneal membrane...
  4. ncbi request reprint Variable renal disease progression in autosomal dominant polycystic kidney disease: a role for nitric oxide?
    Olivier Devuyst
    Department of Nephrology, Catholic University of Louvain Medical School, Brussels, Belgium
    J Nephrol 16:449-52. 2003
    ..These results also suggest that polycystins can participate in the regulation of endothelial NO synthase (eNOS) and that addressing endothelial dysfunction in ADPKD can offer a new perspective to slow renal disease progression...
  5. ncbi request reprint Aquaporin-1 in the peritoneal membrane: implications for peritoneal dialysis and endothelial cell function
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Biol Cell 97:667-73. 2005
    ..The results also emphasize the critical role of AQP1 during PD and suggest that manipulation of AQP1 expression may be used to increase water permeability across the PM...
  6. ncbi request reprint Molecular mechanisms involved in the peritoneal membrane exposed to peritoneal dialysis
    O Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Nefrologia 23:32-7. 2003
  7. ncbi request reprint Genetics of hypercalciuric stone forming diseases
    O Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 72:1065-72. 2007
    ..We also discuss novel strategies that may help to unravel the genetic bases of such complex conditions...
  8. ncbi request reprint Expression of CFTR in human and bovine thyroid epithelium
    O Devuyst
    Department of Physiology, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA
    Am J Physiol 272:C1299-308. 1997
    ..These results 1) demonstrate the expression of CFTR at the mRNA and protein levels in human and bovine thyroid follicular cells and 2) suggest that CFTR expression could be instrumental in follicular enlargement...
  9. ncbi request reprint [Variable progression of autosomal dominant polycystic kidney disease: genetic and molecular counterparts]
    Olivier Devuyst
    Service de Nephrologie, Cliniques Universitaires Saint Luc, Faculte de Medecine, Universite Catholique de Louvain, 10, Avenue Hippocrate, 1200 Bruxelles, Belgique
    Nephrol Ther 2:S104-8. 2006
    ..Substantiating the role of modifier genes will require large familial studies but will probably offer new perspectives to slow renal disease progression in ADPKD...
  10. ncbi request reprint The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland
    Marie France van den Hove
    Cell Biology Unit ICP UCL 7541, 75 av Hippocrate, B 1200 Brussels, Belgium
    Endocrinology 147:1287-96. 2006
    ..Instead, the goiter associated with ClC-5 KO results from impaired rate of apical iodide efflux by down-regulation of pendrin expression...
  11. pmc Nitric oxide synthase isoforms play distinct roles during acute peritonitis
    Jie Ni
    Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 25:86-96. 2010
    ..Increased nitric oxide (NO) release by NO synthase (NOS) isoforms has been implicated in acute peritonitis, but the role played by the NOS isoforms expressed in the peritoneum is unknown...
  12. pmc ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells
    Wânia R Lima
    CELL Unit, de Duve Institute and Université, Catholique de Louvain, Brussels, Belgium
    J Am Soc Nephrol 21:478-88. 2010
    ....
  13. doi request reprint Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Physiol Renal Physiol 298:F454-60. 2010
    ..These data show that SPECT imaging with well-validated radiotracers allows in vivo investigations of specific proximal tubule functions in conscious mice...
  14. doi request reprint Progression of coronary artery calcification and thoracic aorta calcification in kidney transplant recipients
    Céline Maréchal
    Division of Nephrology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Kidney Dis 59:258-69. 2012
    ..Longitudinal studies of vascular calcification in KTRs are few and small and have short follow-up. We assessed the evolution of coronary artery (CAC) and thoracic aorta calcification and their determinants in a cohort of prevalent KTRs...
  15. pmc Renal expression of parvalbumin is critical for NaCl handling and response to diuretics
    Hendrica Belge
    Department of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 104:14849-54. 2007
    ..They also provide insights into the Ca(2+)-sparing action of thiazides and the pathophysiology of distal tubulopathies...
  16. ncbi request reprint PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice
    Ali K Ahrabi
    Division of Nephrology, UCL Medical School, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 18:1740-53. 2007
    ..These data give new insights in the potential roles of polycystin-1 in the AVP and Ca(2+) signaling and the trafficking of AQP2 in the CD...
  17. ncbi request reprint Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5
    Francois Jouret
    Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 65:198-208. 2004
    ..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...
  18. pmc Serum fetuin-A levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients
    Céline Maréchal
    Division of Nephrology, Cliniques Universitaires Saint Luc, UCL Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Clin J Am Soc Nephrol 6:974-85. 2011
    ..We studied the determinants of fetuin-A, a potent circulating calcification inhibitor encoded by the AHSG gene, and tested its association with vascular calcifications and long-term survival and cardiovascular events (CVEs) in RTRs...
  19. ncbi request reprint Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studies
    Gaëlle Gillerot
    Division of Nephrology and Department of Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 64:1883-92. 2003
    ..Although the fibrotic process has been documented in extrarenal tissues, the involvement of the peritoneum, as well as the efficacy of peritoneal dialysis in AAN patients, remain uncertain...
  20. doi request reprint PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta
    Nicole Morel
    Laboratoire de Physiologie Cellulaire, Universite Catholique de Louvain, Avenue Hippocrate 55, UCL 5540, Brussels, Belgium
    Pflugers Arch 457:845-56. 2009
    ....
  21. ncbi request reprint Functional and molecular characterization of a peritoneal dialysis model in the C57BL/6J mouse
    Jie Ni
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 67:2021-31. 2005
    ..Genetically modified mice could provide an attractive alternative to the above models. In this study, we have characterized PD parameters and tested the effect of gender and dialysate volume and/or osmolality in the C57BL/6J mouse...
  22. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ....
  23. ncbi request reprint Corticosteroids induce expression of aquaporin-1 and increase transcellular water transport in rat peritoneum
    Maria S Stoenoiu
    Division of Nephrology and ENDO Unit, Université Catholique de Louvain Medical School, Brussels, Belgium
    J Am Soc Nephrol 14:555-65. 2003
    ..These data emphasize the critical role of AQP1 during PD and suggest that pharmacologic regulation of AQP1 may provide a target for manipulating water permeability across the PM...
  24. ncbi request reprint High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease
    Valeriu Cebotaru
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 68:642-52. 2005
    ..Dent's disease results from mutations of the voltage-gated chloride channel CLC-5...
  25. doi request reprint Diagnosis of cyst infection in patients with autosomal dominant polycystic kidney disease: attributes and limitations of the current modalities
    Francois Jouret
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 27:3746-51. 2012
    ..This review summarizes the attributes and limitations of these recent clinical, biological and imaging advances in the diagnosis of cyst infection in patients with ADPKD...
  26. ncbi request reprint Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA...
  27. ncbi request reprint Transcriptional and functional analyses of SLC12A3 mutations: new clues for the pathogenesis of Gitelman syndrome
    Eva Riveira-Munoz
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    J Am Soc Nephrol 18:1271-83. 2007
    ..These data suggest that the nature/position of SLC12A3 mutation, combined with male gender, is a determinant factor in the severity of GS and provide new insights in the underlying pathogenic mechanisms of the disease...
  28. doi request reprint Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion
    Ali K Ahrabi
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 25:1067-78. 2010
    ..The homozygous deletion of Pkd1 in the mouse results in embryonic lethality with renal cysts and hydrops fetalis, but there is no precise data on the segmental origin of cysts and potential changes associated with polyhydramnios...
  29. doi request reprint A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid
    Maximin Senou
    Unité de Morphologie Expérimentale, Universite Catholique de Louvain, UCL 5251, 52 Avenue E Mounier, B 1200 Brussels, Belgium
    J Clin Endocrinol Metab 95:4021-30. 2010
    ..Pendred syndrome is caused by mutations in the gene coding for pendrin, an apical Cl-/I- exchanger...
  30. ncbi request reprint Genetic and clinical factors influence the baseline permeability of the peritoneal membrane
    Gaëlle Gillerot
    Division of Nephrology, and Division of Epidemiology and Statistics, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 67:2477-87. 2005
    ..The latter parameter determines dialysis prescription and survival. Clinical factors probably influence solute transport across the PM, but the putative role of genetic variants is unknown...
  31. ncbi request reprint Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 18:707-18. 2007
    ..The magnitude of the endocytosis defect that is caused by CFTR versus ClC-5 loss likely reflects functional heterogeneity along the PT...
  32. doi request reprint Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome
    Eva Riveira-Munoz
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels B 1200, Belgium
    Nephrol Dial Transplant 23:3120-5. 2008
    ..Locus heterogeneity could explain the lack of detection of mutant SLC12A3 alleles in GS patients. The renal phenotype of the parvalbumin knockout mice pointed to PVALB as a candidate gene for GS for SLC12A3-negative cases...
  33. ncbi request reprint Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis
    Jie Ni
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Perit Dial Int 25:S11-4. 2005
    ..These results confirm that increased NO mediates permeability modifications during acute peritonitis, and illustrate the potential of mouse models to investigate the molecular mechanisms regulating peritoneal permeability...
  34. doi request reprint Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease
    Claudia Raggi
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Pflugers Arch 462:851-60. 2011
    ..They also demonstrate that the functional loss of these two chloride transporters is associated with impaired uptake of AG in PT cells, reflected by a decreased renal accumulation of the drug...
  35. ncbi request reprint Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla
    Pierre Moulin
    Unit of Pathology, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    J Mol Endocrinol 38:409-22. 2007
    ..The complete protein is addressed to the plasma membrane and the shorter one to the membrane of secretory granules where its function remains to be established...
  36. doi request reprint The pathophysiology of the peritoneal membrane
    Olivier Devuyst
    Division of Nephrology, UCL Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 21:1077-85. 2010
    ..These studies are relevant to mechanisms responsible not only for the major complications of PD but also for endothelial biology, host defense, inflammation, and tissue repair processes...
  37. ncbi request reprint Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients
    Pierre Moulin
    Division of Pathology, and Cell Unit, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 63:1285-95. 2003
    ..Examinations of knockout mice have established the role of ClC-5 in PT endocytosis, but the consequences of ClC-5 mutations on the polarity of H+-ATPase and other plasma membrane proteins remain unknown...
  38. doi request reprint Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease
    Sara Terryn
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200, Brussels, Belgium
    Biochim Biophys Acta 1812:1314-21. 2011
    ..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
  39. doi request reprint A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway
    Salvatore Bellavia
    Division of Nephrology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Bruxelles, Belgium
    Nephrol Dial Transplant 25:4097-102. 2010
    ..This case shows that INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt/β-catenin pathway...
  40. doi request reprint Positron-emission computed tomography in cyst infection diagnosis in patients with autosomal dominant polycystic kidney disease
    Francois Jouret
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Clin J Am Soc Nephrol 6:1644-50. 2011
    ..In most patients, conventional imaging techniques are inconclusive. Isolated observations suggest that (18)fluorodeoxyglucose (¹⁸FDG) positron-emission computed tomography (PET/CT) might help detect cyst infection in ADPKD patients...
  41. ncbi request reprint Icodextrin-associated peritonitis: what conclusions thus far?
    Eric Goffin
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 18:2482-5. 2003
  42. ncbi request reprint Genotyping: a new application for the spent dialysate in peritoneal dialysis
    Gaëlle Gillerot
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 19:1298-301. 2004
    ..We hypothesized that the cells contained in spent dialysate samples obtained at the time of the peritoneal equilibration test (PET) and subsequently stored may represent a source of DNA from a given PD patient...
  43. ncbi request reprint Mice that lack endothelial nitric oxide synthase are protected against functional and structural modifications induced by acute peritonitis
    Jie Ni
    Divisions of Nephrology, Pathology, Experimental Surgery, and Pharmacotherapy, Université Catholique de Louvain Medical School, Brussels, Belgium
    J Am Soc Nephrol 14:3205-16. 2003
    ..The characterization of this mouse model suggests that genetically modified mice represent useful tools to investigate the molecular bases of the peritoneal changes during peritoneal dialysis...
  44. doi request reprint Segmental and subcellular distribution of CFTR in the kidney
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200, Brussels, Belgium
    Methods Mol Biol 741:285-99. 2011
    ..The segmental and subcellular distribution of CFTR in mouse kidney supports a role for CFTR in PT receptor-mediated endocytosis of ultrafiltered LMW proteins...
  45. doi request reprint Coronary artery calcification: a strong predictor of cardiovascular events in renal transplant recipients
    Pauline T H Nguyen
    Nephrology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 25:3773-8. 2010
    ..Whether this applies to renal transplant recipients (RTR) is unknown. This prospective study assessed the prognostic impact of CAC on CVE in RTR...
  46. doi request reprint CFTR and defective endocytosis: new insights in the renal phenotype of cystic fibrosis
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, Avenue Hippocrate, 10, 1200 Brussels, Belgium
    Pflugers Arch 457:1227-36. 2009
    ..The selective proteinuria should be integrated in the pathophysiology of multi-systemic complications increasingly observed in CF patients...
  47. ncbi request reprint Transgenic mouse models
    Tomoya Nishino
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, Brussels, Belgium
    Perit Dial Int 27:625-33. 2007
    ....
  48. ncbi request reprint Regulation of NO synthase isoforms in the peritoneum: implications for ultrafiltration failure in peritoneal dialysis
    O Devuyst
    Division of Nephrology, , Medical School, Brussels, Belgium
    Nephrol Dial Transplant 16:675-8. 2001
    ..Other biological consequences of increased NO levels in the peritoneum might include initiation of angiogenesis or modification of functionally important proteins such as AQP1...
  49. pmc Increased protein glycation in fructosamine 3-kinase-deficient mice
    Maria Veiga da-Cunha
    Laboratory of Physiological Chemistry, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochem J 399:257-64. 2006
    ..Taken together, these data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine...
  50. ncbi request reprint The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover
    Ian V Silva
    Department of Physiology, The Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Bone Miner Res 18:615-23. 2003
    ..These mice data suggest that young patients with this disease may have a propensity for altered bone homeostasis that should be monitored clinically...
  51. ncbi request reprint Comparison between siblings and twins supports a role for modifier genes in ADPKD
    Alexandre Persu
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 66:2132-6. 2004
    ..The analysis of variability in affected siblings and monozygotic (MZ) twins would help evaluate the relative contribution of environment and genetic factors on renal disease progression in ADPKD...
  52. doi request reprint Parvalbumin: calcium and magnesium buffering in the distal nephron
    Eric Olinger
    Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    Nephrol Dial Transplant 27:3988-94. 2012
    ..PV is also considered a reliable marker of chromophobe carcinoma and oncocytoma, two neoplasms deriving from the distal nephron. The putative role of PV in tumour genesis remains to be investigated...
  53. doi request reprint A new role for aquaporin 7 in insulin secretion
    Karim Louchami
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Physiol Biochem 29:65-74. 2012
    ..BACGROUNS/AIMS: Several insulinotropic agents were recently reported to cause β-cell swelling. The possible participation of AQP7 to water transport was investigated in AQP7(+/+) or AQP7(-/-) mice...
  54. doi request reprint The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system
    Eileen Pernot
    Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire, Brussels, Belgium
    Pflugers Arch 462:871-83. 2011
    ..Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts...
  55. doi request reprint Carbohydrate antigen 19-9 as a diagnostic marker for hepatic cyst infection in autosomal dominant polycystic kidney disease
    Nada Kanaan
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Am J Kidney Dis 55:916-22. 2010
    ..Although further study is necessary, these data suggest that serum CA 19-9 level is markedly increased during liver cyst infection in kidney transplant recipients with ADPKD and has potential utility as a diagnostic marker...
  56. ncbi request reprint Peritoneal membrane transport: driving under the influence
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Perit Dial Int 26:35-7. 2006
  57. ncbi request reprint Recombinant adenovirus administration in rat peritoneum: endothelial expression and safety concerns
    Maria Dolores Martin-Martinez
    Department of Biochemistry and Nutrition, Medical School, Universite Libre de Bruxelles, Brussels, Belgium
    Nephrol Dial Transplant 19:1293-7. 2004
    ....
  58. ncbi request reprint Influence of ACE (I/D) and G460W polymorphism of alpha-adducin in autosomal dominant polycystic kidney disease
    Alexandre Persu
    Division of Nephrology, Université Catholique de Louvain Medical School, 1200 Brussels, Belgium
    Nephrol Dial Transplant 18:2032-8. 2003
    ..Small sample size, population admixture and lack of consideration of parameters modulating the effects of ACE genotype, such as gender or alpha-adducin (ADD) genotype, might explain the discrepancy...
  59. ncbi request reprint Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines
    Deanne H Hryciw
    Department of Physiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 278:40169-76. 2003
    ..This study identifies a novel interaction between the C-terminal tail of ClC-5 and cofilin, an actin-associated protein that is crucial in the regulation of albumin uptake by the proximal tubule...
  60. ncbi request reprint Endocytosis of the somatostatin analogue, octreotide, by the proximal tubule-derived opossum kidney (OK) cell line
    Raffaella Barone
    Center of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium
    Kidney Int 67:969-76. 2005
    ..To define the mechanisms of internalization and to identify potential receptors, we have studied the uptake and processing of octreotide by the PTC-derived opossum kidney (OK) cell line...
  61. pmc Dent's disease
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Orphanet J Rare Dis 5:28. 2010
    ..The vital prognosis is good in the majority of patients. Progression to end-stage renal failure occurs between the 3rd and 5th decades of life in 30-80% of affected males...
  62. doi request reprint A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis
    Peggy Raynaud
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 53:1959-66. 2011
    ..In HNF1β-deficient liver, maturation of the primitive ductal structures was impaired. Normal differentiation and maturation but abnormal duct expansion was apparent in cpk mouse livers and in human fetal ARPKD...
  63. ncbi request reprint Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice
    Maximin Senou
    Unité de Morphologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 297:E438-51. 2009
    ..Because the expression and subcellular localization of caveolin-1 were similar between normal human and murine thyroids, our findings in caveolin-1 knockout mice may have direct relevance to the human counterpart...
  64. ncbi request reprint A novel splicing mutation in SLC12A3 associated with Gitelman syndrome and idiopathic intracranial hypertension
    Nathalie Godefroid
    Department of Pediatrics, Division of Nephrology, Center for Human Genetics, Université Catholique de Louvain Medical School, Saint Luc Academic Hospital, Brussels, Belgium
    Am J Kidney Dis 48:e73-9. 2006
    ..This study provides further evidence for the phenotypical heterogeneity of GS and its association with severe manifestations in children. It also shows the independent segregation of familial cavernomatosis and GS...
  65. ncbi request reprint Prevalence and determinants of coronary and aortic calcifications assessed by chest CT in renal transplant recipients
    Pauline T H Nguyen
    Nephrology, Cliniques Universitaires St Luc, Brussels, Belgium
    Am J Nephrol 27:329-35. 2007
    ..We assessed the prevalence and determinants of coronary (CAC) and thoracic aorta (AoC) calcifications in renal transplant recipients (RTR)...
  66. ncbi request reprint Basolateral chloride transporters in autosomal dominant polycystic kidney disease
    Catherine Lebeau
    Department of Physiopathology, Universite Libre de Bruxelles, Brussels, Belgium
    Pflugers Arch 444:722-31. 2002
    ..AE1 might be an alternative basolateral pathway for Cl(-) in a minority of cysts...
  67. ncbi request reprint Chloride channels in the kidney: lessons learned from knockout animals
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Am J Physiol Renal Physiol 283:F1176-91. 2002
    ..Furthermore, observations made in CF mice are potentially relevant to all other models of Cl- channel knockouts because they emphasize the importance of alternative Cl- pathways in such models...
  68. ncbi request reprint A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin
    Karin Dahan
    Universite Catholique de Louvain, Center for Human Genetics, Brussels, Belgium
    J Am Soc Nephrol 14:2883-93. 2003
    ..Mutations in UMOD may critically affect the function of uromodulin, resulting in abnormal accumulation within tubular cells and reduced urinary excretion...
  69. ncbi request reprint Metabolic effects of amino acid solutions infused for renal protection during therapy with radiolabelled somatostatin analogues
    Raffaella Barone
    Center of Nuclear Medicine, University of Louvain Medical School, UCL 54 30, Avenue Hippocrate, 54, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 19:2275-81. 2004
    ..In this study, we investigated the metabolic effects related to the infusion of large amounts of amino acids in patients undergoing positron emission tomography (PET) studies with [(86)Y]DOTA(0)-D-Phe(1)-Tyr(3)-octreotide...
  70. ncbi request reprint Sterile chemical peritonitis secondary to icodextrin: immunohistopathological description
    Eric Goffin
    Department of Nephrology, Universite Catholique de Louvain, Cliniques Universitaires St Luc, Brussels, Belgium
    Perit Dial Int 22:723-6. 2002
  71. ncbi request reprint Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study
    Alexandre Persu
    Nephrology Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Hypertens 23:759-65. 2005
    ..Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension...
  72. pmc A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription
    B J Van den Eynde
    Ludwig Institute for Cancer Research, Brussels Branch, B 1200 Brussels, Belgium
    J Exp Med 190:1793-800. 1999
    ..Therefore, this antigen is not tumor specific, but corresponds to a self-antigen with restricted tissue distribution...
  73. ncbi request reprint Nitric oxide is involved in interleukin-1alpha-induced cytotoxicity in polarised human thyrocytes
    M F van den Hove
    Cell Biology Unit, Christian de Duve Institute of Cellular Pathology and Catholic University of Louvain, Medical School, UCL 7541, 75 av Hippocrate, B 1200 Brussels, Belgium
    J Endocrinol 173:177-85. 2002
    ..In contrast, NO does not appear to mediate the cytokine-induced disruption of the thyroid epithelial barrier...
  74. ncbi request reprint Expression of aquaporin-1 in a long-term peritoneal dialysis patient with impaired transcellular water transport
    E Goffin
    Department of Pathology, University of Louvain Medical School, Brussels, Belgium
    Am J Kidney Dis 33:383-8. 1999
    ..We suggest that an alteration of AQP1 structure, rather than of its expression, accounts for this observation...
  75. ncbi request reprint Morphological and functional changes in the dialysed peritoneal cavity: impact of more biocompatible solutions
    Olivier Devuyst
    Division of Nephrology, St Luc Academic Hospital, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 17:12-5. 2002
    ..The introduction of new more biocompatible solutions potentially allows us to reverse or attenuate these negative changes. This will be discussed in the context of our current understanding of peritoneal pathology in PD...
  76. ncbi request reprint Inhibition of nitric oxide synthase reverses changes in peritoneal permeability in a rat model of acute peritonitis
    M L Ferrier
    Division of Nephrology, , Brussels, Belgium
    Kidney Int 60:2343-50. 2001
    ..By itself, NOS inhibition improves UF and reverses permeability changes, which might offer new therapeutic perspectives in acute peritonitis...
  77. ncbi request reprint Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum
    S Combet
    Department of Nephrology, , Avenue Hippocrate 10, B-1200 Brussels, Belgium
    J Am Soc Nephrol 12:2146-57. 2001
    ..These data suggest an independent contribution of uremia in the peritoneal changes during PD and offer a paradigm to better understand the modifications of serosal membranes in uremia...
  78. ncbi request reprint Intrafamilial phenotype variability in nephrogenic diabetes insipidus
    Karine Kalenga
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Kidney Dis 39:737-43. 2002
    ..Thus, in this family, the R137H mutation is associated with either a mild or severe NDI phenotype. Mechanisms that might account for these findings include genetic and/or environmental modifiers...
  79. ncbi request reprint Experimental diabetes induces functional and structural changes in the peritoneum
    Maria S Stoenoiu
    Department of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 62:668-78. 2002
    ..We have used functional, biochemical and molecular studies in vivo and in vitro to substantiate the changes induced by diabetes and hyperglycemia in the PM...
  80. ncbi request reprint Diabetes-induced microvascular dysfunction in the hydronephrotic kidney: role of nitric oxide
    A S De Vriese
    Renal Unit, Gent University, Gent, and Renal Unit, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 60:202-10. 2001
    ..The present study investigated the controversial role of nitric oxide (NO) in the renal vasodilation in streptozotocin-induced diabetic rats...
  81. ncbi request reprint Renal cyst infection in autosomal dominant polycystic kidney disease
    Gabriela Migali
    Divisions of Nephrology and Nuclear Medicine and Department of Radiology, Cliniques Universitaires St Luc, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 23:404-5. 2008
  82. doi request reprint Cell therapy for cystinosis
    Sara Terryn
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 25:2103-6. 2010
    ..This work suggests that BMC or HSC transplantation is a potential treatment for cystinosis and other renal tubular disorders...
  83. ncbi request reprint Both the wild type and a functional isoform of CFTR are expressed in kidney
    M M Morales
    Department of Physiology, Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA
    Am J Physiol 270:F1038-48. 1996
    ..TNR-CFTR mRNA is produced by an unusual mRNA processing mechanism and is expressed in a tissue-specific manner primarily in renal medulla...
  84. ncbi request reprint Modifier effect of ENOS in autosomal dominant polycystic kidney disease
    A Persu
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Hum Mol Genet 11:229-41. 2002
    ..This effect could be due to a decreased NOS activity and a partial cleavage of eNOS, leading to a further decrease in the vascular production of NO...
  85. ncbi request reprint Molecular mechanisms modifying the peritoneal membrane exposed to peritoneal dialysis
    G Gillerot
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Clin Nephrol 60:1-6. 2003
    ..These new insights into the molecular mechanisms operating in the PM have provided rationale for novel therapeutic strategies including the development of glucose-free PD solutions and two-chamber bags...
  86. ncbi request reprint Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis
    J Ni
    Division of Nephrology and Department of Pathology, UCL Medical School, Brussels, Belgium
    Kidney Int 69:1518-25. 2006
    ..They validate essential predictions of the three-pore model: (i) the ultrasmall pores account for the sodium sieving, and (ii) they mediate 50% of UF during a hypertonic dwell...
  87. ncbi request reprint Which type of dialysis in patients with cholesterol crystal embolism?
    Gaëlle Gillerot
    Division of Nephrology, Saint Luc Academic Hospital, UCL Medical School, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Nephrol Dial Transplant 17:156-8. 2002
  88. doi request reprint Epigenetic control of aquaporin 1 expression by the amyloid precursor protein
    Sandra Huysseune
    Universite Catholique de Louvain, Institute of Neuroscience, FARL5410, Ave Hippocrate 54, B 1200 Brussels, Belgium
    FASEB J 23:4158-67. 2009
    ..Since AQP1 is found in astrocytes surrounding senile plaques, this epigenetic control of AQP1 expression could have important implications in Alzheimer disease...
  89. ncbi request reprint Biochemical characterization of bona fide polycystin-1 in vitro and in vivo
    A Boletta
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Kidney Dis 38:1421-9. 2001
    ..Our data represent the first characterization of polycystin-1 performed under highly controlled conditions...
  90. ncbi request reprint Chloride channels and endocytosis: new insights from Dent's disease and CLC-5 knockout mice
    O Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Bull Mem Acad R Med Belg 159:212-7. 2004
    ..These studies also provided insights in important functions such as apical endocytosis, handling of proteins by renal tubular cells, calcium metabolism, and urinary acidification...
  91. ncbi request reprint Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
    S S Wang
    Department of Physiology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Hum Mol Genet 9:2937-45. 2000
    ..Thus, CLC-5-deficient mice provide a model for Dent's disease and this will help in elucidating the function of this chloride channel in endocytosis and renal calcium homeostasis...
  92. ncbi request reprint CF gene and cystic fibrosis transmembrane conductance regulator expression in autosomal dominant polycystic kidney disease
    A Persu
    Division of Nephrology, Universite Catholique de Louvain, Medical School, Brussels, Belgium
    J Am Soc Nephrol 11:2285-96. 2000
    ..These data do not exclude a potential protective role of some CFTR mutations in ADPKD but suggest that it might be related to the nature of the mutation and renal expression of the mutated CFTR...
  93. ncbi request reprint Expression of the beta2-subunit and apical localization of Na+-K+-ATPase in metanephric kidney
    C R Burrow
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol 277:F391-403. 1999
    ....
  94. ncbi request reprint Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
    O Devuyst
    Division of Nephrology and Cell Unit, Christian de Duve Institute of Cellular Pathology, University of LouvainnMedical School, B 1200 Brussels, Belgium
    Hum Mol Genet 8:247-57. 1999
    ..These results help to elucidate further the patho-physiological basis of the renal tubular defects of Dent's disease...
  95. ncbi request reprint A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
    P Gailly
    Division of Cell Physiology, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 74:52-61. 2008
    ..Our study shows that lack of PT ClC-5 in mice and men is associated with CAIII induction, increased cell proliferation, and oxidative stress...
  96. ncbi request reprint Aseptic peritonitis due to peptidoglycan
    Eric Goffin
    Lancet 366:289-90; author reply 290. 2005
  97. ncbi request reprint The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products
    Eric Boulanger
    Laboratoire de Biologie Vasculaire et Cellulaire, INTS, 6 Rue A Cabanel, 75739 Paris cedex 15, France
    Nephrol Dial Transplant 19:2208-16. 2004
    ....
  98. ncbi request reprint Phenotype and genotype: perspectives for peritoneal dialysis patients
    Eric Goffin
    Nephrol Dial Transplant 21:3018-22. 2006
  99. ncbi request reprint Hypertonicity increases CLC-5 expression in mouse medullary thick ascending limb cells
    Phuong Chi Pham
    Renal Division, Department of Medicine, Olive View UCLA Medical Center, Sylmar, CA 91342, USA
    Am J Physiol Renal Physiol 287:F747-52. 2004
    ..We speculate that the increased CLC-5 levels in mTAL may serve to maintain the endocytotic activity in a hypertonic environment...
  100. ncbi request reprint Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes
    Toshio Miyata
    Molecular and Cellular Nephrology, Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
    Kidney Int 61:375-86. 2002
    ..Furthermore, the progresses made in the dissection of the molecular events leading to peritoneal membrane failure open new avenues to develop safe, more biocompatible peritoneal dialysis technologies...
  101. ncbi request reprint Enos polymorphism and renal disease progression in autosomal dominant polycystic kidney disease
    Olivier Devuyst
    Am J Kidney Dis 41:1125. 2003